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| 1 | Evidence of the Near-Source Accumulation of the Tight Sandstone Gas in Northern Ordos Basin,North-Central China显示文摘The tight sandstone gas in Upper Paleozoic Formation of the northern Ordos Basin is a typical giant unconventional tight gas province. Evidences from geochemistry, reservoir geology and paleotectonic setting all verify that the present-day tight sandstone gas accumulation in the Ordos Basin is the result of near-source accumulation. The evidences are listed as following: tight sandstone gas is mainly distributed in the area with high gas-generating strength; gas composition was not subjected to fractionation; gas saturation significantly decreases with the distance away from the source rocks; gas isotopes suggest their origin is the same and maturity is consistent with in-place source rocks; reservoirs have experienced three types of densification digenesis, including intense compaction, siliceous cementation and calcareous cementation, which took place before the formation of a large amount of tight sandstone gas, forming tight reservoirs with low porosity and permeability, fine pore throat and great capillary resistance; the paleo-structural gradient ratio is small from the main hydrocarbon generation period to present. It is indicated the present distribution of tight sandstone gas in the northern Ordos Basin is the result of near-source and short-distance migration and accumulation. | YANG Zhi LI Qiyan WU Songtao LIN Senhu LIU Xinshen | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 13 |
| 2 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 3 | Shale Oil Geological Characteristics and Resource Potential of Mesozoic Yanchang Formation in Ordos Basin,North-Central China显示文摘Shale oil in this paper is referred to as the matured oil,which is stored in organic-rich shale stratum with nanosized pore-throats,and is a very promising exploration field in future.Taking shale oil of Mesozoic Yanchang Formation in Ordos Basin for example.Shale oil occurs in the organicrich shale in the middle-lower seven member of | LI Qiyan YANG Zhi ZOU Caineng | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 4 | Tectonics and Seismicity of the Yarlung Tsangpo Grand Canyon Region显示文摘The Yarlung Tsangpo Grand Canyon region is located in the frontal zone of the eastern Himalayan syntaxis, where neo-tectonics and seismicity are intensive and closely related to each other. In the region, two sets of fault structures have developed, striking NNE-NE and NWW-NW, respectively. Investigation shows that they differ markedly in terms of scope, property, active times and intensity. The NWW-NW trending faults are large in size, and most are thrust and thrust strike-slip faults, formed in earlier times. The NEE-NE-strike faults are relatively small in size individually, with concentrated distribution, constituting the NNE-trending shear extensional fault zone, which is relatively younger with evident late Quaternary activities. Strong earthquakes occur mainly in the areas or zones of intensive differential movement of the Himalayas, e.g. along the deep and large fault zones around the crustal blocks. Most earthquakes of M≥7.0 are closely related to tectonics, where large-scale Holocene active faults are distributed with complicated fault geometry, or the faults of multiple directions intersect. Among them, earthquakes of M≥7.5 have occurred on the NW and NE-trending faults with a greater strike-slip component in the fault tectonic zones. | Shao Cuiru You Huichuan Cao Zhongquan Wang Chunyong Tang Fangtou Zhang Decheng Lou Hai Xu Guangyin Yang Qiyan Mei Tuo Xie Ping Yu Gang | 2009 | Earthquake Research in China2009，23，2： | 1 |
| 5 | Characteristics,Types,and Prospects of Geological Sweet Sections in Giant Continental Shale Oil Provinces in China显示文摘“Sweet sections”in giant shale oil provinces are preferential fields that primarily support China to increase the reserves and production of continental shale oil.Based on the study of the geological conditions of shale oil in the continental basins in China,it was found that the shale stratum in major oil generation windows generally has higher degrees of oil and gas accumulation,and mostly contains oil.Hydrocarbon generation and reservoir capacities are the two key parameters for evaluating and optimizing favorable shale oil provinces.The evaluation index(volume of shale stratum multiplied by total organic carbon(TOC)multiplied by total porosity)for the giant continental shale oil provinces is also proposed.It is optimized that the Upper Triassic Chang 7 Member in the southcentral Ordos Basin,Lower Cretaceous Qing 1 Member in the Gulong-Changling Sag in the Songliao Basin,Middle-Lower Permian in the Junggar Basin,Da’anzhai Member of the Ziliujing Formation of Lower Jurassic in the central and northern Sichuan Basin,and Paleogene oil-rich sag in the Bohai Bay Basin are the five giant continental shale oil provinces.The word“geological sweet sections”in continental shale oil provinces of China refers to favorable shale intervals which are relatively rich in oil,with superior physical properties,and more easily modified and developed commercially under applicable economic and technological conditions.After evaluation,there are mainly two types of“geological sweet sections”of giant continental shale oil developed onshore in China.One type of“geological sweet sections”is generally mudstone with optimal physical properties or a thin tight reservoir,to which the shale oil migrates a short distance.They are medium-to-high-mature zones with a thin sandy shale stratum in the Chang 7 Member in the Ordos Basin,mixed shale stratum in the mediummature Lucaogou Formation in the Jimsar Sag,and multi-layered mixed Paleogene shale stratum in the Bohai Bay Basin.The other type of“geological sweet sections”is generally shale oil residing in various shale reservoir spaces.This type was developed in the Qing 1 Member in the Gulong Sag and Da’anzhai Member in the north-central Sichuan Basin.Free shale oil mainly occurs in shale,sandycarbonate lamina,micro-lamella structure,and micro-fractures.Layers with lamina,lamination,and micro-fractures are generally shale oil“geological sweet sections.”Starting from field tests and the construction of the“geological sweet sections”in giant continental shale oil provinces,the shale oil industry has been rapidly developing and will become an important supplement to domestic oil production in China. | Zhi Yang Caineng Zou Songtao Wu Songqi Pan Xiaoni Wang Haitao Liu Wenqi Jiang Jiarui Li Qiyan Li Xiaobing Niu Guohui Li Zhenxing Tang Xuguang Guo Dong Huang Qizhao Wei | 2022 | Journal of Earth Science2022，33，5： | 1 |
| 6 | A 2.09 Mb fragment translocation on chromosome 6 causes abnormalities during meiosis and leads to less seed watermelon显示文摘Seedlessness is a valuable agronomic trait in watermelon(Citrullus lanatus)breeding.Conventional less seed watermelons are mainly triploid,which has many disadvantages due to unbalanced genome content.Less seed watermelon can be achieved at the diploid level when certain reproductive genes are mutated or by chromosome translocation,which leads to defects during meiosis.However,the formation mechanism of diploid less seed watermelons remains largely unknown.Here,we identified a spontaneous mutant line,watermelon line“148”,which can set seeds normally when self-pollinated.A total of 148×JM F_(1) hybrid plants exhibited seed number reductions to 50.3%and 47.3%of those of the two parental lines,respectively,which are considered to be less seed.Examination of pollen viability and hybridization experiments revealed that F 1 hybrids produce semisterile pollen and ovules.Further cytological observations indicated that semisterility was a result of a reciprocal translocation of chromosomes,which exhibited one quadrivalent ring of four chromosomes at prometaphase I during meiosis.RT-qPCR analysis indirectly confirmed that the semisterile phenotype is caused by chromosome translocation rather than disruption of specific meiotic gene expression.F 2 population genetic analysis indicated that the“148”watermelon line is a homozygous translocation and that the less seed phenotype of the F_(1) hybrid is prompted by one chromosome fragment translocation.The translocated fragment was further fine mapped to a 2.09 Mb region on chromosome 6 by whole-genome resequencing and genetic map cloning procedures.Our work revealed that a 2.09Mb chromosome fragment translocation on chromosome 6,causing meiotic defects at metaphase I during meiosis,leads to diploid less seed watermelon.Our findings provide a new promising method for less seed watermelon breeding at the diploid level,as well as a fragment size reference for breeding less seed watermelon through artificially induced chromosome translocation. | Shujuan Tian Jie Ge Gongli Ai Jiao Jiang Qiyan Liu Xiner Chen Man Liu Jianqiang Yang Xian Zhang Li Yuan | 2021 | Horticulture Research2021，8，1： | 1 |
| 7 | Geometric Structure and Tectonic Activities of Wanquan Fault,Hebei Province显示文摘Based on detailed investigations and prospecting,this paper describes the geometrical characteristics and tectonic activities of Wanquan fault in northwest of Beijing. This fault strikes mainly northeast or northeast to north,dipping southeast,and extends over a length of 15km. It is a major geological and geomorphological margin,controlling the neotectonic movement in this region. On the southeast side of Wanquan fault are the Late Quaternary unconsolidated deposits,forming a basin or deposition; but on the other side is Mesozoic volcano debris,forming lower-mountains and hills. Wanquan fault is a mid- to-high-angle normal fault dipping southeast. This fault was more active in the Quaternary. Since the middle-late part of the alate Pleistocene,the average rate with vertical slip of a single fault is over 0. 03 ~ 0. 3mm /a,but the fault has multiple slipping surfaces,and a total rate with vertical slip will be estimated. | Zhou Jianglin You Huichuan Zhou Yueling Shao Cuiru Yang Qiyan Li Jinjin Zhang Zhengyu | 2013 | Earthquake Research in China2013，27，2： | 0 |
| 8 | Application of Ultra-shallow Seismic Survey to the Wanggezhuang Fault in Qingdao显示文摘At present,there is less theoretical research and practical experience in the aspect of ultrashallow seismic exploration to the target layers at depths of only tens of meters both at home and abroad. Seismic exploration plays an important role in the location of faults and active structures,but the depth dozens of meters below the ground surface is the blind area of any kind of deep and shallow seismic exploration. Starting from the point of view of detecting urban active faults,and using related theories and methods of geology,geophysics and mathematics,the paper discusses the preconditions for acquiring efficient ultra-shallow seismic survey results in complicated geological backgrounds in Qingdao.Taking the Qingdao area as an example in this paper,we study the depth condition of Quaternary deposits,and apply 4-8 stacking folds to satisfy the requirement to get the exploration results with high-resolution and high-SNR. Preliminary results reveal that selecting a proper surveillance layout is one of the keys to acquire authentic exploration results in ultra-shallow P-wave reflection exploration. Our results also show that ultrashallow seismic reflection method in detecting faults in the Qingdao area has good application prospects. | Yang Qiyan You Huichuan Di Long | 2018 | Earthquake Research in China2018，32，4： | 0 |
| 9 | P-wave tomography and relation between shallow and deep structures beneath the Songliao basin显示文摘We selected relative travel-time residuals from teleseismic waveform data using the waveform correction method and imaged the P wave velocity structure beneath Northeast China.In combination with other geophysical data,we discussed the relation between the shallow and deep structures of the area.The results show that there is a primary high-velocity zone with some high- and low-velocity distribution characters beneath the Songliao basin.The low-velocity anomalies may extend down to the upper mantle,and may be the result of material upwelling.The low-velocity anomaly beneath the southern part of the Songliao basin is connected to those beneath the Changbaishan and A'ershan volcanic areas.It may be an upwelling channel from the mantle beneath the Songliao basin and adjacent area.This finding indicates the Songliao basin was a result of asthenospheric upwelling caused by subduction of the Pacific plate under the Eurasian plate. | Qiyan Yang Qingju Wu Xiaojun Ma Fengxue Zhang Yanrui Sheng | 2015 | Earthquake Science2015，28，4： | 0 |
| 10 | Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma显示文摘In the interaction between a tumor and the immune system,immune checkpoints play an important role,and in tumor immune escape,co-inhibitory immune checkpoints are important.Immune checkpoint inhibitors(ICIs)can enhance the immune system's killing effect on tumors.To date,impressive progress has been made in a variety of tumor treatments;PD1/PDL1 and CTLA4 inhibitors have been approved for clinical use in some tumors.However,glioblastoma(GBM)still lacks an effective treatment.Recently,a phase III clinical trial using nivolumab to treat recurrent GBM showed no significant improvement in overall survival compared to bevacizumab.Therefore,the use of immune checkpoints in the treatment of GBM still faces many challenges.First,to clarify the mechanism of action,how different immune checkpoints play roles in tumor escape needs to be determined;which biomarkers predict a benefit from ICIs treatment and the therapeutic implications for GBM based on experiences in other tumors also need to be determined.Second,to optimize combination therapies,how different types of immune checkpoints are selected for combined application and whether combinations with targeted agents or other immunotherapies exhibit increased efficacy need to be addressed.All of these concerns require extensive basic research and clinical trials.In this study,we reviewed existing knowledge with respect to the issues mentioned above and the progress made in treatments,summarized the state of ICIs in preclinical studies and clinical trials involving GBM,and speculated on the therapeutic prospects of ICIs in the treatment of GBM. | Shaoping Shen Ling Chen Jialin Liu Lin Yang Mengna Zhang Lingxiong Wang Rong Zhang Yasushi Uemura Qiyan Wu Xinguang Yu Tianyi Liu | 2020 | Cancer Biology & Medicine2020，17，3： | 0 |
| 11 | Joint inversion of Rayleigh group and phase velocities for S-wave velocity structure of the 2021 M_(S)6.0 Luxian earthquake source area,China显示文摘On September 16,2021,a MS6.0 earthquake struck Luxian County,one of the shale gas blocks in the Southeastern Sichuan Basin,China.To understand the seismogenic environment and its mechanism,we inverted a fine three-dimensional S-wave velocity model from ambient noise tomography using data from a newly deployed dense seismic array around the epicenter,by extracting and jointly inverting the Rayleigh phase and group velocities in the period of 1.6–7.2 s.The results showed that the velocity model varied significantly beneath different geological units.The Yujiasi syncline is characterized by low velocity at depths of~3.0–4.0 km,corresponding to the stable sedimentary layer in the Sichuan Basin.The eastern and western branches of the Huayingshan fault belt generally exhibit high velocities in the NE-SW direction,with a few local low-velocity zones.The Luxian MS6.0 earthquake epicenter is located at the boundary between the high-and low-velocity zones,and the earthquake sequences expand eastward from the epicenter at depths of 3.0–5.0 km.Integrated with the velocity variations around the epicenter,distribution of aftershock sequences,and focal mechanism solution,it is speculated that the seismogenic mechanism of the main shock might be interpreted as the reactivation of pre-existing faults by hydraulic fracturing. | Wei Xu Pingping Wu Dahu Li Huili Guo Qiyan Yang Laiyu Lu Zhifeng Ding | 2023 | Earthquake Science2023，36，5： | 0 |
| 12 | Use of Qishen granule for the treatment of heart failure: A systematic review and meta-analysis of animal studies显示文摘Objective:To evaluate the effect of Qishen granule(QSG)on heart failure(HF)and the potential mechanisms involved in animal models.Methods:Studies of QSG in animals with HF were identified by searches of eight databases up to August 1,2019.Two authors independently reviewed each study and the Collaborative Approach to Metaanalysis and Review of Animal Data from Experimental Studies 10-item checklist was used for quality assessment.The primary outcomes were indicators of left ventricular ejection fraction and/or left ventricular fractional shortening.The secondary outcome measures were ventricular structure,hemodynamics,myocardial injury-related indicators,and the mechanisms whereby QSG ameliorates HF.A metaanalysis was performed and all the data were analyzed using RevMan 5.3 software.Results:Thirteen studies containing a total of 240 animals met the criteria for the meta-analysis.The quality score of the studies ranged from three to six points.The meta-analysis showed a significant effect of QSG to improve cardiac function,inhibit ventricular remodeling,improve circulation,and attenuate myocardial injury.The possible mechanisms was identified to be suppression of the renin-angiotensinaldosterone system,which has anti-fibrotic,anti-apoptotic,anti-inflammatory,and anti-oxidative effects in the myocardium,the prevention of calcium overload,and the promotion of myocardial energy metabolism.Conclusion:Our review shows that QSG has a cardioprotective effect in animal models of CHF.However,due to the relatively poor quality of the included studies and the differences between humans and animal models,the results should be interpreted with caution. | Junjie Liu Shuangjie Yang Wei Wang Yili Zhang Qiyan Wang Xiaoli Sun Nannan Tan Kangjia Du Yong Wang Huihui Zhao | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 0 |
| 13 | Quantum Bit Commitment Based on Qubit Oblivious Transfer显示文摘 | YANG Wei HUANG Liusheng WANG Qiyan LUO Yonglong | 2009 | Chinese Journal of Electronics2009，18，3： | 0 |
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