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| 1 | 应用化合物组释放动力学方法评价银翘解毒片的释放特征(英文)显示文摘目的:考察中药化合物组释放动力学新理论在银翘解毒片释放特征评价中的适用性。方法:以Kalman滤波法为基础,进行紫外分光光度法测定银翘解毒片化合物组标准谱、线性、精密度、稳定性等方法学研究,测定银翘解毒片及其粉末的化合物组释放特征。结果:方法学结果表明,在0.112~1.120mg生药/mL范围内银翘解毒片化合物组呈线性相关(r=0.9997);高、中、低化合物组浓度测定的RSD分别为0.05%、0.07%和0.31%,浓度分别为0.278,0.556,和1.120mg生药/mL的供试液化合物组在24h内稳定。结论:化合物组释放度能简洁、可视、直观地反映银翘解毒片多组分释放动力学特征,中药化合物组释放动力学新理论可以定量地揭示传统中药制剂的新内涵或其给药系统的活性组分释放特征。 | 陈立兵 王中华 傅丹丹 凌昳 葛卫红 顾景凯 YORK Peter 邵群 张继稳 | 2008 | 中国天然药物2008，6，6： | 17 |
| 2 | Characterization and mapping of the multi-component release kinetics of a Traditional Chinese Medicine dosage form using a modified LC/MS/MS method and chemomic release kinetic theory显示文摘It is essential to develop effective methods for the quality control of the traditional medicine with multiple components.However,few researches on the quality control have been conducted to interpret the holistic characteristics of the traditional medicine in terms of dissolution/release.In this study,the multi-component release kinetics of Traditional Chinese Medicine(TCM)dosage forms was characterized and mapped by multivariate analysis techniques in the field of‘‘-omics’’.The Liuweidihuang pill was used as a model formulation.The multi-component release kinetics of the concentrated and water-honeyed Liuweidihuang pills at rotation speeds of 50 and 100 rpm were analyzed by chemomic release kinetic theory and modified LC/MS/MS method.Mass features of 103(concentrated pills)and 101(water-honeyed pills)were selected with a linear correlation coefficient Z0.99 between mass responses and concentrations.To compose the chemomic standard spectrum,the relative abundance of both mass features was no less than 1%as compared with an internal standard.The correlation coefficients between six samples of various solutions were in line with analytical requirements of precision(rZ0.985).The score plots of principal component analysis showed that the concentrated Liuweidihuang pills presented better chemomic release reproducibility than the water-honeyed pills.Conversely,the impact of rotation speed on the chemomic release was less obvious.The heat maps of hierarchical clustering analysis did not show significant changes in individual clusters of mass features along different time intervals,reflecting the release integrity of the mass features.Therefore,both multivariate analysis methods,the principal component analysis and the hierarchical clustering analysis,seemed to be effective techniques to demonstrate the multiple component release performance of TCM.The research provided the basis of a new strategy for the quality control procedures of the dissolution/release for the traditional medicine and multi-component natural products to address increasing regulatory requirements and scrutiny across the world. | Hai-yan Li Xiang-yong Cui Feng Gao Peter York Qun Shao Xian-zhen Yin Tao Guo Zhen Guo Jing-kai Gu Ji-wen Zhang | 2011 | Acta Pharmaceutica Sinica B2011，1，2： | 3 |
| 3 | Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography显示文摘This study investigated the formulation mechanism of microspheres via internal surfactant distribution. Eudragit L100 based microspheres loaded with bovine serum albumin were prepared by solid in oil in oil emulsion solvent evaporation method using acetone and liquid paraffin system containing sucrose stearate as a surfactant. The fabricated microspheres were evaluated for encapsulation efficiency, particle size, production yield, and in vitro release characteristics. The internal structures of microspheres were characterized using synchrotron radiation X-ray microcomputed tomography(SR-μCT). The enhanced contrast made the sucrose stearate distinguished from Eudragit to have its three dimensional(3D) distribution. Results indicated that the content and concentration determined the state of sucrose stearate and had significant influences on the release kinetics of protein. The dispersity of sucrose stearate was the primary factor that controlled the structure of the microspheres and further affected the encapsulation efficiency, effective drug loading, as well as in vitro release behavior. In conclusion, the 3D internal distribution of surfactant in microspheres and its effects on protein release behaviors have been revealed for the first time. The highly resolved 3D architecture provides new evidence for the deep understanding of the microsphere formation mechanism. | Li Wu Manli Wang Vikramjeet Singh Haiyan Li Zhen Guo Shuangying Gui Peter York Tiqiao Xiao Xianzhen Yin Jiwen Zhang | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，4： | 2 |
| 4 | Employability Through the Curriculum显示文摘 | Peter T. Knight Mantz Yorke | 2002 | Tertiary Education and Management2002，，4： | 2 |
| 5 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 6 | Employability Through the Curriculum显示文摘 | Peter T.Knight Mantz Yorke | | 0，，12： | 1 |
| 7 | Active integrated antennas显示文摘 | KAI CHANG ROBERT A YORK PETER S HALL TATSUO ITOH | 2002 | IEEE Transactions on Microwave Theory and Techniques2002，50，3： | 1 |
| 8 | Acute hypoxia causes anhedonia and weight loss in mice, which is absent after a second hypoxic exposure 显示文摘 | York JM McDaniel AW Peters VA | 2009 | Brain Behavior and Immunity2009，23，7： | 1 |
| 9 | Active Integrated Antennas 显示文摘 | KAI CHANG ROBERT A YORK PETER S | 2002 | IEEE Transactions on Microwave Theory and Techniques2002，50，3： | 1 |
| 10 | Employability Through the Curriculum显示文摘 | Peter T. Knight Mantz Yorke | 2002 | Tertiary Education and Management2002，，4： | 1 |
| 11 | The Undergraduate Curriculum and Employability 显示文摘 | Mantz Yorke Peter Knight | 2005 | Ninth Quality in Higher Education International Seminar in collaboration with ESECT and The Independent2005，，9： | 1 |
| 12 | Bridging the structure gap between pellets in artificial dissolution media and in gastro-intestinal tract in rats显示文摘Changes in structure of oral solid dosage forms(OSDF) elementally determine the drug release and its therapeutic effects.In this research,synchrotron radiation X-ray micro-computed tomography was utilized to visualize the 3 D structure of enteric coated pellets recovered from the gastrointestinal tract of rats.The structures of pellets in solid state and in vitro compendium media were measured.Pellets in vivo underwent morphological and structural changes which differed significantly from those in vitro compendium media.Thus,optimizations of the dissolution media were performed to mimic the appropriate in vivo conditions by introducing pepsin and glass microspheres in media.The sphericity,pellet volume,pore volume and porosity of the in vivo esomeprazole magnesium pellets in stomach for2 h were recorded 0.47,1.55 × 10^(8)μm^(3),0.44 × 10^(8)μm^(3)and 27.6%,respectively.After adding pepsin and glass microspheres,the above parameters in vitro reached to 0.44,1.64 × 10^(8)μm^(3)0.38 × 10^(8)μm^(3)and 23.0%,respectively.Omeprazole magnesium pellets behaved similarly.The structural features of pellets between in vitro media and in vivo condition were bridged successfully in terms of 3 D structures to ensure better design,characterization and quality control of advanced OSDF. | Hongyu Sun Siyu He Li Wu Zeying Cao Xian Sun Mingwei Xu Shan Lu Mingdi Xu Baoming Ning Huimin Sun Tiqiao Xiao Peter York Xu Xu Xianzhen Yin Jiwen Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
| 13 | A study of carbon deposition on catalysts during the partial oxidation of methane to synthesis gas显示文摘 | John B. Claridge Malcolm L. H. Green Shik Chi Tsang Andrew P. E. York Alexander T. Ashcroft Peter D. Battle | 1993 | Catalysis Letters1993，，4： | 1 |
| 14 | Employability Through the Curriculum显示文摘 | Peter T.Knight Mantz Yorke | | 0，，12： | 1 |
| 15 | The effect of experimental design on the modeling of a tablet coating formulation using artificial neural netwoks显示文摘 | Plumb A Philip Rowe Raymond C York Peter | 2002 | European Journal of Pharmaceutical Sciences2002，16，： | 1 |
| 16 | Optimisation of the predictive ability of artificial neural network (ANN) models:A comparison of three ANN programs and four classes of training algorithm显示文摘 | A.Philip Plumb Raymond C.Rowe Peter York | | 0，，4： | 1 |
| 17 | Embedding employability into the curriculum显示文摘 | Mantz Yorke Peter T Knight | 2006 | York: High Education Academy2006，，1： | 1 |
| 18 | Active integrated antennas显示文摘 | KAI CHANG ROBERT A YORK PETER S HALL etal | 2002 | IEEE Transactions on Microwave Theory and Techniques2002，50，3： | 1 |
| 19 | Employability through the curriculum 显示文摘 | PETER Knight MANTZ Yorke | 2002 | Tertiary Education and Management2002，，12： | 1 |
| 20 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
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