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| 1 | Nitrogen Runoff and Leaching Losses During Rice-Wheat Rotations in Taihu Lake Region,China显示文摘尽管通过流量的氮(N) 损失并且从农田沥滤被怀疑贡献包围水系统的恶化,没有最后的证据让水稻土证明这个假设。在这研究,地小区试验被进行通过流量调查 N 损失并且在大米(Oryza sativa L.) 与 3 N 受精率沥滤二连续的年小麦(Triticum aestivum L.) 在泰胡·莱克区域的旋转,中国。一个水收集系统被设计收集流量并且沥滤为米饭和小麦季节的 ates。结果出现了那溶解 N (DN ) ,而非微粒 N (PN ) ,是由流量的 N 损失的主要表格。NO3 ? 在流量的 -N 集中在 0.1 和 43.7 mg L 之间 ? ,而 NH4+-N 集中从在察觉限制下面到 8.5 mg L ? 。由流量的全部的 N (TN ) 负担是 1.0 17.9 和 5.2 38.6 kg 哈?在米饭和小麦季节期间,分别地并且主要损失在庄稼的早成长的阶段发生了。氮集中在沥滤 ates 在米饭季节期间在 1.0 mg L 下面?并且独立于 N 申请率,而那些在小麦季节期间增加了到 8.2 mg L?并且被化肥率影响。通过流量的 TN 的年度损失并且沥滤从大米小麦的 13.7 48.1 kg ha-1 正在收割系统,财务为 5.6%8.3% 总数使用了 N。它被结束在 N 受精率的那减小,特别当庄稼在生物资源是小的时,能为水系统降低 N 污染潜力。 | TIAN Yu-Hua YIN Bin YANG Lin-Zhang YIN Shi-Xue ZHU Zhao-Liang | 2007 | Pedosphere2007，17，4： | 68 |
| 2 | Mechanism of the December 2015 Catastrophic Landslide at the Shenzhen Landfill and Controlling Geotechnical Risks of Urbanization显示文摘 | Yueping Yin Bin Li Wenpei Wang Liangtong Zhan Qiang Xue Yang Gao Nan Zhang Hongqi Chen Tiankui Liu Aiguo Li | 2016 | Engineering2016，2，2： | 64 |
| 3 | Risk factors for intrahepatic cholangiocarcinoma:A case-control study in China显示文摘AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus,hypertention,hepatolithiasis,primary sclerosing cholangitis,liver fluke infection (Clonorchis sinensis ),was investigated through clinical records. Blood from all participants was tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies. Odds ratios (OR) and 95% confi dence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with controls,ICC patients had a higher prevalence of HBsAg seropositivity (48.4% vs 9.6%,P < 0.000),and hepatolithiasis (5.4% vs 1.1%,P = 0.001). By multivariate analysis,the signif icant risk factors for development of ICC were HBsAg seropositivity (adjusted OR,8.876,95% CI,5.973-13.192),and hepatolithiasis (adjusted OR,5.765,95% CI,1.972-16.851). The prevalence of anti-HCV seropositivity,diabetes mellitus,hypertention,cigarette smoking,and alcohol consumption were not significantly different between cases and controls. CONCLUSION: These findings suggest that HBV infection and hepatolithiasis are strong risk factors for development of ICC in China. | Yan-Ming Zhou Zheng-Feng Yin Jia-Mei Yang Bin Li Wen-Yu Shao Feng Xu Yu-Lan Wang Dian-Qi Li | 2008 | World Journal of Gastroenterology2008，14，4： | 51 |
| 4 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 5 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 6 | Denitrification Losses and N_2O Emissions from Nitrogen Fertilizer Applied to a Vegetable Field显示文摘A field experiment was conducted on Chinese cabbage (Brassica campestris L. ssp. pekinensis (Lour.) Olsson) in a Nanjing suburb in 2003. The experiment included 4 treatments in a randomized complete block design with 3 replicates: zero chemical fertilizer N (CK); urea at rates of 300 kg N ha-1 (U300) and 600 kg N ha-1 (U600), both as basal and two topdressings; and polymer-coated urea at a rate of 180 kg N ha-1 (PCU180) as a basal application. The acetylene inhibition technique was used to measure denitrification (N2+N2O) from intact soil cores and N2O emissions in the absence of acetylene. Results showed that compared to CK total denitrification losses were significantly greater (P≤0.05) in the PCU180, U300, and U600 treatments, while N2O emissions in the U300 and U600 treatments were significantly higher (P≤0.05) than CK. In the U300 and U600 treatments peaks of denitrification and N2O emission were usually observed after N application. In the polymer-coated urea treatment (PCU180) during the period 20 to 40 days after transplanting, higher denitrification rates and N2O fluxes occurred. Compared with urea, polymer-coated urea did not show any effect on reducing denitrification losses and N2O emissions in terms of percentage of applied N. As temperature gradually decreased from transplanting to harvest, denitrification rates and N2O emissions tended to decrease. A significant (P≤0.01) positive correlation occurred between denitrification (r = 0.872) or N2O emission (r = 0.781) flux densities and soil temperature in the CK treatment with a stable nitrate content during the whole growing season. | CAO Bing He Fa-Yun Xu Qiu-Ming Yin Bin CAI Gui-Xin | 2006 | Pedosphere2006，16，3： | 28 |
| 7 | Nutrition support in surgical patients with colorectal cancer显示文摘AIM: To review the application of nutrition support in patients after surgery for colorectal cancer, and to propose appropriate nutrition strategies. METHODS: A total of 202 consecutive surgical patients admitted to our hospital with a diagnosis of colon cancer or rectal cancer from January 2010 to July 2010, meeting the requirements of Nutrition Risk Screening 2002, were enrolled in our study. Laboratory tests were performed to analyze the nutrition status of each patient, and the clinical outcome variables, including postoperative complications, hospital stay, cost of hospitalization and postoperative outcome, were analyzed. RESULTS: The 'non-risk' patients who did not receive postoperative nutrition support had a higher rate of postoperative complications than patients who received postoperative nutrition support (2.40 ± 1.51 vs 1.23 ± 0.60, P = 0.000), and had a longer postoperative hospital stay (23.00 ± 15.84 d vs 15.27 ± 5.89 d, P = 0.009). There was higher cost of hospitalization for patients who received preoperative total parenteral nutrition (TPN)than for patients who did not receive preoperative TPN (62 713.50 ± 5070.66 RMB Yuan vs 43178.00 ± 3596.68 RMB Yuan, P = 0.014). Applying postoperative enteral nutrition significantly shortened postoperative fasting time (5.16 ± 1.21 d vs 6.40 ± 1.84 d, P = 0.001) and postoperative hospital stay (11.92 ± 4.34 d vs 15.77 ± 6.03 d, P = 0.002). The patients who received postoperative TPN for no less than 7 d had increased serum glucose levels (7.59 ± 3.57 mmol/L vs 6.48 ± 1.32 mmol/L, P = 0.006) and cost of hospitalization (47 724.14 ± 16 945.17 Yuan vs 38 598.73 ± 8349.79 Yuan, P = 0.000). The patients who received postoperative omega-3 fatty acids had a higher rate of postoperative complications than the patients who did not (1.33 ± 0.64 vs 1.13 ± 0.49, P = 0.041). High level of serum glucose was associated with a high risk of postoperative complications of infection. CONCLUSION: Appropriate and moderate nutritional intervention can improve the postoperative outcome of colorectal cancer patients. | Yang Chen Bao-Lin Liu Bin Shang Ai-Shan Chen Shi-Qing Liu Wei Sun Hong-Zhuan Yin Jian-Qiao Yin Qi su | 2011 | World Journal of Gastroenterology2011，17，13： | 28 |
| 8 | An energy-efficient geographic routing based on cooperative transmission in wireless sensor networks显示文摘In this paper, we propose an energy-efficient cooperative geographic routing (ECGR) to reach energy-efficient routing in wireless sensor networks (WSN). ECGR takes full advantage of cooperative diversity and geographic routing. At physical layer, cooperative nodes transmit the same packet in a cooperative way to achieve farther transmission distance of each hop without more energy consumption. While at the network layer, ECGR adaptively selects the appropriate cooperative nodes to form forwarding clusters to forward the packet to the destination when we consider energy consumption and geographic information of the sensor nodes. Meanwhile, in order to fully assess the energy consumption, we take circuit energy consumption of the sensor nodes into consideration. According to the description above, we increase the transmit distance of each hop; and thereby reducing and balancing the overall network energy consumption among nodes to extend the lifetime of the network. | LI Bin WANG WenJie YIN QinYe LI HongXiang YANG Rong | 2013 | Science China(Information Sciences)2013，56，7： | 26 |
| 9 | Risk factors for early recurrence of small hepatocellular carcinoma after curative resection显示文摘BACKGROUND:Poorer prognosis is seen in patients with hepatocellular carcinoma (HCC) after curative hepatic resection with early recurrence (≤1 year) than in those with late recurrence (>1 year).This study aimed to identify risk factors for postoperative early recurrence of small HCC (≤3 cm in diameter).METHODS:The study population consisted of 158 patients who underwent curative resection for small HCC between January 2002 and July 2004.Risk factors for early recurrence were analyzed.RESULTS:Thirty-three (20.8%) patients developed early recurrence after surgery.Univariate analysis showed the following significant risk factors for early recurrence in small HCC:serum alpha-fetoprotein (AFP) level >100 ng/ml,lack of tumor capsule formation,microscopic vascular invasion,high Edmonson-Steiner grades,and cytokeratin-19 (CK-19) expression (P<0.05).Multivariate stepwise logistic regression analysis showed that serum AFP level >100 ng/ml (odds ratio 2.561,95% confidence interval 1.057 to 6.206,P=0.037) and microscopic vascular invasion (odds ratio 4.549,95% confidence interval 1.865 to 11.097,P=0.001) were independent factors.CONCLUSIONS:Postoperative early recurrence is related to serum AFP level >100 ng/ml and microscopic vascular invasion in patients with small HCC.Adjuvant therapy and careful follow-up are required for patients with these risk factors. | Zhou, Yan-Ming Yang, Jia-Mei Li, Bin Yin, Zheng-Feng Xu, Feng Wang, Bin Xu, Wen Kan, Tong | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 24 |
| 10 | Stapled transanal rectal resection for obstructed defecation syndrome associated with rectocele and rectal intussusception显示文摘AIM:To evaluate the safety and efficacy of stapled transanal rectal resection(STARR),and to analyze the outcome of the patients 12-mo after the operation.METHODS:From May 2007 to October 2008,50 female patients with rectocele and/or rectal intussusception underwent STARR.The preoperative status,perioperative and postoperative complications at baseline,3,6 and 12-mo were assessed.Data were collected prospectively from standardized questionnaires for the assessment of constipation[constipation scoring system,Longo’s obstructed defecation syndrome(ODS)score system,symptom severity score],patient satisfaction (visual analogue scale),and quality of life(Patient Assessment of Constipation-Quality of Life Questionnaire).RESULTS:At a 12-mo follow-up,significant improvement in the constipation scoring system,ODS score system,symptom severity score,visual analog scale and quality of life(P<0.0001)was observed.The symptoms of constipation improved in 90%of patients at 12 mo after surgery.The self-reported definitive outcome was excellent in 15(30%)patients,fairly good in 8(16%),good in 22(44%),and poor in 5(10%).CONCLUSION:STARR can be performed safely without major morbidity.Moreover,the procedure seems to be effective for patients with obstructed defecation associated with symptomatic rectocele and rectal intussusception. | Zhang, Bin Ding, Jian-Hua Yin, Shu-Hui Zhang, Meng Zhao, Ke | 2010 | World Journal of Gastroenterology2010，16，20： | 23 |
| 11 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 12 | Human infection with a novel avian-origin influenza A (H7N9) virus: serial chest radiographic and CT findings显示文摘 | Dai Jian Zhou Xianmei Dong Danjiang Liu Yin Gu Qin Zhu Bin Wu Chao Cai Hourong | 2014 | Chinese Medical Journal2014，，12： | 22 |
| 13 | Hilar cholangiocarcinoma:preoperative evaluation with a three dimensional volumetric interpolated breath-hold examination magnetic resonance imaging sequence显示文摘背景早察觉和精确阶段为计划处理和 hilar cholangiocarcinomas 的改善幸存率是关键的。这研究调查了三维的、宠坏的坡度回响的诊断价值, T1 加权的磁性的回声(先生) 成像顺序(3D 容量的插入内推的呼吸抓住检查, 3D-VIBE ) 在 hilar cholangiocarcinoma.Methods 的外科手术前的评估,有通过手术并且组织学地证实的 hilar cholangiocarcinomas 的 31 个病人经历了外科手术前的先生成像检查。Unenhanced 二维的 T1 加权、 T2 加权的图象, 2D 先生 cholangiopancreatographs (MRCP ) ,金轧提高了 3D-VIBE 图象在早动脉,晚动脉并且静脉的阶段由在平衡的 T1 加权的图象分阶段执行的 2D 跟随了的门被获得。从 3D-VIBE 的图象, 2D T1 加权的提高的序列和 2D MRCP 被二个腹的放射线学者通过以盲目方式读的一致解释,集中于对词法类型的评价,在胆汁管和附近的血容器的参与的肿瘤渗入的纵的程度。3D-VIBE 和 2D 的精确性在估计肿瘤 resectability 的 T1 加权的提高的序列是 compared.Results 而,所有 31 个肿瘤直接在 3D-VIBE 上被显示并且精确地分类图象 8 periductal 渗透肿瘤(8/31, 25.8%) 没在 2D 上被描绘 T1 加权的提高的图象。用铋 Corlette 分类, 3D-VIBE 在描出接近了 MRCP 肿瘤渗入的 intraductal 程度比 2D T1 加权提高(28/31, 90.3% ;10/31,32.3% ;2=22.0, P0.05 ) 。肝的动脉的参与,静脉的箱子和他们的分支比 2D 在 3D VIBE 上更经常被显示出的门 T1 加权的提高的图象。3D-VIBE 的积极预兆的价值和精确性(84.2% ;90.3%) 为估计肿瘤, resectability 比 2D 的那些高 T1 加权的提高的图象(64.0% ;71.0% ,所有 P0.05 ).Conclusion 金轧提高了 3D-VIBE 比 2D 好在对 morphologicalal 类型,渗入程度的 intraductal 和 hilar cholangiocarcinomas 的肿瘤 resectability 的外科手术前的评价的 T1 加权的提高的顺序。 | YIN Long-lin SONG Bin XU Juan LI Ying-chun | 2007 | Chinese Medical Journal2007，，8： | 21 |
| 14 | A High-Throughput Screening System for Arabidopsis Transcription Factors and Its Application to Med25-Dependent Transcriptional Regulation显示文摘抄写因素(TF ) 的活动与特定的 DNA 序列和另外的规章的蛋白质要求相互作用。在 Arabidopsis 检测如此的相互作用,我们与 1589 Arabidopsis TF 的一个网关兼容机 Gal4-ADTF 图书馆开发了一个高产量的屏蔽系统,它能被基于配偶的 yeast-one-hybrid (Y1H ) 和 yeast-two-hybrid (Y2H ) 容易屏蔽方法。系统的效率被检验二个描绘得好的 TFDNA 和 TFprotein 相互作用验证:由由 Y2H 的 Y1H 和 NPR1TGAs 相互作用的 CHECCA1 倡导者相互作用。我们使用了这个系统识别与一个调停人子单元交往的八 TF, Med25,在 JA 发信号的一个关键管理者。我们识别了在 PDF1.2 的倡导者与 GCC 盒子 cis 元素交往了的五 TF, Med25 的下游的基因。我们发现都从 AP2-EREBP 家庭,三这些 TF 与 Med25 和 PDF1.2 的 GCC 盒子两个都直接交往,建议 Med25 调整通过这三 TF 的 PDF1.2 表示。这些结果证明屏蔽系统的这高产量的 Y1H/Y2H 是为在 Arabidopsis 学习 transcriptional 规定网络的一个有效工具。这个系统将为另外的 Arabidopsis 研究人员是可得到的,并且因此,它为 Arabidopsis 社区提供一个重要资源。 | Bin Oua Kang-Quan Yin Sai-Nan Liu Yan Yang Tren Gu Jennifer Man Wing Hui Li Zhang Jin Miao Youichi Kondou Minami Matsui Hong-Ya Gu Li-Jia Qu | 2011 | Molecular Plant2011，4，3： | 19 |
| 15 | Levels of serum homocysteine in depressive patients Self-correlation factor analysis and comparison with healthy subjects显示文摘BACKGROUND: Data indicate that the levels of serum homocysteine in depressive patients are higher than those in normal subjects. OBJECTIVE: To investigate the levels of serum homocysteine in patients with major depressive disorder, to determine whether serum homocysteine levels differ with sex, family history, or drug treatment, and to compare depressive patients with normal subjects. DESIGN: Non-randomized concurrent control trial. SETTING: Mental Heath Center of Shandong Province. PARTICIPANTS: Forty in-patients (23 males and 17 females, 18–63 years old) with major depressive disorder were selected from the Mental Health Center of Shandong Province from January to October 2006. All selected patients met the depressive diagnostic standard of Chinese Classification of Mental Disorder (3rd Edition, CCMD-3), and total scores evaluated by the 17-item Hamilton Rating Scale for Depression (HRSD) were ≥ 20. Meanwhile, 36 healthy subjects (20 males and 16 females, 18–60 years old) were enrolled as controls; their total 17-item HRSD scores were ≤ 7. All selected subjects provided consent, and the study was approved by the local ethics committee. METHODS: Fasting venous blood (3 mL) was drawn in both groups at 8:00 in the morning. The levels of serum homocysteine were determined by a fluorescence polarization immunoassay (FPIA). The 17-item HRSD was also compiled from the patients when entering groups. The higher the scores were, the more severe the depression was. Enumeration data for both groups were compared by Chi-square test, measurement data were compared by t-test, and correlations were detected using Pearson and Spearman correlation analysis. MAIN OUTCOME MEASURES: ① Levels of serum homocysteine; ② incidence of hyperhomocysteinemia (HHcy); ③ correlation between HRSD17 scores and levels of serum homocysteine in depressive patients. RESULTS: Forty depressive patients and 36 control subjects were included in the final analysis without any loss of participants. ① Levels of serum homocysteine and HHcy detection rate: the levels of serum homocysteine in the depressive patients were significantly higher than those in the control group (t = 4.377, P=0.000). Hhcy detection rates were 42% (17/40) and 10% (4/36) in depressive group and control group, respectively. There was a significant difference between two groups (χ2 = 10.912, P = 0.001). In the depressive group, there were no differences in serum homocysteine levels between males and females, before and after treatment, or between patients with positive or negative family histories of depression (t = 0.217–0.520, P > 0.05). ② Correlation analysis: the HRSD17 scores in the depressive group were positively correlated with levels of serum homocysteine (r = 0.724, P = 0.000). CONCLUSION: ① The increase in serum homocysteine levels may play an important role in the pathogenic mechanism of depressive disorder. ② The higher the levels of serum homocysteine are, the more severe the depressive disorder is. ③ There are no significant differences in serum homocysteine levels between patients of different sex or family history, or before and after drug treatment, among depressive patients. | Shanxin Wang Bin Wang Aihua Yin Yang Wang | 2008 | Neural Regeneration Research2008，3，3： | 18 |
| 16 | Soil Erosion Changes over the Past Five Decades in the Red Soil Region of Southern China显示文摘This paper reports the dynamic changes of soil and water loss in the red soil region of Southern China since the 1950s. The red soil region covers eight provinces: Jiangxi, Zhejiang, Fujian, Anhui, Hubei, Hunan, Guangdong and Hainan. From the 1950s to 1986, the annual rate of soil erosion increased by 3.4%. From 1986 to 1996 and from 1996 to 2000, the annual rates of soil erosion decreased by 2.0% and 0.32%, respectively. Field surveys showed that from 2000 to 2005, the area of soil and water loss decreased annually by 1.2%. This decrease was a result of large-scale erosion control activities across China. Although the eroded soil has been restored, the restoration process is very slow and full restoration will take a long time. Our report suggests that controlling soil and water loss is a challenging task, and additional measures must be taken to effectively control the soil erosion in the red soil region. | LIANG Yin LI Decheng LU Xixi YANG Xuan PAN Xianzhang MU Huan SHI Deming ZHANG Bin | 2010 | Journal of Mountain Science2010，7，1： | 18 |
| 17 | Recombinant Newcastle disease virus expressing African swine fever virus protein 72 is safe and immunogenic in mice显示文摘African swine fever(ASF) is a lethal hemorrhagic disease that affects wild and domestic swine. The etiological agent of ASF is African swine fever virus(ASFV). Since the first case was described in Kenya in 1921, the disease has spread to many other countries. No commercial vaccines are available to prevent ASF. In this study, we generated a recombinant Newcastle disease virus(r NDV) expressing ASFV protein 72(p72) by reverse genetics and evaluated its humoral and cellular immunogenicity in a mouse model. The recombinant virus, r NDV/p72, replicated well in embryonated chicken eggs and was safe to use in chicks and mice. The p72 gene in r NDV/p72 was stably maintained through ten passages. Mice immunized with r NDV/p72 developed high titers of ASFV p72 specific Ig G antibody, and had higher levels of Ig G1 than IgG2 a. Immunization also elicited T-cell proliferation and secretion of IFN-γ and IL-4. Taken together, these results indicate that r NDV expressing ASFV p72 might be a potential vaccine candidate for preventing ASF. | Xinxin Chen Jifei Yang Yanhong Ji Edward Okoth Bin Liu Xiaoyang Li Hong Yin Qiyun Zhu | 2016 | Virologica Sinica2016，31，2： | 18 |
| 18 | Association of Estrogen Receptor I Genetic Polymorphisms with Recurrent Spontaneous Abortion Risk显示文摘 | Xun-Qiang Yin Hong-Mei Ju Qiang Guo Lin Zhao Xiao-Xiao Zhu Ran Wei Zhen Zhang Yun-Hong Zhang Bin Wang Xia Li | 2018 | Chinese Medical Journal2018，，15： | 18 |
| 19 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 20 | Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein显示文摘AIM:To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP). METHODS:One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared. RESULTS:The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower. CONCLUSION:ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma. | Yan-Ming Zhou Jia-Mei Yang Bin Li Zheng-Feng Yin Feng Xu Bin Wang Peng Liu Zhi-Min Li | 2008 | World Journal of Gastroenterology2008，14，14： | 17 |
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