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| 1 | Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine显示文摘 | Tingting Zhu Ian A Roundtree Ping Wang Xiao Wang Li Wang Chang Sun Yuan Tian Jie Li Chuan He Yanhui Xu | 2014 | Cell Research2014，24，12： | 28 |
| 2 | ζ-Carotene Isomerase Suppresses Tillering in Rice through the Coordinated Biosynthesis of Strigolactone and Abscisic Acid显示文摘Rice tillering is an important agronomic trait affecting grain yield.Here,we identified a high-tillering mutant tillering20(t20),which could be restored to the wild type by treatment with the strigolactone(SL)analog rac-GR24.T20 encodes a chloroplast ζ-carotene isomerase(Z-ISO),which is involved in the biosynthesis of ca-rotenoids and their metabolites,SL and abscisic acid(ABA).The t20 mutant has reduced SL and ABA,raising the question of how SL and ABA biosynthesis is coordinated,and whether they have overlapping functions in tillering.We discovered that rac-GR24 stimulated T20 expression and enhanced all-trans-p-carotene biosynthesis.Importantly,rac-GR24 also stimulated expression of Oryza sativa 9-CIS-EPOXY-CAROTENOID DIOXYGENASE 1(OsNCED1)through induction of Oryza sativa HOMEOBOX12(0sHOX12),promoting ABA biosynthesis in shoot base.On the other hand,ABA treatment significantly repressed SL biosynthesis and the ABA biosynthetic mutants displayed elevated SL biosynthesis.ABA treatment reduced the number of basal tillers in both t20 and wild-type plants.Furthermore,while ABA-deficient mu-tants aba1 and aba2 had the same number of basal tillers as wild type,they had more unproductive upper tillers at maturity.This work demonstrates complex interactions in the biosynthesis of carotenoid,SLs and ABA,and reveals a role for ABA in the regulation of rice tillering. | Xue Liu Qingliang Hu Jijun Yan Kai Sun Yan Liang Meiru Jia Xiangbing Meng Shuang Fang Yiqin Wang Yanhui Jing Guifu Liu Dianxing Wu Chengcai Chu Steven M.Smith Jinfang Chu Yonghong Wang Jiayang Li Bing Wang | 2020 | Molecular Plant2020，13，12： | 11 |
| 3 | Structural insight into mechanisms for dynamic regulation of PKM2显示文摘Pyruvate kinase isoform M2 (PKM2 ) 把 phosphoenolpyruvate (锐气) 变换成 pyruvate 并且在癌症新陈代谢起一个重要作用。这里,我们证明 translational 以后修正和一个导出病人的变化通过 modulating 调整 PKM2 的 pyruvate kinase 活动 PKM2 tetramer 的符合构造。我们决定了人的 PKM2 异种的水晶结构并且建议了一个跷跷板模型说明在不活跃的 T 状态和 PKM2 的活跃 R 状态 tetramers 之间的 conformational 变化。生物化学、结构的分析表明那 PKM2 <啜class=“ a-plus-plus ”> Y105E ( phosphorylation Y105 模仿)由禁止 FBP 的减少 pyruvate kinase 活动(果糖 1,6-bisphosphate )导致的R状态形成,并且 PKM2 <啜class=“ a-plus-plus ”> K305Q ( acetylation K305 模仿)由妨碍 tetramer 废除这项活动形成。K422R, PKM2 的一个导出病人的变化,因为强壮的分子间的相互作用,赞成稳定的、不活跃的 T 状态 tetramer。我们的学习由 translational 以后修正和一个导出病人的变化为 PKM2 的动态规定揭示机制并且为另外的修正的进一步的调查和还有待于发现的 PKM2 的变化提供一个结构的基础。 | Ping Wang Chang Sun Tingting Zhu Yanhui Xu1 | 2015 | Protein & Cell2015，6，4： | 9 |
| 4 | Modes of Grain Selection in Spiral Selector during Directional Solidification of Nickel-base Superalloys显示文摘The modes of grain selection in spiral selector were investigated by both a ProCAST simulation and experimental confirmation.The results show that the efficiency of grain selection in starter block is associated with the geometry shape.At the early stage of grain selection,the optimization of grain orientation is dominated by competitive grain growth,but the optimization of grain orientation in starter block is gradually dominated by geometry shape at the later stage of grain selection.Besides,the spiral part could also optimize the orientation of the selected single crystal when the initial angle is large enough,and the single crystal selection in spiral parts with different pitch lengths and initial angles is dominated by different modes.The simulation results agree well with experimental ones. | Xiangbin Meng Qi Lu Jinguo Li Tao Jin Xiaofeng Sun Jun Zhang ZhongqiangChen Yanhui Wang Zhuangqi Hu | 2012 | Journal of Materials Science & Technology2012，28，3： | 8 |
| 5 | Experimental investigation on transverse jet penetration into a supersonic turbulent crossflow显示文摘The paper evaluates the evolvement of coherent structures and penetration height of gaseous transverse jet penetration into a supersonic turbulent flow.The high spatiotemporal resolution coherent structures of the jet plume are obtained by utilizing the nanoparticle-based planar laser scattering technique(NPLS).The evolving pattern of the coherent structures generated on the upwind surface of the transverse jet is analyzed based on the NPLS images.The shedding eddies from the jet near-field have lower convection velocity along freestream direction,while vortex growth rate is apparently higher than the far-field.Farther downstream,the large-scale eddies have less deformation and translate at velocities near the freestream velocity.Thus the near-field determines the scale of eddies in the far-field and affects the whole mixing process.The effect of injection stagnation pressure on the coherent structures is discussed and a modified penetration correlation is proposed based on an edge approximation definition and least square method with various injection pressures. | SUN MingBo ZHANG ShunPing ZHAO YanHui ZHAO YuXin LIANG JianHan | 2013 | Science China(Technological Sciences)2013，56，8： | 7 |
| 6 | RLS3, a protein with AAA+ domain localized in chloroplast, sustains leaf longevity in rice显示文摘Leaf senescence plays an important role in crop developmental processes that dramatically affect crop yield and grain quality. The genetic regulation of leaf senescence is complex, involving many metabolic and signaling pathways.Here, we identified a rapid leaf senescence 3(rls3) mutant that displayed accelerated leaf senescence, shorter plant height and panicle length, and lower seed set rate than the wild type. Map-based cloning revealed that RLS3 encodes a protein with AAA+ domain, localizing it to chloroplasts. Sequence analysis found that the rls3 gene had a single-nucleotide substitution(G→A) at the splice site of the 10^(th)intron/11^(th) exon, resulting in the cleavage of the first nucleotide in 11 ^(th) exon and premature termination of RLS3 protein translation.Using transmission electron microscope, the chloroplasts of the rls3 mutant were observed to degrade much faster than those of the wild type. The investigation of the leaf senescence process under dark incubation conditions furtherrevealed that the rls3 mutant displayed rapid leaf senescence.Thus, the RLS3 gene plays key roles in sustaining the normal growth of rice, while loss of function in RLS3 leads to rapid leaf senescence. The identification of RLS3 will be helpful to elucidate the mechanisms involved in leaf senescence in rice. | Yanhui Lin Lubin Tan Lei Zhao Xianyou Sun Chuanqing Sun | 2016 | Journal of Integrative Plant Biology2016，58，12： | 6 |
| 7 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 8 | Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro显示文摘β-mercaptoethanol can induce adult adipose-derived stromal cells to rapidly and efficiently differentiate into typical neuron-like cells in vitro.Immunohistochemistry showed that neuron specific enolase and neurofilament-200 expression gradually increased with the extension of induction time,and peaked at 5 hours.By contrast,glial fibrillary acidic protein was negatively expressed at all time points.Induced cells possessed a typical Nissl body,apoptosis showing condensed chromatin in the nucleus,autophagosomes with a bilayered membrane and autolysosomes in the cytoplasm at 5 hours.TUNEL assay and immunohistochemistry and immunofluorescence demonstrated that apoptosis and caspase-3 expression increased and peaked at 8 hours.Immunohistochemistry and immunofluorescence showed that microtubule-associated protein light chain 3 gradually increased with induction and reached a peak at 5 hours.These results indicate that autophagy played an important role in protecting cells during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro. | Yanhui Lu Xiaodong Yuan Ya Ou Yanan Cai Shujuan Wang Qiaoyu Sun Wenli Zhang | 2012 | Neural Regeneration Research2012，7，16： | 5 |
| 9 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 10 | Electronic-property dependent interactions between tetracycline and graphene nanomaterials in aqueous solution显示文摘Understanding the interactions between graphene nanomaterials(GNMs) and antibiotics in aqueous solution is critical to both the engineering applications of GNMs and the assessment of their potential impact on the fate and transport of antibiotics in the aquatic environment. In this study, adsorption of one common antibiotic, tetracycline, by graphene oxide(GO) and reduced graphene oxide(RGO) was examined with multi-walled carbon nanotubes(MWCNTs) and graphite as comparison. The results showed that the tetracycline adsorption capacity by the four selected carbonaceous materials on the unit mass basis followed an order of GO > RGO > MWCNTs > graphite. Upon normalization by surface area,graphite, RGO and MWCNTs had almost the same high tetracycline adsorption affinity while GO exhibited the lowest. We proposed π-electron-property dependent interaction mechanisms to explain the observed different adsorption behaviors. Density functional theory(DFT) calculations suggested that the oxygen-containing functional groups on GO surface reduced its π-electron-donating ability, and thus decreased the π-based interactions between tetracycline and GO surface. Comparison of adsorption efficiency at different p H indicated that electrostatic interaction also played an important role in tetracycline-GO interactions. Site energy analysis confirmed a highly heterogeneous distribution of the binding sites and strong tetracycline binding affinity of GO surface. | Lin He Fei-fei Liu Mengyao Zhao Zhen Qi Xuefei Sun Muhammad Zaheer Afzal Xiaomin Sun Yanhui Li Jingcheng Hao Shuguang Wang | 2018 | Journal of Environmental Sciences2018，30，4： | 4 |
| 11 | The Contents of Terpene Trilactone and Flavonoid in Leaves of Seedlings from Ancient Female Ginkgo Trees in China显示文摘Flavonoids and terpene trilactones, especially, ginkgo flavonglycosides, ginkgolides and bilobalides in leaves of ginkgo trees, need to be studied for effective application of these active components with high medical and health-care values. This study was aimed to provide scientific bases for genealogies selection and harvest season confirmation for Ginkgo biloba. A high-performance liquid chromatographic method(HPLC-ELSD)was developed to determine the contents of terpene trilactone and flavonoid of 36 ancient G. biloba genealogies from 19 provinces in China.The study indicated that the content gradually increased from April to August, and thereafter declined. Analysis of variance indicated that the contents of terpene trilactone, flavonoids, and their respective components had significant difference among 36 genealogies. The cluster analysis showed that No. 72(Xing'an, Guangxi), No. 58(Youyang, Chongqing), No. 82(Rugao, Jiangsu), No. 123(Huixian, Gansu), No. 99(Dujun, Guizhou),No. 10(Tai'an, Shandong) and No. 133(Mentougou, Beijing) genealogies have higher content of terpene trilactone and flavonoid. These results can help us to select superior variety containing high content of terpene trilactone and flavonoid. | ZHANG Yanhui LIU Peiying KONG Qianqian XING Shiyan LIU Xiaojing SUN Limin | 2017 | Horticultural Plant Journal2017，3，4： | 3 |
| 12 | Observation of coupling between zero- and two- dimensional semiconductor systems based on anomalous diamagnetic effects显示文摘我们报导在一个单个自我装配的 InAs 量点和弄湿的层之间联合的直接观察,基于用磁电机光致发光光谱学的许多身体激子状态的强壮的抗磁的移动。当在弄湿的层的一个电子在量点与一个洞结合时,一个极其大的积极抗磁的系数被观察;系数比在量点限制的激子状态的大将近一个数量级。有在联合系统的一个量点的洞的电子的再结合导致不平常的否定抗磁的效果,它在一个纯量点系统是比那强壮五倍的。这效果能被归因于在再结合以后处于量点的激动的状态在弄湿的层或电子的传播仍然是电子到弄湿的层的 wavefunction 的扩大。在这种情况中,因为洞的缺席,在量点飞机的最后的状态的 wavefunction 程度比起始的状态的大得多吸引电子。在弄湿的层取决于大电子 wavefunction 程度的射出的光子的性质显示联合发生在不同维数的系统之间,它也从在不同配置使用一个磁场获得的结果被验证。这研究铺平一条新道路与零维、二维的结构观察混合状态,它能为调查 Kondo 物理并且实现是有用的基于纺纱固态量信息处理。 | Shuo Cao Jing Tang Yue Sun Kai Peng Yunan Gao Yanhui Zhao Chenjiang Qian Sibai Sun Hassan Ali Yuting Shao Shiyao Wu Feilong Song David A. Williams Weidong Sheng Kuijuan Jin Xiulai Xu | 2016 | Nano Research2016，9，2： | 2 |
| 13 | Effect of solution treatment on microstructures and mechanical properties of AISI 321 service显示文摘A detailed knowledge of changes in microstructures and mechanical properties that occur in AISI 321 stainless steels service before and after solution treatment is of great interest,since the ductility and toughness of AISI 321 stainless steels may change drastically after service for a long time.After solution treatment at 1050 ℃,the microstructures of AISI 321 stainless steels service for 80 000 h at 700 ℃ indicate that the content of sigma phase significantly decreased,the grains of austenite grew and the amount of twins together with the size increased with solution treatment time.The results of mechanical properties tests show that the impact toughness at room temperature was superior at solution treatment,and there was no obvious change in the impact toughness between different times of solution treatment at room temperature. | Yanhui ZHAO Haitao MA Lai WANG Changhai SUN Chao GUO | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，3： | 2 |
| 14 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 15 | Molecular mechanism for the substrate recognition of USP7显示文摘 | Jingdong Cheng (1) (2) Ze Li (1) (2) Rui Gong (1) Jian Fang (1) Yi Yang (1) Chang Sun (1) Huirong Yang (1) Yanhui Xu (1) (2) (3) | 2015 | Protein & Cell2015，6，11： | 1 |
| 16 | Power flow charac- terization of a bidirectional galvanically isolated high-power DC/DC converter over a wide operating range 显示文摘 | XIE Yanhui SUN Jing FREUDENBERG J S | 2010 | IEEE Transactions on Power Electronics2010，25，1： | 1 |
| 17 | Macroscopic, Flexible, High-Performance Graphene Ribbons显示文摘 | Sun Jiankun Li Yanhui Peng Qingyu | 2013 | ACS Nano2013，7，10： | 1 |
| 18 | Power flow characterization of a bidirectional galvanically isolated high-power DC/I)C converter over a wide operating range 显示文摘 | Xie Yanhui Sun J Freudenberg J S | 2010 | IEEE Transactions on Power Electronics2010，25，1： | 1 |
| 19 | Modeling the transient heat transfer for the controlled pulse key-holing process in plasma arc welding显示文摘 | Junhua Sun Chuan Song Wu Yanhui Feng | 2011 | International Journal of Thermal Sciences2011，，9： | 1 |
| 20 | Covalent organic framework nanoparticles for anti-tumor gene therapy显示文摘Covalent organic framework(COF)materials have great development value in the biomedical field.However,the huge size and poor dispersion of COF materials severely limit their application.Here we successfully prepared COF nanoparticles with uniform size and good dispersion under the assistance of microwave.By adding some cationic polymers or small amine molecules,the dispersibility of COF could be further improved and its surface charge also increased.The prepared cationic COF nanoparticles(CLZU NPs)had excellent gene transfection ability and good biocompatibility.Designing low-toxic and highefficiency gene carrier is an important mission in the field of gene therapy.This COF-based gene vector provides a new direction for gene carrier design. | Kai Hao Zhaopei Guo Lin Lin Pingjie Sun Yanhui Li Huayu Tian Xuesi Chen | 2021 | Science China Chemistry2021，64，7： | 1 |
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