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| 1 | Three-dimensional porous graphene sponges assembled with the combination of surfactant and freeze-drying显示文摘与表面活化剂和 freeze-drying 的联合,我们开发了二种 graphene 多孔的结构。在一方面,把肥皂水泡的泡沫用作模板,有富有的层次毛孔的三维的多孔的 graphene 海绵被综合了。材料的毛孔包含长度规模的三个层次,包括毫米,测微计和纳米。结构能被改变结冰媒介调节,调整激动人心的率或增加功能的添加剂。由 graphene 氧化物 / 表面活化剂暂停的直接 freeze-drying,在另一方面,有方向性地排列的毛孔的一个多孔的框架被准备。表面活化剂给 graphene 氧化物表的更好的分散,导致一个高特定的表面区域。两个获得的材料展出优秀吸收能力和好压缩性能,提供大量可能的应用程序,例如吸收剂,存储媒介,和搬运人。 | Rujing Zhang Yachang Cao Peixu Li Xiaobei Zang Pengzhan Sun Kunlin wang Minlin Zhong Jinquan Wei Dehai Wu Feiyu Kang Hongwei Zhu | 2014 | Nano Research2014，7，10： | 10 |
| 2 | Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition显示文摘为健全信号获得和识别的一个便携、高精确的传感器从编织的特殊设计的 graphene 的薄电影被制作织物(GWF ) 。在被拉长之上,随机的裂缝的高密度出现在网络,它减少当前的小径,从而增加电阻。因此,这部电影能对人的喉咙作为一个紧张传感器起作用以便测量通过肌肉运动,一个声音是否被生产的讲话。超离频敏感允许由提取声波的签名特征的快速、低频率的讲话采样的实现。在这研究, 26 封英语信,典型汉字和音调的代表性的信号,甚至短语和句子被测试,揭示在电阻的明显、典型的变化。而且, graphene 传感器的电阻变化与预告录下的声音完美地反应了。由把人工智能与数字信号处理相结合,我们期望以后,这个 graphene 传感器将能成功地达成复杂声学的系统和听觉的数据的大数量。 | Yan Wang Tingting Yang Junchao Lao Rujing Zhang Yangyang Zhang Miao Zhu Xiao Li Xiaobei Zang Kunlin Wang Wenjian YU Hu Jin Li Wang Hongwei Zhu | 2015 | Nano Research2015，8，5： | 8 |
| 3 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 4 | Sleep disorders and its related risk factors in patients undergoing chronic peritoneal dialysis显示文摘 | Li Han Li Xiaobei Feng Sujuan Zhang Guizhi Wang Wei Wang Shixiang | 2014 | Chinese Medical Journal2014，，7： | 5 |
| 5 | Knockdown of long non-coding RNA LCPAT1 inhibits autophagy in lung cancer显示文摘Objective: Long non-coding RNAs(lnc RNAs) are involved in numerous biological processes in lung cancer cells. In our previous studies, we identified a lnc RNA, ENST00000439577, which is highly expressed in lung carcinomas, and termed it lung cancer progression-associated transcript 1(LCPAT1). To characterize the role of LCPAT1 in lung cancer, we conducted the current study.Methods: Expression of LCPAT1 and autophagy-associated markers in tumor tissues and lung cancer cell lines was determined by real-time quantitative polymerase chain reaction(q PCR). Hematoxylin and eosin(HE) staining, q PCR, Western blot, and immunohistochemistry were performed to evaluate xenografted tumor tissues. Autophagy induced by rapamycin was detected by Western blot and immunofluorescence in lung cancer cell lines.Results: Expression of LCPAT1 and microtubule-associated protein 1 light chain 3 beta(LC3B) was positively correlated in lung cancer. Knockdown of LCPAT1 inhibited tumor growth and suppressed cell autophagy in vivo. Moreover, LCPAT1 knockdown in lung cancer cell lines resulted in decreased autophagy-associated gene expression and alleviated the cell autophagy induced by rapamycin.Conclusions: We speculate that LCPAT1 plays a crucial role in regulating autophagy in lung cancer. | Xiao Yu Xiaofei Ye Hongyan Lin Nannan Feng Sumeng Gao Xiaohong Zhang Yu Wang Herbert Yu Xiaobei Deng Biyun Qian | 2018 | Cancer Biology & Medicine2018，15，3： | 5 |
| 6 | Theoretical aspects and sensing demonstrations of cone-shaped inwall capillary-based microsphere resonators显示文摘In this paper, a detailed theoretical study on the characteristics of cone-shaped inwall capillary-based microsphere resonators is described and demonstrated for sensing applications. The maximum, minimum, slope, contrast, and width of the Fano resonance are analyzed. As the transmission coefficient of the capillary resonator increases, the absolute value of the slope of Fano resonances increases to reach its maximum, which is useful for sensors with an ultra-high sensitivity. There occurs another phenomenon of electromagnetically induced transparency when the reflectivity at the capillary–environment interface is close to 100%. We also experimentally demonstrated its capability for temperature and refractive index sensing, with a sensitivity of 10.9 pm∕°C and 431 d B∕RIU basedon the Fano resonance and the Lorentzian line shape, respectively. | XIAOBEI ZHANG YONG YANG HUAWEN BAI JIAWEI WANG MING YAN HAI XIAO TINGYUN WANG | 2017 | Photonics Research2017，5，5： | 5 |
| 7 | Embedded whispering-gallery mode microsphere resonator in a tapered hollow annular core fiber显示文摘We propose and demonstrate a tapered hollow annular core fiber (HACF) coupler for excitation of whisperinggallery modes (WGMs) of an embedded microsphere resonator. The coupler is simply fabricated by fusion splicing of a segment of HACF with the single-mode fiber (SMF), and then improved by tapering the splicing joint to reduce the cone-apex angle. Therefore, the coupling efficiency from the SMF to the HACF is enhanced to excite various WGMs via evanescent field coupling. Normal positive, negative symmetrical Lorentzian and asymmetric Fano line shapes can be obtained by varying the resonator size and location. Another interesting phenomenon is observed that a higher Q-factor mode in a lower Q-factor mode has a contrast as high as 58. Temperature sensing with good stability is also demonstrated. This embedded WGM microsphere resonator in the tapered HACF is expected to promote environmental adaptability in practical applications due to its simplicity and | JIAWEI WANG XIAOBEI ZHANG MING YAN LEI YANG FENGYU HOU WEN SUN XIAOTONG ZHANG LIBO YUAN HAI XIAO TINGYUN WANG | 2018 | Photonics Research2018，6，12： | 4 |
| 8 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hqb50vofpqknu660o.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 9 | Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine显示文摘Dear Editor,Urine passes through the entire kidney and urinary tract system starting from the glomerulus and ending to the urethra.Cells in the kidney and urinary tract could be exfoliated from the epithelium into the urine,while leukocyte could infiltrate from the local tissue into the urine,which makes the urine a useful subject for clinical evaluation of relevant diseases. | Yujia Wang Yu Zhao Zixian Zhao Dandan Li Hao Nie Yufen Sun Xiaobei Feng Ting Zhang Yu Ma Jing Nie Guangyan Cai Xiangmei Chen Wei Zuo | 2021 | Protein & Cell2021，12，4： | 2 |
| 10 | Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy显示文摘Although multifarious tumor-targeting modifications of nanoparticulate systems have been attempted in joint efforts by our predecessors,it remains challenging for nanomedicine to traverse physiological barriers involving blood vessels,tissues,and cell barriers to thereafter demonstrate excellent antitumor effects.To further overcome these inherent obstacles,we designed and prepared mycoplasma membrane(MM)-fused liposomes(LPs)with the goal of employing circulating neutrophils with the advantage of inflammatory cytokine-guided autonomous tumor localization to transport nanoparticles.We also utilized in vivo neutrophil activation induced by the liposomal form of the immune activator resiquimod(LPsR848).Fused LPs preparations retained mycoplasma pathogen characteristics and achieved rapid recognition and endocytosis by activated neutrophils stimulated by LPs-R848.The enhanced neutrophil infiltration in homing of the inflammatory tumor microenvironment allowed more nanoparticles to be delivered into solid tumors.Facilitated by the formation of neutrophil extracellular traps(NETs),podophyllotoxin(POD)-loaded MM-fused LPs(MM-LPs-POD)were concomitantly released from neutrophils and subsequently engulfed by tumor cells during inflammation.MM-LPs-POD displayed superior suppression efficacy of tumor growth and lung metastasis in a 4T1 breast tumor model.Overall,such a strategy of pathogen-mimicking nanoparticles hijacking neutrophils in situ combined with enhanced neutrophil infiltration indeed elevates the potential of chemotherapeutics for tumor targeting therapy. | Xiaobei Cheng Pei Yu Xiang Zhou Jiale Zhu Yubao Han Chao Zhang Lingyi Kong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 11 | Phase-and epidemic region-adjusted estimation of the number of coronavirus disease 2019 cases in China显示文摘The outbreak of the coronavirus disease 2019 in China was first reported in Wuhan in December 2019 and gradually spread to other areas in China.After implementation of prevention and control measures,the estimation of the epidemic trend is needed.A phase-and region-adjusted SEIR model was applied for modeling and predicting the number of cases in Wuhan,Hubei Province and regions outside Hubei Province in China.The estimated number of infections could reach its peak in late February 2020 in Wuhan and Hubei Province,which is 55303–84520 and 83944–129312,respectively,while the epidemic peaks in regions outside Hubei Province in China could appear on February 13,2020 with the estimated 13035–19108 cases.According to the estimation,the outbreak would abate in March and April all over China.Current estimation provided evidence for planned work resumption under stringent prevention and control in China to further support the fight against the epidemic.Nevertheless,there is still possibility of the second outbreak brought by the work resumption and population migration,especially from Hubei Province and high intensity cities outside Hubei Province.Strict prevention and control measures still need to be considered in the regions with high intensity of epidemic and densely-populated cities. | Ruijie Chang Huwen Wang Shuxian Zhang Zezhou Wang Yinqiao Dong Lhakpa Tsamlag Xiaoyue Yu Chen Xu Yuelin Yu Rusi Long Ning-Ning Liu Qiao Chu Ying Wang Gang Xu Tian Shen Suping Wang Xiaobei Deng Jinyan Huang Xinxin Zhang Hui Wang Yong Cai | 2020 | Frontiers of Medicine2020，14，2： | 2 |
| 12 | PpTCP18 is upregulated by lncRNA5 and controls branch number in peach (Prunus persica) through positive feedback regulation of strigolactone biosynthesis显示文摘Branch number is an important agronomic trait in peach(Prunus persica)trees because plant architecture affects fruit yield and quality.Although breeders can select varieties with different tree architecture,the biological mechanisms underlying architecture remain largely unclear.In this study,a pillar peach(‘Zhaoshouhong’)and a standard peach(‘Okubo’)were compared.‘Zhaoshouhong’was found to have significantly fewer secondary branches than‘Okubo’.Treatment with the synthetic strigolactone(SL)GR24 decreased branch number.Transcriptome analysis indicated that PpTCP18(a homologous gene of Arabidopsis thaliana BRC1)expression was negatively correlated with strigolactone synthesis gene expression,indicating that PpTCP18 may play an important role in peach branching.Yeast one-hybrid,electrophoretic mobility shift,dual-luciferase assays and PpTCP18-knockdown in peach leaf buds indicated that PpTCP18 could increase expression of PpLBO1,PpMAX1,and PpMAX4.Furthermore,transgenic Arabidopsis plants overexpressing PpTCP18 clearly exhibited reduced primary rosette-leaf branches.Moreover,lncRNA sequencing and transient expression analysis revealed that lncRNA5 targeted PpTCP18,significantly increasing PpTCP18 expression.These results provide insights into the mRNA and lncRNA network in the peach SL signaling pathway and indicate that PpTCP18,a transcription factor downstream of SL signaling,is involved in positive feedback regulation of SL biosynthesis.This role of PpTCP18 may represent a novel mechanism in peach branching regulation.Our study improves current understanding of the mechanisms underlying peach branching and provides theoretical support for genetic improvement of peach tree architecture. | Xiaobei Wang Qiuping Wang Lixia Yan Yuhang Hao Xiaodong Lian Haipeng Zhang Xianbo Zheng Jun Cheng Wei Wang Langlang Zhang Xia Ye Jidong Li Bin Tan Jiancan Feng | 2023 | Horticulture Research2023，10，1： | 2 |
| 13 | Monitoring and identifying pendant droplets in microbottle resonators显示文摘Optofluidic resonators are capable of characterizing various fluidic media.Here,we propose an optofluidic microbottle resonator(OFMBR)that is applied to generate pendant droplets,whose maximum mass is related to the liquid surface tension.Mass and type of droplets forming along the OFMBR stem can be monitored in real time by spectrum variation.As a pendant droplet grows,increased droplet gravity introduces a decreased coupling gap and compressive force between the tapered fiber and OFMBR,leading to a resonance wavelength shift.The operation mechanism of the proposed sensors is validated by theoretical simulation and experimental results.From the experimental spectra,a liquid mass sensor with maximum sensitivity of−3.34pm/mg is obtained,and distilled water and alcohol can be identified.This scheme provides a new thread for droplet generation as well as fluidic properties characterization. | Zijie Wang Xiaobei Zhang Qi Zhang Yiqi Chen Yong Yang Yang Yu Yang Wang Yanhua Dong Yi Huang Tingyun Wang | 2022 | Photonics Research2022，10，3： | 2 |
| 14 | PM 2.5 -induced oxidative stress triggers autophagy in human lung epithelial A549 cells显示文摘 | Xiaobei Deng Fang Zhang Wei Rui Fang Long Lijuan Wang Zhaohan Feng Deliang Chen Wenjun Ding | 2013 | Toxicology in Vitro2013，，6： | 1 |
| 15 | Study on application of Fenton oxidation method in the treatment of medicine wastewater 显示文摘 | Zhang Yin Ren Nnaqi Liu Xiaobei | 2005 | High Technology Letters2005，11，2： | 1 |
| 16 | On generating interpretable and precise fuzzy systems based on Pareto multi-objective cooperative coevolu- tionary algorithm显示文摘 | ZHANG Yong WU Xiaobei XING Zongyi | 2011 | Applied Soft Computing2011，11，1： | 1 |
| 17 | Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo显示文摘 | Yuanxi Zhu Xiaobei Zhang Yan Liu Sheng Zhang Jingjing Liu Yi Ma Jin Zhang | 2012 | Tumor Biology2012，，5： | 1 |
| 18 | Natural products:potential therapeutic agents for atherosclerosis显示文摘Atherosclerosis(AS)is an invisible killer among cardiovascular diseases(CVD),which has seriously threatened the life of quality.The complex pathogenesis of AS involves multiple interrelated events and cell types,such as macrophages,endothelial cells,vascular smooth muscle cells and immune cells.Currently,the efficacy of recommended statin treatment is not satisfactory.Natural products(NPs)have attracted increasing attention with regard to their broad structural diversity and biodiversity,which makes them a promising library in the demand for lead compounds with cardiovascular protective bio-activity.NPs can preclude the development of AS by regulating lipid metabolism,ameliorating inflammation,stabilizing plaques,and remodeling the gut microbiota,which lays a foundation for the application of NPs in clinical therapeutics. | CHENG Xiaobei ZHAO Caili JIN Zhiwei HU Jianping ZHANG Zhenzhen ZHANG Chao | 2022 | Chinese Journal of Natural Medicines2022，20，11： | 1 |
| 19 | Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells显示文摘 | Xiaobei Deng Fang Zhang Lijuan Wang Wei Rui Fang Long Yong Zhao Deliang Chen Wenjun Ding | 2014 | Apoptosis2014，，7： | 1 |
| 20 | The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation显示文摘Butyrate and butyrate-producing bacteria are important indicators of gut microbial metabolism in human health.Ten non-digestible carbohydrates(NDCs),including inulin,fructooligosaccharide(FOS),oatsβ-glucans(OGS),oatsβ-glucan oligosaccharides(OGOS),Astragalus polysaccharides(APS),Astragalus oligosaccharides(AOS),xanthan gum oligosaccharides(XGOS),gellan gum oligosaccharides(GGOS),curdlan oligosaccharides(COS),and pullulan oligosaccharides(POS)were used to investigate NDC specifi city in modulating butyrate-producing bacteria and butyrate production in 48 h in vitro fermentation studies in combination with fecal inocula from 7 healthy donors and 11 patients with type 2 diabetes(T2D).We observed that the amount of these ten NDCs utilized depended on NDC structure and inter-individual gut microbial differences.XGOS and GGOS fermentations signifi cantly increased butyrate-producing bacteria(especially f_Lachnospiraceae)and butyric acid production.Furthermore,XGOS and GGOS fermentations showed a better ability to consistently modulate gut microbiota composition and metabolic properties between individuals of healthy donors or T2D patients when compared to inulin,FOS,APS,AOS,OGS,OGOS,COS and POS fermentation.This research indicated that xanthan gum and gellan gum oligosaccharides have strong specifi city to enhance butyrate-producing bacteria and butyrate production. | Jingjing Xu Ruyue Wang Weibao Liu Zhongwei Yin Jianrong Wu Xun Yu Wen Wang Hongtao Zhang Zhitao Li Minjie Gao Li Zhu Xiaobei Zhan | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
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