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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Epidemic Update and Risk Assessment of 2019 Novel Coronavirus--China, January 28, 2020显示文摘On December 29,2019,the health authorities in Hubei Province and Wuhan City received a report of a cluster of pneumonia cases of unknown etiology from a local hospital,and all four patients were employees of the Wuhan Huanan Seafood Wholesale Market(HN market for short)(1).By January 8,2020,Chinese authorities had identified a new virus 2019 novel coronavirus(2019-nCoV)linked with the outbreak of disease,which has been named novel coronavirusinfected pneumonia(NCIP)(2).On 15 January,the National Health Commission(NHC)issued guidelines for the diagnosis,treatment,prevention,and control of NCIP.These guidelines directed case monitoring,reporting,diagnosis,treatment,management,close contact management,and laboratory testing. | Wenxiao Tu Houlin Tang Fangfang Chen Yinong Wei Tingling Xu Kaiju Liao Nijian Xiang Guoqing Shi Qun Li Zijian Feng | 2020 | China CDC weekly2020，2，6： | 15 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | RNA Interference-based Suppression of Phosphoenolpyruvate Carboxylase Results in Susceptibility of Rapeseed to Osmotic Stress显示文摘The diverse functions of phosphoenolpyruvate carboxylase(PEPCase;EC 4.1.1.31) in C3 plants are not as well understood as in C4 plants.To investigate the functions of PEPCase in C3 plants,rapeseed(Brassica napus L.) PEPCase gene(referred to as BNPE15) was silenced by the RNA interference(RNAi) technique.Under normal growth conditions,no significant difference in lipid content and fatty acid composition were found between wild-type(WT) and transgenic rapeseed plants.However,when these plants were subjected to osmotic stress induced by osmoticum polyethylene glycol(PEG-6000),membrane permeability and membrane lipid peroxidization in roots and leaves of transgenic plants were higher than those of WT plants.It suggested that transgenic plants are more susceptible to osmotic stress than WT plants.Taken together,the results showed that the suppression of PEPCase by RNAi leads to susceptibility to osmotic stress in rapeseed,and PEPCase is involved in the response of C3 plants to environmental stress. | Mei Chen Yunlai Tang Jingmei Zhang Mingfeng Yang Yinong Xu | 2010 | Journal of Integrative Plant Biology2010，52，6： | 4 |
| 5 | Significance of neuroglobin in serum of acute atherosclerotic cerebral infarction patients显示文摘This study sought to examine neuroglobin (NGB) in the serum of acute cerebral infarction patients with double-antibody sandwich enzyme-linked immunosorbent assay to identify all risk factors, calculate infarct size, assess neurological impairment, and analyze the relation between NGB and each of these factors. The double-antibody sandwich assay indicated that levels of NGB in serum were unaltered within 6 hours following acute cerebral infarction compared with normal levels. NGB levels then underwent a distinct change, peaking at 24 hours then returning to normal levels in 72 hours. The results suggest that the level of NGB might be related to infarct size and low-density lipoprotein at 24 hours after acute cerebral infarction. There were no significant differences in neurological impairment scores and infarct size at different periods following infarction. The findings indicated that the level of NGB in serum of acute cerebral infarction patients was correlated with infarct time. | Shoucai Zhao Zhaohu Chu Lingsong Ma Yinong Chen Lei Wang Benxiao Wang Zili Huang Jun Zhang | 2011 | Neural Regeneration Research2011，6，27： | 4 |
| 6 | Repulsive firefly algorithm-based optimal switching device placement in power distribution systems显示文摘To achieve optimal configuration of switching devices in a power distribution system,this paper proposes a repulsive firefly algorithm-based optimal switching device placement method.In this method,the influence of territorial repulsion during firefly courtship is considered.The algorithm is practically applied to optimize the position and quantity of switching devices,while avoiding its convergence to the local optimal solution.The experimental simulation results have showed that the proposed repulsive firefly algorithm is feasible and effective,with satisfying global search capability and convergence speed,holding potential applications in setting value calculation of relay protection and distribution network automation control. | Yuanpeng Tan Hai Chen Wei Liu Mingze Zhang Yinong Li Xincong Li Hanyang Lin | 2019 | Global Energy Interconnection2019，2，6： | 3 |
| 7 | Bioinformatics analysis on ORFl protein of Torque teno virus(SANBAN isolate)显示文摘Objective:To analyze the sequence of ORFl protein of Torque teno virus to prepare for the future hyhrid experiments.Methods:The sequence of ORFl protein of Torque teno vims was analyzed by bioinformalics using some web lools.Results:The most likely cleavage site was between position 14aa and 15aa and signal peptide may be position laa-14aa.Two possible transmembrane helices from inside to outside and three possible transmembrane helices from outside to inside were found.The position 509(NKTN) was the potential:V-glyeosylation site. The speculative molecular weight of TTV ORF1 protein,which may be a kind of unstable protein was 88 705.7 Da.laa-91aa and 278aa-361aa were localized in non-regular secondary structure region.Conclusions:TTV ORF1 protein may be a nuclear protein which contains two nonregular secondary structure region.265aa to 486aa and 510aa to 679aa may be the two approciale fragments to construct the plasmids,which would be prepared for the future hybrid experiments to study the functional positions of the protein and the interactions between TTV and its hosts. Bioinformatics analysis would possibly make it easier to study the protein’s function. | Chen Jinling Zhu Dandan Shen Pei Sun Wei Xiao Gengfu Duan Yinong Zhu Ying | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 3 |
| 8 | Technologies Supporting Artificial Intelligence and Robotics Application Development显示文摘Artificial intelligence(AI)and robotics have gone through three generations of development,from Turing test,logic theory machine,to expert system and self-driving car.In the third-generation today,AI and robotics have collaboratively been used in many areas in our society,including industry,business,manufacture,research,and education.There are many challenging problems in developing AI and robotics applications.We launch this new Journal of Artificial Intelligence and Technology to facilitate the exchange of the latest research and practice in AI and technologies.In this inaugural issue,we first introduce a few key technologies and platforms supporting the third-generation AI and robotics application development based on stacks of technologies and platforms.We present examples of such development environments created by both industry and academia.We also selected eight papers in the related areas to celebrate the foundation of this journal. | Yinong Chen Gennaro De Luca | 2021 | Journal of Artificial Intelligence and Technology2021，1，1： | 2 |
| 9 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 10 | EXPERIMENTAL RESEARCH ON EVALUATING STRUCTURE DAMAGE WITH PIEZOELECTRIC DYNAMIC IMPEDANCE显示文摘A dynamic impedance-based structural health monitoring technique is introduced. According to the direct and the converse piezoelectric property of piezoelectric materials, the piezoceramic ( PZT ) can be used as an actuator and a sensor synchronously. If damages like cracks, holes, debonding or loose connections are presented in the structure, the physical variations of the structure will cause the mechanical impedance modified. On the basis of introducing the principle and the theory, the experiment and the analysis on some damages of the structure are studied by means of the dynamic impedance technique. On the view of experiment, kinds of structural damages are evaluated by the information of dynamic impedance in order to validate the feasibility of the method. | Li Yinong Zheng Ling Chen BingkuiState Key Laboratory of Mechanical Transmission, Chongqing University, Chongqing 400044, ChinaWen BangchunNortheastern University | 2002 | Chinese Journal of Mechanical Engineering2002，15，3： | 2 |
| 11 | Changes in Thermostability of Photosystem Ⅱ and Leaf Lipid Composition of Rice Mutant with Deficiency of Light-harvesting Chlorophyll a/b Protein Complexes显示文摘 | Yunlai Tang Mei Chen Yinong Xu Tingyun Kuang | 2007 | Journal of Integrative Plant Biology2007，49，4： | 2 |
| 12 | Degradation of a COTS linear CCD induced by proton irradiation显示文摘 | WANG Zujun LIU Yinong CHEN Wei | 2010 | Nuclear instruments and methods in physics research B2010，268，6： | 1 |
| 13 | Degradation of a COTS linear CCD induced by proton irradiation显示文摘 | Wang Zujun Liu Yinong Chen Wei | | 0，，17： | 1 |
| 14 | Visual programming language environment for different IoT and robotics platforms in computer science education显示文摘 | Gennaro De Luca Zhongtao Li Sami Mian Yinong Chen | 2018 | CAAI Transactions on Intelligence Technology2018，3，2： | 1 |
| 15 | Robust perfluorinated porous organic networks: Succinct synthetic strategy and application in chlorofluorocarbons adsorption显示文摘Fluorinated porous organic networks(F-PONs)have demonstrated unique properties and applications,but approaches capable of affording F-PONs with high fluorine content and robust nanoporous architecture under metal-free and easy handling conditions are still rarely reported.Herein,using polydivinylbenzene(PDVB)as an easily available precursor,a novel and straightforward approach was developed to afford F-PONs via a dehydrative Friedel-Crafts reaction using perfluorinated benzylic alcohols as the cross-linking agent promoted by Bronsted acid(trifluoromethanesulfonic acid).The afforded material(F-PDVB)featured high fluorine content(22 at.%),large surface area(771 m^(2)·g^(-1)),and good chemical/thermal stability,rendering them as promising candidates for the adsorption of CO_(2),hydrocarbons,fluorocarbons,and chlorofluorocarbons,with weight capacities up to 520 wt.%being achieved.This simple methodology can be extended to fabricate fluorinated hyper-crosslinked polymers(F-HCPs)from rigid aromatic monomers.The progress made in this work will open new opportunities to further expand the involvement of fluorinated materials in large scale applications. | Yali Luo Zhenzhen Yang Xian Suo Hao Chen Tao Wang Ziqian Wang Yunfei Liu Yinong Lyu llja Popovs Sheng Dai | 2021 | Nano Research2021，14，9： | 1 |
| 16 | Enhancing THz fingerprint detection on the planar surface of an inverted dielectric metagrating显示文摘Terahertz(THz)molecular fingerprint sensing provides a powerful label-free tool for the detection of traceamount samples.Due to the weak light–matter interaction,various metallic or dielectric metasurfaces have been adopted to enhance fingerprint absorbance signals.However,they suffer from strong background damping or complicated sample coating on patterned surfaces.Here,we propose an inverted dielectric metagrating and enhance the broadband THz fingerprint detection of trace analytes on a planar sensing surface.Enhancement of the broadband signal originates from the effects of evanescent waves at the planar interface,which are excited by multiplexed quasi-bound states in the continuum(quasi-BICs).One can evenly boost the near-field intensities within the analytes by tuning the asymmetry parameter of quasi-BIC modes.The multiplexing mechanism of broadband detection is demonstrated by manipulating the incident angle of excitation waves and thickness of the waveguide layer.Compared to the conventional approach,the THz fingerprint peak value is dramatically elevated,and the largest peak enhancement time is 330.Our work gives a promising way to facilitate the metasensing of the THz fingerprint on a planar surface and will inspire universal THz spectral analysis for trace analytes with different physical states or morphologies. | XUEYING LIU WEI CHEN YONGJIE MA YINONG XIE JUN ZHOU LIGUO ZHU YADONG XU JINFENG ZHU | 2022 | Photonics Research2022，10，12： | 1 |
| 17 | Degradation of a COTS linear CCD induced by protonirradiation显示文摘 | Wang Zujun Liu Yinong Chen Wei | 2010 | Nuclear Instruments and Methods inPhysics Research B2010，268，6： | 1 |
| 18 | Efficient 3D Hilbert Curve Encoding and Decoding Algorithms显示文摘Hilbert curve describes a one-to-one mapping between multidimensional space and 1 D space.Most traditional 3D Hilbert encoding and decoding algorithms work on order-wise manner and are not aware of the difference between different input data and spend equivalent computing costs on them,thus resulting in a low efficiency.To solve this problem,in this paper we design efficient 3D state views for fast encoding and decoding.Based on the state views designed,a new encoding algorithm(JFK-3HE)and a new decoding algorithm(JFK-3HD)are proposed.JFK-3HE and JFK-3HD can avoid executing iteratively encoding or decoding each order by skipping the first 0 s in input data,thus decreasing the complexity and improving the efficiency.Experimental results show that JFK-3HE and JFK-3HD outperform the state-of-the-arts algorithms for both uniform and skew-distributed data. | JIA Lianyin LIANG Binbin LI Mengjuan LIU Yong CHEN Yinong DING Jiaman | 2022 | Chinese Journal of Electronics2022，31，2： | 1 |
| 19 | Bounds on the reliability of distributed systems with unreliable nodes & links 显示文摘 | CHEN Yinong HE Zhongshi | 2004 | IEEE Transactions on Reliability2004，53，2： | 1 |
| 20 | A new semi -active suspen- sion control strategy through mixed H2/H∞ robust technique 显示文摘 | Zheng Ling Li Yinong Chen Bingkui | 2010 | Journal of CentralSouth University of Technology ( Enlish Edition)2010，，17： | 1 |
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