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| 1 | Velocity and pressure distributions in discharge tunnel of rotary-obstruction composite inner energy dissipation显示文摘On the basis of model test and theoretical analysis of velocity and pressure distributions,an hypothesis is presented that the distribution of tangential velocity in radial direction seems to be a combinational distribution of a quasi-free vortex and a quasi-forced vortex for the discharge tunnel of rotary-obstruction composite inner energy dissipation.The variations of corresponding parameters about the hypothesis are obtained under test conditions in this paper.The formula of pressure distribution in radial direction is deduced theoretically,and the theoretical values of pressure distribution computed by the formula are well consistent with the measured ones,showing that the formula is correct and can be applied to the computation and analysis of pressure distribution of this discharge tunnel. | CAO ShuangLi 1,NIU ZhengMing 1,YANG Jian 2 & LU HongBo 1 1 Xi’an University of Technology,Xi’an 710048,China 2 China Water Resources Pearl River Planning,Surveying & Designing Co.Ltd,Guangzhou 510610,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 10 |
| 2 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 3 | Effect of a single oral dose of rabeprazole on nocturnal acid breakthrough and nocturnal alkaline amplitude显示文摘AIM: To study the effect of rabeprazole (RAB) on nocturnal acid breakthrough (NAB) and nocturnal alkaline amplitude (NAKA) and to compare it with omeprazole (OME) and pantoprazole (PAN).METHODS: By an open comparative study, forty patients with active peptic ulcer were randomly assigned to receive one of the three PPIs (proton pump inhibitor) with a single oral dose. They were divided into RAB group (10 mg), OME group(20 mg) and PAN group (40 mg). Twenty healthy volunteers were enrolled to the control group (without taking any drug). Intragastric pH monitoring was then performed 1 hour before and 24 hours after the dose was given.RESULTS: No clinically undesirable signs and symptoms possibly attributed to the administration of RAB or OME and PAN were recognizable throughout the study period. All subjects completed the study according to the protocol. All data were processed by a computer using the Student ttest or t' test followed by an analysis of covariance. P<0.05 was considered to have statistical significance. The intragastric pH of NAB was significantly higher in RAB group (1.84±0.55) than in either OME group (1.15±0.31) or PAN group (1.10±0.30) (both P<0.01). RAB produced a longer sustaining time (4.65±1.22 h) on NAKA than OME (3.22±1.89 h) (P<0.05),PAN (3.15±1.92 h) (P<0.05), and the sustaining time of NAKA in RAB group was longer than that in the healthy control group (P<0.01) too. In addition, RAB produced a much higher pH on NAKA (6.41±0.45) in comparison with PAN (6.01±0.92) (P<0.05).CONCLUSION: A single oral dose of 10 mg RAB may increase the pH of NAB and shorten the sustaining time of NAB, and it may increase the pH of NAKA as well as prolong the sustaining time of NAKA. | Jin-Yan Luo Chun-Yan Niu Xue-Qin Wang You-Ling Zhu Jun Gong, Department of Gastroenterology, The Second Hospital of Xi’an Jiaotong Uuniversity, Xi’an 710004, Shanxi Province, China | 2003 | World Journal of Gastroenterology2003，9，11： | 9 |
| 4 | The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport显示文摘retromer 是调停的蛋白质建筑群后退到 trans-Golgi 网络(TGN ) 的从内涵体的 transmembrane 货物的运输。它由 Vps26, Vps29 和 Vps35 的货物选择 subcomplex 和排序 nexins (SNX ) 的膜绑定上衣 subcomplex 组成。以前的研究作为第二 SNX 的候选人作为 SNX subcomplex,和 SNX5/6 的部件之一识别了 SNX1/2。联系 retromer 的货物怎么被分子的马达认出并且搬运,大部分是未知的。在这研究,我们发现了一个 SNX1/2 的 dimerization 搭挡, SNX6,与 dynein/dynactin 马达建筑群的 p150Glued 子单元交往。我们 SNX6 是 retromer 的一个部件的现在的证据,和到联系膜的 retromer 的马达建筑群的那招募要求 SNX6-p150Glued 相互作用。在从内涵体在一些 CI-MPR 检索从内涵体和结果排序结构到 TGN 的 tubulovesicular 的形成和分开的 SNX6-p150Glued 相互作用原因失败的混乱。这些观察显示除了 SNX1/2,与 dynein/dynactin 建筑群联合的 SNX6 驾驶形成和运动管状后退中介。 | Zhi Hong Yanrui Yang Cheng Zhang Yang Niu Ke Li Xi Zhao Jia-JiaLiu | 2009 | Cell Research2009，19，12： | 8 |
| 5 | Model Predictive Current Control with Adaptive-adjusting Timescales for PMSMs显示文摘A model predictive current control(MPCC)with adaptive-adjusting method of timescales for permanent magnet synchronous motors(PMSMs)is proposed in this paper to improve the dynamic response and prediction accuracy in transient-state,while lessening the computational burden and improving the control performance in steady-state.The timescale characteristics of different parts of MPCC,such as signal sampling,prediction calculation,control output,model error correction,are analyzed,and the algorithm architecture of MPCC with multi-timescale is proposed.The difference between reference and actual speed,and the change rate of actual speed are utilized to discriminate the transient state of speed change and load change,respectively.Adaptive-adjusting method of control period and prediction stepsize are illustrated in detail after operation condition discrimination.Experimental results of a PMSM are presented to validate the effectiveness of proposed MPCC.In addition,comparative evaluation of single-step MPCC with fixed timescale and proposed MPCC is conducted,which demonstrates the superiority of proposed control strategy. | Feng Niu Xi Chen Shaopo Huang Xiaoyan Huang Lijian Wu Kui Li Youtong Fang | 2021 | CES Transactions on Electrical Machines and Systems2021，5，2： | 8 |
| 6 | Accelerated Aging Behaviors and Mechanism of Fluoroelastomer in Lubricating Oil Medium显示文摘The aging behaviors and mechanism of fluoroelastomer(FKM)under lubricating oil(FKM-O)and air(FKM-A,as a comparison)at elevated temperatures were studied from both physical and chemical viewpoints.The obvious changes of mechanical and swelling performances indicate that the coupling effect of lubricating oil and temperature causes more serious deterioration of FKM-O compared to that of FKM-A.Meanwhile,much stronger temperature dependence of both bulk properties and micro-structures for FKM-O is found.Three-stage physical diffusion process is defined in FKM-O due to the competition between oil diffusion and elastic retraction of network.FTIR results reveal that the dehydrofluorination reaction causes the fracture of C-F bonds and produces a large number of C=C bonds in the backbone.The coupling effect of oil medium and high temperature could accelerate the scission of C=C bonds and generate a series of fragments with different molecular sizes.The TGA results,crosslinking density Ve,and glass transition temperature Tg derived from different measurements coherently demonstrate the network destruction in the initial stage and the simultaneous reconstruction occurring at the final stage.The newly formed local network induced by reconstruction cannot compensate the break of the original rubber network and thus only provides lower tensile strength and thermal stability. | Qi-Long Wang Jing-Ke Pei Gao Li Xi He Yan-Hua Niu Guang-Xian Li | 2020 | Chinese Journal of Polymer Science2020，38，8： | 7 |
| 7 | Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogeninderived peptide on initial caries lesions显示文摘In this study,we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel(CS-QP5 hydrogel),and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries lesions.The results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm,lactic acid production and the metabolic activity over a prolonged period of time.Moreover,the CS-QP5 hydrogel promoted the remineralization of early enamel lesions,which were indicated by surface microhardness(,polarized light microscopy and transverse microradiography.In conclusion,the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time. | Qian Ren Zhongcheng Li Longjiang Ding Xiuqing Wang Yumei Niu Xi Qin Xuedong Zhou Linglin Zhang | 2018 | Regenerative Biomaterials2018，5，2： | 5 |
| 8 | Study on structure-activity relationship of mutation-dependent herbicide resistance acetohydroxyacid synthase through 3D-QSAR and mutation显示文摘Seventy-four sulfonylureas were synthesized and tested for their inhibitory activity against the whole enzyme of E. coli acetohydroxyacid synthase (AHAS, EC 2.2.1.6) isoenzyme II, and 3D-QSAR analyses were performed based on these inhibitory activities. The binding conformation of chlorimuron-ethyl, a commercial herbicide of AHAS, in the crystal structure of AHAS complex was extracted and used as template to build the initial three-dimensional structure of other sulfonylureas, and then all structures were fully geometry optimized. After systematic optimization of the alignment rule, molecular orienta- tion, grid space and attenuation factor, two satisfactory models with excellent performances (CoMFA: q2 = 0.735, r2 = 0.954, n = 7, r 2 pred = 0.832; CoMSIA: q2 = 0.721, r2 = 0.913, n = 8, r 2pred = 0.844) were estab- lished. By mapping the 3D contour maps of CoMFA and CoMSIA models into the possible inhibitory active site in the crystal structure of catalytic subunit of yeast AHAS, a plausible binding model for AHAS, with best fit QSAR in the literature so far, was proposed. Moreover, the results of 3D-QSAR were further utilized to interpret resistance of site-directed mutants. A relative activity index (RAI) for AHAS enzyme mutant was defined for the first time to relate the 3D-QSAR and resistance of mutants. This study, for the first time, demonstrated that combination of 3D-QSAR and enzyme mutation can be used to decipher the molecular basis of ligand-receptor interaction mechanism. This study refined our understanding of the ligand-receptor interaction and resistance mechanism in AHAS-sulfonylurea system, and provided basis for designing new potent herbicides to combat the herbicide resistance. | YU ZhiHong NIU CongWei BAN ShuRong WEN Xin XI Zhen | 2007 | Chinese Science Bulletin2007，52，14： | 5 |
| 9 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 10 | Microcystis aeruginosa/Pseudomonas pseudoalcaligenes interaction effects on off-flavors in algae/bacteria co-culture system under different temperatures显示文摘We conducted an experiment to study the interaction effects of Microcystis aeruginosa and Pseudomonas pseudoalcaligenes on off-flavors in an algae/bacteria co-culture system at three temperatures(24, 28 and 32℃). Gas chromatography–mass spectrometry was applied to measure off-flavor compounds dimethyl sulfide(DMS), dimethyl trisulfide(DMTS),2-methylisoborneol, geosmin(GEO) and β-cyclocitral. During the lag phase of co-cultured M. aeruginosa(first 15 days), P. pseudoalcaligenes significantly increased the production of DMS, DMTS and β-cyclocitral at all three temperatures. In the exponential phase of co-cultured M. aeruginosa(after 15 days), M. aeruginosa became the main factor on off-flavors in the co-culture system, and β-cyclocitral turned to the highest off-flavor compound. These results also indicated that DMS, DMTS and β-cyclocitral were the main off-flavor compounds in our M. aeruginosa/P. pseudoalcaligenes co-culture system. Univariate analysis was applied to investigate the effects of M. aeruginosa and P. pseudoalcaligenes on the production of off-flavors. The results demonstrated that both M. aeruginosa and P. pseudoalcaligenes could increase the production of DMS and DMTS, while β-cyclocitral was mainly determined by M. aeruginosa. Our results also provide some insights into understanding the relationship between cyanobacteria and heterotrophic bacteria. | Xi Yang Ping Xie Yunzhen Yu Hong Shen Xuwei Deng Zhimei Ma Peili Wang Min Tao Yuan Niu | 2015 | Journal of Environmental Sciences2015，27，5： | 4 |
| 11 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 12 | Homologous and heterologous interactions between catalytic and regulatory subunits of Escherichia coli acetohydroxyacid synthaseⅠand Ⅲ显示文摘Homologous and heterologous interactions between acetohydroxyacid synthase (AHAS) I and Ⅲ from E. coli have been studied by surface plasmon resonance (SPR). The catalytic and regulatory subunits association for AHAS I (KD = 1.13 × 10-7 M) was stronger than that for AHAS Ⅲ (KD = 5.29 × 10-7 M). A strong heterologous association between regulatory and catalytic subunits and heterologous activation of catalytic subunits were observed. SPR results combined with enzyme kinetics indicate that the reconstituted heterologous enzymes had similar kinetic properties as homologous enzymes, implying that the regulatory subunit of AHAS I could be replaced by the regulatory subunit of AHAS Ⅲ and vice versa. This work may be useful to further understandings of the mechanism of regulation of AHAS. | NIU CongWei, FENG Wei, ZHOU YanFei, WEN Xin & XI Zhen State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, Nankai University, Tianjin 300071, China | 2009 | Science China Chemistry2009，52，9： | 3 |
| 13 | From ice superlubricity to quantum friction: Electronic repulsivity and phononic elasticity显示文摘Superlubricity means non-sticky and frictionless when two bodies are set contacting motion.Although this occurrence has been extensively investigated since 1859 when Faraday firstly proposed a quasiliquid skin on ice,the mechanism behind the superlubricity remains uncertain.This report features a consistent understanding of the superlubricity pertaining to the slipperiness of ice,self-lubrication of dry solids,and aqueous lubricancy from the perspective of skin bond-electron-phonon adaptive relaxation.The presence of nonbonding electron polarization,atomic or molecular undercoordination,and solute ionic electrification of the hydrogen bond as an addition,ensures the superlubricity.Nonbond vibration creates soft phonons of high magnitude and low frequency with extraordinary adaptivity and recoverability of deformation.Molecular undercoordination shortens the covalent bond with local charge densification,which in turn polarizes the nonbonding electrons making them localized dipoles.The locally pinned dipoles provide force opposing contact,mimicking magnetic levitation and hovercraft.O:H−O bond electrification by aqueous ions has the same effect of molecular undercoordination but it is throughout the entire body of the lubricant.Such a Coulomb repulsivity due to the negatively charged skins and elastic adaptivity due to soft nonbonding phonons of one of the contacting objects not only lowers the effective contacting force but also prevents charge from being transited between the counterparts of the contact.Consistency between theory predictions and observations evidences the validity of the proposal of interface elastic Coulomb repulsion that serves as the rule for the superlubricity of ice,wet and dry frictions,which also reconciles the superhydrophobicity,superlubricity,and supersolidity at contacts. | Xi ZHANG Yongli HUANG Zengsheng MA Lengyuan NIU Chang Qing SUN | 2015 | Friction2015，3，4： | 3 |
| 14 | Clinical Features and Prognostic Risk Factors of Choroic Plexus Tumors in Children显示文摘Background:Decision-making concerning the treatment ofchoroid plexus tumor (CPT)in pediatric patients remains a topic of considerable debate.The aim of this work was to describe clinical features and prognostic risk factors of CPT in the pediatric population and to provide theoretical opinions regarding clinical decisions for CPT. Methods:The data of 96 patients with CPT and younger than 14 years were retrospectively analyzed.Clinical characteristics such as pathological type of CPTs,rate and severity of hydrocephalus,treatment and outcome,and recurrence were investigated.For categorical variables,the Pearson's Chi-square test was performed.The Mann-Whitney U-test was used for comparisons between nonnormally distributed parameters.Log-rank test was used for progression-free survival (PFS). Results:The study included 70 choroid plexus papilloma (CPP)cases,17 atypical choroid plexus papilioma (aCPP)cases,and 9 choroid plexus carcinoma (CPC)cases.Compared with patients with CPP or aCPP,patients with CPC had a shorter disease course (median:CPP, 4 months;aCPP,2 months;CPC,1 month;H:23.5,P <0.001),higher rate of acute hydrocephalus (CPP,27.1%;aCPP,52.9%;CPC, 77.8%;x^2 =10.9,P <0.05),and lower incidence of cure rate (CPP,85.7%;aCPP,70.5%;CPC,33.3%;x^2 =13.5,P <0.05).The severity of hydrocephalus with tumor in the lateral or third ventricle was significantly higher than that with tumors in the fourth ventricle (severe hydrocephalus:lateral ventricle,51.7%;third ventricle,47.0%;fourth ventricle,11.1%;x^2 =26.0,P <0.001).Patients with gross total surgical resection had no better PFS than those with partial resection because of the use of adjuvant therapy in the latter (x^2 =4.0,P >0.05). Patients with CPC experienced shorter time for recurrence than those with CPP or aCPP (x^2 =40.1,P <0.0001). Conclusions:Our results indicated that CPP in the fourth ventricle could trigger serious clinical symptoms at an early stage,requiring early intervention.Adjuvant treatment might be necessary for patients with partially resected CPP,aCPP,and CPC to achieve a favorable outcome. | Wen-Jian-Long Zhou Xi Wang Jia-Yi Peng Shun-Chang Ma Dai-Nan Zhang Xiu-Dong Guan Jin-Fu Diao Jian-Xing Niu Chun-De Li Wang Jia | 2018 | Chinese Medical Journal2018，，24： | 3 |
| 15 | Landing site topographic mapping and rover localization for Chang’e-4 mission显示文摘This paper presents the techniques and results of landing-site topographic mapping and rover localization using orbital,descent and rover images in the Chang’e-4 mission.High-resolution maps of the landing site are generated from orbital and descent images.Local digital elevation models and digital orthophoto maps with 0.02 m resolution are generated at each waypoint.The location of the lander is determined as(177.588?E,45.457?S)using festure-matching techniques.The cross-site visual localization method is routinely used to localize the rover at each waypoint to reduce error accumulation from wheel slippage and IMU drift in dead reckoning.After the first five lunar days,the rover travels 186.66 m from the lander,according to the cross-site visual localization.The developed methods and results have been directly utilized to support the mission’s operations.The maps and localization information are also valuable for supporting multiple scientific explorations of the landing site. | Zhaoqin LIU Kaichang DI Jian LI Jianfeng XIE Xiaofeng CUI Luhua XI Wenhui WAN Man PENG Bin LIU Yexin WANG Sheng GOU Zongyu YUE Tianyi YU Lichun LI Jia WANG Chuankai LIU Xin XIN Mengna JIA Zheng BO Jia LIU Runzhi WANG Shengli NIU Kuan ZHANG Yi YOU Bing LIU Jiangang LIU | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 16 | ACADEMIC EXPL ORATION Is It Possible to Stody the Pharmacokinetics of Chemical Componentof Herbal Recipe?显示文摘ACADEMICEXPLORATIONIsItPossibletoStodythePharmacokineticsofChemicalComponentofHerbalRecipe?HuangXi(黄熙);JiangYong-pei(姜永培)andW... | $$$$Huang Xi(黄熙) Jiang Yong-pei(姜永培) and Wen Ai-dong (文爱东)(The Hijing Hospital, The Fourth Military Medical University, Hi’an 710032)Zang Yi-ming (臧益民) and Niu Guo-bao (牛国保)(Department of Physiology, The fourth Military Medical University, | 1995 | Chinese Journal of Integrative Medicine1995，1，4： | 3 |
| 17 | Application of DNA barcoding to the identification of Hymenoptera parasitoids from the soybean aphid (Aphis glycines) in China显示文摘蚜虫属 glycines Matsumura 是在亚洲和北美洲的大豆的一个重要害虫。Hymenoptera parasitoids 玩在大豆蚜虫的控制的一个关键角色。parasitoids 的正确鉴定是先于对他们的潜在的生物控制代理人的评价的关键步。攻击大豆蚜虫的种类的多数的精确鉴定经常要求精致的标本准备和专家分类知识。在这研究,我们由使用跟随初步的词法鉴定的一条 DNA barcoding 途径便于大豆蚜虫 parasitoids 的鉴定。我们从 mitochondrial COI 基因和 28S rDNA 的 D2 区域产生了 DNA 顺序数据在种类在中国从大豆蚜虫出现以内并且在 parasitoid 之间估计基因变化。属于五个家庭的 10 个类的十五 Hymenoptera parasitoid 种与很少 intra 特定的变化(为 28S 的 0.09%±0.06% 和为 COI 的 0.36%±0.18%) 和大种间的分叉(为 28S 的 30.46%±3.42% 和为 COI 的 20.4%±1.20%) 被识别。 | Qing-Song Zhou Yu-Qiang Xi Fang Yu Xu Zhang Xue-Jun Li Chun-Lai Liu Ze-Qing Niu Chao-Dong Zhu Ge-Xia Qiao Yan-Zhou Zhang | 2014 | Insect Science2014，21，3： | 2 |
| 18 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 19 | Study on the bioactivity changes of hydroxylated sulfonylureas derivatives: A possible metabolism显示文摘Some new sulfonylureas and their hydroxylation products had been synthesized from 2-amino-4-methylpyrimidine. Their bioactivities against E. coli AHAS II in vitro were tested and the results indicated that the hydroxylation decreased the inhibition activities of sulfonylureas significantly. Subsequently herbicidal tests against stem-growth of barnyard grass and root-growth of rape confirmed the above conclusion. The preliminary molecular docking studies were also carried out to investigate the binding modes of non-hydroxylated and hydroxylated sulfonylureas with AHAS. | Shu Rong Ban Cong Wei Niu Wen Bin Chen Zhi Hong Yu Si Wu Chen Wang Zhen Xi | 2007 | Chinese Chemical Letters2007，18，2： | 2 |
| 20 | Preparation and in vitro Release Properties of Mercaptopurine Drug-loaded Magnetic Microspheres显示文摘Magnetic Fe3O4 nanoparticles were synthesized by co-precipitation method and the mercaptopurine(MER) drug-loaded magnetic microspheres were obtained through emulsion cross-linking methods. The efficiency of this approach was evaluated in terms of drug loading content(DLC), encapsulation efficiency(EE) and delivery properties in vitro, determined by high performance liquid chromatograph(HPLC). The microspheres showed good DLC values of 11.8%, as well as good EE values of 79.4%. The in vitro drug release study was carried out in phosphate buffer solution(PBS) simulated body fluid, at 37 ℃ with pH=7.4. The release profiles showed an initial fast release rate, which decreased as time progressed and about 84 % had been released after 48 h. The experimental results indicated that the prepared magnetic microspheres may be useful for potential applications of MER for magnetically targeted chemotherapy. | XU Haixing ZHANG Yu NIU Xiaoqian WANG Ling CHEN Hui ZHANG Xi TANG Qiuhan HUANG Zhijun LIU Hui XU Peihu | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，6： | 2 |
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