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| 1 | Effects of Nd^(3+)on the microstructure and magnetic properties of Ni-Zn ferrites显示文摘Ni0.4Zn0.6Fe2 ? 铁酸盐与 Nd2O3 的不同数量做了的 xNdxO4 (x = 0-0.07 ) 用标准陶器的技术被准备。样品单轴地被压并且在 1250D 的 | FAN Xiufeng REN Huiping ZHANG Yanghuan GUO Shihai WANG Xinlin | 2008 | Rare Metals2008，27，3： | 7 |
| 2 | Genomic landscape of gastric cancer: molecular classification and potential targets显示文摘Gastric cancer imposes a considerable health burden worldwide, and its mortality ranks as the second highest for all types of cancers. The limited knowledge of the molecular mechanisms underlying gastric cancer tumorigenesis hinders the development of therapeutic strategies. However, ongoing collaborative sequencing efforts facilitate molecular classification and unveil the genomic landscape of gastric cancer. Several new drivers and tumorigenic pathways in gastric cancer, including chromatin remodeling genes, Rho A-related pathways, TP53 dysregulation, activation of receptor tyrosine kinases, stem cell pathways and abnormal DNA methylation, have been revealed. These newly identified genomic alterations await translation into clinical diagnosis and targeted therapies. Considering that loss-of-function mutations are intractable, synthetic lethality could be employed when discussing feasible therapeutic strategies. Although many challenges remain to be tackled, we are optimistic regarding improvements in the prognosis and treatment of gastric cancer in the near future. | Jiawei Guo Weiwei Yu Hui Su Xiufeng Pang | 2017 | Science China(Life Sciences)2017，60，2： | 6 |
| 3 | Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment显示文摘Salmonella:mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models,but the detailed mechanism remains unsolved.In this report,the active involvement of the host immune response in this process was confirmed by comparing the tumor-suppressive effects of Salmonella in immunocompetent and immunodeficient mice bearing melanoma allografts.Since flagella are key inducers of the host immune response during bacterial infection,flagella were genetically disrupted to analyse their involvement in Salmonella-mediated cancer therapy.The results showed that flagellum-deficient strains failed to induce significant anti-tumor effects,even when more bacteria were administered to offset the difference in invasion efficiency.Flagella mainly activate immune cells via Flagellin/Toll-like receptor 5(TLR5)signalling pathway.Indeed,we showed that exogenous activation of TLR5 signalling by recombinant Flagellin and exogenous expression of TLR5 both enhanced the therapeutic efficacy of flagellum-deficient Salmonella against melanoma.Our study highlighted the therapeutic value of the interaction between Salmonella and the host immune response through Flagellin/TLR5 signalling pathway during Salmonella-mediated cancer therapy,thereby suggesting the potential application of TLR5 agonists in the cancer immune therapy. | Jianxiang Chen Yiting Qiao Guo Chen Cunjie Chang Heng Dong Bo Tang Xiawei Cheng Xiufeng Liu Zichun Hua | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 4 | Numerical simulation of the effect of lower positive charge region in thunderstorms on different types of lightning显示文摘Combined with the existing stochastic lightning parameterization scheme, a classic tripole charge structure in thunderstorms is assumed in the paper, and then 2-dimensional fine-resolution lighting discharge simulations are performed to quantitatively investigate the effect of lower positive charge(LPC) on different types of lightning. The results show:(1) The LPC plays a key role in generating negative cloud-to-ground(CG) flashes and inverted intra-cloud(IC) lightning, and with the increase of charge density or distribution range of LPC region, lightning type changes from positive polarity IC lightning to negative CG flashes and then to inverted IC lightning.(2) Relative to distribution range of charge regions, the magnitude of charge density of the LPC region plays a dominant role in lightning type. Only when the maximal charge density value of LPC region is within a certain range, can negative CG flashes occur, and the occurrence probability is relatively fixed.(3) In this range, the charge density and distribution range of LPC region jointly determine the occurrence of negative CG flashes, which has a linear boundary with the trigger condition of IC lightning.(4) The common effect of charge density and distribution range of the LPC region is to change the distribution of positive potential well of bottom part of thunderstorms, and inverted IC lightning occurs when the initial reference potential is close to 0 MV, and negative CG flashes occur when the initial reference potential is far less than 0 MV. | TAN YongBo LIANG ZhongWu SHI Zheng ZHU JunRu GUO XiuFeng | 2014 | Science China Earth Sciences2014，57，9： | 5 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | A parameterization scheme for upward lightning in the cloud model and a discussion of the initial favorable environmental characteristics in the cloud显示文摘The upward lightning(UL) initiated from the top of tall buildings(at least above 100 m) is a type of atmospheric discharge. Currently, we understand the nature of the UL from ground observations, but the corresponding theoretical research is lacking. Based on an existing bidirectional leader stochastic model, a stochastic parameterization scheme for the UL has been built and embedded in an existing two-dimensional thundercloud charge/discharge model. The ULs simulated from the experiments with two-dimensional high resolution agree generally with the observation results. By analyzing the charge structure of thunderstorm clouds, we determined the in-cloud environmental characteristics that favor the initiation of conventional cloud-to-ground(CG) flashes and analyzed the differences and similarities of some characteristics of the positive and the negative UL. Simulation results indicate that the positive ULs are typically other-lightning-triggered ULs(OLTUL) and are usually a discharge phenomenon between the ground and the lower positive charge region appearing below the main middle negative charge region. The effect of the previous in-cloud lightning(IC) process of space electrical field provides favorable conditions for the initiation of a positive UL. Its entire discharge process is limited, and the branches of the leader are fewer in number as its discharge is not sufficient. A negative UL is generally a discharge phenomenon of the dipole charge structure between the ground and the main negative charge region. The lower temperature stratification and the sinking of the hydrometeors typically initiate a negative UL. Negative ULs develop strongly and have more branches. The OLTUL is initiated mainly during the development stage of a thunderstorm, while the self-triggered UL(STUL) is initiated mainly during the dissipation stage of a thunderstorm. | TAN Yong Bo CHEN Chao ZHOU Jie Chen ZHOU Bo Wen ZHANG DongDong GUO XiuFeng | 2016 | Science China Earth Sciences2016，59，7： | 3 |
| 7 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 8 | Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-term Results From a Randomized, Multicenter Trial显示文摘 | Chengyu Luo Wenbin Guo Jie Yang Qiuru Sun Wei Wei Suhua Wu Shubing Fang Qingliang Zeng Zhensheng Zhao Fanjie Meng Xuandong Huang Xianlan Zhang Ruihua Li Xiufeng Ma Chaoying Luo Yun Yang | 2012 | Mayo Clinic Proceedings2012，，12： | 1 |
| 9 | Simulated impacts of atmospheric gravity waves on the initiation and optical emissions of sprite halos in the mesosphere显示文摘The correlation between atmospheric gravity waves(GWs) and Transient Luminous Events(TLEs) has been poorly studied using both synchronous observations and numerical simulations. To investigate the modulation effects of GWs on TLEs,a troposphere-mesosphere quasi-electrostatic field model is developed in three-dimensional Cartesian coordinates, and the effects of GW perturbations on the initiation and optical emissions of sprite halos are simulated using the model. Simulation results indicate that the atmospheric density at lower ionosphere altitudes becomes inhomogeneous due to GW perturbations, and sprite halos tend to initiate in the GW troughs due to the lower electric breakdown threshold. GW perturbations cause the deformation of sprite halos, strong luminous regions distribute mainly along the GW troughs while optical intensities along the GW peaks is relatively weak. Larger GW perturbations lead to more pronounced deformation of sprite halos, however, stronger lightning discharges in the troposphere result in less optical perturbations of sprite halos. The observed luminous intensities and optical morphology of sprite halos are also affected by the observing orientations and the lightning polarities. | Jinbo ZHANG Qilin ZHANG Xiufeng GUO Wenhao HOU Haiyang GAO | 2019 | Science China Earth Sciences2019，62，4： | 1 |
| 10 | Two-Dimensional Pnictogen for Field-Effect Transistors显示文摘Two-dimensional(2D)layered materials hold great promise for various future electronic and optoelectronic devices that traditional semiconductors cannot afford.2D pnictogen,group-VA atomic sheet(including phosphorene,arsenene,antimonene,and bismuthene)is believed to be a competitive candidate for next-generation logic devices.This is due to their intriguing physical and chemical properties,such as tunable midrange bandgap and controllable stability.Since the first black phosphorus fieldeffect transistor(FET)demo in 2014,there has been abundant exciting research advancement on the fundamental properties,preparation methods,and related electronic applications of 2D pnictogen.Herein,we review the recent progress in both material and device aspects of 2D pnictogen FETs.This includes a brief survey on the crystal structure,electronic properties and synthesis,or growth experiments.With more device orientation,this review emphasizes experimental fabrication,performance enhancing approaches,and configuration engineering of 2D pnictogen FETs.At the end,this review outlines current challenges and prospects for 2D pnictogen FETs as a potential platform for novel nanoelectronics. | Wenhan Zhou Jiayi Chen Pengxiang Bai Shiying Guo Shengli Zhang Xiufeng Song Li Tao Haibo Zeng | 2019 | Research2019，，1： | 1 |
| 11 | Nonreciprocal coherent coupling of nanomagnets by exchange spin waves显示文摘Nanomagnets are widely used to store information in non-volatile spintronic devices.Spin waves can transfer information with low-power consumption as their propagations are independent of charge transport.However,to dynamically couple two distant nanomagnets via spin waves remains a major challenge for magnonics.Here we experimentally demonstrate coherent coupling of two distant Co nanowires by fast propagating spin waves in an yttrium iron garnet thin film with sub-50 nm wavelengths.Magnons in two nanomagnets are unidirectionally phase-locked with phase shifts controlled by magnon spin torque and spin-wave propagation.The coupled system is finally formulated by an analytical theory in terms of an effective non-Hermitian Hamiltonian.Our results are attractive for analog neuromorphic computing that requires unidirectional information transmission. | Hanchen Wang Jilei Chen Tao Yu Chuanpu Liu Chenyang Guo Song Liu Ka Shen Hao Jia Tao Liu Jianyu Zhang Marco A.Cabero Z Qiuming Song Sa Tu Mingzhong Wu Xiufeng Han Ke Xia Dapeng Yu Gerrit E.W.Bauer Haiming Yu | 2021 | Nano Research2021，14，7： | 1 |
| 12 | Ethanol gas sensor based on CoFe2O4 nano-crystallines prepared by bydrothermal method显示文摘 | CHOU Xiufeng JIANG Dongli GUO Yu | 2006 | Sens Actuators B2006，120，： | 1 |
| 13 | Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles—time for a new embryo transfer strategy?显示文摘 | Dandan Zhu Juanjuan Zhang Shanren Cao Junqiang Zhang Boon Chin Heng Meiling Huang Xiufeng Ling Tao Duan Guo Qing Tong | 2011 | Fertility and Sterility2011，，5： | 1 |
| 14 | Crystal Growth and Characterization of Ca3NbGa3Si2O14 Single Crystal显示文摘Single crystals of Ca3NbGa3Si2O14 (CNGS) with ordered Ca3Ga2Ge4O14 (CGG) structure were successfully grown from stoichiometric melts by conventional Czochralski technique along the a-axis and two large (001) facets and two small (100) facets appear in every crystal. An arrangement of parallel steps and a clear height change were observed in (001) facet by atomic force microscopy (AFM). High-resolution X-ray diffraction (HRXRD) results indicate that CNGS crystals have good quality and free low-angle boundaries. The crystals also exhibit good optical quality and high optical transmittance in c-direction. | Shi Xuzhong Yuan Duorong Cheng Xiufeng Guo Shiyi Yu Guangwei Li Zhanfa | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 15 | Master crack types and typical acoustic emission characteristics during rock failure显示文摘Acoustic emission(AE)signals contain substantial information about the internal fracture characteristics of rocks and are useful for revealing the laws governing the release of energy stored therein.Reported here is the evolution of rock failure with diferent master crack types as investigated using Brazilian splitting tests(BSTs),direct shear tests(DSTs),and uniaxial compression tests(UCTs).The AE parameters and typical modes of each fracture type were obtained,and the energy release characteristics of each fracture mechanism were discussed.From the observed changes in the AE parameters,the rock fracture process exhibits characteristics of staged intensifcation.The scale and energy level of crack activity in the BSTs were signifcantly lower than those in the DSTs and UCTs.The proportion of tensile cracks in the BSTs was 65%–75%,while the proportions of shear cracks in the DSTs and UCTs were 75%–85%and 70%–75%,respectively.During the rock loading process under diferent conditions,failure was accompanied by an increased number of shear cracks.The amplitude,duration,and rise time of the AE signal from rock failure were larger when the failure was dominated by shear cracks rather than tensile ones,and most of the medium-and high-energy signals had medium to low frequencies.After calculating the proposed energy amplitude ratio,the energy release of shear cracks was found to exceed that of tensile cracks at the same fracture scale. | Tongbin Zhao Pengfei Zhang Yaxun Xiao Weiyao Guo Yulong Zhang Xiufeng Zhang | 2023 | International Journal of Coal Science & Technology2023，10，1： | 0 |
| 16 | The response law of far-field seismic ground motion of the Wenchuan earthquake and its damaging mechanism in the Loess Plateau显示文摘A series of housing collapses and other serious damage was caused by the 2008 Wenchuan M_(S)8.0 earthquake in the seismic intensity Ⅵ areas of the Loess Plateau, which is hundreds of kilometers away from the epicenter, and which showed a remarkable seismic intensity anomaly. The seismic disasters are closely related to the seismic response characteristics of the site, therefore, the systematic study of the far-field seismic response law of the Wenchuan earthquake in the Loess Plateau is of great significance to prevent the far-field disaster of great earthquake. In this paper, the seismic acceleration records of several bedrock stations and loess stations from the seismogenic fault of the Wenchuan earthquake to the Loess Plateau were collected, and the attenuation law of ground motion along the propagation path and the characteristics of seismic response on the loess site are studied,and the mechanism of amplification effect of ground motion is analyzed based on the dynamic feature parameters of the loess site obtained through the HVSR method. Taking a typical loess site of thick deposit as the prototype, a series of shaking table tests of dynamic response of loess site models with different thicknesses were carried out.Amplification effect, spectral characteristics of acceleration in model sites were analyzed under the action of a farfield seismic wave of the Wenchuan earthquake. The results show that seismic attenuation on the propagation path along the NE strike of the seismogenic fault to the Loess Plateau is slower than that in other directions, and the predominant period range of ground motion on bedrock site of the Loess Plateau presents broadband characteristics. Because the natural periods of loess sites with thick deposits are within the predominant period range of bedrock input wave, loess sites appear significant amplification effect of ground motion, the horizontal acceleration of ground motion exceeds 0.1 g, the seismic intensity reaches 7°. The thicker the loess deposit is, the more significant the change of spectral characteristics of ground motion on loess sites, and the narrower the predominant period range of ground motion becomes, and the closer it is to the natural period of loess sites.Therefore, for some old houses on thick loess sites, the poor seismic performance and strong seismic response eventually led to their collapses and damages because their natural periods are very close to the predominant period of ground motion of the Wenchuan earthquake on thick loess sites;For these damaged high-rise buildings,the resonance effect might be the main reason for their damages because their natural periods are included in the predominant period range of ground motion of the Wenchuan earthquake on thick loess sites.These research results would provide a basis for seismic disasters prediction and evaluation and seismic design of construction engineering in the Loess Plateau. | Xiaowu Pu Lanming Wang Ping Wang Xiufeng Tian Shiyang Xu Shaofeng Chai Haitao Guo | 2022 | Earthquake Research Advances2022，2，3： | 0 |
| 17 | Role of tannin pretreatment in flotation separation of magnesite and dolomite显示文摘Flotation separation of magnesite and its calcium-containing carbonate minerals is a difficult problem.Recently,new regulat-ors have been proposed for magnesite flotation decalcification,although traditional regulators such as tannin,water glass,sodium carbon-ate,and sodium hexametaphosphate are more widely used in industry.However,they are rarely used as the main regulators in research because they perform poorly in magnesite and dolomite single-mineral flotation tests.Inspired by the limonite presedimentation method and the addition of a regulator to magnesite slurry mixing,we used a tannin pretreatment method for separating magnesite and dolomite.Microflotation experiments confirmed that the tannin pretreatment method selectively and largely reduces the flotation recovery rate of dolomite without affecting the flotation recovery rate of magnesite.Moreover,the contact angles of the tannin-pretreated magnesite and dolomite increased and decreased,respectively,in the presence of NaOl.Zeta potential and Fourier transform infrared analyses showed that the tannin pretreatment method efficiently hinders NaOl adsorption on the dolomite surface but does not affect NaOl adsorption on the magnesite surface.X-ray photoelectron spectroscopy and density functional theory calculations confirmed that tannin interacts more strongly with dolomite than with magnesite. | Xiufeng Gong Jin Yao Jun Guo Bin Yang Haoran Sun Wanzhong Yin Yulian Wang Yafeng Fu | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，3： | 0 |
| 18 | First-principle study of puckered arsenene MOSFET显示文摘Two-dimensional material has been regarded as a competitive silicon-alternative with a gate length approaching sub-10 nm,due to its unique atomic thickness and outstanding electronic properties.Herein,we provide a comprehensively study on the electronic and ballistic transport properties of the puckered arsenene by the density functional theory coupled with nonequilibrium Green’s function formalism.The puckered arsenene exhibits an anisotropic characteristic,as effective mass for the electron/hole in the armchair and zigzag directions is 0.35/0.16 m0 and 1.26/0.32 m0.And it also holds a high electron mobility,as the highest value can reach 20045 cm2V–1s–1.Moreover,the puckered arsenene FETs with a 10-nm channel length possess high on/off ratio above 105 and a steep subthreshold swing below 75 mV/dec,which have the potential to design high-performance electronic devices.Interestingly,the channel length limit for arsenene FETs can reach 7-nm.Furthermore,the benchmarking of the intrinsic arsenene FETs and the 32-bit arithmetic logic unit circuits also shows that the devices possess high switching speed and low energy dissipation,which can be comparable to the CMOS technologies and other CMOS alternatives.Therefore,the puckered arsenene is an attractive channel material in next-generation electronics. | Hengze Qu Ziwei Lin Ruijuan Guo Xiyu Ming Wenhan Zhou Shiying Guo Xiufeng Song Shengli Zhang Haibo Zeng | 2020 | Journal of Semiconductors2020，41，8： | 0 |
| 19 | Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate显示文摘Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals,controlling metabolic states beyond energy metabolism.However,whether glycolytic metabolites also play a role in controlling cell fate remains unexplored.Here,we find that low levels of glycolytic metabolite 3-phosphoglycerate(3-PGA)can switch phosphoglycerate dehydrogenase(PHGDH)from cataplerosis serine synthesis to pro-apoptotic activation of p53.PHGDH is a p53-binding protein,and when unoccupied by 3-PGA interacts with the scaffold protein AXIN in complex with the kinase HIPK2,both of which are also p53-binding proteins.This leads to the formation of a multivalent p53-binding complex that allows HIPK2 to specifically phosphorylate p53-Ser46 and thereby promote apoptosis.Furthermore,we show that PHGDH mutants(R135W and V261M)that are constitutively bound to 3-PGA abolish p53 activation even under low glucose conditions,while the mutants(T57A and T78A)unable to bind 3-PGA cause constitutive p53 activation and apoptosis in hepatocellular carcinoma(HCC)cells,even in the presence of high glucose.In vivo,PHGDH-T57A induces apoptosis and inhibits the growth of diethylnitrosamine-induced mouse HCC,whereas PHGDH-R135W prevents apoptosis and promotes HCC growth,and knockout of Trp53 abolishes these effects above.Importantly,caloric restriction that lowers whole-body glucose levels can impede HCC growth dependent on PHGDH.Together,these results unveil a mechanism by which glucose availability autonomously controls p53 activity,providing a new paradigm of cell fate control by metabolic substrate availability. | Yu-Qing Wu Chen-Song Zhang Jinye Xiong Dong-Qi Cai Chen-Zhe Wang Yu Wang Yan-Hui Liu Yu Wang Yiming Li Jian Wu Jianfeng Wu Bin Lan Xuefeng Wang Siwei Chen Xianglei Cao Xiaoyan Wei Hui-Hui Hu Huiling Guo Yaxin Yu Abdul Ghafoor Changchuan Xie Yaying Wu Zheni Xu Cixiong Zhang Mingxia Zhu Xi Huang Xiufeng Sun Shu-Yong Lin Hai-Long Piao Jianyin Zhou Sheng-Cai Lin | 2023 | Cell Research2023，33，11： | 0 |
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