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| 1 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
| 2 | Study on Flexible Power Generation Device Using Piezoelectric Film显示文摘 | Yoshikazu Tanaka Keitaro Matsumura Hidemi Mutsuda | 2012 | Journal of Energy and Power Engineering2012，6，3： | 2 |
| 3 | Recent Progress of Flower Colour Modification by Biotechnology 显示文摘 | YOSHIKAZU TANAKA FILiPPA BRUGLIERA STEVE CHANDLER | 2009 | Int J Mol Sei2009，10，： | 1 |
| 4 | Expression of Δ6, Δ5 desaturase and GLELO elongase genes from Mortierella alpina for production of arachidonic acid in soybean [ Glycine max (L.) Merrill] seeds显示文摘 | Ren Chen Keisuke Matsui Miyuki Ogawa Mieko Oe Misa Ochiai Hiroshi Kawashima Eiji Sakuradani Sakayu Shimizu Masao Ishimoto Makoto Hayashi Yoshikatsu Murooka Yoshikazu Tanaka | 2005 | Plant Science2005，，2： | 1 |
| 5 | Heat resistence properities of poly (p phenylene-2, 6-benzobisoxazole) fiber显示文摘 | Tadao Kuroki Yoshikazu Tanaka Toshiki Hokudoh | 1997 | J Appl Polym Sci1997，65，5： | 1 |
| 6 | Seeing is believing: engineering anthocyanin and carotenoid biosynthetic pathways显示文摘 | Yoshikazu Tanaka Akemi Ohmiya | 2008 | Current Opinion in Biotechnology2008，，2： | 1 |
| 7 | Genetic engineering in floriculture显示文摘 | Yoshikazu Tanaka Yukihisa Katsumoto Filippa Brugliera John Mason | 2005 | Plant Cell Tissue and Organ Culture2005，，1： | 1 |
| 8 | Heat resistanee properties of poly (p-phenylene 2, 6- benzobisoxazole) fiber 显示文摘 | Kuroki Tadao Tanaka Yoshikazu Hokudoh Toshiaki | 1997 | Journal of Applied Polymer Science1997，65，5： | 1 |
| 9 | Heat Resistence Properities of Poly(p-phenylene-2,6-benzobisoxazole) Fiber显示文摘 | Tadao Kuroki Yoshikazu Tanaka Toshiaki Hokudoh | 1997 | Appl Polym Sci1997，，65： | 1 |
| 10 | Changes in tissue blood flow and sympathetic activities to various organs during prolonged hemorrhagic bypotension in monkeys显示文摘 | Satoshi Tanaka Yoshikazu Matsuda Toshishige Shibamoto and Hong-Gang Wang | 1996 | Journal of the Autonomic Nervous System1996，60，3： | 1 |
| 11 | Characteristics of AI doped zinc oxide(ZAO) thin films deposited by RF magnetron sputtering显示文摘 | Satoshi Kobayakawa Yoshikazu Tanaka Ari Ide-Ektessa- bi | 2006 | Nuclear Instru- ments and Methods in Physics Research B2006，249，： | 1 |
| 12 | IFN-[gamma] and TNF-[alpha] Synergistically Induce microRNA-155 Which Regulates TAB2/IP-10 Expression in Human Mesangial Cells显示文摘 | Imaizumi Tadaatsu Tanaka Hiroshi Tajima Atsushi Yokono Yoshikazu Matsumiya Tomoh Yoshida Hidemi Tsuruga Kazushi Aizawa-yashiro Tomomi Hayakari Ryo Inoue Ituro Ito Etsuro Satoh Kei | 2010 | American Journal of Nephrology2010，，5： | 1 |
| 13 | Early dietary treatments with Lorenzo’s oil and docosahexaenoic acid for neurological development in a case with Zellweger syndrome显示文摘 | Kyoko Tanaka Toshiaki Shimizu Yoshikazu Ohtsuka Yuichiro Yamashiro Kyoichi Oshida | 2007 | Brain and Development2007，，9： | 1 |
| 14 | The Relationship Between the Anatomy of the Nuchal Ligament and Postoperative Axial Pain After Cervical Laminoplasty: Cadaver and Clinical Study显示文摘 | Atsushi Ono Yoshikazu Tonosaki Takuya Numasawa Kanichiro Wada Yoshihito Yamasaki Toshihiro Tanaka Gentaro Kumagai Shuichi Aburakawa Kazunari Takeuchi Toru Yokoyama Kazumasa Ueyama Yasuyuki Ishibashi Satoshi Toh | 2012 | Spine2012，，26： | 1 |
| 15 | Wind Energy Harvesting Using Flexible Piezoelectric Device显示文摘 | Hidemi Mutsuda Junpei Miyagi Yasuaki Doi Yoshikazu Tanaka | 2013 | Journal of Energy and Power Engineering2013，7，6： | 1 |
| 16 | Biosynthesis of plant pigments: anthocyanins, betalains and Carotenoids显示文摘 | Yoshikazu Tanaka Nobuhiro Sasaki Akemi Ohmiya | 2008 | The Plant Journal2008，54，： | 1 |
| 17 | Two flavonoid glucosyltransferases from Petunia hybrida: molecular cloning, biochemical properties and developmentally regulated expression显示文摘 | Mami Yamazaki Emiko Yamagishi Zhizhong Gong Masako Fukuchi-Mizutani Yuko Fukui Yoshikazu Tanaka Takaaki Kusumi Masaatsu Yamaguchi Kazuki Saito | 2002 | Plant Molecular Biology2002，，4： | 1 |
| 18 | Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study显示文摘 | Shigeatsu Endo Yasushi Suzuki Gaku Takahashi Tatsuyori Shozushima Hiroyasu Ishikura Akira Murai Takeshi Nishida Yuhei Irie Masanao Miura Hironobu Iguchi Yasuo Fukui Kimiaki Tanaka Tsuyoshi Nojima Yoshikazu Okamura | 2012 | Journal of Infection and Chemotherapy2012，，6： | 1 |
| 19 | Myoepithelial hamartoma of the small bowel: Report of a case显示文摘 | Noritake Tanaka Tomoko Seya Masahiko Onda Yoshikazu Kanazawa Zenya Naitoh Goro Asano Kunihiko Hao | 1996 | Surgery Today1996，，12： | 1 |
| 20 | Flower colour and cytochromes P450显示文摘 | Yoshikazu Tanaka | 2006 | Phytochemistry Reviews2006，，2： | 1 |
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