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| 1 | Holmium laser versus conventional transurethral resection of the bladder tumor显示文摘 | TENG Jing-fei WANG Kai YIN Lei QU Fa-jun ZHANG Dong-xu CUI Xin-gang XU Dan-feng | 2013 | Chinese Medical Journal2013，，9： | 32 |
| 2 | Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome显示文摘OBJECTIVE: To compare the impacts of electroacupuncture(EA) and moxibustion(Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P(SP) and vasoactive intestinal peptide(VIP)in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome(IBS-D and IBS-C,respectively).METHODS: Eighty-five IBS patients were randomly allocated to the EA and Mox groups. Zusanli(ST 36)and Shangjuxu(ST 37) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for 14 consecutive days. Before and after the treatment sessions,a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms. There were four dropout cases,leaving 81 participants(41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions. During colonoscopy,sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.RESULTS: Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients. However,Mox was more effective at reducing diarrhea in IBS-D patients,whereas EA was more effective at improving constipation in IBS-C patients. EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa,with no significant difference shown between the two treatments.CONCLUSION: Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients. | Lu Zhenzhong Yin Xiaojun Teng Weijun Chen Yuehua Sun Jie Zhao Jimeng Wang Anqi Bao Chunhui Shi Yin | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 24 |
| 3 | Transmission of climate change impacts from temperature change to grain harvests, famines and peasant uprisings in the historical China显示文摘Because of the complexity of social responses to climate change,as well as limitations of proxy data concerning interactions between climate change and human responses,the social impacts of past climate change and associated response mechanisms,thus,require further investigation.To shed light on the transmission of climate change impacts within historical Chinese society,we selected 30-year resolution sequences of temperature anomalies in eastern China and 10-year resolution sequences of grain harvest grades,famine indices,and frequencies of peasant uprisings in China over the past 2000 years.Using a food security perspective,we analyzed the impacts of temperature changes historically transmitted through Chinese production,population,and social subsystems,and differences in transmission characteristics between cold and warm units.Our results were as follows.(1)From 210 BC to 1910 AD,temperature changes in China were significantly positively correlated with grain harvest grades(correlation coefficient,0.338),and significantly negatively correlated with famine indices,and frequencies of peasant uprisings(correlation coefficients,-0.301 and-0.277,respectively).The correlation coefficients between famine indices and grain harvest grades or frequencies of peasant uprisings were very low.(2)There was a higher proportion of bumper or normal harvests(86.5%of the total decades),more moderate and mild famines(76%),and a lower proportion of peasant uprisings(33.3%)in the 30-year warm units.Conversely,there was a higher proportion of poor or normal harvests(70.7%),a greater proportion of moderate and severe famines(77.6%),and more peasant uprisings(51.7%)in the 30-year cold units.(3)Of the 23 main transmission pathways extending from temperature change to the social subsystem,13 occurred in cold units,of which 7 had an endpoint of peasant uprisings,and 10 occurred in warm units of which 3 had an endpoint of peasant uprisings.The main transmission pathways that were more likely to be associated with the impacts of temperature change were:Cold→poor harvests→severe famines→more uprisings;cold→poor harvests→moderate famines→more uprisings;warm→bumper harvests→mild famines→no uprisings;warm→bumper harvests→moderate harvests→no uprisings;warm→normal harvests→mild famines→no uprisings;and warm→normal harvests→moderate famines→no uprisings.(4)The transmission of the impacts of temperature change was a complex process.Within this process,famine was most prone to being modulated by human society.In the transmission pathways from the production to the social subsystem,there was a stepwise decrease in the occurrence rate of decades that were probably affected by climate change.In all cold units,10.4%of decades ending in more uprisings were most likely to be associated with the impacts of temperature change.In all warm units,47.9%of decades ending in no uprisings were most likely to be associated with the impacts of temperature change.This research can contribute a better understanding on the past interaction mechanisms and processes within the human-climate-ecosystem complex,as well as a better response to the impacts of the ongoing climate change. | FANG XiuQi SU Yun YIN Jun TENG JingChao | 2015 | Science China Earth Sciences2015，58，8： | 15 |
| 4 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 5 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 6 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 7 | Low-latency deep-reinforcement learning algorithm for ultrafast fiber lasers显示文摘The application of machine learning to the field of ultrafast photonics is becoming more and more extensive.In this paper,for the automatic mode-locked operation in a saturable absorber-based ultrafast fiber laser(UFL),a deep-reinforcement learning algorithm with low latency is proposed and implemented.The algorithm contains two actor neural networks providing strategies to modify the intracavity lasing polarization state and two critic neural networks evaluating the effect of the actor networks.With this algorithm,a stable fundamental modelocked(FML)state of the UFL is demonstrated.To guarantee its effectiveness and robustness,two experiments are put forward.As for effectiveness,one experiment verifies the performance of the trained network model by applying it to recover the mode-locked state with environmental vibrations,which mimics the condition that the UFL loses the mode-locked state quickly.As for robustness,the other experiment,at first,builds a database with UFL at different temperatures.It then trains the model and tests its performance.The results show that the average mode-locked recovery time of the trained network model is 1.948 s.As far as we know,it is 62.8%of the fastest average mode-locked recovery time in the existing work.At different temperatures,the trained network model can also recover the mode-locked state of the UFL in a short time.Remote algorithm training and automatic mode-locked control are proved in this work,laying the foundation for long-distance maintenance and centralized control of UFLs. | QIUQUAN YAN QINGHUI DENG JUN ZHANG YING ZHU KE YIN TENG LI DAN WU TIAN JIANG | 2021 | Photonics Research2021，9，8： | 7 |
| 8 | Energy budget of surface waves in the global ocean显示文摘Mechanical energy input from atmosphere and losses from wave-breaking dissipation of sea surface waves are estimated by a direct scheme. This scheme is based on the integration in the wavenumber space of the wind input and breaking dissipation source functions of the MASNUM wave model. The global amount of wind energy input, averaged in 2005, is about 57 TW, and the wave-breaking dissipation summed in deep-water is about 33 TW, over a half of the wind energy input. The residual may be dissipated by beach processes. Global distributions of the energy input and breaking dissipation concentrate in the westerlies of the Southern Hemisphere. | TENG Yong YANG Yongzeng QIAO Fangli LU Jing YIN Xunqiang | 2009 | Acta Oceanologica Sinica2009，28，3： | 6 |
| 9 | Analysis of a FBG sensing system with transverse uniform press by using genetic algorithm显示文摘An analytical method in a quasi-static fiber grating sensing system under transverse uniform press is proposed based on genetic algorithm The effect of population size, generations, crossover ratio and mutation ratio to genetic algorithm, and the optimization parameters of genetic algorithm were given. The relevant experimental system is constructed. The simulation and experiments show that the analytical method proposed can be applied to analyze the reflective spectra of the quasi-static FBG sensing system at transverse uniform press, the strain measurement with high-precision of 0.91% can be | TENG Feng-cheng YIN Wen-wen WU Fei LI Zhi-quang WU Ti-hua | 2008 | Optoelectronics Letters2008，4，2： | 5 |
| 10 | Numerical study on effect of tidal phase on storm surge in the South Yellow Sea显示文摘Because of the special topography and large tidal range in the South Yellow Sea,the dynamic process of tide and storm surge is very complicated.The shallow water circulation model Advanced Circulation(ADCIRC)was used to simulate the storm surge process during typhoon Winnie,Prapiroon,and Damrey,which represents three types of tracks attacking the South Yellow Sea,which are,moving northward after landing,no landing but active in offshore areas,and landing straightly to the coastline.Numerical experiments were carried out to investigate the effects of tidal phase on the tide-surge interaction as well as storm surge.The results show that the peak surge caused by Winnie and Prapiroon occurs 2-5 h before the high tide and its occurring time relative to high tide has little change with tidal phase variations.On the contrary,under the action of Damrey,the occurring time of the peak surge relative to high tide varies with tidal phase.The variation of tide-surge interaction is about 0.06-0.37 m,and the amplitude variations of interaction are smooth when tidal phase changes for Typhoon Winnie and Prapiroon.While the interaction is about 0.07-0.69 m,and great differences exists among the stations for Typhoon Damrey.It can be concluded that the tide-surge interaction of the former is dominated by the tidal phase modulation,and the time of surge peak is insensitive to the tidal phase variation.While the interaction of the latter is dominated by storm surge modulation due to the water depth varying with tide,the time of surge peak is significantly affected by tidal phase.Therefore,influence of tidal phase on storm surge is related to typhoon tracks which may provide very useful information at the design stage of coastal protection systems. | ZHANG Weisheng TENG Ling ZHANG Jinshan XIONG Mengjie YIN Chengtuan | 2019 | Journal of Oceanology and Limnology2019，37，6： | 5 |
| 11 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 12 | Principal component analysis and belief-rule-base aided health monitoring method for running gears of high-speed train显示文摘Dear editor,We propose a data-driven health monitoring method for running gears of a high-speed train.In the proposed approach,the principal component analysis(PCA)method is used to perform feature extraction while the belief-rule-base(BRB)method is used to perform health monitoring tasks.To improve the monitoring performance. | Chao CHENG Xinyu QIAO Wanxiu TENG Mingliang GAO Bangcheng ZHANG Xiaojing YIN Hao LUO | 2020 | Science China(Information Sciences)2020，63，9： | 4 |
| 13 | Facile Synthesis of Cellulose Acetate Ultrafiltration Membrane with Stimuli-Responsiveness to pH and Temperature Using the Additive of F127-b-PDMAEMA显示文摘 | Naixu Li Jun Yin LingfeiWei Quanhao Shen Wei Tian Jing Li Yong Chen Jing Jin Hongcheng Teng Jiancheng Zhou | 2017 | Chinese Journal of Chemistry2017，35，7： | 4 |
| 14 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 15 | Statistical analysis of fracture properties based on particle swarm optimization and Pearson correlation coefficient method显示文摘Prediction of reservoir fracture is the key to explore fracture-type reservoir. When a shear-wave propagates in anisotropic media containing fracture,it splits into two polarized shear waves: fast shear wave and slow shear wave. The polarization and time delay of the fast and slow shear wave can be used to predict the azimuth and density of fracture. The current identification method of fracture azimuth and fracture density is cross-correlation method. It is assumed that fast and slow shear waves were symmetrical wavelets after completely separating,and use the most similar characteristics of wavelets to identify fracture azimuth and density,but in the experiment the identification is poor in accuracy. Pearson correlation coefficient method is one of the methods for separating the fast wave and slow wave. This method is faster in calculating speed and better in noise immunity and resolution compared with the traditional cross-correlation method. Pearson correlation coefficient method is a non-linear problem,particle swarm optimization( PSO) is a good nonlinear global optimization method which converges fast and is easy to implement. In this study,PSO is combined with the Pearson correlation coefficient method to achieve identifying fracture property and improve the computational efficiency. | ZHOU Yin FENG Xuan Enhedelihai LUO Teng YANG Xueting HE Mei | 2015 | Global Geology2015，18，1： | 4 |
| 16 | Measurement-device-independent quantum key distribution for nonstandalone networks显示文摘Untrusted node networks initially implemented by measurement-device-independent quantum key distribution(MDI-QKD)protocol are a crucial step on the roadmap of the quantum Internet.Considering extensive QKD implementations of trusted node networks,a workable upgrading tactic of existing networks toward MDI networks needs to be explicit.Here,referring to the nonstandalone(NSA)network of 5G,we propose an NSA-MDI scheme as an evolutionary selection for existing phase-encoding BB84 networks.Our solution can upgrade the BB84 networks and terminals that employ various phase-encoding schemes to immediately support MDI without hardware changes.This cost-effective upgrade effectively promotes the deployment of MDI networks as a step of untrusted node networks while taking full advantage of existing networks.In addition,the diversified demands on security and bandwidth are satisfied,and network survivability is improved. | GUAN-JIE FAN-YUAN FENG-YU LU SHUANG WANG ZHEN-QIANG YIN DE-YONG HE ZHENG ZHOU JUN TENG WEI CHEN GUANG-CAN GUO ZHENG-FU HAN | 2021 | Photonics Research2021，9，10： | 3 |
| 17 | Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats显示文摘The α5 subunit-containing gamma-amino butyric acid type A receptors(α5 GABAARs) are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in hippocampal neurons. These tonic currents can be enhanced by low-dose isoflurane, which is associated with learning and memory impairment. Inverse agonists of α5 GABAARs, such as L-655,708, are able to reverse the short-term memory deficit caused by low-dose isoflurane in young animals. However, whether these negative allosteric modulators have the same effects on aged rats remains unclear. In the present study, we mainly investigated the effects of L-655,708 on low-dose(1.3%) isoflurane-induced learning and memory impairment in elderly rats. Young(3-month-old) and aged(24-month-old) Wistar rats were randomly assigned to receive L-655,708 0.5 hour before or 23.5 hours after 1.3% isoflurane anesthesia.The Morris Water Maze tests demonstrated that L-655,708 injected before or after anesthesia could reverse the memory deficit in young rats. But in aged rats, application of L-655,708 only before anesthesia showed similar effects. Reverse transcription-polymerase chain reaction showed that low-dose isoflurane decreased the mRNA expression of α5 GABAARs in aging hippocampal neurons but increased that in young animals. These findings indicate that L-655,708 prevented but could not reverse 1.3% isoflurane-induced spatial learning and memory impairment in aged Wistar rats. All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Academy of Military Medical Science of China(approval No. NBCDSER-IACUC-2015128) in December 2015. | Zi-Fang Zhao Lei Du Teng Gao Lin Bao Yuan Luo Yi-Qing Yin Yong-An Wang | 2019 | Neural Regeneration Research2019，14，6： | 3 |
| 18 | Identification, expression, and characterization of the highly conserved D-xylose isomerase in animals显示文摘d 木糖是为动物的必要的糖。从一个软体动物的 xylanase, Ampullaria crossean,被我们的实验室以前报导。这 xylanase 能降级木聚糖进 d 木糖。但是仍然在我们它的新陈代谢的小径上的知识有差距。问题是木糖怎么进入戊糖小径吗?在 genomic 数据库和生物信息的工具的帮助下,我们发现一些动物例如细菌,有高度保存的 d 木糖 isomerase (EC 5.3.1.5 ) 。从海喷射的木糖 isomerase, Ciona intestinalis,不同类地在 Escherichia coli 被表示并且净化了证实它的功能。recombinant 酶面对 Mg2+ 有好热稳定性。在最佳温度和最佳 pH 环境,它 d 木糖上的特定的活动是 0.331 mol/mg/min。这酶在许多广泛地存在动物,而是它消失在像两栖纲的 Xenopus laevis 的染色体。它的顺序高度被保存。从动物的木糖 isomerases 是为进化的学习的很有趣的蛋白质。 | Ming Ding Yigang Teng Qiuyu Yin Wei Chen Fukun Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，2： | 3 |
| 19 | Purification and characterization of a novel endo-β-1,4-glucanase, AfEG22, from the giant snail, Achatina fulica frussac显示文摘在这研究,我们证实了那至少三 endo -- 1,4-glucanases 在巨大的蜗牛的消化果汁存在, Achatina fulica ferussac,由刚果红染色试金。这些酶之一,新奇 endo -- 1,4-glucanase (AfEG22 ) ,是由胶化过滤,阴离子交换,和恐水病的相互作用层析的净化的 29.5 褶层。净化的酶的 carboxymethyl 纤维素(CMC ) hydrolytic 活动是 12.3 U/mg 蛋白质。AfEG22 的分子的团是 MALDI-TOF 决定的 22081 Da。N 终端氨基酸定序揭示了 EQRCTNQGGILKYYNT 的一个序列,它没在强风数据库与任何蛋白质有重要相同。为向 CMC 的 hydrolytic 活动的最佳的 pH 和温度是 pH 4.0 和 | Yigang Teng Qiuyu Yin Ming ding Fukun Zhao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 3 |
| 20 | Surface treatment of 3D printed porous Ti6Al4V implants by ultraviolet photofunctionalization for improved osseointegration显示文摘Three-dimensional(3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects.However,its osseointegration capacity needs to be further improved,and related methods are inadequate,especially lacking customized surface treatment technology.Consequently,we aimed to design an omnidirectional radiator based on ultraviolet(UV)photofunctionalization for the surface treatment of 3D-printed porous Ti6Al4V implants,and studied its osseointegration promotion effects in vitro and in vivo,while elucidating related mechanisms.Following UV treatment,the porous Ti6Al4V scaffolds exhibited significantly improved hydrophilicity,cytocompatibility,and alkaline phosphatase activity,while preserving their original mechanical properties.The increased osteointegration strength was further proven using a rabbit condyle defect model in vivo,in which UV treatment exhibited a high efficiency in the osteointegration enhancement of porous Ti6Al4V scaffolds by increasing bone ingrowth(BI),the bone-implant contact ratio(BICR),and the mineralized/osteoid bone ratio.The advantages of UV treatment for 3D-printed porous Ti6Al4V implants using the omnidirectional radiator in the study were as follows:1)it can significantly improve the osseointegration capacity of porous titanium implants despite the blocking out of UV rays by the porous structure;2)it can evenly treat the surface of porous implants while preserving their original topography or other morphological features;and 3)it is an easy-to-operate low-cost process,making it worthy of wide clinical application. | Chuan Yin Teng Zhang Qingguang Wei Hong Cai Yan Cheng Yun Tian Huijie Leng Caimei Wang Shiqing Feng Zhongjun Liu | 2022 | Bioactive Materials2022，7，1： | 2 |
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