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| 1 | Thrombomodulin in the management of acute cholangitisinduced disseminated intravascular coagulation显示文摘AIM: To evaluate the need for thrombomodulin(r TM) therapy for disseminated intravascular coagulation(DIC) in patients with acute cholangitis(AC)-induced DIC. METHODS: Sixty-six patients who were diagnosedwith AC-induced DIC and who were treated at our hospital were enrolled in this study. The diagnoses of AC and DIC were made based on the 2013 Tokyo Guidelines and the DIC diagnostic criteria as defined by the Japanese Association for Acute Medicine, respectively. Thirty consecutive patients who were treated with r TM between April 2010 and September 2013(r TM group) were compared to 36 patients who were treated without r TM(before the introduction of r TM therapy at our hospital) between January 2005 and January 2010(control group). The two groups were compared in terms of patient characteristics at the time of DIC diagnosis(including age, sex, primary disease, severity of cholangitis, DIC score, biliary drainage, and anti-DIC drugs), the DIC resolution rate, DIC score, the systemic inflammatory response syndrome(SIRS) score, hematological values, and outcomes. Using logistic regression analysis based on multivariate analyses, we also examined factors that contributed to persistent DIC. RESULTS: There were no differences between the r TM group and the control group in terms of the patients' backgrounds other than administration. DIC resolution rates on day 9 were higher in the r TM group than in the control group(83.3% vs 52.8%, P < 0.01). The mean DIC scores on day 7 were lower in the r TM group than in the control group(2.1 ± 2.1 vs 3.5 ± 2.3, P = 0.02). The mean SIRS scores on day 3 were significantly lower in the r TM group than in the control group(1.1 ± 1.1 vs 1.8 ± 1.1, P = 0.03). Mortality on day 28 was 13.3% in the r TM group and 27.8% in the control group; these rates were not significantly different(P = 0.26). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC(P < 0.01, OR = 12, 95%CI: 2.3-60). Although the difference did not reach statistical significance, primary diseases(malignancies)(P = 0.055, OR = 3.9, 95%CI: 0.97-16) and the non-use of r TM had a tendency to be associated with persistent DIC(P = 0.08, OR = 4.3, 95%CI: 0.84-22).CONCLUSION: The add-on effects of r TM are anticipated in the treatment of AC-induced DIC, although biliary drainage for AC remains crucial. | Keigo Suetani Chiaki Okuse Kazunari Nakahara Yosuke Michikawa Yohei Noguchi Midori Suzuki Ryo Morita Nozomi Sato Masaki Kato Fumio Itoh | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 2 | Plasma levodopa peak delay and impaired gastric emptying in Parkinson’s disease显示文摘 | Hirokazu Doi Ryuji Sakakibara Mitsutoshi Sato Tohru Masaka Masahiko Kishi Akihiko Tateno Fuyuki Tateno Yohei Tsuyusaki Osamu Takahashi | 2012 | Journal of the Neurological Sciences . 2012 (1-2)2012，，1： | 2 |
| 3 | Simulating spatial urban expansion based on a physical process显示文摘 | Lin Li Yohei Sato Haihong Zhu | 2002 | Landscape and Urban Planning2002，，1： | 2 |
| 4 | Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity显示文摘 | Ayumi Yoshizaki Kazuhiro Komura Yohei Iwata Fumihide Ogawa Toshihide Hara Eiji Muroi Motoi Takenaka Kazuhiro Shimizu Minoru Hasegawa Manabu Fujimoto Shinichi Sato | 2009 | Journal of Clinical Immunology2009，，2： | 1 |
| 5 | Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39显示文摘 | Masataka Narukawa Chiaki Noga Yohei Ueno Tsutomu Sato Takumi Misaka Tatsuo Watanabe | 2011 | Biochemical and Biophysical Research Communications2011，，4： | 1 |
| 6 | Sorption of dissolved lead from shooting range soils using hydroxyapatite amendments synthesized from industrial byproducts as affected by varying pH conditions显示文摘 | Yohey Hashimoto Tomohiro Taki Takeshi Sato | 2008 | Journal of Environmental Management2008，，： | 1 |
| 7 | Farmers managed irrigation districts in Japan :Assessing how fairness may contribute to sustainablity 显示文摘 | YUKIO TANAKA YOHEI SATO | 2005 | Agricul- tural Water Management2005，77，22： | 1 |
| 8 | Nizatidine Ameliorates Slow Transit Constipation in Parkinson’s Disease显示文摘 | Ryuji Sakakibara Hirokazu Doi Mitsutoshi Sato Shigekazu Hirai Tohru Masaka Masahiko Kishi Yohei Tsuyusaki Akihiko Tateno Fuyuki Tateno Yosuke Aiba Tsuyoshi Ogata Yasuo Suzuki | 2015 | J Am Geriatr Soc2015，，2： | 1 |
| 9 | Post - weld formability of friction stir welded Al alloy 5052 显示文摘 | Yutaka S Sato Yusuke Sugiura Yohei Shoji | 2004 | Materials Science & Engineering A2004，369，： | 1 |
| 10 | Simulating spatial urban expansion based on a physical process 显示文摘 | Lin Li Yohei Sato Haihong Zhu | 2003 | Landscape and Urban Planning2003，64，： | 1 |
| 11 | Construction of a foxtail millet linkage map and mapping of spikelet - tipped bristles 1 ( stb1 ) by using transposon display markers and simple sequence repeat markers with genome sequence information显示文摘 | Kei Sato Yohei Mukainari Ken Naito Kenji Fukunaga | 2013 | Molecular Breeding2013，，3： | 1 |
| 12 | Simulating spatial urban expansion based on physical process显示文摘 | LIN LI YOHEI SATO HAIHONG ZHU | 2003 | Landscape and Urban Planning2003，，64： | 1 |
| 13 | Effect of a late evening snack using branched‐chain amino acid‐enriched nutrients in patients undergoing hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma显示文摘 | Yohei Harima Takahiro Yamasaki Satoe Hamabe Issei Saeki Kohsuke Okita Shuji Terai Isao Sakaida | 2010 | Hepatology Research2010，，6： | 1 |
| 14 | Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis显示文摘 | Kayoko Kimura Takanori Kanai Atsushi Hayashi Yohei Mikami Tomohisa Sujino Shinta Mizuno Tango Handa Katsuyoshi Matsuoka Tadakazu Hisamatsu Toshiro Sato Toshifumi Hibi | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 15 | Simulating spatial urban expansion based on a physical process显示文摘 | LIN LI YOHEI SATO HAIHONG ZHU | 2003 | Landscape and Urban Planning2003，64，： | 1 |
| 16 | Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39显示文摘 | Masataka Narukawa Chiaki Noga Yohei Ueno Tsutomu Sato Takumi Misaka Tatsuo Watanabe | 2011 | Biochemical and Biophysical Research Communications2011，，4： | 1 |
| 17 | CFD simulation of 3-dimensional motion of a ship in waves: Application to an advancing ship in regular heading waves显示文摘 | Yohei Sato Hideaki Miyata Torn Sato | 1999 | Journal of Marine Science and Technology1999，，4： | 1 |
| 18 | Usefulness of Transcription–Reverse Transcription Concerted Reaction Method for Detecting Circulating Tumor Cells in Patients With Colorectal Cancer显示文摘 | Nobutaka Sato Naoko Hayashi Yu Imamura Yohei Tanaka Koichi Kinoshita Jyunji Kurashige Seiya Saito Ryuichi Karashima Kotaro Hirashima Yohei Nagai Yuji Miyamoto Masaaki Iwatsuki Yoshifumi Baba Masayuki Watanabe Hideo Baba | 2012 | Annals of Surgical Oncology2012，，6： | 1 |
| 19 | Phosphorylated mTOR Expression is Associated with Poor Prognosis for Patients with Esophageal Squamous Cell Carcinoma显示文摘 | Kotaro Hirashima MD Yoshifumi Baba MD PhD Masayuki Watanabe MD PhD Ryu-ichi Karashima MD Nobutaka Sato MD Yu Imamura MD PhD Yukiharu Hiyoshi MD PhD Yohei Nagai MD Naoko Hayashi MD PhD Ken-ichi Iyama MD PhD Hideo Baba MD PhD | 2010 | Annals of Surgical Oncology2010，，9： | 1 |
| 20 | Simulating spatial urban expansion based on a physical process显示文摘 | Lin Li Yohei Sato Haihong Zhu | 2002 | Landscape and Urban Planning2002，，1： | 1 |
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