|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure显示文摘Dear Editor,Acute liver failure(ALF)is a complicated disorder showing a nearly 80%mortality rate,and there is currently no effective medical solutions for ALF except liver transplantation.1 Bio-artificial liver(BAL)system is a device that consists of a bioreactor filled with hepatocytes,which could potentially rescue ALF patients by providing partial liver function until a suitable donor liver can be found or the native liver has self-regenerated. | Sitong Chen Jinglin Wang Haozhen Ren Yinan Liu Chengang Xiang Cheng Li Shichun Lu Yan Shi Hongkui Deng Xiaolei Shi | 2020 | Cell Research2020，30，1： | 9 |
| 2 | Review of micromachined optical accelerometers:from mg to sub-μg显示文摘Micro-Opto-Electro-Mechanical Systems(MOEMS)accelerometer is a new type of accelerometer which combines the merits of optical measurement and Micro-Electro-Mechanical Systems(MEMS)to enable high precision,small volume and anti-electromagnetic disturbance measurement of acceleration.In recent years,with the in-depth research and development of MOEMS accelerometers,the community is flourishing with the possible applications in seismic monitoring,inertial navigation,aerospace and other industrial and military fields.There have been a variety of schemes of MOEMS accelerometers,whereas the performances differ greatly due to different measurement principles and corresponding application requirements.This paper aims to address the pressing issue of the current lack of systematic review of MOEMS accelerometers.According to the optical measurement principle,we divide the MOEMS accelerometers into three categories:the geometric optics based,the wave optics based,and the new optomechanical accelerometers.Regarding the most widely studied category,the wave optics based accelerometers are further divided into four sub-categories,which is based on grating interferometric cavity,Fiber Bragg Grating(FBG),Fabry-Perot cavity,and photonic crystal,respectively.Following a brief introduction to the measurement principles,the typical performances,advantages and disadvantages as well as the potential application scenarios of all kinds of MOEMS accelerometers are discussed on the basis of typical demonstrations.This paper also presents the status and development tendency of MOEMS accelerometers to meet the ever-increasing demand for high-precision acceleration measurement. | Qianbo Lu Yinan Wang Xiaoxu Wang Yuan Yao Xuewen Wang Wei Huang | 2021 | Opto-Electronic Advances2021，4，3： | 8 |
| 3 | Atmospheric Profiling Synthetic Observation System in Tibet显示文摘1.Introduction The Atmosphere Profiling Synthetic Observation System(APSOS)is the first ground-based facility for profiling atmospheric variables and multiple constituents in the whole(neutral)atmosphere from the surface up to the lower thermosphere.It enables simultaneous observations and extensive studies of the atmospheric vertical structure and | Daren LU Weilin PAN Yinan WANG | 2018 | Advances in Atmospheric Sciences2018，35，3： | 8 |
| 4 | The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity显示文摘A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes,opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation,C1q also regulates cell differentiation,adhesion,migration,activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article,we discuss the basic properties of C1q,its expression,and classical and regulatory functions. | Jinhua Lu Boon King Teh Linda Wang Yinan Wang Yen Seah Tan Min Chern Lai Kenneth B. M. Reid | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 5 | Risks Associated with Misuse of Ketamine as a Rapid-Acting Antidepressant显示文摘Major depression is a serious psychiatric disorder and remains a leading cause of disability worldwide.Conventional antidepressants take at least several weeks to achieve a therapeutic response and this lag period has hindered their ability to attain beneficial effects in depressed individuals at high risk of suicide.The non-competitive Nmethyl-D-aspartate glutamate receptor antagonist ketamine has been shown to have rapid antidepressant effects in both rodents and humans.The emergence of ketamine as a fastacting antidepressant provides promising new insights into the development of a rapid treatment response in patients with clinical depression.However,its safety and toxicity remain a concern.In this review,we focus on the limitations of ketamine,including neurotoxicity,cognitive dysfunction,adverse events associated with mental status,psychotomimetic effects,cardiovascular events,and uropathic effects.Studies have shown that its safety and tolerability profiles are generally good at low doses and with short-term treatment in depressed patients.The adverse events associated with ketamine usually occur with very high doses that are administered for prolonged periods of time and can be relieved by cessation.The antidepressant actions of its two enantiomers,S-ketamine(esketamine) and R-ketamine,are also discussed.R-ketamine has greater antidepressant actions than S-ketamine,without ketamine-related sideeffects.Future treatment strategies should consider using Rketamine for the treatment of depressed patients to decrease the risk of adverse events associated with long-term ketamine use. | Weili Zhu Zengbo Ding Yinan Zhang Jie Shi Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 6 | Magnetic plasmon resonances in nanostructured topological insulators for strongly enhanced light-MoS_(2) interactions显示文摘Magnetic resonances not only play crucial roles in artificial magnetic materials but also offer a promising way for light control and interaction with matter.Recently,magnetic resonance effects have attracted special attention in plasmonic systems for overcoming magnetic response saturation at high frequencies and realizing high-performance optical functionalities.As novel states of matter,topological insulators(TIs)present topologically protected conducting surfaces and insulating bulks in a broad optical range,providing new building blocks for plasmonics.However,until now,high-frequency(e.g.visible range)magnetic resonances and related applications have not been demonstrated in TI systems.Herein,we report for the first time,to our knowledge,a kind of visible range magnetic plasmon resonances(MPRs)in TI structures composed of nanofabricated Sb_(2)Te_(3) nanogrooves.The experimental results show that the MPR response can be tailored by adjusting the nanogroove height,width,and pitch,which agrees well with the simulations and theoretical calculations.Moreover,we innovatively integrated monolayer MoS_(2) onto a TI nanostructure and observed strongly reinforced light-MoS_(2) interactions induced by a significant MPR-induced electric field enhancement,remarkable compared with TI-based electric plasmon resonances(EPRs).The MoS_(2) photoluminescence can be flexibly tuned by controlling the incident light polarization.These results enrich TI optical physics and applications in highly efficient optical functionalities as well as artificial magnetic materials at high frequencies. | Hua Lu Zengji Yue Yangwu Li Yinan Zhang Mingwen Zhang Wei Zeng Xuetao Gan Dong Mao Fajun Xiao Ting Mei Weiyao Zhao Xiaolin Wang Min Gu Jianlin Zhao | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 7 | Solubility determination and thermodynamic modeling of bis-2-hydroxyethyl terephthalate(BHET)in different solvents显示文摘Studies on the degradation process of waste polyethylene terephthalate(PET)have become increasingly mature,but there are relatively few studies on the separation of degradation products.The products contain many components and the separation of which is difficult.Therefore,the study on phase equilibrium thermodynamics of bis-2-hydroxyethyl terephthalate(BHET)is of great theoretical significance and practical value to provide basic data for the BHET crystallization separation.In this work,the degraded products were purified and characterized.The solubility of BHET in methanol,ethanol,ethylene glycol,water and the mixture of ethylene glycol+water were determined by static method.The experimental results were correlated with different models,such as ideal solution(IS)model,λh equation,Apelblat equation and NRTL model.Based on the van’t Hoff equation,the mixing Gibbs energy,enthalpy and entropy were calculated.From this work,the basic data which can be used to guide the crystallization process of BHET were obtained,including solubility data,correlation model and thermodynamic properties. | Haoyu Yao Dongxia Yan Xingmei Lu Qing Zhou Yinan Bao Junli Xu | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 1 |
| 8 | A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering显示文摘Rheumatoid arthritis(RA)is exacerbated by TNF-alpha signaling.However,it remains unclear whether TNF-α-activated TNFR1 and TNFR2 are regulated by extracellular factors.Here,we showed that soluble glycosylated interleukin-17 receptor D(sIL-17RD),which was produced by proteolytic cleavage,enhanced TNF-α-induced RA.We revealed that IL-17RD shedding was induced by the proteolytic enzyme TACE and enhanced by TNF-αexpression in macrophages.Intriguingly,sIL-17RD was elevated in the sera of arthritic mice and rats.Recombinant sIL-17RD significantly enhanced the TNF-α-induced proinflammatory response by promoting TNF-α-TNFR-sIL-17RD complex formation and receptor clustering,leading to the accelerated development of collagen-induced arthritis.Our observations revealed that ectodomain shedding of IL-17RD occurred in RA to boost the TNF-α-induced inflammatory response.Targeting sIL-17RD may provide a new strategy for the therapy of RA. | Sihan Liu Yanxia Fu Kunrong Mei Yinan Jiang Xiaojun Sun Yinyin Wang Fangli Ren Congshan Jiang Liesu Meng Shemin Lu Zhihai Qin Chen Dong Xinquan Wang Zhijie Chang Shigao Yang | 2021 | Cellular & Molecular Immunology2021，18，8： | 1 |
| 9 | A multi-location joint field observation of the stratosphere and troposphere over the Tibetan Plateau显示文摘The unique geographical location and high altitude of the Tibetan Plateau can greatly influence regional weather and climate.In particular, the Asian summer monsoon(ASM) anticyclone circulation system over the Tibetan Plateau is recognized to be a significant transport pathway for water vapor and pollutants to enter the stratosphere. To improve understanding of these physical processes, a multi-location joint atmospheric experiment was performed over the Tibetan Plateau from late July to August in 2018, funded by the fiveyear(2018–2022) STEAM(stratosphere and troposphere exchange experiment during ASM) project, during which multiple platforms/instruments—including long-duration stratospheric balloons, dropsondes, unmanned aerial vehicles, special sounding systems, and ground-based and satellite-borne instruments—will be deployed. These complementary methods of data acquisition are expected to provide comprehensive atmospheric parameters(aerosol, ozone, water vapor, CO_2, CH_4, CO, temperature, pressure,turbulence, radiation, lightning and wind); the richness of this approach is expected to advance our comprehension of key mechanisms associated with thermal, dynamical, radiative, and chemical transports over the Tibetan Plateau during ASM activity. | JinQiang Zhang Yi Liu HongBin Chen ZhaoNan Cai ZhiXuan Bai LingKun Ran Tao Luo Jing Yang YiNan Wang YueJian Xuan YinBo Huang XiaoQing Wu JianChun Bian DaRen Lu | 2019 | Earth and Planetary Physics2019，3，2： | 1 |
| 10 | A study of the chemical composition and transport of marine aerosols over the ocean near China显示文摘In this paper the authors cite the aerosol samples collected with a KA-200 Anderson cascade Impactor and a KB-120 sampler during the first cruise of the Kuroshio investigation operated by the People’s Republic of China and Japan cooperative program, from July 23 to August 21, 1987. The concentration size distributions and composition of marine aerosols over the Kuroshio area are analyzed. Neutron activation analysis is used to determine the elemental composition of the aerosols. The authors also discuss some characteristics of marine aerosols relating to long-range transport of crustal and anthropogenic elements from the continent to the remote ocean. Analytical results indicate that elements Al, Fe, Sc and Sb over this area are obviously influenced by the continent of Asia, and the size distributions are changed after long-range transport. The concentration of large particles increase. The concentrations of the elements C1 and Na are closely related to ocean conditions; the source of the elements Cl | Zhang Ni, Zhou Mingyu, Lu Naiping, F. P. Parungo, Wen Yupu, Yang Shaojing, Yang Yinan and Chen Binru National Research Center for Marine Environmental Forecasts, State Oceanic Administration, Beijing, ChinaNational Oceanic and Atmospheric Administration, Environmental Research Laboratories, Air Resources Laboratory, Boulder,CO, U.S. A.Academy of Meteorological Sciences, State Meteorological Administration, Beijing, ChinaInstitute of High Energy Physics, Academia Sinica, Beijing, China | 1991 | Acta Oceanologica Sinica1991，10，3： | 1 |
| 11 | Duplex micro RNAs assay based on target-triggered universal reporter hybridization显示文摘In this paper, we designed and evaluated a duplex detection strategy for micro RNAs(mi RNAs) using universal probe-based target-triggered double hybridization and fluorescent microsphere-based assay system(x MAP array). In the absence of target mi RNA, reporter DNA cannot hybridize stably with the immobilized capture DNA due to its low melting temperature. Only after adding target mi RNA, can reporter probe hybridize with capture probe to form a stable three-component complex. This targettriggered stable hybridization makes this method possible for highly selective and sensitive detection of multiple mi RNAs. We exemplified a quantitative detection of duplex mi RNAs with a limit of detection of40 p M. The x MAP array platform holds the potential of extending this approach to simultaneous detection of up to 100 mi RNA targets. Considering the simplicity, rapidity and multiplexing, this work promised a potential detection of multiple mi RNA biomarkers for early disease diagnosis and prognosis. | Yinan Wang Yue Sun Choiwan Lau Jianzhong Lu | 2018 | Journal of Pharmaceutical Analysis2018，8，4： | 1 |
| 12 | Effect of hydrogen on grain boundary migration in tungsten显示文摘Motivated by a grain boundary(GB) healing mechanism that GB turns into a mobile sink through migration to eliminate the vacancies in a bulk, we have further investigated the influence of the retained hydrogen(H) on the GB migration in tungsten using a molecular dynamics simulation. We show that H hinders the GB migration at different H concentrations and temperatures, and such friction of GB migration due to the presence of H increases with the H concentration and decreases with temperature. We demonstrate that H follows the GB-migration as the temperature is higher than 300 K. Most importantly, the presence of H induces a disordering of GB, which affects the GB migration significantly. | YU Yi SHU XiaoLin LIU YiNan NIU LiangLiang JIN Shuo GAO Fei LU GuangHong | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，7： | 1 |
| 13 | Optimal active-disturbance-rejection control for propulsion of anchor-hole drillers显示文摘Dear editor,The propulsion module of an anchor-hole driller controls the drilling speed with a hydraulic cylinder that provides the axial force when driving a drilling rig to break the surrounding rocks.This drilling process is traditionally controlled manually by operators that tend to set the machine at the maximum drilling speed. | Yinan GUO Zhen ZHANG Dunwei GONG Xiwang LU Yang ZHANG Wei CHENG | 2021 | Science China(Information Sciences)2021，64，5： | 1 |
| 14 | Pb nanoparticle tipped ZnO nanowires heterostructures by long-pulse-width laser ablation of binary metal target in diluted gas显示文摘 | Fei Tian Yongguang Zhao Yinan Liu Hongmei Cao Jing Zhao Xiaozuo Lu | 2013 | Materials Letters2013，，： | 1 |
| 15 | Biomedical Event Extraction Using a New Error Detection Learning Approach Based on Neural Network显示文摘Supervised machine learning approaches are effective in text mining,but their success relies heavily on manually annotated corpora.However,there are limited numbers of annotated biomedical event corpora,and the available datasets contain insufficient examples for training classifiers;the common cure is to seek large amounts of training samples from unlabeled data,but such data sets often contain many mislabeled samples,which will degrade the performance of classifiers.Therefore,this study proposes a novel error data detection approach suitable for reducing noise in unlabeled biomedical event data.First,we construct the mislabeled dataset through error data analysis with the development dataset.The sample pairs’vector representations are then obtained by the means of sequence patterns and the joint model of convolutional neural network and long short-term memory recurrent neural network.Following this,the sample identification strategy is proposed,using error detection based on pair representation for unlabeled data.With the latter,the selected samples are added to enrich the training dataset and improve the classification performance.In the BioNLP Shared Task GENIA,the experiments results indicate that the proposed approach is competent in extract the biomedical event from biomedical literature.Our approach can effectively filter some noisy examples and build a satisfactory prediction model. | Xiaolei Ma Yang Lu Yinan Lu Zhili Pei Jichao Liu | 2020 | Computers, Materials & Continua2020，，5： | 1 |
| 16 | Inverse design and realization of an optical cavity-based displacement transducer with arbitrary responses显示文摘Optical cavity has long been critical for a variety of applications ranging from precise measurement to spectral analysis.A number of theories and methods have been successful in describing the optical response of a stratified optical cavity,while the inverse problem,especially the inverse design of a displacement sensitive cavity,remains a significant challenge due to the cost of computation and comprehensive performance requirements.This paper reports a novel inverse design methodology combining the characteristic matrix method,mixed-discrete variables optimization algorithm,and Monte Carlo method-based tolerance analysis.The material characteristics are indexed to enable the mixed-discrete variables optimization,which yields considerable speed and efficiency improvements.This method allows arbitrary response adjustment with technical feasibility and gives a glimpse into the analytical characterization of the optical response.Two entirely different light-displacement responses,including an asymmetric sawtooth-like response and a highly symmetric response,are dug out and experimentally achieved,which fully confirms the validity of the method.The compact Fabry-Perot cavities have a good balance between performance and feasibility,making them promising candidates for displacement transducers.More importantly,the proposed inverse design paves the way for a universal design of optical cavities,or even nanophotonic devices. | Qianbo Lu Qingxiong Xiao Chengxiu Liu Yinan Wang Qixuan Zhu Manzhang Xu Xuewen Wang Xiaoxu Wang Wei Huang | 2023 | Opto-Electronic Advances2023，6，3： | 0 |
| 17 | The Novel Instance Segmentation Method Based on Multi-Level Features and Joint Attention显示文摘Instance segmentation is an important task in computer vision.In order to enhance the multi-level features expression ability of the segmentation networks,a novel module is proposed in this paper.Firstly,we design a weighted bi-directional feature fusion way by computing the weight distribution function of bi-directional feature pyramid network.Secondly,we propose a joint attention mechanism to effectively filter different levels of feature information by adopting serial and parallel ways to combine the channel attention and spatial attention modules.At the same time,the module uses dynamic convolution to stabilize the calculation speed while improve the 6.7%mean average precision of segmentation.The experiments on the COCO dataset demonstrate that the module can effectively improve the performance of the existing instance segmentation networks. | XU Bowen LU Yinan WU Tieru GUO Xiaoxin | 2023 | Chinese Journal of Electronics2023，32，5： | 0 |
| 18 | Comparative and population genomics of buckwheat species reveal key determinants of flavor and fertility显示文摘Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide distribution.Due to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly important throughout the world.The availability of a high-quality reference genome sequence and population genomic data will accelerate the breeding of common buckwheat,but the high heterozygosity due to the outcrossing nature has greatly hindered the genome assembly.Here we report the assembly of a chromosome-scale high-quality reference genome of F.esculentum var.homotropicum,a homozygous self-pollinating variant of common buckwheat.Comparative genomics revealed that two cultivated buckwheat species,common buckwheat(F.esculentum)and Tartary buckwheat(F.tataricum),underwent metabolomic divergence and ecotype differentiation.The expansion of several gene families in common buckwheat,including FhFAR genes,is associated with its wider distribution than Tartary buckwheat.Copy number variation of genes involved in the metabolism of flavonoids is associated with the difference of rutin content between common and Tartary buckwheat.Furthermore,we present a comprehensive atlas of genomic variation based on whole-genome resequencing of 572 accessions of common buckwheat.Population and evolutionary genomics reveal genetic variation associated with environmental adaptability and floral development between Chinese and non-Chinese cultivated groups.Genome-wide association analyses of multi-year agronomic traits with the content of flavonoids revealed that Fh05G014970 is a potential major regulator of flowering period,a key agronomic trait controlling the yield of outcrossing crops,and that Fh06G015130 is a crucial gene underlying flavor-associated flavonoids.Intriguingly,we found that the gene translocation and sequence variation of FhS-ELF3 contribute to the homomorphic self-compatibility of common buckwheat.Collectively,our results elucidate the genetic basis of speciation,ecological adaptation,fertility,and unique flavor of common buckwheat,and provide new resources for future genomics-assisted breeding of this economically important crop. | Kaixuan Zhang Yuqi He Xiang Lu Yaliang Shi Hui Zhao Xiaobo Li Jinlong Li Yang Liu Yinan Ouyang Yu Tang Xue Ren Xuemei Zhang Weifei Yang Zhaoxia Sun Chunhua Zhang Muriel Quinet Zlata Luthar Mateja Germ Ivan Kreft Dagmar Janovska Vladimir Meglic Barbara Pipan Milen I.Georgiev Bruno Studer Mark A.Chapman Meiliang Zhou | 2023 | Molecular Plant2023，16，9： | 0 |
| 19 | Polystyrene Microspheres Coupled with Hybridization Chain Reaction for Dual‑Amplified Chemiluminescence Detection of Specific DNA Sequences显示文摘We report on a highly sensitive chemiluminescence(CL)assay for the detection of specific DNA sequence,where streptavidin-modified polystyrene microspheres(PS–SA)coupled with hybridization chain reaction(HCR)were employed as dual amplification platform.Briefly,a“sandwich-type”detection strategy was proposed in our design,which involved capture probe DNA immobilized on the surface of carboxyl-terminated magnetic beads(MB)and the reporter DNA combined with the HCR trigger immobilized on the surface of PS–SA.After that,two hairpin-type monomers were added to initiate the HCR.In the detection system,CL signal was obtained via the instantaneous derivatization reaction between 3,4,5-trimethoxylphenylglyoxal(TMPG)and guanine bases in the target and the HCR complex binding on the magnetic beads.As compared to traditional sandwich type(capture/target/reporter)assays,this dual-amplified strategy for sequence-specific DNA detection showed better specificity,lower detection limit and wider linear response range(linear range of 0.01 fmol–10 pmol and a low detection limit of 5 amol).Moreover,this approach could be easily extended to detect a wide range of specific DNA sequences by modification of the hybridization region.We believe this simple technique will present a significant step towards early diagnoses of diseases. | Ying Zhou Yinan Wang Xin Wang Jianzhong Lu | 2017 | Journal of Analysis and Testing2017，1，4： | 0 |
| 20 | Image Motion Compensation of Off-Axis TMA Three-Line ArrayAerospace Mapping Cameras显示文摘To enhance the image motion compensation accuracy of off-axis three-mirror anastigmatic( TMA)three-line array aerospace mapping cameras,a new method of image motion velocity field modeling is proposed in this paper. Firstly,based on the imaging principle of mapping cameras,an analytical expression of image motion velocity of off-axis TMA three-line array aerospace mapping cameras is deduced from different coordinate systems we established and the attitude dynamics principle. Then,the case of a three-line array mapping camera is studied,in which the simulation of the focal plane image motion velocity fields of the forward-view camera,the nadir-view camera and the backward-view camera are carried out,and the optimization schemes for image motion velocity matching and drift angle matching are formulated according the simulation results. Finally,this method is verified with a dynamic imaging experimental system. The results are indicative of that when image motion compensation for nadir-view camera is conducted using the proposed image motion velocity field model,the line pair of target images at Nyquist frequency is clear and distinguishable. Under the constraint that modulation transfer function( MTF) reduces by 5%,when the horizontal frequencies of the forward-view camera and the backward-view camera are adjusted uniformly according to the proposed image motion velocity matching scheme,the time delay integration( TDI) stages reach 6 at most. When the TDI stages are more than 6,the three groups of camera will independently undergo horizontal frequency adjustment. However, when the proposed drift angle matching scheme is adopted for uniform drift angle adjustment,the number of TDI stages will not exceed 81. The experimental results have demonstrated the validity and accuracy of the proposed image motion velocity field model and matching optimization scheme,providing reliable basis for on-orbit image motion compensation of aerospace mapping cameras. | Yongchang Li Pengluo Lu Longxu Jin Guoning Li Yinan Wu | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员