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88篇 您的检索式:作者名="Yiwu"
    题名 作者 年代 出处 被引量
1Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model显示文摘Yiwu Yan Zhen Zou Yang Sun Xiao Li Kai-Feng Xu Yuquan Wei Ningyi Jin Chengyu Jiang 2013Cell Research2013,23,2:36
2IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang 2012Cell Research2012,22,3:22
3大豆抗胞囊线虫病种质rhg_1和Rhg_4位点的单核苷酸多态性(SNPs)显示文摘研究以 5 7份中美大豆抗胞囊线虫病种质资源为实验材料 ,利用基于检测微珠的单碱基延伸方法 ,对与大豆胞囊线虫病 (SCN)抗性基因rhg1和Rhg4紧密连锁的SNPs进行分析 ,目的是阐明我国大豆抗性种质在这两个位点的SNPs等位变异分布频率 ,为中国大豆种质抗SCN资源的利用奠定基础。分析结果表明 ,SNPs的抗性等位基因与中国大豆种质综合抗性的关系比不同生理小种的抗性关系更为密切。在rhg1和Rhg4位点 ,美国的 9份抗性种质中 ,有 7份抗性种质的SNPs均为纯合抗病基因型 ,而中国 4 8份抗性种质中有 32份 ,分别占鉴定总数的 77 8%和 6 6 7% ,推测大豆抗SCN种质中 ,以rhg1和Rhg4这两个基因协同作用表现出的抗性可能占多数 ,但还存在其他的抗性机制。邱丽娟 常汝镇 王文辉 Perry Cregan Dechun Wang Yiwu Chen 马凤鸣 2003植物遗传资源学报2003,4,2:19
4Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse显示文摘Dear Editor,Since the first recognized case of human infection with avian influenza H5N1 virus in 1997,the worldwide spread and re-emergence of this highly pathogenic influenza virus have led to 694 human infection cases.Of these cases,402died from 2003 to 2015(http://gffzz36b398b81f8a4a4chovcwuonu6vuo6c0v.ffgz.tsg.suse.edu.cn/influenza/humananimalinterface/ENGIP20150106CumulativeNumber H5N1cases.pdf?ua=1),with a morbidity rateYAN YiWu LIU Qiang LI Ning DU JianChao LI Xiao LI Chang JIN NingYi JIANG ChengYu 2015Science China(Life Sciences)2015,58,2:12
5CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang 2014Cell Research2014,24,6:7
6Polyacrylic acid sodium salt film entrapped Ag-nanocubes as molecule traps for SERS detection显示文摘提高表面的拉曼光谱学(重量的单位) 是为踪迹化学药品的一种快分析技术;然而,吸附 analytes 要求活跃重量的单位底层,因此为底层与需要的亲密关系限制目标种类到那些。这里我们现在的联网的 polyacrylic 酸钠盐(PAAS ) 电影骗诱 Ag-nanocubes (作为 Ag-nanocubes@PAAS 表示了) 作为为有或没有高亲密关系的 analytes 的有效重量的单位底层。一次 analyte 水的答案在干燥 Ag-nanocubes@PAAS 底层上被扔,嗜酒的 PAAS 变得肿强迫 Ag-nanocubes 松开,当时在在 Ag-nanocubes 之中的空隙弥漫的 analytes。当弄干时, PAAS 缩小并且拉 Ag-nanocubes 回到他们的以前的聚集的状态,当 PAAS 网络为重量的单位察觉在在 Ag-nanocubes 之间的小差距耽搁 analytes 时。没有强壮的亲密关系,策略为 Ag 为不仅 singleanalytes 而且 multi-analytes 被证明有效,在环境在能吸附、非能吸附的污染物质的基于重量的单位的同时的 multi-analyte 察觉显示出它的潜力。Zhulin Huang Guowen Meng Qing Huang Bin Chen Fei Zhou Xiaoye Hu Yiwu Qian Haibin Tang Fangming Han Zhaoqin Chu 2014Nano Research2014,7,8:6
7Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients.Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian 2020National Science Review2020,7,12:6
8Histopathological Features and Viral Antigen Distribution in the Lung of Fatal Patients with Enterovirus 71 Infection显示文摘Dear Editor,Enterovirus 71(EV71)infection causes hand-foot-andmouth disease(HFMD)in infants and children.Patients with HFMD usually have good prognosis;however,in some extreme cases the infection can be accompanied by central nervous system diseases,eventually leading to cardiorespiratory failure,and even death.Currently。Zhenli Liang Hongbo Pan Xijing Wang Yinchuan Zhu Yiwu Dang Xiaohui Fan Lingxi Gao Zengfeng Zhang 2018Virologica Sinica2018,33,3:4
9Ray-optics model for optical force and torque on a spherical metal-coated Janus microparticle显示文摘In this paper, we develop a theoretical method based on ray optics to calculate the optical force and torque on a metallo-dielectric Janus particle in an optical trap made from a tightly focused Gaussian beam. The Janus particle is a 2.8 μm diameter polystyrene sphere half-coated with gold thin film several nanometers in thickness. The calculation result shows that the focused beam will push the Janus particle away from the center of the trap,and the equilibrium position of the Janus particle, where the optical force and torque are both zero, is located in a circular orbit surrounding the laser beam axis. The theoretical results are in good agreement qualitatively and quantitatively with our experimental observation. As the ray-optics model is simple in principle, user friendly in formalism, and cost effective in terms of computation resources and time compared with other usual rigorous electromagnetics approaches, the developed theoretical method can become an invaluable tool for understanding and designing ways to control the mechanical motion of complicated microscopic particles in various optical tweezers.Jing Liu Chao Zhang Yiwu Zong Honglian Guo Zhi-Yuan Li 2015Photonics Research2015,3,5:4
10Regularized Robust Filter for Spacecraft Attitude Determination显示文摘一个修改调整柔韧的过滤器面对态度传感器的相对错误排列为太空船态度决心被建议。在在测量模型有参量的无常条件下,过滤器被设计最小化最糟可能的剩余标准。剩余标准的 weighting 矩阵被设计最小化评价错误变化的上面的界限。建议态度决心的性能柔韧的过滤器从一个真实三漂流的回转仪与真实测试数据的使用被说明。模拟结果证明态度评价精确性被使用建议算法改进。XIONG Kai LIU Liangdong LIU Yiwu 2011Chinese Journal of Aeronautics2011,24,4:4
11SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can lead to respiratory illness and multi-organ failure in critically ill patients.Although the virus-induced lung damage and inflammatory cytokine storm are believed to be directly associated with coronavirus disease 2019(COVID-19)clinical manifestations,the underlying mechanisms of virus-triggered inflammatory responses are currently unknown.Here we report that SARS-CoV-2 infection activates caspase-8 to trigger cell apoptosis and inflammatory cytokine processing in the lung epithelial cells.The processed inflammatory cytokines are released through the virus-induced necroptosis pathway.Virus-induced apoptosis,necroptosis,and inflammation activation were also observed in the lung sections of SARS-CoV-2-infected HFH4-hACE2 transgenic mouse model,a valid model for studying SARS-CoV-2 pathogenesis.Furthermore,analysis of the postmortem lung sections of fatal COVID-19 patients revealed not only apoptosis and necroptosis but also massive inflammatory cell infiltration,necrotic cell debris,and pulmonary interstitial fibrosis,typical of immune pathogenesis in the lung.The SARS-CoV-2 infection triggered a dual mode of cell death pathways and caspase-8-dependent inflammatory responses may lead to the lung damage in the COVID-19 patients.These discoveries might assist the development of therapeutic strategies to treat COVID-19.Shufen Li Yulan Zhang Zhenqiong Guan Huiling Li Meidi Ye Xi Chen Jun Shen Yiwu Zhou Zheng-Li Shi Peng Zhou Ke Peng 2020Signal Transduction and Targeted Therapy2020,5,1:3
12A New Species of the Genus Sinomicrurus Slowinski,Boundy and Lawson,2001 (Squamata:Elapidae) from Hainan Province,China显示文摘A new species of the coral snake genus Sinomicrurus is described based on four specimens from southern Hainan Island(three specimens from Tianchi,Jianfengling National Nature Reserve,one specimen from Diaoluoshan National Nature Reserve),Hainan Province,China.Morphologically,the new species is rather similar to Sinomicrurus kelloggi.However,it is distinct from S.kelloggi by the pattern on the head,the head length,head length/width,the number of infralabial scales,number of bands on dorsal body,and number of blotches on the belly.Lifang PENG Lijun WANG Li DING Yiwu ZHU Jian LUO Diancheng YANG Ruyi HUANG Shunqing LU Song HUANG 2018Asian Herpetological Research2018,9,2:3
13Singular formalism and admissible control of spacecraft with rotating flexible solar array显示文摘This paper is concerned with the attitude control of a three-axis-stabilized spacecraft which consists of a central rigid body and a flexible sun-tracking solar array driven by a solar array drive assembly. Based on the linearization of the dynamics of the spacecraft and the modal identities about the flexible and rigid coupling matrices,the spacecraft attitude dynamics is reduced to a formally singular system with periodically varying parameters,which is quite different from a spacecraft with fixed appendages. In the framework of the singular control theory,the regularity and impulse-freeness of the singular system is analyzed and then admissible attitude controllers are designed by Lyapunov's method. To improve the robustness against system uncertainties,an H1optimal control is designed by optimizing the H1norm of the system transfer function matrix.Comparative numerical experiments are performed to verify the theoretical results.Lu Dongning Liu Yiwu 2014Chinese Journal of Aeronautics2014,27,1:3
14ZnO-nanotaper array sacrificial templated synthesis of noble-metal building-block assembled nanotube arrays as 3D SERS-substrates显示文摘这份报纸描述一个 ZnO-nanotaper 数组为有试管墙的 nanotubes 的数组的制造的合成途径由 Ag-nanoplates, Au-nanorods, Pt-nanothorns 或 Pd-nanopyramids 的大楼块装配了的牺牲的 templated,因此拥有高密度的 3D 在有 nano 尖端,角落或边的附近的积木的 sub-10-nm 差距的热点。另外,这些层次 nanostructure 数组与富有的表面化学拥有高表面区域,对捕获 analyte 有益。Ag-nanoplateassembled nanotube 数组能被用作散布的敏感提高表面的拉曼(重量的单位) 有好信号一致性和重制度的底层。用如此的 Ag ,层次 nanostructure 作为重量的单位底层穿,不是仅仅有 10 <啜class=“ a-plus-plus ”> 14 M 玫瑰精 6G 识别,而且 10 <啜class=“ a-plus-plus ”> 7 M polychlorinated 联本基(印刷电路板,坚持的器官的污染物质的一个臭名昭著的班)被认出,并且甚至印刷电路板的二同种的物能在混合物被识别,在环境器官的污染物质的基于重量的单位的快速的察觉显示出材料的潜在的应用。Chuhong Zhu Guowen Meng Qing Huang Xiujuan Wang Yiwu Qian Xiaoye Hu Haibin Tang Nianqiang Wu 2015Nano Research2015,8,3:3
15The Arabidopsis catalase triple mutant reveals important roles of catalases and peroxisome-derived signaling in plant development显示文摘Hydrogen peroxide(H_2O_2)is generated in many metabolic processes.As a signaling molecule,H_2O_2plays important roles in plant growth and development,as well as environmental stress response.In Arabidopsis,there are three catalase genes,CAT1,CAT2,and CAT3.The encoded catalases are predominately peroxisomal proteins and are critical for scavenging H_2O_2.Since CAT1 and CAT3 are linked on chromosome 1,it has been almost impossible to generate cat1/3 and cat1/2/3 mutants by traditional genetic tools.In this study,we constructed cat1/3 double mutants and cat1/2/3 triple mutants by CRISPR/Cas9 to investigate the role of catalases.The cat1/2/3 triple mutants displayed severe redox disturbance and growth defects under physiological conditions compared with wild-type and the cat2/3 double mutants.Transcriptome analysis showed a more profound transcriptional response in the cat1/2/3 triple mutants compared to the cat2/3 mutants.These differentially expressed genes are involved in plant growth regulation as well as abiotic and biotic stress responses.In addition,expression of OXI1(OXIDATIVE SIGNAL INDUCIBLE 1)and several MAPK cascade genes were changed dramatically in the catalase triple mutant,suggesting that H_2O_2produced in peroxisomes could serve as a peroxisomal retrograde signal.Tong Su Pingping Wang Huijuan Li Yiwu Zhao Yao Lu Peng Dai Tianqi Ren Xiaofeng Wang Xuezhi Li Qun Shao Dazhong Zhao Yanxiu Zhao Changle Ma 2018Journal of Integrative Plant Biology2018,60,7:3
16Co-integration Analysis of the Relationship between Logistics Transportation and Economic Growth of Agriculture in Zhejiang Province显示文摘The thesis selects freight volume and passenger capacity from 1978 to 2008 in Zhejiang Province and the total output value of the primary industry as the object of research, uses quantitative method of co-integration analysis to analyze the freight volume and passenger capacity, and the total output value of the primary industry in Zhejiang Province. After the stationary test of the time sequence, I conduct the regression analysis of the relationship between freight volume and the total output value of agriculture, and the relationship between passenger capacity and the total output value of agriculture. In addition, I conduct Granger causality test of the relationship between freight volume and passenger capacity, and the total output value of agriculture. The results show that the transportation of Zhejiang Province has promoted the development of agricultural economy prominently, and the development of agricultural economy plays indistinctive role in promoting the transportation volume in Zhejiang Province.WANG Dong-hui Yiwu Industrial and Commercial College,Yiwu 322000, China 2010Asian Agricultural Research2010,2,12:2
17Trace Ir(Ⅲ)complex enhanced electrochemiluminescence of AIE-active Pdots in aqueous media显示文摘Trace Ir(Ⅲ)complex enhanced aggregation-induced electrochemiluminescence(AIECL)of poly-tetraphenylethene(p TPE)in aqueous media was investigated for the first time.The poly-TPE end-capped by Ir(Ⅲ)complex(Ir@p TPE)and its corresponding model polymer poly-TPE(Ph@pTPE)could be synthesized by Suzuki coupling polymerization reaction of 1,2-bis(4-bromophenyl)-1,2-diphenylethene(M-1)with 1,2-diphenyl-1,2-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethene(M-2)and the continuous Suzuki coupling end-capped reaction of poly-TPE-pinacol boronate with(pq)2 Ir(pico)Br and bromobenzene,respectively.Subsequently,the corresponding Ir@p TPE Pdots and Ph@p TPE Pdots encapsulated with poly(styrene-co-maleicanhydride)(PSMA)could be obtained by nanoprecipitation method.Compared with Ph@p TPE Pdots,the Ir@p TPE Pdots with a trace amount of Ir(Ⅲ)complex(1.34‰of Ir(Ⅲ)content,wt)could exhibit 9.9-fold enhancement of the electrochemiluminescence(ECL)signal for visual emission.This work provided a novel strategy on designing highly efficient ECL materials based on trace Ir(Ⅲ)-end capping AIE-active polymer dots.Hang Gao Nan Zhang Yang Li Wei Zhao Yiwu Quan Yixiang Cheng Hong-Yuan Chen Jing-Juan Xu 2020Science China Chemistry2020,63,5:2
18The staphylococcal nuclease prevents biofilm formation in Staphylococcus aureus and other biofilm-forming bacteria显示文摘The staphylococcal nuclease, encoded by the nuc1 gene, is an important virulence factor of Staphylococcus aureus. However, the physiological role of the nuclease has not been fully characterized. The current study observed that biofilm development could be prevented in staphylococcal nuclease-producing strains of S. aureus; however, when the nuc1 gene was knocked out, the ability to form a biofilm significantly increased. Scanning electron and confocal scanning laser microscopy were used to evaluate the role of the nuc1 gene in biofilm formation. Moreover, the nuc1 gene product, staphylococcal nuclease, and recombinant NUC1 protein were found to have a visible effect on other biofilm-forming bacteria, such as Pseudomonas aeruginosa, Actinobacillus pleuropneumoniae, and Haemophilus parasuis. The current study showed a direct relationship between staphylococcal nuclease production and the prevention of biofilm development. The findings from this study underscore the important role of staphylococcal nuclease activity to prevent biofilm formation in S. aureus. They also provided evidence for the biological role of staphylococcal nucleases in other organisms.TANG JunNi KANG MingSong CHEN HuanChun SHI XianMing ZHOU Rui CHEN Juan DU YiWu 2011Science China(Life Sciences)2011,54,9:2
19Compositional dependence of hydrogenation performance of Ti-Zr-Hf-Mo-Nb high-entropy alloys for hydrogen/tritium storage显示文摘A series of Ti-Zr-Hf-Mo-Nb high-entropy alloys with different Mo concentrations were developed as candidate materials for hydrogen/tritium storage in solid phase.The crystal structures and hydrogenation properties of the Ti-Zr-Hf-Mo-Nb alloys were investigated by X-ray diffraction and differential scanning calorimetry techniques.All the alloys have a body-centred cubic single phase structure.The results demonstrate that the cell volume of the Ti-Zr-Hf-Mo-Nb hydride decreases with increasing Mo concentration,which reduces their thermal stability.The theoretical calculation proposes that the lower binding energy of the Ti-Zr-Hf-Mo-Nb hydride decreases the thermal stability of Ti-Zr-Hf-Mo-Nb alloys with higher Mo content.The great hydrogenation performance for all the Ti-Zr-Hf-Mo-Nb alloys is owing to their reversible single-phase transformation during the hydrogen absorption-desorption cycle,which would be bene ficial to improving the hydrogen recycling rate and preventing the disproportionation.The compositional dependence of the hydrogenation performance of the Ti-Zr-Hf-Mo-Nb alloys was established and will be useful in designing novel hydrogen/tritium storage materials to satisfy the requirements of diffe rent application fields in hydrogen,solar thermal and nuclear energy.Huahai Shen Jutao Hu Pengcheng Li Gang Huang Jianwei Zhang Jinchao Zhang Yiwu Mao Haiyan Xiao Xiaosong Zhou Xiaotao Zu Xinggui Long Shuming Peng 2020Journal of Materials Science & Technology2020,52,20:2
20Intrusions of Kuroshio and Shelf Waters on Northern Slope of South China Sea in Summer 2015显示文摘The northern slope region of the South China Sea(SCS) is a biological hot spot characterized by high primary productivity and biomasses transported by cross-shelf currents, which support the spawning and growth of commercially and ecologically important fish species. To understand the physical and biogeochemical processes that promote the high primary production of this region, we conducted a cruise from June 10 and July 2, 2015. In this study, we used fuzzy cluster analysis and optimum multiparameter analysis methods to analyze the hydrographic data collected during the cruise to determine the compositions of the upper 55-m water masses on the SCS northern slope and thereby elucidate the cross-slope transport of shelf water(SHW) and the intrusions of Kuroshio water(KW). We also analyzed the geostrophic currents derived from acoustic Doppler current profiler measurements and satellite data. The results reveal the surface waters on the northern slope of the SCS to be primarily composed of waters originating from South China Sea water(SCSW), KW, and SHW. The SCSW dominated a majority of the study region at percentages ranging between 60% and 100%. We found a strong cross-slope current with speeds greater than 50 cms^(-1) to have carried SHW into and through the surveyed slope area, and KW to have intruded onto the slope via mesoscale eddies, thereby dominating the southwestern section of the study area.LI Denghui ZHOU Meng ZHANG Zhaoru ZHONG Yisen ZHU Yiwu YANG Chenghao XU Mingquan XU Dongfeng HU Ziyuan 2018Journal of Ocean University of China2018,17,3:2
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