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| 1 | Development of gene-tagged molecular markers for starch synthesis-related genes in rice显示文摘Improving grain quality is an important goal in breeding new elite rice varieties,requiring effective tools for the identification of target genotypes.Molecular marker-aided selection(MAS),combined with conventional breeding approaches,enables us to pre-cisely identify the individual genotypes that are associated with different grain quality features,which can dramatically improve the breeding efficiency.However,to date,the number of molecular markers used in MAS for grain quality improvement is still somewhat limited.In this study,based on our previous study that rice grain quality is strongly associated with starch synthesis in the endosperm,we developed 51 gene-tagged molecular markers according to sequence variations in 18 starch synthesis-related genes from 16 typical rice cultivars.These markers can discriminate the different alleles among rice germplasms.These novel markers will provide effective tools in improving grain quality via the breeding new elite rice varieties. | TIAN ZhiXi YAN ChangJie QIAN Qian YAN Song XIE HuiLan WANG Fang XU JieFen LIU GuiFu WANG YongHong LIU QiaoQuan TANG ShuZhu LI JiaYang GU MingHong | 2010 | Chinese Science Bulletin2010，55，33： | 12 |
| 2 | Computational pharmacological studies on cardiovascular disease by Qishen Yiqi Diwan显示文摘Computational pharmacological methods were used to study the distribution of 1729 compounds contained in a Chinese medicine,Qishen Yiqi Diwan,in chemical space.The results show that most of these compounds have good drug-like properties.Molecular docking was used to study the interactions between 1729 compounds of Qishen Yiqi Diwan and 26 drug targets related to cardiovascular disease and the distribution of 1729 compounds in drug-target space.The results may shed light on the action mechanism and the search for the active compounds in Qishen Yiqi Diwan. | GU JiangYong YUAN Gu ZHU YongHong XU XiaoJie | 2009 | Science China Chemistry2009，52，11： | 9 |
| 3 | The Major Controlling Factors and Different Oolitic Shoal Reservoir Characteristics of the Triassic Feixianguan Formation,Eastern Longgang Area,NE Sichuan Basin,SW China显示文摘Based on comprehensive analyses of occurrence,petrological observation,pore structure and geochemistry,the different reservoir characteristics and reservoir evolutionary pathways between different oolitic shoal reservoir types of the Feixianguan Formation on the west side of the Kaijiang-Liangping Trough have been studied.There exist three stages of high-energy slope break belts in the Feixianguan period,the corresponding three stages of oolitic shoals gradually migrating in the direction of the trough.Three types of oolitic shoal reservoirs,namely,residual-oolitic dolomite,mold-oolitic dolomite and sparry oolitic limestone,were formed during sedimentary-diagenetic evolution,the pore types being intergranular dissolved pore,mold pore(or intragranular dissolved pore)and residual intergranular pore,respectively.The petrology,physical properties and pore structure of the different types of oolitic shoal reservoirs are quite different.Residual-oolitic dolomite reservoirs have the best quality,while sparry oolitic limestone reservoirs have the poorest.Combined with analyses of trace elements,rare earth elements and carbon-oxygen isotopes,it is suggested that the formation of residual-oolitic dolomite reservoirs is jointly controlled by penesaline seawater seepage-reflux dolomitization and hydrothermal dolomitization.Mold-pore oolitic dolomite reservoirs are controlled by penesaline seawater seepage-reflux dolomitization and meteoric water solution.The burial dissolution of organic acid not only further improves the reservoir qualities of previously formed oolitic dolomite reservoirs,but also preserves residual intergranular pores in the sparry oolitic limestone reservoirs. | GU Yifan JIANG Yuqiang LEI Xiaohua CHEN Zhiyong ZHOU Lu FU Yonghong JIANG Zengzheng | 2021 | Acta Geologica Sinica(English Edition)2021，95，3： | 3 |
| 4 | Improvement in Resolution of Multiphoton Scanning Structured Illumination Microscopy via Harmonics显示文摘We describe a multiphoton(mP)-structured illumination microscopy(SIM)technique,which demonstrates substantial improvement in image resolution compared with linear SIM due to the nonlinear response of fluorescence.This nonlinear response is caused by the effect of nonsinusoidal structured illumination created by scanning a sinusoidally modulated illumination to excite an mP fluorescence signal.The harmonics of the structured fluorescence illumination are utilised to improve resolution.We present an mP-SIM theory for reconstructing the super-resolution image of the system.Theoretically,the resolution of our m P-SIM is unlimited if all the high-order harmonics of the nonlinear response of fluorescence are considered.Experimentally,we demonstrate an 86 nm lateral resolution for two-photon(2P)-SIM and a 72 nm lateral resolution for second-harmonic-generation(SHG)-SIM.We further demonstrate their application by imaging cells stained with F-actin and collagen fibres in mouse-tail tendon.Our method can be directly used in commercial mP microscopes and requires no specific fluorophores or high-intensity laser. | Lei Wang Xiaomin Zheng Jie Zhou Meiting Wang Jiajie Chen Youjun Zeng Gaixia Xu Ying Wang Haixia Qiu Yonghong Shao Junle Qu Bruce Zhi Gao Ying Gu | 2022 | Engineering2022，，9： | 1 |
| 5 | C-reactive protein promotes vascular endothelial dysfunction partly via activating adipose tissue inflammation in hyperlipidemic rabbits显示文摘 | YangXin Chen XiaoQiao Wang JingTing Mai XiaoMiao Zhao YongHong Liang MiaoNing Gu ZhongQing Chen RuQiong Nie JingFeng Wang | 2013 | International Journal of Cardiology2013，，： | 1 |
| 6 | Preparation and Characterization of Uniform-sized Chitosan Micro- spheres Containing Insulin by Membrane Emulsification and a Two-step Solidification Process显示文摘 | Wang Lianyan Gu Yonghong Zhou Qingzhu | 2006 | Colloids and Surfaces B: Biointerfaces2006，50，2： | 1 |
| 7 | First Isolation and Characterization of Ochrobactrum anthropi from Pig显示文摘One Gram-negative Bacillus was isolated from a brain sample of a pig with neurological symptoms.Pathological examination showed meningitis at necropsy. Ochrobactrum anthropi (O. anthropi) was successfully isolated from the brain sample and was confirmed by biochemical reaction results (API 20 NE) and gene sequencing. The strain was highly resistant to b-lactam antibiotics. Mice were experimentally infected with O. anthropi and showed typical meningitis. This is the first report on O. anthropi isolated from a pig, and indicates that O. anthropi may have a broader host spectrum of infection. | Shijiang Gu Ruiqing Hou Shengguo Gao Zhe Sun Xiangdong Li Lufeng Zhai Yunyun Jin Qiaoyan Zhu Yonghong Liao Kegong Tian | 2020 | Engineering2020，6，1： | 1 |
| 8 | Preparation and characterization of uniform-sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification process 显示文摘 | Wang Lianyan Gu Yonghong Zhou Qingzhu | 2006 | Colloids and Surfaces B : Biointerfaces2006，50，： | 1 |
| 9 | Clinicopathological char- acteristics of kidney mucinous tubular and spindle cell carcinoma 显示文摘 | Qian Chen Yonghong Gu Binghui Liu | 2015 | Int J Clin Exp Pathol2015，8，1： | 1 |
| 10 | 促进晚期癌症恶性进展的新型红细胞样亚群Ter细胞的发现显示文摘文章简介医学界对于癌症患者出现全身性异常变化越来越重视,但对于远端器官异常在晚期癌症转移以及恶性进展中的作用尚不十分清楚。通过动态分析早晚期癌症宿主主要器官中的细胞异常变化,在晚期癌症宿主肿大的脾脏中发现了一种称之为Ter细胞的新型红细胞样亚群. | 韩岩梅 刘秋燕 侯晋 Yan Gu Yi Zhang Zhubo Chen Jia Fan Weiping Zhou Shuangjian Qiu Yonghong Zhang Tao Dong Ning Li Zhengping Jiang Ha Zhu Qian Zhang Yuanwu Ma Lianfeng Zhang Qingqing Wang Yizhi Yu Nan Li 曹雪涛 | 2019 | 科学新闻2019，0，2： | 0 |
| 11 | Formaldehyde accelerates cellular senescence in HT22 cells: possible involvement of the leptin pathway显示文摘甲醛(FA ) ,一种著名环境污染物质,是在民族生活的广泛地使用的化学混合物。深刻研究证明了 FA 在中央神经系统上有有毒的效果[1 ] 。然而,位于导致 FA 的 neurotoxicity 下面的机制充分没被调查。发现一个方法阻止并且慢下来引起 FA 的 neurotoxicity 的前进也是必要的。细胞的老朽,导致永久房间周期拘捕的规划房间回答,能被象 oncogene 激活,照耀, DNA 损坏和氧化应力那样的各种各样的细胞的压力导致[2 ] 。最近的研究建议了在大脑的衰老的房间可以贡献 neurodegenerative 变化[3 ] 。有趣地,积累了 FA 在使个人变老的大脑被报导了并且贡献年龄相关的 neurodegenerative 症状[4 ] 。因此, FA 能加速细胞的老朽,这被假设并且它可以接着贡献得到 FA 的 neurotoxicity。 | Kebin Zhan Min Ning Chunyan Wang Yonghong Tang Hongfeng Gu Canqun Yan Xiaoqing Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 0 |
| 12 | Deammoniative Condensation of Primary Allylic Amines with Nonallylic Amines显示文摘An unprecedented deammoniative condensation reaction of primary allylic amines with nonallylic amines has been developed through C-N bond cleavage.In the presence of 5 mol%palladium diacetate,10 mol%1,4-bis(diphenylphosphino)butane(dppb),and 5 mol%p-toluenesulfonic acid(TsOH),a range of α-unbranched primary allylic amines smoothly underwent deammoniative condensation with nonallylic amines in an α-selective fashion to give structurally diverse secondary and tertiary amines in good to excellent yields and E selectivity.Replacing dppb with racemic 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl(BINAP)permitted the deammoniative condensation of enantioenriched α-chiral primary allylic amines with nonallylic amines to proceed with complete retention of configuration.Electrospray ionization(ESI)mass spectrometric analysis of the reaction mixture permitted the identification of some π-allylpalladium intermediates,and plausible mechanisms have been proposed to account for the regioselectivity and stereospecificity of the deammoniative condensation reaction. | Yong Wang Manbo Li Xiantao Ma Congrong Liu Yonghong Gu Shi-Kai Tian | 2014 | Chinese Journal of Chemistry2014，32，8： | 0 |
| 13 | Microscopic pore-fracture configuration and gas-filled mechanism of shale reservoirs in the western Chongqing area,Sichuan Basin,China显示文摘Taking the Upper Ordovician Wufeng Formation to Lower Silurian Longmaxi Formation shale reservoirs in western Chongqing area as the study target,the argon ion polishing scanning electron microscope and nuclear magnetic resonance(NMR)experiments of different saturated wetting media were carried out.Based on the image processing technology and the results of gas desorption,the pore-fracture configuration of the shale reservoirs and its influence on gas-filled mechanism were analyzed.(1)The reservoir space includes organic pores,inorganic pores and micro-fractures and there are obvious differences between wells in the development characteristics of micro-fractures;the organic pores adjacent to the micro-fractures are poorly developed,while the inorganic pores are well preserved.(2)According to the type,development degree and contact relationship of organic pore and micro-fracture,the pore-fracture configuration of the shale reservoir is divided into four types.(3)Based on the differences in NMR T_(2) spectra of shale samples saturated with oil and water,an evaluation parameter of pore-fracture configuration was constructed and calculated.The smaller the parameter,the better the pore-fracture configuration is.(4)The shale reservoir with good pore-fracture configuration has well-developed organic pores,high porosity,high permeability and high gas content,while the shale reservoir with poor pore-fracture configuration has micro-fractures developed,which improves the natural gas conductivity and leads to low porosity and gas content of the reservoir.(5)Based on pore-fracture configuration,from the perspective of organic matter generating hydrocarbon,micro-fracture providing migration channel,three types of micro gas-filled models of shale gas were established. | FU Yonghong JIANG Yuqiang DONG Dazhong HU Qinhong LEI Zhi'an PENG Hao GU Yifan MA Shaoguang WANG Zimeng YIN Xingping WANG Zhanlei | 2021 | Petroleum Exploration and Development2021，48，5： | 0 |
| 14 | Angiopoietin-1 mRNA and Bcl-2 expression following estradiol treatment in ovariectomized rats with focal cerebral ischemia/reperfusion injury显示文摘BACKGROUND:Estrogen has been clinically demonstrated to attenuate ischemic brain injury. However,the precise mechanisms remain controversial. OBJECTIVE:To investigate the effects of estradiol on angiopoietin-1 mRNA and Bcl-2 expression, as well as apoptosis and cerebral blood flow,in ovariectomized rats with focal cerebral ischemia following reperfusion. DESIGN,TIME AND SETTING:Randomized,controlled,animal experiment.The study was performed at the Central Laboratory,Chongqing Medical University from September to December 2005. MATERIALS:Estradiol benzoate was purchased from Shanghai Ninth Pharmaceutical Factory; com oil was purchased from Walmart Supercenter;TUNEL kit,rabbit anti-rat Bcl-2 polyclonal antibody,and biotin-labeled goat anti-rabbit antibody were purchased from Wuhan Boster,China. METHODS:Healthy,female,6-month-old Wistar rats-wild-type and estrogen alpha receptor gene knockout(ERKO)-were randomly divided into estradiol and control groups with 25 animals in each group.The rats were intramuscularly injected with estradiol benzoate(100μg/kg per day) at 30 days following bilateral ovariectomy or corn oil(1 mL/kg per day) for seven consecutive days.Following administration,cerebral ischemia/reperfusion models were established using the right middle cerebral artery occlusion(MCAO) method.After 30 minutes of MCAO,estradiol and control groups were separately injected with estradiol benzoate and corn oil with the above-mentioned doses. MAIN OUTCOME MEASURES:Cell apoptosis was determined by TUNEL;angiopoietin-1 mRNA and Bcl-2 gene expression was determined,respectively,by immunohistochemical staining and RT-PCR.In addition,changes in cerebral blood flow were measured by laser Doppler flowmetry. RESULTS:Changes in angiopoietin-1 mRNA and cerebral blood flow in estradiol-treated,wild-type, MCAO rats following ischemia/reperfusion were greater than in control rats(P<0.01 or 0.05). However,no significant difference was observed between estradiol-treated ERKO MCAO rats and control rats.In addition,estradiol-treated wild-type and ERKO MCAO rats exhibited significantly increased Bcl-2 expression(P<0.05) and decreased number of apoptotic cells in brain tissues compared with control groups(P<0.05). CONCLUSION:Estradiol upregulated angiopoietin-1 mRNA and Bcl-2 expression,suggesting that estradiol might be involved in protective mechanisms of cerebral ischemia/reperfusion injury. | Rong Gu Minghua Liu Yonghong Wang Yuanda Zhou Haixia He | 2009 | Neural Regeneration Research2009，4，10： | 0 |
| 15 | Diagnosis of knee osteoarthritis by OCT and surface-enhanced Raman spectroscopy显示文摘In this paper,optical coherence tomography(OCT)and surface-enhanced Raman spectroscopy(SERS)were used to characterize normal knee joint(NKJ)tissue and knee osteoarthritis(KOA)tissue ex vivo.OCT images show that there is a clear hierarchical structure in NKJ tissue,including surface layer,transitional layer,radiation layer and cartilage matrix calcification layer tissue structure,while the hierarchical structure of KOA tissue is not clear and unevenly distributed,and the pathological tissues at different stages also show significant di®erences.SERS shows that NKJ tissue and mild osteoarthritic knee cartilage(MiKOA)tissue have strong characteristic Raman peaks at 964,1073(1086),1271,1305,1442,1660 and 1763 cm^(-1).Compared with the Raman spectrum of NKJ tissue,the Raman characteristic peaks of MiKOA tissue have some shifts,moving from 1073 cm^(-1)to 1086 cm^(-1)and from 1542 cm^(-1)to 1442 cm^(-1).There is a characteristic Raman peak of 1271 cm^(-1)in MiKOA tissue,but not in NKJ tissue.Compared with NKJ tissue,severely degenerated cartilage(SdKOA)tissues show some new SERS peaks at 1008,1245,1285,1311 and 1321 cm^(-1),which are not seen in SERS spectra of NKJ tissue.Principal component analysis(PCA)was used to analyze the Raman spectra of 1245–1345 cm^(-1)region.The results show that PCA can distinguish NKJ,MiKOA and SdKOA tissues and the accuracy is about 90%.These results indicate that OCT can clearly distinguish NKJ,MiKOA,moderate osteoarthritic knee cartilage(MoKOA)and SdKOA tissue,while SERS can provide further judgment basis.The results also prove that the contents of protein and polysaccharide in knee tissue are changed during the pathological process of knee tissue,which is the cause of pain caused by poor friction in knee joint during movement. | Ran An Huaimin Gu Zhouyi Guo Huiqing Zhong Huajiang Wei Guoyong Wu Yonghong He Shusen Xie Hongqin Yang | 2022 | Journal of Innovative Optical Health Sciences2022，15，5： | 0 |
| 16 | Investigation of the Current Situation of Innovation Ability Education of Vocational College Students Under the Guidance of Ideological and Political Education显示文摘Innovation ability is the ability to continuously provide new ideas,theories,methods,and inventions with economic,social,and ecological values in the fields of technology and various practical activities.The ideological and political education of vocational school students should be student-oriented and close to reality and life.It is necessary to improve the pertinence,effectiveness,attractiveness,and infectiousness of ideological and political education,and cultivate socialist builders and successors with all-round development of morality,intelligence,physique,and beauty.In this paper,we investigate and understand the practice of innovation ability education in colleges and universities at home and abroad,especially the current situation of professional practice teaching in Xinjiang Vocational Colleges.The construction of a professional practice base in vocational colleges is systematically studied. | Xiaolin Fan Nurjulidezi Baheti Yonghong Gu | 2024 | Journal of Contemporary Educational Research2024，8，3： | 0 |
| 17 | Control of crystal growth to obtain needle-shaped violet phosphorus with excellent photocatalytic degradation performance显示文摘The control of crystal growth is important but challenging for multi-disciplinary research.Violet phosphorus,the most stable phosphorus allotrope,has recently been produced as a unique semiconducting layered structure.The crystal orientation and morphology bring extra performance due to its unique structure and anisotropy.Herein,the layered violet phosphorus has been controlled to grow along the c-axis to give tunable length up to centimeters with the assistance of tin,while the reported flat bulk ones with thickness are limited to micrometers.The as-produced needle-shaped violet phosphorus has also been demonstrated to significantly enhance the photocatalytic degradation of methyl orange pollutants due to its special crystallographic orientation.About 98.6%of methyl orange pollutants with a concentration of 50 ppm were degraded within 80 min under visible light conditions by needle-shaped violet phosphorus,which is much more effective than that of amorphous red phosphorus with only 14.1%degradation. | Mengting Jin Yanhao Wang Mengyue Gu Xuewen Zhao Rongzheng Zhao Yuhao Zhang Yonghong Cheng Jinying Zhang | 2023 | Nano Research2023，16，2： | 0 |
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