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| 1 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 2 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 3 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 4 | Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas显示文摘Epstein-Barr virus(EBV)is associated with nasopharyngeal carcinoma(NPC)tumorigenesis.However,the mechanism(s)connecting EBV infection and NPC remain unclear.Recently,a new class of EBV microRNAs(miRNAs)has been described.To determine how EBV miRNAs control the expression of host genes,and to understand their potential role in NPC tumorigenesis,we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues.We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC.Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC.A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated,suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis.An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis. | ZENG ZhaoYang HUANG HongBin HUANG LiLi SUN MengXi YAN QiJia SONG YaLi WEI Fang BO Hao GONG ZhaoJian ZENG Yong LI Qiao ZHANG WenLing LI XiaYu XIANG Bo LI XiaoLing LI Yong XIONG Wei LI GuiYuan | 2014 | Science China(Life Sciences)2014，57，3： | 10 |
| 5 | Epidermal growth factor improves intestinal morphology by stimulating proliferation and differentiation of enterocytes and mTOR signaling pathway in weaning piglets显示文摘Epidermal growth factor(EGF) has been shown to improve piglet intestinal morphology and epithelial recovery. In an attempt to further understand the mechanisms behind these improvements, this study tested the hypothesis that dietary EGF may affect intestinal morphology by stimulating the proliferation and differentiation of enterocytes in weaning piglets. In piglets receiving200 μg kg^-1 EGF, crypt depth and villus height increased(P<0.05). Adding 400 μg kg^-1 EGF increased villus height-to-crypt depth ratio(P<0.05), but reduced crypt depth(P<0.05). Dietary supplementation with 200 μg kg^-1 EGF significantly increased the number of Ki67-positive cells(P<0.01) and tended to increase the mRNA level of proliferating cell nuclear antigen(P<0.10).However, this supplementation decreased the expression level of intestinal fatty acid-binding protein(P<0.05). Piglets fed with400 μg kg^-1 EGF had an increased mRNA level of intestinal alkaline phosphatase(P<0.05). The phosphorylation of m TOR(mammalian target of rapamycin) was observed in the 200 μg kg^-1 EGF group. These results suggest that dietary supplementation with a low level of EGF improved piglet intestinal morphology through stimulating the proliferation and differentiation of enterocytes, and the mTOR signaling pathway may partly be involved in this process. | Lixia Wang Fan Zhu Huansheng Yang Jianzhong Li Yali Li Xueqin Ding Xia Xiong Fengjie Ji Hanlin Zhou Yulong Yin | 2020 | Science China(Life Sciences)2020，63，2： | 7 |
| 6 | Influences of laser powers on microstructure and properties of the coatings on the AZ91HP magnesium alloy显示文摘Al-Si alloy coatings were prepared on AZ91HP magnesium alloy by broad-beam laser cladding; the influences of the powers on the microstructure and properties of the coatings were discussed. It was found that the microstructure of the coatings at the powers of 3 and 3.5 kW was characterized by Mg2Si dendrites, and needle-like Mg2Al3 (hcp) dispersing in the Mg17Al12 matrix, whereas the coating at the power of 2.5 kW was composed of the petal-like Mg2Al3 (fcc) as well as the needle-like Mg2Al3 (hcp). The coating at the power of 4 kW appeared as α-Mg solid solution and Mg2Si, Mg17Al12, as well as Mg2Al3 (hcp). The coatings with the powers of 3 and 3.5 kW exhibited higher microhardness and better wear resistance because of more Mg2Si and Mg17Al12. However, the coating at the power of 2.5 kW displayed better corrosion resistance. | Yali GAO Dangsheng XIONG Cunshan WANG Yongzhe CHEN | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，3： | 2 |
| 7 | Study on the Resistance Phenotype end Expression Level of femA of Staphylococcus Aureus显示文摘 | Yali Xiong Xinjian Fan Lei Zhang | 2007 | J Sichuan Uni(Med Sd Edi)2007，38，2： | 1 |
| 8 | Mesenchymal Stem Cells Promote Epithelial to Mesenchymal Transition and Metastasis in Gastric Cancer Though Paracrine Cues and Close Physical Contact显示文摘 | Zengfu Xue Xiumin Wu Xiong Chen Yali Liu Xin Wang Kaichun Wu Yongzhan Nie Daiming Fan | 2015 | Biochem2015，，4： | 1 |
| 9 | PGE geo- chemistry and Re-Os dating of massive sulfide ores from the Baimazhai Cu-Ni deposit, Yunnan Province, China 显示文摘 | Sun Xiaoming Wang Shengwei Sun Weidong Shi Guiyong Sun Yali Xiong Dexin Qu Wenjun Du Andao | 2008 | Lithos2008，105，12： | 1 |
| 10 | New physical insights on power MOSFET switching losses显示文摘 | XIONG Yali SUN Shan JIA Hongwei | 2009 | IEEE Transactions on Power Electronics2009，24，2： | 1 |
| 11 | Power MOSFET Switching Loss Analysis: A New Insight 显示文摘 | Shen Z John Xiong Yali Cheng Xu | 2006 | Industry Apllications Conference2006，3，2： | 1 |
| 12 | PGE geochemistry and Re-Os dating of massive sulfide ores from the Baimazhai Cu-Ni deposit,Yunnan province,China显示文摘 | Sun Xiaoming Wang Shengwei Sun Weidong Shi Guiyong Sun Yali Xiong Dexin Qu Wenjun Du Andao | 2008 | Lithos2008，105，： | 1 |
| 13 | Mesenchymal Stem Cells Promote Epithelial to Mesenchymal Transition and Metastasis in Gastric Cancer Though Paracrine Cues and Close Physical Contact显示文摘 | Zengfu Xue Xiumin Wu Xiong Chen Yali Liu Xin Wang Kaichun Wu Yongzhan Nie Daiming Fan | 2015 | J. Cell. Biochem2015，，： | 1 |
| 14 | Cyclin D1 G870A polymorphism and the risk of hepatocellular carcinoma in a Chinese population显示文摘 | Zhangyong Hu Zhipeng Zhou Guolian Xiong Yali Wang Yi Lai Lan Deng Jinliang Yang | 2014 | Tumor Biology2014，，6： | 1 |
| 15 | New physical insights on power MOSFET switching losses显示文摘 | Xiong Yali Sun Shan Jia Hongwei | 2009 | IEEE Trans- actions on Power Electronics2009，24，2： | 1 |
| 16 | New physical insights on power MOSFET switching losses显示文摘 | Xiong Yali Sun Shan Wei hong | 2009 | IEEE Transactions on Power Electronics2009，24，2： | 1 |
| 17 | Therapeutic potential of bright light therapy for the non-motor symptoms in Parkinson's disease显示文摘To the Editor:Alterations of circadian rhythms seem to be the casual contribution to sleep disturbances,depression,and other non-motor symptoms in Parkinson's disease(PD).[1,2]By restoring the circadian rhythm,bright light therapy(BLT)might be a potentially new treatment option for PD.However,no studies have conclusively demonstrated the effects of BLT on the non-motor symptoms in PD. | Yun Shen Siyi Gong Yulu Liu Jie Li Kangping Xiong Chengjie Mao Yali Wang Dan Li Fen Wang Hua Hu Chunfeng Liu | 2022 | Chinese Medical Journal2022，，2： | 0 |
| 18 | SALL4A蛋白与TET家族双加氧酶协同调节5-甲基胞嘧啶的逐级氧化显示文摘哺乳动物DNA的胞嘧啶甲基化(5mC)修饰被认为是最稳定的表观遗传修饰。近年研究发现,TET家族蛋白能够将5mC逐步氧化成5-羟甲基胞嘧啶(5hmC)、5-醛基胞嘧啶(5fC)和5-羧基胞嘧啶(5caC),并走向最终的去甲基化。 | Jun Xiong 张珠强 Jiayu Chen Hua Huang Yali Xu Xiaojun Ding Yong Zheng Ryuichi Nishinakamura Guo-Liang Xu Hailin Wang She Chen Shaorong Gao 朱冰 | 2017 | 科学新闻2017，19，4： | 0 |
| 19 | Efficient and selective electro-reduction of nitrobenzene by the nano-structured Cu catalyst prepared by an electrodeposited method via tuning applied voltage显示文摘有毒的硝基苯引起的污染是一颗普遍环境担心。到苯胺的硝基苯的选择减小是有益的推进有效、划算的生物学的处理。电气化学的减小是一个有希望的方法,基于 Cu 的催化剂被发现了是为这个目的有效阴极材料。在这个工作,有不同形态学的 Cu 催化剂经由调节应用电压用一个灵巧的 electrodepositon 方法在 Ti 板上被制作。在高应用的电压获得的树枝状的组织 nano 的 Cu 催化剂向硝基苯的减小展出了优秀效率和选择到苯胺。到用 Cu/Ti 电极的苯胺的硝基苯的选择减小上的工作潜力和起始的硝基苯集中的效果被调查。0.0251 min 1 和 97.1% 苯胺选择的一个高率常数被完成。制作组织 nano 的 Cu 催化剂也展出了好稳定性。这个工作提供一个灵巧的方法为污染物质减小准备高度有效、划算、稳定的组织 nano 的 electrocatalysts。 | Yali CHEN Lu XIONG Weikang WANG Xing ZHANG Hanqing YU | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 0 |
| 20 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
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