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30篇 您的检索式:作者名="Wenwei Yu"
    题名 作者 年代 出处 被引量
1The regulation of MDM2 oncogene and its impact on human cancers显示文摘肿瘤 suppressor p53 在阻止肿瘤形成起一个中央作用。p53 的层次和活动在紧密的 regulationto 下面保证它的合适的功能。鼠科的双分钟 2 (MDM2 ) , p53 目标基因,是 E3 ubiquitin ligase。MDM2 是 p53 蛋白质的一个 keynegative 管理者,并且与 p53 形成一个自动调整的反馈环。MDM2 是有两 p53-dependentand 的 oncogene p53 独立的 oncogenic 活动,并且经常在许多人的癌症增加了表示层次。ishighly 调整的 MDM2;MDM2 的层次和功能在 transcriptional 被调整,翻译并且 post-translationallevels。这评论提供 MDM2 的规定的概述。MDM2 的 Dysregulation 在 p53functions 之上显著地影响,并且接着 tumorigenesis。就 MDM2 在人的癌症起的关键作用而言,更好的 understandingof MDM2 的规定将帮助我们得新奇、更有效的癌症在房间指向 MDM2 andactivate p53 的治疗学的策略。Yuhan Zhao Haiyang Yu Wenwei Hu 2014Acta Biochimica et Biophysica Sinica2014,46,3:18
2Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition显示文摘改变的新陈代谢是癌症房间的特点之一。戊糖磷酸盐小径(PPP ) 是细胞的新陈代谢的一个基本部件。Glucose-6-phosphate 脱氢酶(G6PD ) , PPP 的限制率的酶,在许多癌症被提高并且由通过 PPP 生产 ribose-5-phosphate 和 NADPH 贡献肿瘤生长。然而,在 hepatocellular 的 G6PD 的角色癌(HCC ) 转移和在 HCC 前进和预后的 G6PD 的临床的意义一直不是很好坚定的。在这研究,由从 HCC 病人和 HCC 房间线调查织物样品,我们发现那提高的 G6PD 表情显著地与 HCC 转移和差的预后被联系 HCC,和那 G6PD 击倒在 vitro 禁止 HCC 房间线的增长,移植和侵略。进一步的研究表明 G6PD 由通过信号变换器的激活和抄写 3 的使活跃之物(STAT3 ) 导致上皮间充质的转变贡献 HCC 移植和 hepatocellular 癌房间的侵略小径。我们的调查结果建议那指向的 G6PD 能为转移干预开创可能性并且为 HCC 改进病人结果。Ming Lu Lu Lu Qiongzhu Dong Guangyang Yu Jinhong Chen Lunxiu Qin Lianxin Wang Wenwei Zhu Huliang Jia 2018Acta Biochimica et Biophysica Sinica2018,50,4:10
3Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC.Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun 2022Cancer Communications2022,42,12:8
4一种基于sEMG评估上肢康复机器人有效性的方法显示文摘将表面肌电信号(sEMG)运用到上肢康复机器人的有效性评估方面,提供一种方便有效的针对外骨骼康复机器人的训练效果评估方法,有利于针对不同机械结构的外骨骼机器人采用不同的康复医疗方案。利用肌电信号时域分析的积分机电值iEMG和均方根值RMS等肌电信号特征,并结合对肌电图的分析设计出针对六自由度上肢外骨骼机器人的对应训练方案,并对该套机器人系统进行科学的有效性评估。王源 于海龙 Suzuki Hiroyuki 谢叻 Yu Wenwei 李海丽 2013中国数字医学2013,8,2:3
5Human Vγ9Vδ2-T cells efficiently kill influenzavirus-infected lung alveolar epithelial cells显示文摘Hong Li Zheng Xiang Ting Feng Jinrong Li Yinping Liu Yingying Fan Qiao Lu Zhongwei Yin Meixing Yu Chongyang Shen Wenwei Tu 2013Cellular & Molecular Immunology2013,10,2:3
6Mechanisms behind the accelerated extracellular electron transfer in Geobacter sulfurreducens DL-1 by modifying gold electrode with self-assembled monolayers显示文摘有羧基的酸的电极表面的修正终止了自我装配的单层(SAM ) 被发现了是一条有效途径在电极表面上改进电气化学地活跃的细菌(EAB ) 的细胞外的电子转移(EET ) 的 alkanethiol,但是在这后面的内在的机制提高了 EET 遗体不清楚。在这个工作,金电极由 mercapto 醋性的酸和 mercaptoethylamine 修改了(Au-COOH, Au-NH 2) 在与 Geobacter sulfurreducens DL-1,和他们的电气化学的表演接种的微生物引起的电解房间(MEC ) 被用作阳极,细菌电极相互作用被调查。结果证明 Fe (CN )63-/4- 氧化还原作用反应在 Au 或 Au-COOH 上比那与更高的率和一个更低的电阻发生在 Au-NH 2 上。两个都,有 Au-COOH 和 Au-NH 2 阳极的 MEC 与赤裸的 Au 阳极比那展出了更高当前的密度。当 Au-NH 2 上的 biofilm 有更大的厚度时,在 Au-COOH 上形成的 biofilm 在赤裸的 Au 上是比那稠密的,建议在这个系统的直接 EET 的一个关键角色。这个工作建议那如此的 as-COOH and-NH 2 能提拔的功能的组由在电极表面上加速 EAB 的直接 EET 的电极性能。Feng ZHANG Shengsong YU Jie LI Wenwei LI Hanqing YU 2016Frontiers of Environmental Science & Engineering2016,10,3:2
7LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process显示文摘Yi Qin Wenwei Zhu Wenyan Xu Bo Zhang Si Shi Shunrong Ji Jiang Liu Jiang Long Chen Liu Liang Liu Jin Xu Xianjun Yu 2014Cancer Letters2014,,:1
8Review of In‑Vehicle Optical Fiber Communication Technology显示文摘With the continuous development of automotive intelligent networking and autonomous driving technologies,the number of in-vehicle electronic systems and applications is increasing rapidly.This change increases the amount of data to be transmitted in the vehicle and puts forward further requirements of higher speed and safety for in-vehicle communication.Traditional vehicle bus technologies are no longer sufficient to meet today’s high-speed transmission requirements,in which copper cables are used extensively,resulting in serious electromagnetic interference(EMI).Vehicle optical fiber communication technology,besides greatly improving the data transmission rate,has the advantages of anti-EMI,reducing cable space and vehicle mass.This paper first presents the motivation of applying vehicle optical fiber communication technology and reviews the development history of vehicle optical fiber communication technology.Then,the paper researches the devel-opment trend of automotive electrical and electronic architecture(EEA),from distributed EEA to domain centralized EEA and zone-oriented EEA.Based on the discussion of the development trend of automotive EEA,an EEA based on vehicle optical fiber communication technology is proposed.Finally,the key points and future directions of vehicle optical fiber communication technology research are highlighted,including vehicle multi-mode optical fiber technology,vehicle optical fiber network protocol,and topology.Wenwei Wang Shiyao Yu Wanke Cao Kaidi Guo 2022Automotive Innovation2022,5,3:1
9Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates显示文摘Jinrong Li Hong Li Huawei Mao Meixing Yu Ting Feng Fan Yang Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Wenwei Tu Meng Mao 2013Cellular & Molecular Immunology2013,10,3:1
10Holocene vegetation and climate histories in the eastern Tibetan Plateau: controls by insolation-driven temperature or monsoon-derived precipita- tion changes? 显示文摘Zhao Yan Yu Zicheng Zhao Wenwei 2011Quaternary Science Reviews2011,30,:1
11Heating Lithium-Ion Batteries at Low Temperatures for Onboard Applications:Recent Progress,Challenges and Prospects显示文摘Lithium-ion batteries(LIBs)are commonly used in electric vehicles(EVs)due to their good performance,long lifecycle,and environmentally friendly merits.Heating LIBs at low temperatures before operation is vitally important to protect the battery from serious capacity degradation and safety hazards.This paper reviews recent progress on heating methods that can be used onboard.The existing methods are divided into two categories,namely external heating methods and internal heating methods,mechanisms,advantages and limitations of each method are systematically reviewed.Then,the rates of temperature rise,energy consumptions,and maximum temperature gradient of different methods are quantitatively summa-rized to compare the heating performances of each method.In addition,features related to the onboard application of each method are qualitatively compared,which is essential for the rapid cold start of EVs in frigid weather.Finally,prospects of external and internal heating methods are given.This paper aims to provide researchers and engineers with guidelines about how to select a method based on their requirements and application environments.Cheng Lin Weifeng Kong Yu Tian Wenwei Wang Mingjie Zhao 2022Automotive Innovation2022,5,1:1
12Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped RNA betacoronavirus,1 that has spread globally since December 2019.As of July 22,2020,more than 14,000,000 confirmed cases and 607,781 deaths from COVID-19 have been reported to the World Health Organization from 216 areas and territories.2 Patientswithmore prominent laboratory abnormalities may develop acute respiratory distress syndrome(ARDS),which potentially leads tomultiple organ failure and death.1,3 However,at present,there are no regulatory approved antiviralmedicines,vaccines,or specific clinical treatments for COVID-19.Junping Wu Cherie S.Tan Hongzhi Yu Youwei Wang Yutao Tian Wenwei Shao Yifei Zhang Kuo Zhang Hongxia Shao Guangjian Ni Jun Shen Antonio Carlo Galoforo Qi Wu Dong Ming 2020The Innovation2020,1,3:1
13Holocene vegetation and climate histories in the eastern Tibetan Plateau: controls by insolation-driven temperature or monsoon-derived precipitation changes?显示文摘Yan Zhao Zicheng Yu Wenwei Zhao 2011Quaternary Science Reviews2011,,9:1
14AI-aided on-chip nucleic acid assay for smart diagnosis of infectious disease显示文摘Global pandemics such as COVID-19 have resulted in significant global social and economic disruption.Although polymerase chain reaction(PCR)is recommended as the standard test for identifying the SARS-CoV-2,conventional assays are time-consuming.In parallel,although artificial intelligence(AI)has been employed to contain the disease,the implementation of AI in PCR analytics,which may enhance the cognition of diagnostics,is quite rare.The information that the amplification curve reveals can reflect the dynamics of reactions.Here,we present a novel AI-aided on-chip approach by integrating deep learning with microfluidic paper-based analytical devices(μPADs)to detect synthetic RNA templates of the SARS-CoV-2 ORF1ab gene.TheμPADs feature a multilayer structure by which the devices are compatible with conventional PCR instruments.During analysis,real-time PCR data were synchronously fed to three unsupervised learning models with deep neural networks,including RNN,LSTM,and GRU.Of these,the GRU is found to be most effective and accurate.Based on the experimentally obtained datasets,qualitative forecasting can be made as early as 13 cycles,which significantly enhances the efficiency of the PCR tests by 67.5%(∼40 min).Also,an accurate prediction of the end-point value of PCR curves can be obtained by GRU around 20 cycles.To further improve PCR testing efficiency,we also propose AI-aided dynamic evaluation criteria for determining critical cycle numbers,which enables real-time quantitative analysis of PCR tests.The presented approach is the first to integrate AI for on-chip PCR data analysis.It is capable of forecasting the final output and the trend of qPCR in addition to the conventional end-point Cq calculation.It is also capable of fully exploring the dynamics and intrinsic features of each reaction.This work leverages methodologies from diverse disciplines to provide perspectives and insights beyond the scope of a single scientific field.It is universally applicable and can be extended to multiple areas of fundamental research.Hao Sun Linghu Xiong Yi Huang Xinkai Chen Yongjian Yu Shaozhen Ye Hui Dong Yuan Jia Wenwei Zhang 2022Fundamental Research2022,2,3:0
15DOA Estimation Based on Root Sparse Bayesian Learning Under Gain and Phase Error显示文摘The direction of arrival(DOA)is approximated by first-order Taylor expansion in most of the existing methods,which will lead to limited estimation accuracy when using coarse mesh owing to the off-grid error.In this paper,a new root sparse Bayesian learning based DOA estimation method robust to gain-phase error is proposed,which dynamically adjusts the grid angle under coarse grid spacing to compensate the off-grid error and applies the expectation maximization(EM)method to solve the respective iterative formula-based on the prior distribution of each parameter.Simulation results verify that the proposed method reduces the computational complexity through coarse grid sampling while maintaining a reasonable accuracy under gain and phase errors,as compared to the existing methods.Dingke Yu Xin Wang Wenwei Fang Zixian Ma Bing Lan Chunyi Song Zhiwei Xu 2022Journal of Communications and Information Networks2022,7,2:0
16Dynamic single-cell mapping unveils Epstein-Barr virusimprinted T-cell exhaustion and on-treatment response显示文摘Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy response.However,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined.This study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/BCR-seq.EBV(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration.Miao-Zhen Qiu Chaye Wang Zhiying Wu Qi Zhao Zhibin Zhao Chun-Yu Huang Wenwei Wu Li-Qiong Yang Zhi-Wei Zhou Yu Zheng Hong-Ming Pan Zexian Liu Zhao-Lei Zeng Hui-Yan Luo Feng Wang Feng-Hua Wang Si-Yu Yang Meng-Xing Huang Zhexiaon Lian Haiyan Zhang Rui-Hua Xu 2023Signal Transduction and Targeted Therapy2023,8,10:0
17Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry显示文摘The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience.Bin Liu Xuedong Zhou Lin Yue Benxiang Hou Qing Yu Bing Fan Xi Wei Lihong Qiu Zhengwei Huang Wenwei Xia Zhe Sun Hanguo Wang Liuyan Meng Bin Peng Chen Zhang Shuli Deng Zhaojie Lu Deqin Yang Tiezhou Hou Qianzhou Jiang Xiaoli Xie Xuejun Liu Jiyao Li Zuhua Wang Haipeng Lyu Ming Xue Jiuyu Ge Yi Du Jin Zhao Jingping Liang 2023International Journal of Oral Science2023,15,3:0
18Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19显示文摘Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of infection.The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients.Main recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)Healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease control.Changes in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)Healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19.Wei Song Jie Wei Xiangdong Jian Deren Wang Yanhong Ouyang Yuanshui Liu Xianjin Du Ying Chen Yingqi Zhang Heping Xu Shuming Xianyu Qiong Ning Xiang Li Xiaotong Han Feng Zhan Tao Yu Wenteng Chen Jun Zhang Wenwei Cai Sheng’ang Zhou Shengyang Yi Yu Cao Xiaobei Chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng Yuhong Mi Sisen Zhang Rongjia Yang Shouchun Yan Wenbin Han Yong Lin Chuanyun Qian Wenwu Zhang Yan Xiong Jun Lv Baochi Liu Yan Cao Xiaojun He Xuelian Sun Yufang Cao Tian’en Zhou 2021Asian Pacific Journal of Tropical Medicine2021,14,6:0
19Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents显示文摘The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet elucidated.In this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents.At 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 doses.The antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of BNT162b2.Compared to adults,humoral responses for the third dose were non-inferior or superior in adolescents.The S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or non-inferior.Interestingly,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and BA.5.Sera from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise BA.1.Our study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau 2023Signal Transduction and Targeted Therapy2023,8,1:0
20Isolating the cDNA fragment inhibiting nontargeted mutagenesis in vero cell by antisense technology显示文摘Among the expressed sequence tags (ESTs) which were isolated from genetically instable monkey kidney vero cells induced by N-methyI-N’-nitro-N-nitrosoguanidine (MNNG), a fragment 9 was isolated. When the expression of fragment 9 was blocked through transcripting antisense RNA, MNNGinduced nontargeted mutation frequency enhanced significantly compared with control ( P < 0.05). The result showed that the relevant gene of fragment 9 might participate in maintaining cellular genetic stability and be involved in inhibition of nontargeted mutagenesis.Wenwei Hu Yingnian Yu Xingruo Chen Tao Song Haiyang Xie 1999Chinese Science Bulletin1999,44,6:0
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