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| 1 | Autophagy process is associated with anti-neoplastic function显示文摘Autophagy 是细胞的降级的一个高度保存的过程,它在酵母,植物,和哺乳动物是在场的。在正常生理的条件下面, autophagy 行动维持细胞的动态平衡并且调整细胞器的周转。响应细胞的压力, autophagy 阻止损害蛋白质和细胞器的累积,它服务禁止 carcinogenesis。在这个基础上,这广泛地被接受大多数肿瘤 suppressors,例如 beclin, 1 联系蛋白质, forkhead 框类 O (FoxO ) 家庭蛋白质, Rapamycin (mTOR ) inactivators 的多重哺乳动物的目标,和原子 p53 在导致 autophagy 起一个作用。这里,我们集中 autophagy 的过程怎么与反肿瘤的功能被联系。 | Chong Wang Yachen Wang Michael A. McNutt Wei-Guo Zhu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 18 |
| 2 | Cucurbitacin and Triterpenoid Glycosides from Hemsleya giganthy显示文摘From rhizomes of Hemsleya giganthy collected in Shichuan of China, 16 compounds were isolated. Among them, three compounds (8, 9, 15) are new natural products called Hemslecins G; Hemsgiganosides A and B; respectively. Their structures were elucidated as 7- hydroxy-23, 24-dihydro-cucurbitacin F-25-O-acetate (8); 3-O-(6-butyl ester-)-b-D-glu- curono- pyranosyl)-oleanolic acid-28-O-a-L-arabinopyranoside(9); 3-O-b-D-glucuropyranosyl oleanolic acid -28-O-b-D-gluco pyranosyl-(16)- b-D-glucopyranoside(15) by spectroscopic and chemical means. | YaCHEN MingHuaCHIU KunGU ZhongRongLI | 2003 | Chinese Chemical Letters2003，14，5： | 10 |
| 3 | Applications of post-translational modifications of FoxO family proteins in biological functions显示文摘The functions of the FoxO family proteins,in particular their transcriptional activities,are modulated by post-translational modifi-cations(PTMs),including phosphorylation,acetylation,ubiquitination,methylation and glycosylation.These PTMs occur in response to different cellular stresses,which in turn regulate the subcellular localization of FoxO family proteins,as well as their half-life,DNA binding,transcriptional activity and ability to interact with other cellular proteins.In this review,we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases. | Ying Zhao Yachen Wang Wei-Guo Zhu | 2011 | Journal of Molecular Cell Biology2011，3，5： | 9 |
| 4 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 5 | Fabrication and characterization of biodegradable Mg-Zn-Y-Nd-Ag alloy:Microstructure,mechanical properties,corrosion behavior and antibacterial activities显示文摘Magnesium(Mg),a potential biodegradable material,has drawn wide attention in the bone reconstruction field.However,Mg alloys,served as the bone graft substitution,remain a clinical challenge,the antibacterial activity of which is required to be enhanced.Here,we prepared biodegradable magnesium Mg-Zn-Y-Nd-Ag and then had it been further densified by extruding.The microstructure evolution of the as-cast and as-extruded Mg-Zn-Y-Nd-Ag was characterized using optical microscope and X-ray diffraction analyses(XRD).The results showed that the microstructure of the as-cast alloys was mainly dendrites,between which,the second phase was mainly distributed;with the increase of Ag additions,grain structure was further refined as well as the increase of amount of the second phase.After the extrusion,the grains were further refined.Microhardness tests indicated that both of the increase of Ag content and the extrusion process improved the microhardness of the alloys,specially the later.A systematic investigation of the in vivo antibacterial capability of Staphylococcus aurous and Escherichia coli was performed,and the results of which indicated that all Mg-Zn-Y-N-xAg(x?0.2,0.4,0.6,0.8)alloys exhibited certain antibacterial property,which would increased with the increase of Ag content.Taken all together,the antimicrobial property of the as-extruded alloy containing 0.4 wt%Ag exhibited the relatively better antimicrobial properties and mechanical property with the relatively small loss in corrosion resistance,which suggested the potential utility of as-extruded Mg-Zn-Y-N-0.4Ag in treating orthopedic infections. | Yashan Feng Shijie Zhu Liguo Wang Lei Chang Yachen Hou Shaokang Guan | 2018 | Bioactive Materials2018，3，3： | 7 |
| 6 | Tribological properties of nanometer cerium oxide as additives in lithium grease显示文摘This paper presents a comparative study of the influence of nanometer-CeO_2(nano-CeO_2) and temperature on tribological and lubricating properties of lithium grease. The morphology and structure of nanocrystals were characterized by means of transmission electron microscopy(TEM) and X-ray diffraction(XRD), respectively. Friction and wear tests were conducted on the friction and wear tester.Results show that the lithium grease with addition of nanometer-CeO_2 has much better friction-reducing and anti-wear performance than that of base grease. When the additive in grease is 0.6 wt%, the friction coefficient(COF) and wear scar diameter(WSD) decrease by 28% and 13% comparing with base grease,respectively. The base grease and grease with 0.6 wt% nanometer-CeO_2 both possess the lowest average COF and wear width at 50 ℃. The worn surface morphology after friction test was analyzed by scanning electron microscopy(SEM) and NANOVEA three-dimensional profilometer. Under the lubrication of the lithium grease containing 0.6 wt% nano-CeO_2. few shallow furrows can be observed on the quite smoothed surface and the WSD decreased. Moreover, It was found that the nano-CeO_2 has been incorporated into the surface protective and lubricious layer by energy dispersive spectrometer(EDS) analysis. | Qiang He Anling Li Yachen Guo Songfeng Liu Yong Zhang Linghao Kong | 2018 | Journal of Rare Earths2018，36，2： | 6 |
| 7 | Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats显示文摘Caveolin-1 is involved in the regulation of synaptic plasticity,but the relationship between its expression and cognitive function during aging remains controversial.To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory,we examined caveolin-1 expression in the hippocampus,cortex and cerebellum of rats at different ages.We also examined the relationship between the expression of caveolin-1 and synaptophysin,a marker of synaptic plasticity.Hippocampal caveolin-1 and synaptophysin expression in aged(22–24 month old)rats was significantly lower than that in young(1 month old)and adult(4 months old)rats.Expression levels of both proteins were significantly greater in the cortex of aged rats than in that of young or adult rats,and levels were similar between the three age groups in the cerebellum.Linear regression analysis revealed that hippocampal expression of synaptophysin was associated with memory and learning abilities.Moreover,synaptophysin expression correlated positively with caveolin-1 expression in the hippocampus,cortex and cerebellum.These results confirm that caveolin-1 has a regulatory effect on synaptic plasticity,and suggest that the downregulation of hippocampal caveolin-1 expression causes a decrease in synaptic plasticity during physiological aging. | Yang Liu Zhanhua Liang Jing Liu Wei Zou Xiaoyan Li Yachen Wang Lijia An | 2013 | Neural Regeneration Research2013，8，29： | 6 |
| 8 | Progress and Challenges for Live-cell Imaging of Genomic Loci Using CRISPR-based Platforms显示文摘Chromatin conformation,localization,and dynamics are crucial regulators of cellular behaviors. Although fluorescence in situ hybridization-based techniques have been widely utilized for investigating chromatin architectures in healthy and diseased states,the requirement for cell fix-ation precludes the comprehensive dynamic analysis necessary to fully understand chromatin activ-ities. This has spurred the development and application of a variety of imaging methodologies for visualizing single chromosomal loci in the native cellular context. In this review,we describe currently-available approaches for imaging single genomic loci in cells,with special focus on clus-tered regularly interspaced short palindromic repeats (CRISPR)-based imaging approaches. In addition,we discuss some of the challenges that limit the application of CRISPR-based genomic imaging approaches,and potential solutions to address these challenges. We anticipate that,with continued refinement of CRISPR-based imaging techniques,significant understanding can be gained to help decipher chromatin activities and their relevance to cellular physiology and pathogenesis. | Xiaotian Wu Shiqi Mao Yachen Ying Christopher J.Krueger Antony K. Chen | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 5 |
| 9 | Gleaning insights from German energy transition and large-scale underground energy storage for China’s carbon neutrality显示文摘The global energy transition is a widespread phenomenon that requires international exchange of experiences and mutual learning.Germany’s success in its first phase of energy transition can be attributed to its adoption of smart energy technology and implementation of electricity futures and spot marketization,which enabled the achievement of multiple energy spatial–temporal complementarities and overall grid balance through energy conversion and reconversion technologies.While China can draw from Germany’s experience to inform its own energy transition efforts,its 11-fold higher annual electricity consumption requires a distinct approach.We recommend a clean energy system based on smart sector coupling(ENSYSCO)as a suitable pathway for achieving sustainable energy in China,given that renewable energy is expected to guarantee 85%of China’s energy production by 2060,requiring significant future electricity storage capacity.Nonetheless,renewable energy storage remains a significant challenge.We propose four large-scale underground energy storage methods based on ENSYSCO to address this challenge,while considering China’s national conditions.These proposals have culminated in pilot projects for large-scale underground energy storage in China,which we believe is a necessary choice for achieving carbon neutrality in China and enabling efficient and safe grid integration of renewable energy within the framework of ENSYSCO. | Yachen Xie Xuning Wu Zhengmeng Hou Zaoyuan Li Jiashun Luo Christian Truitt Lüddeke Liangchao Huang Lin Wu Jianxing Liao | 2023 | International Journal of Mining Science and Technology2023，33，5： | 4 |
| 10 | Diffusion and sound absorption properties of the quadratic residue diffuser structure with perforated panel显示文摘Acoustic structure study always is the academic research interest. Diffusion ab?sorbing structure(DiflFsorber) has good research value because it has both diflFusion property and sound absorption property. Quadratic residue diffusers(QRD) structure which had good diffusion property was combined with the perforated panel which had good sound absorption property in this study. According to standard AES-4id-2001, the diffusion experiments were carried out to study QRD structure and ones composited with perforated-panels which had1 mm-thickness and perforated percentage of 3%, 5%, 8% respectively. The polar coordinate diagrams of different structure were analyzed to derive the diffusion coefficients. Results showed that the composite structure still had good diffusion performance in the frequency range from100 Hz to 800 Hz. The reflection sound energy of composite structure reduced obviously in the perforated panel resonance frequency range where there was about 2 dB reduction averagely.The study result can provide the reference for the design and development of diifsorber. | CAI Jun BAO Fei WANG Yachen WANG Yanqin | 2016 | Chinese Journal of Acoustics2016，35，3： | 3 |
| 11 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 12 | Graph Computing Based Security Constrained Unit Commitment in Hydro-thermal Power Systems Incorporating Pumped Hydro Storage显示文摘This paper proposes a graph computing based mixed integer programming(MIP)framework for solving the security constrained unit commitment(SCUC)problem in hydro-thermal power systems incorporating pumped hydro storage(PHS).The proposed graph computing-based MIP framework considers the economic operations of thermal units,cascade hydropower stations and PHS stations,as well as their technical impacts towards the network security.First,the hydro-thermal power system data and unit information are stored in a graph structure with nodes and edges,which enables nodal and hierarchical parallel computing for the unit commitment(UC)solution calculation and network security analysis.A MIP model is then formulated to solve the SCUC problem with the mathematical models of thermal units,cascade hydropower stations and PHS stations.In addition,two optimization approaches including convex hull reformulation(CHR)and special ordered set(SOS)methods are introduced for speeding up the MIP calculation procedure.To ensure the system stability under the derived UC solution,a parallelized graph power flow(PGPF)algorithm is proposed for the hydro-thermal power system network security analysis.Finally,case studies of the IEEE 118-bus system and a practical 2749-bus hydro-thermal power system are introduced to demonstrate the feasibility and validity of the proposed graph computing-based MIP framework. | Longfei Wei Guangyi Liu Shen Yan Renchang Dai Yachen Tang | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 2 |
| 13 | Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis显示文摘RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers.However,efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging.Recently,more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating.Due to the flexibility and deformability of nucleic acids,the nanoassemblies could be fabricated with different shapes and structures.With hybridization,nucleic acid nanoassemblies,including DNA and RNA nanostructures,can be applied to enhance RNA therapeutics and diagnosis.This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development. | Mengnan Zhao Rujing Wang Kunmeng Yang Yuhong Jiang Yachen Peng Yuke Li Zhen Zhang Jianxun Ding Sanjun Shi | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 14 | Gurney flap-lift enhancement,mechanisms and applications显示文摘 | Wang Jinjun Li Yachen Choi K S | 2008 | Progress in Aerospace Sciences2008，44，1： | 1 |
| 15 | Learning with privileged information using Bayesian networks显示文摘 | Shangfei WANG Menghua HE Yachen ZHU Shan HE Yue LIU Qiang JI | 2015 | Frontiers of Computer Science2015，9，2： | 1 |
| 16 | Oxidized LowDensity lipoprotein and C-Reactive protein have combined utility for better predicting prognosis after acute coronary syndrome显示文摘 | ZHANG Yachen TANG Yong CHEN Yu | 2014 | Cell Biochemistry and Biophysics2014，68，2： | 1 |
| 17 | Phenological records in Guanzhong Area in central China between 600 and 902 AD as proxy for winter half-year temperature reconstruction显示文摘Phenological data obtained from historical documents constitute highly important ecological evidence for the pre-instrumental period, and can be used in analyzing climatic change in history. In this study, 87 phenological records about seasonality of non-biological events(e.g., first frost date), agriculture and ornamental plants(e.g., first flowering date) over 77 years were extracted from historical documents from the Sui and Tang dynasties in China to reconstruct the winter half-year(from October to next April) temperatures in the Guanzhong Area(located in central China) from 600 to 902 AD. Transfer functions between temperature and phenophases with significant correlations were established by using modern observation data. Temperatures from the study period were reconstructed by applying the transfer functions to historical phenological data. The reconstruction indicates that the winter half-year temperatures during 600–902 AD were 0.23°C higher than the reference period(1961–1990). The temperature changed with two distinct stages. During the 600s–800s, temperatures were approximately 0.38°C higher than at present but then temperatures decreased in the subsequent period(800–902 AD). These results are similar to ones from previous studies on the mean temperature and the divisions between warm and cold periods during the study period, though differences were found in the degree of warmness/coldness. This reconstruction provides a valuable contribution to a better understanding of climatic variability during the Sui and Tang dynasties in China. | LIU YaChen DAI JunHu WANG HuanJiong YE Yu LIU HaoLong | 2016 | Science China Earth Sciences2016，59，9： | 1 |
| 18 | Near-infrared to visible up-conversion emissions of Er^(3+) doped Al_2O_3 powders derived from the sol-gel method显示文摘The Er3+ doped Al2O3 powders were prepared by the sol-gel method using the aluminium isopropoxide [Al(OC3H7)3]-derived Al2O3 sols with addition of the erbium nitrate [Er(NO3)3.5H2O]. The different phase structure, including three crystalline types of (Al,Er)2O3 phases, γ, θ, α, and two Er-Al-O phases, ErAlO3 and Al10Er6O24, was obtained with the 1 mol% Er3+ doped Al2O3 powders at the different sintering temperatures of 600―1200℃. The green and red up-conversion emissions centered at about 523, 545 and 660 nm, corresponding respectively to the 2H11/2, 4S3/2→4I15/2 and 4F9/2→4I15/2 transitions of Er3+, were detected by a 978 nm semiconductor laser diodes excitation. The phase structure and OH content had evident influence on the up-conversion emissions intensity. The maximum intensities of both the green and red emissions were obtained respectively for the Er3+ doped Al2O3 powders sintered at 1200 ℃, which was composed mainly of α-(Al,Er)2O3, less of ErAlO3 and Al10Er6O24 phases, and with the least OH content. The two-photon absorption up-conversion process was involved in the green and red up-conversion emissions of the Er3+ doped Al2O3 powders. | DONG Bin GAO YaChen XU XueSong SUN Min LI Lei | 2007 | Chinese Science Bulletin2007，52，19： | 1 |
| 19 | Photo Responsive Silver Nanoparticles Incorporated Liquid Crystalline Elastomer Nanocomposites Based on Surface Plasmon Resonance显示文摘 | ZHANG Jindi WANG Jun ZHAO Lina YANG Wenlong BI Meng WANG Yuchang NIU Hongyan LI Yuxin WANG Binsong GAO Yachen LI Chensha HUANG Xuezhen | 2017 | Chemical Research in Chinese Universities2017，33，5： | 1 |
| 20 | Synthesis and nonlinear optical properties of reduced graphene oxide hybrid material covalently functionalized with zinc phthalocyanine显示文摘 | Weina Song Chunying He Wang Zhang Yachen Gao Yixiao Yang Yiqun Wu Zhimin Chen Xiaochen Li Yongli Dong | 2014 | Carbon2014，，： | 1 |
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