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| 1 | Remediation of Heavy Metal-Polluted Agricultural Soils Using Clay Minerals: A Review显示文摘Heavy metal contamination of agricultural soils poses risks and hazards to humans. The remediation of heavy metal-polluted soils has become a hot topic in environmental science and engineering. In this review, the application of clay minerals for the remediation of heavy metal-polluted agricultural soils is summarized, in terms of their remediation effects and mechanisms, influencing factors,and future focus. Typical clay minerals, natural sepiolite, palygorskite, and bentonite, have been widely utilized for the in-situ immobilization of heavy metals in soils, especially Cd-polluted paddy soils and wastewater-irrigated farmland soils. Clay minerals are able to increase soil p H, decrease the chemical-extractable fractions and bioavailability of heavy metals in soils, and reduce the heavy metal contents in edible parts of plants. The immobilization effects have been confirmed in field-scale demonstrations and pot trials. Clay minerals can improve the environmental quality of soils and alleviate the hazards of heavy metals to plants. As main factors affecting the immobilization effects, the p H and water condition of soils have drawn academic attention. The remediation mechanisms mainly include liming, precipitation, and sorption effects. However, the molecular mechanisms of microscopic immobilization are unclear. Future studies should focus on the long-term stability and improvement of clay minerals in order to obtain a better remediation effect. | XU Yi LIANG Xuefeng XU Yingming QIN Xu HUANG Qingqing WANG Lin SUN Yuebing | 2017 | Pedosphere2017，27，2： | 66 |
| 2 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 3 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 4 | Biological drug and drug delivery-mediated immunotherapy显示文摘The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld. | Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 15 |
| 5 | An Atypical Thioredoxin Imparts Early Resistance to Sugarcane Mosaic Virus in Maize显示文摘 | Qingqing Liu Huanhuan Liu Yangqing Gong Yongfu Tao Lu Jiang Weiliang Zuo Qin Yang Jianrong Ye Jinsheng Lai Jianyu Wu Thomas Lubberstedt Mingliang Xu | 2017 | Molecular Plant2017，10，3： | 14 |
| 6 | Optimization and test for spraying parameters of cotton defoliant sprayer显示文摘Boom sprayer is widely used in large farm crops because of its high working efficiency and favorable spraying effect.But there are still some problems in cotton defoliant spraying in Xinjiang,China.Cotton is planted in a high density in Xinjiang,the row space is(10+66)cm,leaves in two adjacent rows are seriously overlapped,the lower leavers are poorly sprayed,so the defoliation effect is poor,and the cotton quality is degraded.To solve this problem and improve the defoliant droplets coverage on the cotton canopy,the original boom spraying was modified,and the spraying pardameters was optimized by the central combination test and design concept of Box-Behnken based on a single-factor test.A quadratic polynomial model of droplets coverage was created by using working parameters including horizontal spraying boom height,hang boom height and nozzles angle as the influential factors and the mean droplets coverage on cotton canopy as the target function,and the effectiveness of mode and interaction of factors were analyzed.The model was optimized and analyzed using the regression analysis method and response surface analysis method of software Design-Expert 7.0.0,and the optimal combination of spraying parameters was obtained.The results showed that the droplets coverage on cotton canopy were influenced by boom height,sprayer height and angled nozzles sequentially from large to small,and the optimal combination of spraying parameters was under horizontal spraying boom height of 134 cm,hang spraying boom height of 27.5 cm and nozzles angle of 21°.The mean droplets coverage of experimental value and predicted value on cotton canopy were 19.6%and 20.43%respectively in such conditions,and the relative error to the estimated value on the model was–4.25%.The research result can provide a reference for further optimizing the spraying parameters of cotton defoliant sprayer. | Qin Weicai Xue Xinyu Cui Longfei Zhou Qingqing Xu Zhufeng Chang Feilong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 9 |
| 7 | Electrical properties of fly ash and its decarbonization by electrostatic separation显示文摘The basic principle of fly ash triboelectrification is analysed. The mineral electrical index and test method are introduced. The electric difference of different mineral composition of fly ash is discussed by analysis of chemical and mineral composition of fly ash in Xinwen power plant. The dielectric constant and charge–mass ratio of carbon and ash of fly ash are tested. Combined with the experimental study on rotary triboelectrostatic separation, the charged characteristic of fly ash particles with different size is gained. The results show that the dielectric constant of fly ash with different grain size decreased with the decrease of particle size, which lead to the poor electrical conductivity. Thus it can be seen that particle size plays a leading role in conductivity. The charge of carbon and ash with each size increased with the decreased of particle size; and the charge–mass ratio between carbon and ash with the same size larger with the decrease of size, which indicated that the finer particle size, the more favorable for triboelectrification separation. In the same conditions, the best decarburization effect is realized when the particle size ranges from 0.038 to 0.074 mm, whose decarbonization rate and efficiency index reached 38.93% and120.83% respectively. | Tao Youjun Ding Qingqing Deng Mingrui Tao Dongping Wang Xu Zhang Jie | 2015 | International Journal of Mining Science and Technology2015，25，4： | 8 |
| 8 | MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling显示文摘发信号的 BMP 怎么集成到并且使动摇人的 pluripotent 干细胞(hPSCs ) 的 pluripotency 电路开始区别进单个细菌层是一个长期的难题。这里,我们报导肌肉片断 homeobox 2 (MSX2 ) , msh 家庭的一个 homeobox 抄写因素, BMP 发信号的直接目标基因和 hPSC 到 mesendoderm 的区别的一个主人调停人。MSX2 的强制表示足够废除 pluripotency 并且导致 hPSCs 的指导 mesendoderm 区别,当 MSX2 弄空损害 mesendoderm 正式就职时。MSX2 是在 hPSCs 的 BMP 小径的直接目标基因,并且能被 Wnt 信号 synergistically 在 mesendoderm 正式就职期间经由 LEF1 激活。而且, MSX2 使动摇通过到 SOX2 倡导者和 SOX2 抄写的压抑的直接绑定的 pluripotency 电路,当 MSX2 通过节的倡导者的直接绑定和激活由 SOX2 的同时的抑制和节的表示的正式就职控制 mesendoderm 系承诺时。有趣地, SOX2 能支持 MSX2 蛋白质的降级,建议在在干细胞命运的控制的二个指定系的因素之间的相互的对抗。一起,我们的调查结果揭示使动摇的关键新机制在 hPSCs 的 pluripotency 和指导系承诺。 | Qingqing Wu Leisheng Zhang Pei Su Xiaohua Lei Xin Liu Hongtao Wang Lisha Lu Yang Bai Tao Xiong Dong Li Zhengmao Zhu Enkui Duan Erlie Jiang Sizhou Feng Mingzhe Hang Yuanfu Xu Fei Wang Jiaxi Zhou | 2015 | Cell Research2015，25，12： | 8 |
| 9 | Aboveground biomass and corresponding carbon sequestration ability of four major forest types in south China显示文摘We estimated aboveground biomass carbon (TABC) and net carbon accumulation rates (TNEP) for trees in four major forest types based on national forest inventory data collected in 1994-1998 and 1999-2003. The four types were Pinus massoniana forest, Cunninghamia lanceolata forest, hard broad-leaved evergreen forest and soft broad-leaved evergreen forest. We analyzed variations in TABC and TNEP for five stand ages (initiation, young, medium, mature and old). In both time periods, estimated TABC in all four forest types increased consistently with forest stand age and the oldest stage had the largest TABC compared with other stages. Broad-leaved forests (hard and soft) had higher TABC than needle-leaved forests (Pinus massoniana and Cunninghamia lanceolata) for each of the five age stages. The difference of TABC between broad-leaved and needle-leaved forests increased with forest stand age. Comparison of estimated TNEP by age category indicated TNEP increased from the initiation stage to the young stage, and then decreased from the mature stage to old stage in all four forest types. TNEP for any particular stage depended on the forest type; for instance, broad-leaved forests at both the mature and old stages had greater TNEP than in needle-leaved forests. A logistic curve was applied to fit the relationship between TABC and forest stand age. In each period, correlations in all four forest types were all statistically significant (P < 0.01) with R2 > 0.95. TABC was therefore predicted by these regression functions from 2000 to 2050 and the mean TNEP during the predicted period was estimated to be about 41.14, 31.53, 75.50 and 75.68 gCm-2a-1 in Pinus massoniana forest, Cunninghamia lanceolata forest, hard broad-leaved forest and soft broad-leaved forest, respectively. Results from both forest inventory and regression prediction suggest broad-leaved forests are greater carbon sinks, and hence have greater carbon sequestration ability especially in the mature and old stages when compared to needle-leaved forests. Broad-leaved forests should have high levels of carbon sequestration when compared with needle-leaved forests in south China. | CHEN QingQing XU WeiQiang LI ShengGong FU ShengLei YAN JunHua | 2013 | Chinese Science Bulletin2013，58，13： | 8 |
| 10 | A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice显示文摘Dear Editor,Since the beginning of this century,humanity has been struck three times by the coronavirus outbreak.The most recent one is caused by the SARS-CoV-2 virus,which was first reported in January 2020 and spread rapidly worldwide,developing into a global coronavirus disease pandemic coded COVID-19.1 By July 28,2020,SARS-CoV-2 has caused over sixteen million COVID-19 cases worldwide and 650,805 deaths.2 Such a grave situation has made the development of a COVID-19 vaccine imperative and urgent. | Jing Lu Guoliang Lu Shudan Tan Jia Xia Hualong Xiong Xiaofei Yu Qingqing Qi Xiang Yu Li Li Hang Yu Ningshao Xia Tianying Zhang Yingjie Xu Jinzhong Lin | 2020 | Cell Research2020，30，10： | 5 |
| 11 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 12 | A novel microwave absorber——BaAl_2Fe_(10)O_(19)/poly(m-toluidine) composite:Preparation and electromagnetic properties显示文摘BaFe10Al2O19 /poly(m-toluidine)(BFA/PMT) composites were synthesized by in-situ polymerization of m-toluidine in the presence of BaFe10Al2O19 particles.The structure,composition and morphology of the obtained samples were characterized by using XRD,FT-IR,UV-visible spectroscopy,SEM and TEM techniques.Their electrical conductivity,magnetic property and microwave absorbing property were measured by the four-probe meter,the vibrating sample magnetometer and the vector network analyzer,respectively.The results indicated that BFA particles were coated effectively by PMT polymer and some interactions between PMT and BFA particles existing in the composites.The conductivity of BFA/PMT composite is smaller than that of pure polymers and its saturation magnetization is a little smaller than that of pure BFA.The influence of the constitution and film thickness of absorbent on its microwave absorbing property is evident.The microwave absorbing properties of the BFA/PMT composites are better than those of pure BFA and PMT.When optimizing the mass rate of BFA/PMT to 0.3,the absorbent with 2 mm film thickness has the minimum reflection loss of 28.26 dB at approximate 14.24 GHz,and the maximum available bandwidth of 8.8 GHz,respectively.The results show that these composites can be used as advancing absorption and shielding materials due to their favorable microwave absorbing property. | CHEN KeYu XU QingQing LI LiangChao GONG PeiJun CHEN HaiFeng XIAO QiuShi Xu Feng | 2012 | Science China Chemistry2012，55，7： | 4 |
| 13 | Controlled fabrication and electrical-magnetic properties of Poly(OT-co-AN)/Ba_(0.8)La_(0.2)Al_2Fe_(10)O_(19) composites显示文摘Poly(OT-co-AN)/Ba0.8La0.2Al2Fe10O19(Poly(OT-co-AN)/BLAF) composites were fabricated by in situ polymerization method.It was investigated that of mass rate of momomer(mOT/mAN),polymeration temperature and time,and feeding ratio of BLAF effect on the structures,morphology,conductivity,magnetic property of composites by the orthogonal optimum design.The results indicated that poly(OT-co-AN) copolymer had a better coating on BLAF particles,and there were some interactions between components in the composites.The magnetic properties of the composites were related to content of the magnetic BLAF particles in it.The feeding ratio of BLAF had a significant influence on constitute and conductivity of the composites,followed by the temperature.The reflection loss and the effective bandwidth of composites for electromagnetic wave were at-tributed to the synergistic effect between poly(OT-co-AN) and BLAF.The poly(OT-co-AN)/BLAF composites with mass ratio of BLAF to mix monomer(mOT/mAN =1:1) equal to 5/1 at 10 h in 25°C had a maximum synergistic effect between its compo-nents,showed a maximum reflection loss of ?26.94 dB at 14.10 GHz and an available bandwidth of 8.54 GHz.It was sug-gested that the composites can be used as a advancing absorption and shielding materials for electromagnetic wave due to their favorable microwave absorption properties. | CHEN KeYu XU QingQing LI LiangChao TONG GuoXiu QIAN HaiSheng XIAO QiuShi XU Feng | 2012 | Science China(Technological Sciences)2012，55，1： | 4 |
| 14 | Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes显示文摘人的乳头状瘤病毒(HPV ) 包括高风险(HR ) 并且低风险(LR ) 子类型在遗传型和显型上有可区分的变化。多重 HR-HPVs 的合作感染,由 HPV16 出发了,在在女性的颈的癌症是普通的。最近积累的报告集中了于在病毒和主人之间的相互作用,特别地在由指向病毒的染色体的抗病毒的防卫的人的 microRNAs (miRNAs ) 的角色。这里,我们在大多数 HR-HPVs,不是 LR-HPVs 的染色体发现了 miRNAs 的一个保存得好的目标地点,由扫描风险的不含糊的子类型的 24 HPV 上的人的 miRNAs 的所有潜在的目标地点。这个地点被二不太普通的人的 miRNAs, miR-875 和 miR-3144 指向,并且位于 E6 oncogene 开的读框架(ORF ) 和有第一种选择的重叠拼接病毒的早抄本的 exon。在确认测试, miR-875 和 miR-3144 被识别显著地压制目标记者活动并且禁止两综合地外长的 E6 和内长的 E6 oncogene 的表示。二 miRNAs 的高水平能禁止房间生长并且在 HPV16 积极的颈的癌症房间支持 apoptosis。这研究为大多数 HR-HPVs 提供 miRNAs 的一个有希望的普通目标并且在瘤抑制上加亮二低表示人的 miRNAs 的效果。 | Lin Lin Qingqing Cai Xiaoyan Zhang Hongwei Zhang Yang Zhong Congjian Xu Yanyun Li | 2015 | Protein & Cell2015，6，8： | 3 |
| 15 | Electrospinning in membrane contactor:manufacturing Elec-PVDF/SiO2 superhydrophobic surface for efficient flue gas desulphurization applications显示文摘In membrane contactors,maintaining a high SO_(2)absorption flux and an excellent wetting resistance are crucial for hazardous gas removal.In this study,we adopted an electrospinning strategy to fabricate highly robust superhydrophobic dual-layer Elec-PVDF/SiO_(2)composite membrane contactors used for flue gas desulfurization.The composite membrane contactor consisted of a durable and ultrathin three-dimensional(3D)superhydrophobic surface and a porous supporting layer,where the formulation was optimized by regulating the PVDF concentration,solvent ratio and SiO_(2)particles content in electrospinning solution.The scanning electronic microscopy(SEM),EDS-mapping,water contact angle(WCA)and surface roughness of as-prepared Elec-PVDF/SiO_(2)composite membrane contactors were conducted to explore the physical and chemical structure.The SiO_(2)nanoparticles were uniformly loaded in ElecPVDF/SiO_(2)composite membrane contactor,and constructed micro-nano dual-coarse lotus-leaf-like morphology,which noticeably elevated surface roughness(Ra).The SiO_(2)nanoparticles also functioned as hydrophobic modifiers,which boosted the WAC up to 155.The SO_(2)absorption fluxes and SO_(2)removal efficiencies were investigated.In particular,the membrane contactor doped with 20 wt%SiO_(2)nanoparticles significantly elevated the stability of desulfurization performance.Besides,the membrane mass transfer coefficient(Km)and corresponding membrane mass transfer resistance(H/Km)were explored. | Qingping Xin Kaiqiang Xie Qingqing Liang Xu Li Yinan Zeng Yuhang Zhao Lei Zhang Shaofei Wang Hong Li Yuzhong Zhang | 2021 | Green Chemical Engineering2021，2，1： | 3 |
| 16 | Black goji berry (Lycium ruthenicum) tea has higher phytochemical contents and in vitro antioxidant properties than red goji berry (Lycium barbarum) tea显示文摘Goji berry tea, a traditional herbal tea, is the main ate mode of goji berry in Asia, yet few studies in comparison with red goji berry tea and black goji berry tea are carried out. This study investigated the effects of water temperature and soak time on the colour, phytochemicals, and the antioxidant capacity [2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), and the ferric-reducing antioxidant power (FRAP)] of two goji berry tea. A comparison of the bioactive compounds and antioxidant activities between black and red goji berry tea was conducted. Results showed that both red and black goji berry tea were rich in phytochemicals, giving high antioxidant ability. The levels of bioactive compounds and the antioxidant activity of the two goji berry tea increased as the increases in soak temperature and time. Black goji berry tea had higher phytochemicals and antioxidant property than those of red goji berry tea. Infused at 100° water for the same time, the levels of total polysaccharides (150 mg/100 ml), total polyphenols (238 mg/ml), and antioxidant capacity (550 μmol/100 ml) of black goji berry tea were 3.5, 2, and 5 times higher, respectively, in comparison with red goji berry tea. The results of this study demonstrate that hot drink of goji berry in China is a good habit and black goji berry tea may be a better choice. | Bei Liu Qingqing Xu Yujing Sun | 2020 | Food Quality and Safety2020，4，4： | 3 |
| 17 | Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages显示文摘Epigenetic modification,including histone modification,precisely controls target gene expression.The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I interferons has been fully elucidated,whereas the roles of histone modification alteration and epigenetic modifiers in regulating inflammatory responses need to be further explored.Di/tri-methylation modifications of histone 3 lysine 79(H3K79me2/3)have been shown to be associated with gene transcriptional activation.Disruptor of telomeric silencing-1-like(Dot1l)is the only known exclusive H3K79 methyltransferase and regulates the proliferation and differentiation of tumor cells.However,the roles of Dot1l and Dot1l-mediated H3K79 methylation in innate immunity and inflammatory responses remain unclear.Here,we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters,as well as H3K79me2 modification at the Tnfαpromoter,were increased in macrophages activated by Toll-like receptor(TLR)ligands or virus infection.The innate signals upregulated Dot1l expression in macrophages and THP1 cells.Dot1l silencing or a Dot1l inhibitor preferentially suppressed the production of IL-6 and interferon(IFN)-βbut not of TNFαin macrophages and THP1 cells triggered by TLR ligands or virus infection.Dot1l was recruited to the proximal promoter of the Il6 and Ifnb1 but not Tnfαgene and then mediated H3K79me2/3 modification at the Il6 and Ifnb1 promoters,consequently facilitating the transcription and expression of Il6 and Ifnb1.Thus,Dot1l-mediated selective H3K79me2/3 modifications at the Il6 and Ifnb1 promoters are required for the full activation of innate immune responses.This finding adds new insights into the epigenetic regulation of inflammatory responses and pathogenesis of autoimmune diseases. | Xiang Chen Xingguang Liu Yunkai Zhang Wanwan Huai Qingqing Zhou Sheng Xu Xi Chen Nan Li Xuetao Cao | 2020 | Cellular & Molecular Immunology2020，17，1： | 3 |
| 18 | Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy显示文摘Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects.Unfortunately,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements.In this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting mitochondria.When irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation.More importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO)with higher cytotoxicity enables NO to sensitize PDT in cancer treatment.Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently.The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome. | Lingdong Jiang Danyang Chen Zhaokui Jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He | 2022 | Bioactive Materials2022，7，6： | 3 |
| 19 | Establishment of a highly efficient hematopoietic differentiation model from human embryonic stem cells for functional screening显示文摘Human embryonic stem cells(hESCs)have been successfully differentiated into hematopoietic progenitor cells with colony formation capacity and further into various kinds of blood cells including erythrocytes,megakaryocytes,neutrophils,nature killer cells and T lymphocytes[1 7].Nevertheless,the differentiation efficiency is extremely low. | PANG SuLei WU QingQing TIAN Sha SU Pei BAI Yang GAO Jie YANG YiQing LIU Xin ZHU ZhengMao XU YuanFu ZHOU JiaXi | 2013 | Science China(Life Sciences)2013，56，12： | 3 |
| 20 | Adaptive Fuzzy Sliding Mode Controller with Nonlinear Observer for Redundant Manipulators Handling Varying External Force显示文摘 | Jun He Minzhou Luo Qingqing Zhang Jianghai Zhao Linsen Xu | 2016 | Journal of Bionic Engineering2016，13，4： | 3 |
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