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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | A review of rapid transport of pesticides from sloping farmland to surface waters: Processes and mitigation strategies显示文摘Pesticides applied to sloping farmland may lead to surface water contamination through rapid transport processes as influenced by the complex topography and high spatial variability of soil properties and land use in hilly or mountainous regions. However, the fate of pesticides applied to sloping farmland has not been sufficiently elucidated. This article reviews the current understanding of pesticide transport from sloping farmland to surface water. It examines overland flow and subsurface lateral flow in areas where surface soil is underlain by impervious subsoil or rocks and tile drains. It stresses the importance of quantifying and modeling the contributions of various pathways to rapid pesticide loss at catchment and regional scales. Such models could be used in scenario studies for evaluating the effectiveness of possible mitigation strategies such as constructing vegetated strips, depressions, wetlands and drainage ditches, and implementing good agricultural practices. Field monitoring studies should also be conducted to calibrate and validate the transport models as well as biophysical-economic models, to optimize mitigation measures in areas dominated by sloping farmland. | Xiangyu Tang Bo Zhu Hidetaka Katou | 2012 | Journal of Environmental Sciences2012，24，3： | 13 |
| 3 | A Review of Colloid Transport in Fractured Rocks显示文摘Recent recognition of colloid and colloidassociated transport of strongly sorbing contaminants in fractured rocks highlights the importance of exploring the transport behavior of colloids under conditions prevailing in the field.The rapid transport of colloids through fractured rocks-as affected by the hydraulic properties of the flow system,the properties of fracture surface and the geochemical conditionshas not been sufficiently elucidated,and predictions of colloid transport through fractures have encountered difficulties,particularly at the field scale.This article reviews the current understanding of the mechanisms and modeling of colloid transport and retention in fractured rocks.Commonly used experimental techniques and approaches for conducting colloid transport experiments at different scales,ranging from the laboratory to the field scale,are summarized and commented upon.The importance of various interactions(e.g.,dissolution,colloid deposition,generation,mobilization and deposition of filling materials within fractures) between the flowing solution and the fracture walls(in many cases,with skin or coating on the host rock at the liquid-solid interface) has been stressed.Colloid transport through fractures of high heterogeneity has not yet been well understood and modeled at the field scale.Here,we summarize the current knowledge and understanding accumulated in the last two decades in regard to colloid and colloidassociated transport through fractures.Future research needs are also discussed. | ZHANG Wei TANG Xiangyu WEISBROD Noam GUAN Zhuo | 2012 | Journal of Mountain Science2012，9，6： | 12 |
| 4 | Studies on Factors Influencing Hydrodynamic Characteristics of Plates Used in Artificial Reefs显示文摘As a simplified model of artificial reefs, a series of plate models punched with square or circular openings are designed to investigate the effects of openings on the hydrodynamic characteristics of artificial reefs. The models are grouped by various opening numbers and opening-area ratios. They are physically tested in a water flume or used in the numerical simulation to obtain the drag force in the uniform flow with different speeds. The simulation results are found in good agreement with the experimental measurements. By the non-dimensional analysis, the drag coefficient specified to each model is achieved and the effects of openings are examined. It is found that the key factor affecting the drag coefficient is the open-area ratio. Generally, the drag coefficient is a linear function of the open area ratio with a minus slope. The empirical formulae for the square and circular openings respectively are deduced by means of the multiple regression analysis based on the measured and numerical data. They will be good references for the design of new artificial reefs. As a result of numerical simulation, the vorticity contours and pressure distribution are also presented in this work to better understand the hydrodynamic characteristics of different models. | TANG Yanli YANG Wenzhao SUN Liyuan ZHAO Fenfang LONG Xiangyu WANG Gang | 2019 | Journal of Ocean University of China2019，18，1： | 6 |
| 5 | Sequential auto-reclosing strategy for hybrid HVDC breakers in VSC-based DC grids显示文摘The use of overhead lines for power transmission in the future high-voltage and large-capacity voltagesource converter(VSC)-based direct current(DC) grid will significantly increase the probability of temporary faults.To eliminate potential adverse impacts such as erroneous protection, line-insulation failure, and even damage to power electronic devices resulting from a DC breaker reclosing operation with the traditional sequential autoreclosing strategy, a new sequential auto-reclosing strat-egy for hybrid HVDC breakers(HHBs) in VSC-based DC grids is proposed. This strategy is based on the step-by-step operation of the transfer branch in the HHB. As a result,du/dt resulting from the HHB reclosing operation is greatly reduced, and therefore those potential negative impacts can be eliminated. Several other advantages are also presented.The feasibility and validity of the proposed strategy are verified in a four-terminal annular VSC-based DC grid electromagnetic transient model. | Xiangyu PEI Guangfu TANG Shengmei ZHANG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 5 |
| 6 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 7 | Influence of Synthesis Parameters with Low Seed Addition on the Crystallinity of ZSM-5显示文摘ZSM-5 zeolite microparticles(MPs)were synthesized under hydrothermal condition using a low crystal seed addition approach without template.The synthesis parameters such as the seed addition amount,the SiO2/Al2O3ratio,the aluminum source,the feeding addition method,aging,and crystallization were investigated.The structure,morphology and composition of the as-synthesized ZSM-5 zeolite MPs were characterized by X-ray powder diffraction(XRD),scanning electron microscopy(SEM),laser particle size distribution(PSD)measurements,and inductively coupled plasma-atomic emission spectrometry(ICP-AES).The SiO2/Al2O3ratio of ZSM-5 zeolite MPs was in the range of 20—80.The low seed addition was beneficial to improving the crystallinity and shortening the crystallization time,and the suitable amount of seed was 0.25%(SiO2).The ZSM-5 zeolite MPs synthesized with aluminium nitrate nonahydrate used as the aluminum source exhibited a relatively high crystallinity.An appropriate aging time could eliminate the effect of feeding addition method and effectively adjust particle size.The particle size of ZSM-5 zeolite obtained at an aging time of 20 h was around 2.0μm.Prolonging the aging time appropriately could also shorten the high-temperature crystallization time.The suitable aging time was 24 h,and the relative crystallinity of ZSM-5 zeolite could reach up to 99%after crystallization for 24 h at 180℃. | Wang Songlin Wei Huijuan Tang Ying Wang Xiangyu Li Baojun | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，4： | 3 |
| 8 | Theoretical study on rotary-sliding disk triboelectric nanogenerators in contact and non-contact modes显示文摘摩擦电 nanogenerator (TENG ) 作为收获技术的一个新、有效的机械精力出现了。在这个工作,为有栅栏结构的旋转滑动的磁盘 TENG 的一个理论模型被构造,包括 dielectric-to-dielectric 和 conductor-to-dielectric 盒子。有限元素方法(女性) 被利用描绘在接触和非接触模式工作的 rotarysliding 磁盘 TENG 的基本物理。磁盘 TENG 的基本性质被发现被象 tribo 表面间距,栅栏数字,和几何尺寸那样的结构的参数控制。从女性的计算,一种近似 V-Q- 关系通过插值方法被造,然后有任意的负担抵抗的 TENG 动态产量特征是数字地计算的。最后,结构的参数和旋转上的力量和匹配的抵抗评估的输出的相关性被揭示。现在的工作提供旋转滑动的磁盘 TENG 的工作原则的深入的理解并且为在特定的应用程序优化 TENG 输出性能用作重要指导。 | Tao Jiang Xiangyu Chen Keda Yang Changbao Han Wei Tang Zhong Lin Wang | 2016 | Nano Research2016，9，4： | 3 |
| 9 | Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta)显示文摘 | Lifang Jin Shaohui Ji Xianghui Tang Xiangyu Guo Yongqing Lu Hongwei Chen Hongkui Deng Qi Zhou Weizhi Ji | 2009 | Cell Research2009，19，2： | 2 |
| 10 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hcbk995ufuq0w6ucn.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 11 | Calibration of Mars Energetic Particle Analyzer (MEPA)显示文摘The first Mars exploration mission of China(Tianwen-1)is scheduled to be launched in 2020;a charged particle telescope,the Mars Energetic Particle Analyzer(MEPA),is carried as one of the payloads on the orbiter.The MEPA is designed to measure solar energetic particles(SEPs)and galactic cosmic rays(GCRs)in the near-Mars space and in the transfer orbit from Earth to Mars.Before the launch,the MEPA was calibrated in ground experiments with radioactive sources,electronic pulses,and accelerator beams.The calibration parameters,such as energy conversion constants,threshold values for the triggers,and particle identification criteria,were determined and have been stored for onboard use.The validity of the calibration parameters has been verified with radioactive sources and beams.The calibration results indicate that the MEPA can measure charged particles reliably,as designed,and that it can satisfy the requirements of the Tianwen-1 mission. | ShuWen Tang Yi Wang HongYun Zhao Fang Fang Yi Qian YongJie Zhang HaiBo Yang CunHui Li Qiang Fu Jie Kong XiangYu Hu Hong Su ZhiYu Sun YuHong Yu BaoMing Zhang Yu Sun ZhiPeng Sun | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 12 | Potential for natural and enhanced attenuation of sulphanilamide in a contaminated chalk aquifer显示文摘Understanding antibiotic biodegradation is important to the appreciation of their fate and removal from the environment. In this research an Isotope Ratio Mass Spectrometry(IRMS)method was developed to evaluate the extent of biodegradation of the antibiotic,sulphanilamide, in contaminated groundwater. Results indicted an enrichment in δ^(13)C of8.44‰ from-26.56(at the contaminant source) to-18.12‰(300 m downfield of the source).These results confirm reductions in sulphanilamide concentrations(from 650 to 10 mg/L)across the contaminant plume to be attributable to biodegradation(56%) vs. other natural attenuation processes, such as dilution or dispersion(42%). To understand the controls on sulphanilamide degradation ex-situ microcosms assessed the influence of sulphanilamide concentration, redox conditions and an alternative carbon source. Results indicated, high levels of anaerobic capacity(~50% mineralisation) to degrade sulphanilamide under high(263 mg/L), moderate(10 mg/L) and low(0.02 mg/L) substrate concentrations. The addition of electron acceptors; nitrate and sulphate, did not significantly enhance the capacity of the groundwater to anaerobically biodegrade sulphanilamide. Interestingly, where alternative carbon sources were present, the addition of nitrate and sulphate inhibited sulphanilamide biodegradation. These results suggest, under in-situ conditions, when a preferential carbon source was available for biodegradation, sulphanilamide could be acting as a nitrogen and/or sulphur source. These findings are important as they highlight sulphanilamide being used as a carbon and a putative nitrogen and sulphur source, under prevailing iron reducing conditions. | Karen A.Bennett Simon D.Kelly Xiangyu Tang Brian J.Reid | 2017 | Journal of Environmental Sciences2017，29，12： | 2 |
| 13 | The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity显示文摘The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well characterized.In particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is elusive.Here,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 levels.Alternatively,these patients mounted potent virus-specific TH1 and CD8+T cell responses.In sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these patients.These results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines. | Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang Jianfang Tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 14 | Space-frequency-polarization-division multiplexed wireless communication system using anisotropic space-time-coding digital metasurface显示文摘In the past few years,wireless communications based on digital coding metasurfaces have gained research interest owing to their simplified architectures and low cost.However,in most of the metasurface-based wireless systems,a single-polarization scenario is used,limiting the channel capacities.To solve the problem,multiplexing methods have been adopted,but the system complexity is inevitably increased.Here,a space-frequency-polarization-division multiplexed wireless communication system is proposed using an anisotropic space-time-coding digital metasurface.By separately designing time-varying control voltage sequences for differently oriented varactor diodes integrated on the metasurface,we achieve frequency-polarization-division multiplexed modulations.By further introducing different time-delay gradients to the control voltage sequences in two polarization directions,we successfully obtain space-frequency-polarization-division multiplexed modulations to realize a wireless communication system with a new architecture.The new communication system is designed with compact dual-polarized meta-elements,and can improve channel capacity and space utilization.Experimental results demonstrate the high-performance and real-time transmission capability of the proposed communication system,confirming its potential application in multiple-user collaborative wireless communications. | Jun Chen Ke Xiangyu Chen Wankai Tang Ming Zheng Chen Lei Zhang Li Wang Jun Yan Dai Jin Yang Jun Wei Zhang Lijie Wu Qiang Cheng Shi Jin Tie Jun Cui | 2022 | National Science Review2022，9，11： | 2 |
| 15 | Placenta-derived IL-32β activates neutrophils to promote preeclampsia development显示文摘Immune activation at the maternal-fetal interface is a main pathogenic factor of preeclampsia(PE).Neutrophils(PMNs)are activated in PE patients,but the mechanism and consequences of PMN activation need to be further explored.Here,we demonstrated that interleukin-32(IL-32)expression was significantly upregulated in syncytiotrophoblasts(STBs)and that IL-32β was the major isoform with increased expression in the placenta of severe PE(sPE)patients.Furthermore,the level of IL-32 expression in the placenta was correlated with its level in the serum of sPE patients,indicating that IL-32 in the serum is derived mainly from the placenta.Then,in vitro experiments showed that IL-32β could highly activate PMNs and that these IL-32β-activated PMNs were better able to adhere to endothelial cells(HUVECs)and enhance the expression of vascular cell adhesion molecule-1(VCAM-1)and intercellular cell adhesion molecule-1(ICAM-1)in HUVECs,which could be reversed by preincubation with the NADPH oxidase inhibitor VAS 2870.In addition,we showed that IL-32β mainly activated PMNs by binding to proteinase 3.Finally,IL-32β administration induced a PE-like phenotype in a pregnant mouse model.This study provides evidence of the involvement of IL-32β in the pathogenesis of PE. | Dan Liu Qiang Li Hailin Ding Guangfeng Zhao Zhiyin Wang Chenrui Cao Yimin Dai Mingming Zheng Xiangyu Zhu Qianwen Wu Ya Wang Honglei Duan Huirong Tang Xianyan Lu Yayi Hou Yali Hu | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 16 | DETERMINATION OF CHLORPYRIFOS AND ITS MAIN DEGRADATION PRODUCT TCP IN WATER SAMPLES BY DISPERSIVE LIQUID–LIQUID MICROEXTRACTION BASED ON SOLIDIFICATION OF FLOATING ORGANIC DROPLET COMBINED WITH HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY显示文摘 | Jianfei Xiong Guangming Zhou Zhuo Guan Xiangyu Tang Qiang He Limin Wu | 2014 | Journal of Liquid Chromatography & Related Technologies2014，，11： | 1 |
| 17 | Influence of reaction conditions on product distribution in the green oxidation of cyclohexene to adipic acid with hydrogen peroxide显示文摘 | Peng Jin Zhonghua Zhao Zhipeng Dai Donghui Wei Mingsheng Tang Xiangyu Wang | 2011 | Catalysis Today2011，，1： | 1 |
| 18 | Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19显示文摘COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection.It is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 patients.In a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent NAbs.Furthermore,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms.These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness. | Xiangyu Chen Zhiwei Pan Shuai Yue Fei Yu Junsong Zhang Yang Yang Ren Li Bingfeng Liu Xiaofan Yang Leiqiong Gao Zhirong Li Yao Lin Qizhao Huang Lifan Xu Jianfang Tang Li Hu Jing Zhao Pinghuang Liu Guozhong Zhang Yaokai Chen Kai Deng Lilin Ye | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 19 | Efficacy of catgut embedding in Baihui(GV20)and Feishu(BL13)and Pishu(BL20)on lung tissue,brain tissue and blood related indexes in rats with allergic rhinitis of lung deficiency type显示文摘OBJECTIVE:To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue,blood immunoglobulin E(IgE)and interleutin-4(IL-4),brain tissue microglia x-42(OX-42)and toll-like receptor-2(TLR-2)in rats with allergic rhinitis of lung deficiency type.METHODS:Forty-five female Sprague-Dawley rats were randomly divided for two times.The first time,they were randomly divided into model group and blank group(Group C)according to 2∶1,and the second time,the model group were randomly divided into model control group(Group B)and intervention treatment group(Group A)according to 1∶1.15 in each group.For Group A and Group B,the lung deficiency model was made by'sulfur–moxa fumigation',and then the allergic rhinitis model was established by'ovalbumin(OVA)sensitization'.Then catgut embedding was performed at acupoints in Group A and not in Group B.After 3 weeks,collect lung tissue samples for hematoxylin-eosin staining,then take blood to observe the concentration of IgE and IL-4,and finally take brain tissue to observe the results of OX-42 and TLR-2.RESULTS:IgE level(μg/m L)was(3.11±0.20)in the Group A,(4.19±0.44)in the Group B,and(2.29±0.30)in the Group C(all P<0.001).IL-4 level(pg/mL)was(14.2±0.7)in the Group A,(18.6±2.4)in the Group B,and(11.4±1.2)for the Group C(all P<0.001).The mean OD for OX-42 is(0.1728±0.0016)in the Group A,(0.1810±0.0046)in the Group B and(0.1674±0.0025)in the Group C(all P<0.001).CONCLUSION:Although 3 weeks of acupoint catgut embedding already showed obvious efficacy on rats with allergic rhinitis,the allergic reaction in the body still continued.To achieve further treatment,prolonging the catgut embedding time is necessary. | HUANG Heyin WANG Yichen ZHANG Qinxiu WU Xiaojuan WANG Jiang Li Xiangyu PANG Rui FAN Li CAO Liu TANG Luo | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 1 |
| 20 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
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