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| 1 | Human Bone Marrow-Derived Mesenchymal Stem Cells produced TGFbeta Contributes to Progression and Metastasis of Prostate Cancer显示文摘 | Huamao Ye Jiwen Cheng Yuanjie Tang Zhiyong Liu Chuanliang Xu Yan Liu Yinghao Sun | | Cancer Investigation0，，： | 1 |
| 2 | Adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation显示文摘A UV-activated room temperature chemiresistive gas sensor based on ZnO nanocrystals film was fabricated. Its gas sensing properties under various conditions were also investigated in detail. The results shed new insight into the adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation. The chemisorbed oxygen species(O^-2(ads)(hv)) induced by UV light govern the adsorption and desorption ways of other gas molecules on the surface of ZnO nanocrystals, which is dependent on the electron affinity of gas molecules. Gas molecules with higher electron affinity than oxygen molecules can be adsorbed on the surface by the competitive adsorption way, extracting electrons from the surface. Gas molecules with lower electron affinity than oxygen molecules are attracted by the adsorbed O^-2(ads)(hv)layer, releasing electrons to the surface. These processes can influence the gas sensing properties of the sensor. Our findings will pave the way for the fundamental understanding and design of UV-activated gas sensor in the future. | ZHANG QiuPing XIE GuangZhong DU HongFei YANG Jing SU YuanJie TAI HuiLing XU Ming ZHAO Kang | 2019 | Science China(Technological Sciences)2019，62，12： | 1 |
| 3 | Effects of vacancy defect on the tensile behavior of graphene显示文摘Graphene is the strongest material but its performance is significantly weakened by vacancy defects. We use molecular dynamics simulations to investigate the tensile behavior of a graphene which contains a single vacancy defect.Our results suggest that because of the single vacancy, the fracture strength of graphene losses about 17.7%. The stress concentration around the vacancy defect leads to the destruction of nearby six-member rings structure, which forms the initial crack. The propagation direction of this crack in defective graphene is at an angle of 60° to the tensile direction initially, but then becomes perpendicular to the tensile direction. | Xiaoyu Sun Zuoguang Fu Mingtan Xia Yuanjie Xu | 2014 | Theoretical & Applied Mechanics Letters2014，4，5： | 1 |
| 4 | W-band GaN MMIC PA with 257 mW output power at 86.5 GHz Project supported by the National Natural Science Foundation of China (No. 61306113).显示文摘 | Xu Peng Song Xubo Lü Yuanjie Wang Yuangang Dun Shaobo Yin Jiayun Fang Yulong Gu Guodong Feng Zhihong Cai Shujun | 2015 | Journal of Semiconductors2015，，8： | 1 |
| 5 | Scalp acupuncture Yikang therapy on Baihui(GV20),Sishencong(EX-HN1),Zhisanzhen,Niesanzhen improves neurobehavior in young rats with cerebral palsy through Notch signaling pathway显示文摘OBJECTIVE:To investigate the efficacy of scalp acupuncture Yikang therapy on Baihui(GV20),Sishencong(EX-HN1),Zhisanzhen,Niesanzhen,on neurobehavior in young rats with cerebral palsy based on Notch signaling pathway.METHODS:Thirty 7-day-old rats were randomly divided into sham,model and acupuncture,10 rats in each group.The cerebral palsy model was established by the accepted modeling method,the acupuncture group selected'Baihui(GV20)','Sishencong(EX-HN1)','Zhisanzhen'and'Niesanzhen'for intervention 24 h after the model was made.The body masses were recorded before and after the treatment,respectively.After the intervention,the rats were subjected to suspension experiment,slope experiment,tactile stimulation experiment and Morris water maze experiment.After the end of the experiment,the morphological changes of hippocampal histology were observed by hematoxylineosin(HE)staining under light microscope,and the expression of Notch1,Notch3 and Hes5 were detected by Western blot and quantitative real-time polymerase chain reaction(PCR).RESULTS:The changes in body mass of the rats in each group were different;in behavioral experiments,compared with the sham,the suspension time of the model was shortened,the slope experiment,tactile stimulation experiment,and escape latency time were prolonged,and the number of platform crossing was reduced in the model,compared with the model,the suspension time of the acupuncture was prolonged,the slope experiment,tactile stimulation experiment,and escape latency time were shortened,and the number of platform crossing times was increased;HE staining showed severe hippocampal damage in the model and reduced hippocampal damage in the acupuncture.Western Blot and real-time fluorescence quantitative PCR showed that the expression of Notch1,Notch3 and Hes5 were increased in the model and the expression of Notch1,Notch3,Hes5 in acupuncture were decreased.CONCLUSIONS:Scalp acupuncture Yikang therapy may improve neurobehavior and reduce brain injury in rats with cerebral palsy by downregulating the expression of Notch1,Notch3,and Hes5. | XUE Jianyi XU Jinyan HUANG Mao YU Wentao YAN Yihui YAN Yuanjie YIN Zhenjin LU Qian PENG Wanying YAN Siyang | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 1 |
| 6 | FK228 induces mitotic catastrophe in A549 cells by mistargeting chromosomal passenger complex localization through changing centromeric H3K9 hypoacetylation显示文摘以前的研究证明了 histone deacetylase 禁止者(HDACis ) 能杀死癌症房间。另外, HDACis 能由于 chromosomal 旅客建筑群(CPC ) 的不够的本地化在癌症房间导致有丝分裂的大祸到着丝点。然而,在这些现象后面的机制仍然保持不清楚。在这研究,我们发现那 HDACi , FK228 ,包括 histone H3 离氨酸 9 的提高的 acetylation ( H3K9 ),着丝点的影响多重 epigenetic 修正特征减少了 H3K9 的 trimethylation ,并且减少 histone H3 丝氨酸 10 的 phosphorylation ( H3S10 )和着丝点蛋白质 A ( CENP --一)。这些 epigenetic 变化暗示 H3K9 hyperacetylation 禁止 CPC 招募,导致损害着丝点汇编和功能,并且最后导致异常有丝分裂。这些数据建议在 pericentromere 的 histone 的 hypoacetylation 是为招募的最重要的里程碑 CPC 并且在癌症房间的导致 HDACi 的杀死导致有丝分裂的大祸。 | Xuhui Zhang Zhiyi Zhang Guozhu Chen Ming Zhao Di Wang Xuemin Zhang Zhiyan Du Yuanji Xu Xiaodan Yu | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 1 |
| 7 | Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2interactions显示文摘 | Yunbo Jiang Huihua Chen Haiquan Jia Yuanji Xu Gang Liu Yan Wang Xiaohe Yang Yinglin Lu | 2010 | Experimental and Therapeutic Medicine2010，，2： | 1 |
| 8 | AN EFFECT ITERATION ALGORITHM FOR NUMERICAL SOLUTION OF DISCRETE HAMILTON-JACOBI-BELLMAN EQUATIONS显示文摘An algorithm for numerical solution of discrete Hamilton-Jacobi-Bellman equations is proposed.The method begins with a suitable initial guess value of the solution,then finds a suitable matrix to linearize the system and constructs an iteration algorithm to generate the monotone sequence.The convergence of the algorithm for nonlinear discrete Hamilton-Jacobi-Bellman equations is proved.Some numerical examples are presented to confirm the effciency of this algorithm. | Cheng Xiaoliang Xu Yuanji Meng Bingquan | 2005 | Applied Mathematics(A Journal of Chinese Universities)2005，20，3： | 1 |
| 9 | Effects of foliar applications of nitric oxide and salicylic acid on salt-induced changes in photosynthesis and antioxidative metabolism of cotton seedlings显示文摘 | Shuang Liu Yuanjie Dong Linlin Xu Jing Kong | 2014 | Plant Growth Regulation2014，，1： | 1 |
| 10 | Synthesis and properties of Mo and W ions co-doped porous nano-structured VO2 films by sol-gel process显示文摘 | Xu Yuanjie Huang Wanxia Shi Qiwu | 2012 | Journal of Sol-Gel Science and Technology2012，64，2： | 1 |
| 11 | Does greater piezo-resistive transduction give rise to higher anchor loss in a square-extensional mode micromechanical resonator显示文摘 | Xu Yuanjie Lee J E Y | 2013 | Sensors and Actuators A:Physical2013，202，： | 1 |
| 12 | Evolutionary game- based trust strategy adjustment among nodes in Wireless Sensor Networks 显示文摘 | LI Yuanjie XU Hongyun CAO Qiying | 2015 | International Journal of Distributed Sensor Networks2015，2015，818903： | 1 |
| 13 | Signaling game based strategy of intrusion detection in wireless sensor networks显示文摘 | Shigen Shen Yuanjie Li Hongyun Xu Qiying Cao | 2011 | Computers and Mathematics with Applications2011，，： | 1 |
| 14 | Random fuzzy demand newsboy problem 显示文摘 | Xu Yuanji Hu Jinsong | 2012 | Physics Procedia2012，25，： | 1 |
| 15 | BFP Net: Balanced Feature Pyramid Network for Small Apple Detection in Complex Orchard Environment显示文摘Despite of significant achievements made in the detection of target fruits,small fruit detection remains a great challenge,especially for immature small green fruits with a few pixels.The closeness of color between the fruit skin and the background greatly increases the difficulty of locating small target fruits in the natural orchard environment.In this paper,we propose a balanced feature pyramid network(BFP Net)for small apple detection. | Meili Sun Liancheng Xu Xiude Chen Ze Ji Yuanjie Zheng Weikuan Jia | 2022 | Plant Phenomics2022，4，1： | 1 |
| 16 | Coeffect of trapping behaviors on the performance of GaN-based devices显示文摘Trap-induced current collapse has become one of the critical issues hindering the improvement of Ga Nbased microwave power devices. It is difficult to study the behavior of each trapping effect separately with the experimental measurement. Transient simulation is a useful technique for analyzing the mechanism of current collapse. In this paper, the coeffect of surface-and bulk-trapping behaviors on the performance of Al Ga N/Ga N HEMTs is investigated based on the two-dimensional(2 D) transient simulation. In addition, the mechanism of trapping effects is analyzed from the aspect of device physics. Two simulation models with different types of traps are used for comparison, and the simulated results reproduced the experimental measured data. It is found that the final steady-state current decreases when both the surface and bulk traps are taken into account in the model.However, contrary to the expectation, the total current collapse is dramatically reduced(e.g. from 18% to 4% for the 90 nm gate-length device). The results suggest that the surface-related current collapse of Ga N-based HEMTs may be mitigated in some degree due to the participation of bulk traps with short time constant. The work in this paper will be helpful for further optimization design of material and device structures. | Xingye Zhou Xin Tan Yuangang Wang Xubo Song Peng Xu Guodong Gu Yuanjie Lü Zhihong Feng | 2018 | Journal of Semiconductors2018，39，9： | 1 |
| 17 | In situ SR-CT Experimental Study on the Directional Sintering of High-Temperature Superconductor YBCO Materials in the Microwave Fields显示文摘YBa_(2)Cu_(3)O_(7-x)(YBCO)is a kind of high-temperature superconducting material that has important application in information,energy,medical treatment,etc.,and the superconducting properties of YBCO are closely related to its internal microstructure.In this study,the microwave heating method was adopted to prepare the YBCO materials.The internal 3 D online evolution observation based on the synchrotron radiation computed tomography technology shows that there was directional grain growth phenomenon of YBCO during microwave sintering process.In local regions with special microstructure,these particles grew to the same point.Here,the theoretical models of single and multiple particles in the microwave electromagnetic fields were established.Based on these theoretical models and finite element analysis,it shows that the YBCO particles can modulate the distribution of electromagnetic fields,resulting in the significantly higher electric field intensity at the particle junctions than other regions.Moreover,there were very high electric field intensity and temperature gradients in the directions of particle growth.These factors were crucial in directional sintering.These results will provide theoretical basis and technical guidance for the controllable preparation and performance optimization of the internal microstructure of superconducting materials in the preparation process. | Liangyuan Wang Lei Shen Yongcun Li Yuanjie Wang Yu Xiao Xingyi Zhang Feng Xu Xiaofang Hu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 0 |
| 18 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 19 | Theoretical calculation on permeation of gas molecules through crystalline poly(p-xylylene)(PPX) films显示文摘Molecular mechanics(MM) and the gradually reduced size(GRS) techniques were used to construct the crystalline poly-p-xylylene(PPX) films,including PPX N,PPX C and PPX D.The corresponding chain-end area of crystalline PPX films provides enough free volumes for adsorbing and transferring gas molecules.Then,the permeable properties of gases were calculated using Grand Canonical Monte Carlo(GCMC),NVT-Molecular Dynamics(MD) and cluster analysis methods.The calculated diffusion coefficients are in the same order of magnitude over a range of temperatures and pressures.And there is no permeation property of gases in the inner part of the crystalline PPX films. | BIAN Liang SHU YuanJie XU JinBao WANG Lei | 2013 | Science China(Technological Sciences)2013，56，1： | 0 |
| 20 | Preparation and Properties of Multiphase Composite Photocatalytic Materials Based on Spindle α-Fe_(2)O_(3) Nanoparticles显示文摘The spindle-shaped α-Fe_(2)O_(3) was prepared by hydrothermal method,Fe_(2)O_(3)/ZnO and Fe_(2)O_(3)/ZnO/PANI photocatalytic composite materials were successfully prepared,and their structure and photocatalytic properties were studied.The results show that different amount of PANI has different photocatalytic performance,and the addition of PANI improves the photocatalytic properties of the composite.In addition,Fe_(2)O_(3)/ZnO/PANI(10%) exhibits the best photocatalytic performance.After two hours of UV irradiation,the degradation rates of methyl orange and orange II reach 68.1% and 75.4%,respectively. | 高芳 LI Baoliu ZHENG Yuanjie XU Ping | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，5： | 0 |
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