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44篇 您的检索式:作者名="Yali Han"
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1Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity.LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang 2013Chinese Science Bulletin2013,58,23:40
2The biomechanical study of lower limb during human walking显示文摘The coordinates of the marked points of joints and the changes of foot force in the human walk motion are obtained with systems of motion image acquisition and force measuring.The effects of kinematics and dynamics on the human lower limb in different loads(0,10,20,30 kg) and walking speeds(0.8,1.3,1.7 m/s) have been investigated using the human dynamics model,.The results were as follows.First,with the increasing load,the dorsiflexion angle of ankle joint increased during the procedure of toe-off,the range of motion of the knee joint decreased,the flexion angle of the hip joint increased,and oppositely,the extension angle of the hip joint decreased.Second,with the increasing speed,the range of motion of the ankle joint,the maximum flexion angle of the knee joint,the flexion angle,extension angle of the hip joint and the range of motion of hip joint increased.Finally,the torque and power of the ankle joint,the knee joint and the hip joint increased with the increasing speed and load.The results can provide an important basis for the mechanism design of lower limb power-assisted exoskeleton.HAN YaLi WANG XingSong 2011Science China(Technological Sciences)2011,54,4:14
3I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han 2014Cellular & Molecular Immunology2014,11,2:14
4Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu 2021China CDC weekly2021,3,41:13
5Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrowderived macrophage显示文摘Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear.In this study,we genetically targeted Notch signaling by disrupting the transcription factor recombination signal binding protein-JK(RBP-J),to reveal its role in regulation of macrophages during the unilateral ureteral obstruction(UUO)-induced murine renal fibrosis.Myeloid-specific disruption of RBP-J attenuated renal fibrosis with reduced extracellular matrix deposition and myofibroblast activation,as well as attenuated epithelial-mesenchymal transition,likely owing to the reduced expression of TGF-β.Mean while,RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney,although their proliferation appeared unaltered.By using macrophage clearance experiment,we found that kidney resident macrophages made negligible contribution,but bone marrow(BM)-derived macrophages played a major role in renal fibrogenesis.Further mechanistic analyses showed that Notch blockade reduced monocyte emigration from BM by down-regulating CCR2 expression.Finally,we found that myeloid-specific Notch activation aggravated renal fibrosis,which was mediated by CCR2^+macrophages infiltration.In summary,our data have unveiled that myeloid-specific targeting of Notch could ameliorate renal fibrosis by regulating BM-derived macrophages recruitment and activation,providing a novel strategy for intervention of this disease.Yali Jiang Yuanyuan Wang Pengfei Ma Dongjie An Junlong Zhao Shiqian Liang Yuchen Ye Yingying Lu Peng Zhang Xiaowei Liu Hua Han Hongyan Qin 2019Protein & Cell2019,10,3:10
6Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome:a 15-year follow-up from a prospective cohort study显示文摘The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone conditions of SARS patients. We evaluated the recovery from lung damage and femoral head necrosis in an observational cohort study of SARS patients using pulmonary CT scans, hip joint MRI examinations, pulmonary function tests and hip joint function questionnaires. Eighty medical staff contracted SARS in 2003. Two patients died of SARS, and78 were enrolled in this study from August 2003 to March 2018. Seventy-one patients completed the 15-year follow-up. The percentage of pulmonary lesions on CT scans diminished from 2003(9.40 ± 7.83)% to 2004(3.20 ± 4.78)%(P < 0.001) and remained stable thereafter until 2018(4.60 ± 6.37)%. Between 2006 and 2018, the proportion of patients with interstitial changes who had improved pulmonary function was lower than that of patients without lesions, as demonstrated by the one-second ratio(FEV1/FVC%, t = 2.21, P = 0.04) and mid-flow of maximum expiration(FEF25%–75%, t = 2.76, P = 0.01). The volume of femoral head necrosis decreased significantly from 2003(38.83 ± 21.01)% to 2005(30.38 ± 20.23)%(P = 0.000 2), then declined slowly from 2005 to 2013(28.99 ± 20.59)% and plateaued until 2018(25.52 ± 15.51)%. Pulmonary interstitial damage and functional decline caused by SARS mostly recovered, with a greater extent of recovery within 2 years after rehabilitation. Femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was not progressive and was partially reversible.Peixun Zhang Jia Li Huixin Liu Na Han Jiabao Ju Yuhui Kou Lei Chen Mengxi Jiang Feng Pan Yali Zheng Zhancheng Gao Baoguo Jiang 2020Bone Research2020,8,1:8
7Crescentic dune migration and stabilization: Implications for interpreting paleo-dune deposits as paleoenvironmental records显示文摘Paleo-dune deposits have been widely used as a proxy indicator of past dune activity, which is further used to reconstruct paleoclimates. However, recent studies have critically examined the reproducibility of dune chronologies and the complexity of paleo-dune deposits as paleoenvironmental records. This paper addresses questions on the paleoenvironmental implications of dune chronostratigraphies that have been raised by those reviews, in the specific case of crescentic dunes, using a case study from the Mu Us dune field, north-central China. The processes of turn-over and stabilization of relatively small crescentic dunes are first investigated by observational evidence. In combination with the analysis of a simplified sand preservation model and stratigraphic records, the effect of dune morphodynamics on sand preservation is demonstrated. It is especially evident that thick, nearly instantaneously deposited sand units record dune stabilization near the very end of a dune activity episode, while thin sand units may signal the preservation of sand deposited earlier in episodes of activity. Interpreting the distribution of luminescence ages that indicate sand deposition over time is not as simple as assumed in some previous work. Low frequency of sand ages could indicate an interval of either dune field stabilization or extensive dune activity but poor sand preservation. A peak of sand age frequency likely represents a shift in dune field activity towards stabilization, not a peak of active dune extent, especially if it partially overlaps with an independently identified interval of stabilization(e.g. one recorded by paleosols). The nature and magnitude of these biases in the distribution of sand ages over time are strongly affected by the magnitude of net sand accumulation, which is in turn related to sand supply, transport capacity and sand availability, and ultimately climate change. Relatively short dune stabilization and turn-over time(10~1 to 10~2 yrs) indicate that dune geomorphic processes can quickly respond to short-term disturbance, but the chronology of that response must be interpreted in light of how those processes influence age distributions.XU Zhiwei Joseph A. MASON LU Huayu YI Shuangwen ZHOU Yali WU Jiang HAN Zhiyong 2017Journal of Geographical Sciences2017,27,11:7
8Coupling Relationship Analysis on Households′ Production Behaviors and Their Influencing Factors in Nature Reserves:A Structural Equation Model显示文摘A households′production behavior directly influences the quality of the environment and determines the successful development of nature reserves.Meanwhile,the households′production behaviors are complicated by interrelated factors,such as protection attitudes,resource endowment,and family wealth.This research evaluated households near the Crested Ibis National Nature Reserve in Shaanxi Province,acquiring data from 436 households around Yang County and Ningshan County in the south slope of Qinling Mountains,China.Based on the collected data,we developed a structural equation model to evaluate the coupling relationships among households′ protection attitudes,production behaviors,resource endowment,and family wealth.The results showed that:1) households with great resource endowment had more negative attitudes,probably due to their greater protection costs;2) the households with higher education levels had worse protection attitudes;3) the households with more family wealth were likely to use fewer fertilizers,pesticides,and firewood;4) the households with more resource endowment showed less production and management behaviors;5) the enhancement of households' attitudes improved production behaviors to protection the environment,but the effects were not statistically significant.Our results provide a basis for the government's protection policy making,exploring the effective management measures that are beneficial for both nature reserve management and community development.WANG Changhai WEN Yali DUAN Wei HAN Feng 2013Chinese Geographical Science2013,23,4:6
9Study on the Estimation of Groundwater Withdrawals Based on Groundwater Flow Modeling and Its Application in the North China Plain显示文摘The amount of water withdrawn by wells is one of the quantitative variables that can be applied to estimate groundwater resources and further evaluate the human influence on groundwater systems. The accuracy for the calculation of the amount of water withdrawal significantly influences the regional groundwater resource evaluation and management. However, the decentralized groundwater pumping, inefficient management, measurement errors and uncertainties have resulted in considerable errors in the groundwater withdrawal estimation. In this study, to improve the estimation of the groundwater withdrawal, an innovative approach was proposed using an inversion method based on a regional groundwater flow numerical model, and this method was then applied in the North China Plain. The principle of the method was matching the simulated water levels with the observation ones by adjusting the amount of groundwater withdrawal. In addition, uncertainty analysis of hydraulic conductivity and specific yield for the estimation of the groundwater withdrawal was conducted. By using the proposed inversion method, the estimated annual average groundwater withdrawal was approximately 24.92×109 m3 in the North China Plain from 2002 to 2008. The inversion method also significantly improved the simulation results for both hydrograph and the flow field. Results of the uncertainty analysis showed that the hydraulic conductivity was more sensitive to the inversion results than the specific yield.Jingli Shao Yali Cui Qichen Hao Zhong Han Tangpei Cheng 2014Journal of Earth Science2014,25,6:6
10Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan 2018Protein & Cell2018,9,3:4
11Platinum-group element geochemistry of Cenozoic basalts from the North China Craton: Implications for mantle heterogeneity显示文摘42 新生代(主要中新世) 从北方中国 Craton 的 Jining, Chifeng, Fansi, Xiyang,和 Zuoquan 区域的暗岩样品(NCC 暗岩此后) 为铂组元素(PGE,包括的 O,红外, Ru, Rh,磅,和 Pd ) 被分析。他们中的大多数是碱的暗岩和 tholeiites,所有几乎不他们显示很少外壳的污染。NCC 暗岩的全部的 PGE 内容从 0.1 ~ 0.9 ppb 变化,原始披风的比那些低的大部分 23.5 珍视 ppb。这些暗岩的原始使披风正常化的 PGE 模式定义积极斜坡和 Pd/Ir 比率从 1.2 ~ 25 变化。以 PGE 内容和 Pd/Ir 比率,他们相当类似于海中央山脉暗岩。在 PGE 之间没有明显的否定关联,显示在 magmatic 期间的橄榄石,辉石,或硫化物的部分结晶化处理对在 NCC 暗岩的 MgO, Ni,和 Cu 不能是为观察 PGE 变化的控制因素。NCC 暗岩的观察 Pd/Ir 变化要求异构的披风采购的 non-chondritic 的参与。基于 Sr-Nd-Pb-Hf 同位素的 systematics 和不兼容元素的签名,一混合部分在岩流圈的顶从 asthenospheric 橄榄岩和围住的披风 eclogites 融化为这些 NCC 暗岩的起源被建议。eclogites 的透镜从再循环的大陆人外壳的 upwelling 被导出在期间向西从 600 km 断绝地区的和平的板的 subduction。这些暗岩的 PGE 地球化学提供独立证据支持这个结论和观察 Pd/Ir 变化可以在拍的 peridotitic 的比例反映变化, eclogitic 融化。ZHANG WenHui ZHANG HongFu SUN YaLi FAN WeiMing HAN BaoFu TANG YanJie 2015Science China Earth Sciences2015,58,6:4
12Diagnostic value of negative enrichment and immune fluorescence in situ hybridization for intraperitoneal free cancer cells of gastric cancer显示文摘Objective:To explore the intraperitoneal free cancer cell(IFCC)detection value of negative enrichment and immune fluorescence in situ hybridization(NEimFISH)on chromosomes(CEN)8/17.Methods:To verify the reliability of NEimFISH,29 gastric cancer tumors,their adjacent tissues and greater omental tissues were tested.Our study then included 105 gastric cancer patients for IFCC.We defined patients as IFCC-positive if a signal was detected,regardless of the detailed cancer cell numbers.A comparison of clinicopathological features was conducted among IFCC groups.We also compared the diagnosis value and peritoneal recurrence predictive value among different detection methods.The comparison of IFCC number was also conducted among different groups.Results:A cutoff of 2.5 positive cells could distinguish all benign tissue samples and 97%of malignant tissue samples in our study.Compared to intestinal gastric cancer,patients with diffuse gastric cancer tended to have more IFCCs(6 vs.4,P=0.002).The IFCC counts were often higher in the lymphovascular invasion positive group than negative group(3 vs.1,P=0.022).All IFCC samples that were considered positive using conventional cytology were also found to be positive using NEimFISH.When compared to conventional cytology and paraffin pathology,NEimFISH had a higher IFCC positive rate(68.9%)and higher one-year peritoneal recurrence predictive value with area under the curve(AUC)of 0.922.Conclusions:Gastric cancer could be effectively diagnosed by NEimFISH.The IFCC number found using NEimFISH on CEN8/17 is closely associated with Lauren type and vascular invasion of cancer.NEimFISH is a reliable detection modality with a higher positive detection rate,higher one-year peritoneal recurrence predictive value and quantitative features for IFCC of gastric cancer.Anqiang Wang Zhongwu Li Qian Wang Yali Bai Xin Ji Tao Fu Ke Ji Yanwen Xue Tingxu Han Xiaojiang Wu Ji Zhang Yingjie Yang Guobin Xu Zhaode Bu Jiafu Ji 2019Chinese Journal of Cancer Research2019,31,6:3
13OGT Mediated Histone H2B S112 Glc NAcylation Regulates DNA Damage Response显示文摘O-GlcNAcylation is an important post-translational modification and has been implicated in many fundamental cellular processes. Recent studies showed that O-linked N-acetylglucosamine(GlcNAc) transferase(OGT) mediated O-Glc NAcylation of histone H2B Ser 112(H2B S112 Glc NAcylation) plays an important role in gene transcription. However, the role of this histone modification in DNA damage response has not been studied yet. In this study, we found that OGT and OGT mediated H2B S112 Glc NAcylation are involved in DNA damage response for maintaining genomic stability and are required for resistance to many DNA-damaging and replication stressinducing agents. OGT mediated H2B S112 GlcNAcylation increased locally upon the induction of double-strand breaks(DSBs), and depletion of OGT or overexpression of H2B S112A mutant impaired homologous recombination(HR) and nonhomologous end-joining(NHEJ). Mechanistically, H2B S112 GlcNAcylation could bind Nijmegen breakage syndrome 1(NBS1) and regulate NBS1 foci formation. Taken together, our results demonstrate a new function of histone O-GlcNAcylation in DNA damage response(DDR).Panfei Wang Changmin Peng Xia Liu Hailong Liu Yali Chen Li Zheng Baolin Han Huadong Pei 2015Journal of Genetics and Genomics2015,42,9:3
14Comparative study of mutation spectrums ofMT-RNR1m.1555A〉G, GJB2, and SLC26A4 between familial and sporadic patients with nonsyndromic sensorineural hearing loss in Chinese Han显示文摘Li Qian Ji Yubin Han Bing Zong Liang Lan Lan Zhao Yali Wang Hongyang Wang Dayong Wang Qiuju 2014Chinese Medical Journal2014,,18:3
15Consideration of Monkeypox Surveillance in China,2022显示文摘Since the first monkeypox cases were confirmed in England in May 2022(1),100 countries worldwide have reported 53,027 confirmed cases and 15 deaths as of September 2(2).This is the largest and most widespread monkeypox epidemic in the world since monkeypox virus was discovered and identified in 1958,involving the largest number of countries and transmitting primarily in non-endemic countries(3).Moreover,the currently ongoing monkeypox epidemic also has some characteristics that are different from previous outbreaks(4).For example,most cases have a history of sexual contact,with an overwhelming majority of men who have sex with men(MSM)(5).On July 23,the WHO declared the global monkeypox outbreak a Public Health Emergency of International Concern(PHEIC)in order to address the ongoing outbreak with the required urgency(6).Lei Zhou Yali Wang Dan Li Mengjie Han Guoqing Shi Qun Li 2022China CDC weekly2022,4,41:2
16Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors.Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang 2022Cell Research2022,32,11:2
17Spatial and temporal dynamics of microbial community composition and factors influencing the surface water and sediments of urban rivers显示文摘The temporal and spatial characteristics of urban river bacterial communities help us understand the feedback mechanism of bacteria to changes in the aquatic environment.The Fuhe River plays an important role in determining the water ecological environment of Baiyangdian Lake.16S rRNA gene sequencing was used to study the microbial distribution characteristics in the Fuhe River in different seasons.The results showed that some environmental factors of the surface water(ammonia nitrogen(NH_(3)^(-)N),total nitrogen(TN),and total phosphorus(TP))were different on the spatial and temporal scales.Moreover,there were no seasonal differences in the contents of TN,TP,total organic carbon(TOC),or heavy metals in the sediments.The distributions of Cyanobacteria,Actinomycetes and Firmicutes in the water and Actinomycetes and Planctomycetes in the sediments differed significantly among seasons(P<0.05).There were significant spatial differences in bacteria in the surface water,with the highest abundance of Proteobacteria recorded in the river along with the highest nutrient concentration,while the abundance of Bacteroidetes was higher in the upstream than the downstream.Microbial communities in the water weremost sensitive to temperature(T)and the TP concentration(P<0.01).Moreover,differences in the bacterial community were better explained by the content of heavy metals in the sediments than by the chemical characteristics.A PICRUStmetabolic inference analysis showed that the effect of high summer temperatures on the enzyme action led to an increase in the abundances of the metabolic-related genes of the river microorganisms.Hongjie Wang Xingchun Liu Yali Wang Shengqi Zhang Guangming Zhang Yangyang Han Mengxiang Li Ling Liu 2023Journal of Environmental Sciences2023,,2:2
18Diagnosis of the pathological exposure of the mastoid portion of the facial nerve by CT scanning显示文摘Zilong Yu Demin Han Haijiang Dai Shouqin Zhao Yali Zheng 2007Acta Oto-Laryngologica2007,,3:1
19The global competitiveness of the Chinese wooden furniture industry显示文摘Xiao Han Yali Wen Shashi Kant 0,,11:1
20Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors显示文摘Sai Li Yanfang Zhao Kewen Wang Yali Gao Jianming Han Bingbing Cui Ping Gong 2013Bioorganic & Medicinal Chemistry2013,,11:1
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