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| 1 | Biostratigraphy of Triassic Marine Reptiles in Southwest Guizhou and Its Adjacent Area显示文摘This paper briefly reviews the Triassic marine reptile fossils inGuizhou Province, especially the fossils that have been recently found in the Guanling area. Based on three sections at Guanling and Xingyi, Guizhou Province and Luoping, Yunnan Province, four horizons with vertebrate fossils are recognized in the Middle and Upper Triassic of this area; They are from bottom to top: Member I and Member Ⅱ of the Guanling Formation, and the Zhuganpo Member and the Wayao Member of the Falang Formation. | WANG Liting, LI Jinling, WANG Xinjin, LI Chun,WU Tianzhuang and LIU Jun Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550004 Institute of Vertebrate Palaeontology and Palaeoanthropology,Chinese Academy of Sciences, Beijing 100044 Guizhou Museum, Guiyang 550004 | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 17 |
| 2 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 3 | Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma显示文摘Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are biliary tract cancers with poor five-year survival and high recurrence rates.Both CCA and GBC patients suffer from lack of circulating diagnostic biomarkers at the early stage.Extracellular vesicles,especially exosomes,have been emerged as promising diagnostic sources for cancers due to easy and quick accessibility.Hence,identification of exosomal biomarkers provides a novel strategy for CCA and GBC diagnosis.Here,five CCA patients and four GBC patients were enrolled for exosomal small RNA sequencing.Our data showed that exosomal piwi-interacting RNA(piRNA)populations were altered in the plasma of CCA and GBC patients.In comparison to healthy individuals,694 and 323 piRNAs were upregulated in CCA and GBC,respectively,while 36 and 191 piRNAs were down regulated.Interestingly,sequencing results predicted that piR-2660989,piR-10506469,piR-20548188,piR-10822895,piR-hsa-23209,and piR-18044111 were upregulated in both CCA and GBC plasma.Importantly,we further included blood samples from 50 health individuals,40 CCA patients,and 25 GBC patients and found that piR-10506469 were significantly increased in the exosomes of plasma from both CCA and GBC patients.Moreover,we analyzed the expression levels of differentially expressed exosomal piRNAs in the plasma of CCA and GBC patient before and after surgeries and found that piR-10506469 and piR-20548188 were significantly decreased in patients underwent surgeries.Taken together,our data revealed that exosomal piRNAs those are differentially expressed in CCA and GBC plasma may serve as potential biomarkers for the diagnosis of CCA and GBC. | Xinjin Gu Chen Wang Hui Deng Chong Qing Rong Liu Sanhong Liu Xinying Xue | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 7 |
| 4 | Risk identification and risk mitigation during metro station construction by enlarging shield tunnel combined with cut-and-cover method显示文摘Constructing a metro station by enlarging shield tunnels combined with a mining/cut-and-cover method provides a new method to solve the contradictions of construction time limits of shield tunnels and stations. As a new-style construction method, there are several specific risks involved in the construction process. Based on the test section of Sanyuanqiao station on Beijing metro line 10, and combined with the existing methods of risk identification at present, including a review of world-wide operational experience of similar projects, the study of generic guidance on hazards associated with the type of work being undertaken, and discussions with qualified and experienced staff from the project team, etc., the specific risks during the construction process of the metro station constructed by enlarging shield tunnels combined with the cut-and-cover method are identified. The results show that the specific risks mainly come from three construction processes which include constructing upper enclosure structures, excavating the soil between shield tunnels and demolishing shield segments. Then relevant risk mitigation measures are put forward. The results can provide references for scheme improvement and a comprehensive risk assessment of the new-style construction method. | Zhang, Xinjin Liu, Weining Lu, Meili | 2008 | Journal of Southeast University(English Edition)2008，24，S1： | 3 |
| 5 | Shale pore characteristics of Shahejie Formation: Implication for pore evolution of shale oil reservoirs in Dongying sag, north China显示文摘The pore characteristics of shale reservoirs in the lower submember of Member 3 to upper submember of Member 4 of Shahejie Formation in Dongying sag are analyzed,influences of mineral content and organic matter content on porosity and pore size are also investigated,and through the diagenetic thermal simulation experiment,the main pore evolution is further discussed.The results show that the pore structure of shale reservoirs is complex,the micron-nanometer pores can storage liquid hydrocarbons,and the free-phase crude oil is mainly distributed in intergranular dissolution pores of calcite,recrystallized intergranular pores,intergranular shrinkage fractures of clay mineral which have large pore size.Framework minerals and organic matter content directly influence porosity and pore size of shale reservoirs,relationship between porosity and content of felsic mineral as well as content of organic matter content is linear and positive,while relationship between content of carbonated mineral is negative.At the buried depth from 2500 to 3500 m,concentration of organic acid from hydrocarbon generation and expulsion of organic matter,increasing range of pressure coefficient,are well corresponding to highporosity intervals;pore formation in shale oil reservoirs are almost controlled by diagenetic evolution of clay minerals;framework storage spaces formed by carbonate grain crystals as well as intergranular and intergranular dissolution pores of carbonate increases porosity of shale oil reservoirs;local increase of porosity at the depth of 3500e3800 m is mainly caused by coupling of hydrocarbon-generating overpressure and dissolution,and size,distribution and connectivity of pores are enhanced obviously. | Shun Zhang Huimin Liu Min Wang Xinjin Liu Huilai Liu Youshu Bao Weiqing Wang Runze Li Xin Luo Zhengwei Fang | 2019 | Petroleum Research2019，4，2： | 2 |
| 6 | Productivity properties of protein-lipid film (Yuba) prepared from different soybean cultivars in China显示文摘 | SHEN Qun ZHANG Xinjin HAN Zhi el al | | 0，，01： | 1 |
| 7 | Purification,composition analysis and antioxidant activity of the polysaccharides from Dendrobium nobile Lindl显示文摘 | Aoxue LUO Xinjin He | 2010 | Carbohydrate Polymers2010，79，： | 1 |
| 8 | Research on sirospun yarn torque using airflow false twisting device显示文摘 | LIU Xinjin SU Xuzhong | 2013 | Journal of the Textile Institute2013，104，5： | 1 |
| 9 | Industrial m engineering显示文摘 | Xinjin Harding R H | 1999 | Chemistry Research1999，38，10： | 1 |
| 10 | A unified framework of error evaluation and adjustment in machining显示文摘 | WAN Xinjin XIONG Caihua ZHAO Can | 2008 | International Journal of Machine Tools and Manufacture2008，48，11： | 1 |
| 11 | Propofol pretreatment attenuates remote kidney injury induced by orthotopicliver autotransplantation, which is correlated with the activation of Nrf2 inrats显示文摘 | Mian Ge Gangjian Luo Weifeng Yao Chenfang Luo Shaoli Zhou Dongdong Yuan Xinjin Chi Ziqing Hei | 2015 | Molecular Medicine Reports2015，，5： | 1 |
| 12 | Metabolic and immune responses in Chinese mitten-handed crab (Eriocheir sinensis) juveniles exposed to elevated ambient ammonia 显示文摘 | Hong Meiling Chen Liqiao Sun Xinjin | 2007 | Comparative Biochemistry and Physiology2007，145，3： | 1 |
| 13 | Suppressing FCC gasoline olefinicity while managing light olefins production显示文摘 | Raymond W Mott Roberie Terry Zhao Xinjin | 1998 | NPRA Annual Meeting1998，，： | 1 |
| 14 | Fungal-derived selenium nanoparticles and their potential applications in electroless silver coatings for preventing pin-tract infections显示文摘Pin-tract infections(PTIs)are a common complication of external fixation of fractures and current strategies for preventing PTIs have proven to be ineffective.Recent advances show that the use of anti-infection coatings with local antibacterial activity may solve this problem.Selenium has been considered as a promising anti-infection agent owing to its antibacterial and antibiofilm activities.In this study,selenium nanoparticles(SeNPs)were synthesized via a cost-effective fungi-mediated biorecovery approach and demonstrated excellent stability and homogeneity.To investigate their anti-infection potential,the SeNPs were doped in silver coatings through an electroless plating process and the silver–selenium(Ag–Se)coatings were tested for antibacterial and antibiofilm properties against Staphylococcus aureus F1557 and Escherichia coli WT F1693 as well as corrosion resistance in simulated body fluid.It was found that the Ag–Se coating significantly inhibited S.aureus growth and biofilm formation on the surface,reducing 81.2%and 59.7%of viable bacterial adhesion when compared with Ag and Ag–PTFE-coated surfaces after 3 days.The Ag–Se coating also exhibited improved corrosion resistance compared with the Ag coating,leading to a controlled release of Ag^(+),which in turn reduced the risk of cytotoxicity against hFOBs.These results suggest that the fungal-derived SeNPs may have potential in use as implant coatings to prevent PTIs. | Xinjin Liang Shuai Zhang Geoffrey Michael Gadd John McGrath David W.Rooney Qi Zhao | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 15 | 高强度聚焦超声对中晚期胰腺癌的止痛作用(英文)显示文摘Objective: The aim of this study was to evaluate the analgesic effect of high intensity focused ultrasound (HIFU) in patients with advanced pancreatic cancer. Methods: A total of 106 patients with advanced pancreatic cancer accompanied by abdominal pain were treated by HIFU. Pain intensities and quantities of morphine consumption before and after treatment were observed and compared. Results: The average pain intensities before treatment, and at d3, d7 after treatment were 5.80 ± 2.14, 2.73 ± 2.68, 2.45 ± 2.43 respectively (P < 0.01). Fifty-nine cases (55.7%) got to extremely effective, and 29 cases (27.4%) effective. Total efficient rate was 83.0 %. The average quantities of morphine consumption before and after treatment in the patients with grade III pain were 114.9 ± 132.5 mg, 16.8 ± 39.7 mg each person everyday respectively (P < 0.01). Conclusion: HIFU can relieve pain suffered by patients with pancreatic cancer effectively. It is a new adjuvant treatment for pancreatic cancer pain. | Xinjin Tan Jian Chen Li Ren Ruilu Lin Zailian Chen | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，8： | 0 |
| 16 | Bacterial coinfections contribute to severe COVID-19 in winter显示文摘Dear Editor,Although most cases of COVID-19 caused by SARS-CoV-2 Omicron variants are mild or asymptomatic worldwide,coinfection with SARS-CoV-2 and other respiratory pathogens may still aggravate the severity of the illness.1,2 The current literature indicates that coinfection with COVID-19 could occur in 3.70%–9.7%of patients.1,3,4 The proportion of bacterial,and other respiratory viral coinfections may range from 3.02%to 9.7%and 5.41%to 6.61%,respectively.However,these studies demonstrated that coinfections with respiratory pathogens are not common. | Hui Fan Li Zhou Jingjun Lv Shimin Yang Guozhong Chen Xinjin Liu Chunyan Han Xue Tan Shengnan Qian Zegang Wu Shan Yu Ming Guo Chengliang Zhu Yu Chen Ke Lan | 2023 | Cell Research2023，33，7： | 0 |
| 17 | Copper-Mediated Deuterotrifluoromethylation of α-Diazo Esters显示文摘α
的调停铜的 deuterotrifluoromethylation ? 在重氢氧化物的提升下面的重氮基的酉旨(D 2 O ) 为标记重氢的 trifluoromethyl 混合物的合成被开发了。这 deuterotrifluoromethylation 反应具有宽广范围并且能负担得起 deuterated 产品与比 99% 同位素的纯净高。而且,这调查的结果也提供一些试验性的证据支持我们的以前建议的 trifluoromethylation 机制。 | Mingyou Hu Qiqiang Xie Xinjin Li Chuanfa Ni Jinbo Hu | 2016 | Chinese Journal of Chemistry2016，34，5： | 0 |
| 18 | ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles显示文摘Similar to that of other enteroviruses, the replication of enterovirus 71(EV71) occurs on rearranged membranous structures called replication organelles(ROs). Phosphatidylinositol 4-kinase Ⅲ(PI4KB), which is required by enteroviruses for RO formation, yields phosphatidylinositol-4-phosphate(PI4P) on ROs. PI4P then binds and induces conformational changes in the RNA-dependent RNA polymerase(Rd Rp) to modulate Rd Rp activity. Here, we targeted 3D polymerase, the core enzyme of EV71 ROs, and found that the host factor Annexin A2(ANXA2) can interact with 3 D polymerase and promote the replication of EV71. Then, an experiment showed that the annexin domain of ANXA2, which possesses membranebinding capacity, mediates the interaction of ANXA2 with EV71 3 D polymerase. Further research showed that ANXA2 is localized on ROs and interacts with PI4KB. Overexpression of ANXA2 stimulated the formation of PI4P, and the level of PI4P was decreased in ANXA2-knockout cells. Furthermore, ANXA2, PI4KB, and 3D were shown to be localized to the viral RNA replication site, where they form a higher-order protein complex, and the presence of ANXA2 promoted the PI4 KB-3D interaction. Altogether, our data provide new insight into the role of ANXA2 in facilitating formation of the EV71 RNA replication complex. | Qiuhan Zhang Siliang Li Ping Lei Zixian Li Feifei Chen Qi Chen Yulu Wang Jiami Gong Qi Tang Xinjin Liu Ke Lan Shuwen Wu | 2021 | Virologica Sinica2021，36，6： | 0 |
| 19 | A new model of the harmonic control based on Hadamard product显示文摘In terms of Hadamard product, a new model is proposed for the control of connection coefficients of the state variables of the systems. The control law to stabilize the systems via the regulations of connection coefficients is obtained via a Hadamard product involved bilinear matrix inequalities. This new control model may be of significant applications in many fields, especially may be of some special sense in the emergency control such as isolation and obstruction control. | Xinjin LIU Yun ZOU Xiefei YAN | 2009 | 控制理论与应用(英文版)2009，7，4： | 0 |
| 20 | Gas-assisted microfluidic step-emulsification forgenerating micron- and submicron-sized droplets显示文摘Micron- and submicron-sized droplets have extensive applications in biomedical diagnosis and drug delivery.Moreover, accurate high-throughput analysis requires a uniform droplet size distribution and high production rates.Although the previously reported microfluidic coflow step-emulsification method can be used to generate highlymonodispersed droplets, the droplet diameter (d) is constrained by the microchannel height (b), d\3b, while theproduction rate is limited by the maximum capillary number of the step-emulsification regime, impedingemulsification of highly viscous liquids. In this paper, we report a novel, gas-assisted coflow step-emulsificationmethod, where air serves as the innermost phase of a precursor hollow-core air/oil/water emulsion. Air graduallydiffuses out, producing oil droplets. The size of the hollow-core droplets and the ultrathin oil layer thickness bothfollow the scaling laws of triphasic step-emulsification. The minimal droplet size attains d 1:7b, inaccessible instandard all-liquid biphasic step-emulsification. The production rate per single channel is an order-of-magnitudehigher than that in the standard all-liquid biphasic step-emulsification and is also superior to alternative emulsificationmethods. Due to low gas viscosity, the method can also be used to generate micron- and submicron-sized droplets ofhigh-viscosity fluids, while the inert nature of the auxiliary gas offers high versatility. | Biao Huang Xinjin Ge Boris Y.Rubinstein Xianchun Chen Lu Wang Huiying Xie Alexander M.Leshansky Zhenzhen Li | 2023 | Microsystems & Nanoengineering2023，9，4： | 0 |
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