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| 1 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 2 | A novel impedance immunosensor based on O-phenylenediamine modified gold electrode to analyze abscisic acid显示文摘An impedance immunosensor based on O-phenylenediamine modified gold electrode for the determination of phytohormone abscisic acid(ABA) was proposed.The operating pH,absorption time,absorption temperature and concentration of anti-ABA antibody were investigated to optimize the analytical performance.The calibration curve for the determination of ABA was obtained from this impedance immunosensor under optimal conditions.The results showed that the detection limit at about 1 ng/mL in the range of 10-5000 ng... | Li, Qian Wang, Ruo Zhong Huang, Zhi Gang Li, He Song Xiao, Lang Tao | 2010 | Chinese Chemical Letters2010，21，4： | 7 |
| 3 | Formation of ZrB2in MgO-C Composite Materials Using In-Situ Synthesis Method显示文摘ZrB2 in MgO-C composite materials obtained by both microwave sintering synthesis and in-situ reaction at lower temperature was investigated. The test result shows that 66.67% of reactant changed into ZrB2, and the other form Al2O3, which could optimize the properties of carbon-containing materials. Therefore, the method of in-situ synthesizing ZrB2 acting as antioxidant in carbon-containing materials is considered as one of best ways to reduce the cost and ZrB2 as refractories is used on a large-scale. | LI Lin HONG Yan ruo SUN Jia-lin HE Zhi-yong PENG Xiao-yan | 2006 | Journal of Iron and Steel Research(International)2006，13，1： | 3 |
| 4 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 5 | The structure of the nucleosome core particle of chromatin in chicken erythrocytes visualized by using atomicforce microscopy显示文摘INTRODUCTIONAlleukaryoticchromosomesconsistsofaregularlyrepeatingprotein--DNAcomplexcalledthenucleosome(Kornberg,1977)[if.Itistraditionallyconsideredtobethefundamentalunitofchromatinstructure.Thephysicalpropertiesofnucleosomedependonsolutioncondition... | ZHAO HUI YI ZHANG SHU BING ZHANG CHUJIANG QI YE HE MIN QIAN LI RUO LANQIAN( Shanghai Institute of Cell Biology, Chinese Academyof Sciences, Shanghai 200031, China)( Shanghai Institute of Nuclear Research, ChineseAcademy of Sciences, Shanghai 201800, | 1999 | Cell Research1999，9，4： | 2 |
| 6 | STUDIES ON THE STRURE OF LIGUSTIPHENOL FROM LIGUSTICUM SINENCE OLIV显示文摘STUDIES ON THE STRURE OF LIGUSTIPHENOL FROM LIGUSTICUM SINENCE OLIV.￣1)STUDIESONTHESTRUREOFLIGUSTIPHENOLFROMLIGUSTICUMSINENCE... | De Quan YU Feng Zhi XIE Ruo Yun CHEN and Yan He HUANG(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050) | 1996 | Chinese Chemical Letters1996，7，8： | 2 |
| 7 | Phosphorus interception in floodwater of paddy field during the rice-growing season in TaiHu Lake Basin显示文摘 | ZHANG Zhijian ZHANG Jianying HE Ruo | 2007 | Environmental Pollution2007，145，： | 1 |
| 8 | Gene-Environment Interactions between Environmental Noise and Apo E4 Causes AD-Like Neuropathology in the Hippocampus in Male Rats显示文摘Experimental evidence has demonstrated that environmental hazards can induce neurodegeneration such as Alzheimer's disease(AD)^([1]).The pathogenesis of AD,characterized by a gradual cognitive decline,overproduction ofβ-amyloid(Aβ),and hyperphosphorylated tau in specific brain areas,is considered to involve the interaction of several internal(individual)and external environmental factors. | LI Wen Long LI Yuan Yuan LI Yu Xin FU Yu HE Xian Zhi TAO Fei Yan YOU Ruo Lan ZHANG Ruo Yu ZHONG Ming Qing CHI Hui Min ZHAI Qing Feng | 2022 | Biomedical and Environmental Sciences2022，35，3： | 1 |
| 9 | Effect of dis- solved oxygen on nitrogen purification of microbial ecosystem in sediments显示文摘 | RUAN Aidong HE Ruo XU Shengyou | 2009 | Journal of Environmental Science and Health Part A2009，44，4： | 1 |
| 10 | Characteristics of the bioreactor landfill system using an anaerobic-aerobic process for nitrogen removal 显示文摘 | Ruo He Xin-wen Liu Zhi-jian Zhang Dong-sheng Shen | 2007 | Bioresource Technology2007，98，： | 1 |
| 11 | Self-consistent Field Crystal Orbital Study on One-dimensional C_(60) Polymer显示文摘Self┐consistentFieldCrystalOrbitalStudyonOne┐dimensionalC60Polymer*HUANGYuan-he**,CHENGuang-juandLIURuo-zhuang(DepartmentofCh... | HUANG Yuan he ** , CHEN Guang ju and LIU Ruo zhuang (Department of Chemistry, Beijing Normal University, Beijing, 100875) | 1997 | Chemical Research in Chinese Universities1997，13，2： | 1 |
| 12 | Preparation and characterization of PEG/SiO2 composites as shape- stabilized phase change materials for thermal energy storage 显示文摘 | LI Jing- ruo HE Li - hang LIU Tang- zhi | 2013 | Sol Energy Mater Sol Cells2013，118，： | 1 |
| 13 | A Novel Dihydroflavone from the Roots of Uvaria Macrophylla显示文摘A new dihydroflavone (1), named macrophyllol A, was isolated from the roots of Uvaria macrophylla. Its structure was elucidated on the basis of spectroscopic evidence. | Si WANG, Pei Cheng ZHANG, Ruo Yun CHEN, Ying Hong WANG, Wen Yi HE, De Quan YU* Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 | 2002 | Chinese Chemical Letters2002，13，9： | 1 |
| 14 | Effect of Fenton oxidation on biodegradability, biotoxicity and dissolved organic matter distribution of concentrated landfill leachate derived from a membrane process 显示文摘 | Ruo He Bao-Hu Tian Qi-Qi Zhang | 2015 | Waste Management2015，38，： | 1 |
| 15 | A new antibody immobilization strategy based on electro-deposition of gold nanoparticles and Prussian Blue for label-free amperometric immunosensor显示文摘 | Xiulan He Ruo Yuan Yaqin Chai | 2007 | Bioteehnol Lett2007，29，： | 1 |
| 16 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping ZhuZhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
| 17 | Transgenic mice overexpressingγ-aminobutyric acid transporter subtypeⅠ develop obesity显示文摘Transgenic mice ubiquitously overexpressing murine γ aminobutyric acid transporter subtype Ⅰ were created. Unexpectedly, these mice markedly exhibited heritable obesity, which features significantly increased body weight and fat deposition. Behavioral examination revealed that transgeinc mice have slightly reduced spontaneous locomotive capacity and altered feeding pattern. Tills preliminary finding indicates that the inappropriate level of γ-aminobutyric acid transporters may be directly or indirectly involved in the pathogenic mechanism underlying certain types of obesity. | MA YING HUA JIA HUA HU XIAO GANG ZHOU RUO WANG ZENG ZHEN TONG MEI JIAN FEI LI HE GUO Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China Shanghai Institute of | 2000 | Cell Research2000，10，4： | 0 |
| 18 | Research on PbS Nanoparticles Coated with 2,6-O-Diallyl-β-CD显示文摘PbS nanoparticles coated with 2.6-O-dial1yl-β-CD were prepared successfully and characterized by transmission electron microscope (TEM), X-ray photoelectron spectrometer (XPS). The sample shows a very rapid induced | Yun LING Lin GUO Liang ZHANG Xi Cheng AI Ruo Nong FU Qian Shu LI He Sun ZHU (College of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing 100081) (Correspond author) | 1997 | Chinese Chemical Letters1997，8，3： | 0 |
| 19 | On-chip stackable dielectric laser accelerator显示文摘In this paper,we propose a novel stacked laser dielectric acceleration structure.This structure is based on the inverse Cherenkov effect and represented by a parametric design formulation.Compared to existing dielectric laser accelerators relying on the inverse Smith–Purcell effect,the proposed structure provides an extended-duration synchronous acceleration field without requiring the pulse front tilting technique.This advantage significantly reduces the required pulse duration.In addition,the easy to integrate layered structure facilitates cascade acceleration,and simulations have shown that low-energy electron beams can be cascaded through high gradients over extended distances.These practical advantages demonstrate the potential of this new structure for future chip accelerators. | Bin Sun Yang‑Fan He Ruo‑Yun Luo Tai‑Yang Zhang Qiang Zhou Shao‑Yi Wang Jian Zheng Zong‑Qing Zhao | 2023 | Nuclear Science and Techniques2023，34，2： | 0 |
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