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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Phosphate removal from domestic wastewater using thermally modified steel slag显示文摘This study was performed to investigate the removal of phosphate from domestic wastewater using a modified steel slag as the adsorbent. The adsorption effects of alkalinity, salt, water,and thermal modification were investigated. The results showed that thermal activation at 800℃ for 1 hr was the optimum operation to improve the adsorption capacity. The adsorption process of the thermally modified slag was well described by the Elovich kinetic model and the Langmuir isotherm model. The maximum adsorption capacity calculated from the Langmuir model reached 13.62 mg/g. Scanning electron microscopy indicated that the surface of the modified slag was cracked and that the texture became loose after heating. The surface area and pore volume did not change after thermal modification. In the treatment of domestic wastewater, the modified slag bed(35.5 kg) removed phosphate effectively and operated for 158 days until the effluent P rose above the limit concentration of 0.5 mg/L. The phosphate fractionation method, which is often applied in soil research, was used to analyze the phosphate adsorption behavior in the slag bed. The analysis revealed that the total contents of various Ca–P forms accounted for 81.4%–91.1%, i.e., Ca10–P 50.6%–65.1%, Ca8–P 17.8%–25.0%,and Ca2–P 4.66%–9.20%. The forms of Al–P, Fe–P, and O–P accounted for only 8.9%–18.6%. The formation of Ca10–P precipitates was considered to be the main mechanism of phosphate removal in the thermally modified slag bed. | Jian Yu Wenyan Liang Li Wang Feizhen Li Yuanlong Zou Haidong Wang | 2015 | Journal of Environmental Sciences2015，27，5： | 13 |
| 3 | Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways显示文摘Objective: Despite evidence that estrogens and insulin are involved in the development and progression of many cancers, their synergistic role in endometrial carcinoma(EC) has not been analyzed yet.Methods: Here, we investigated how estrogens act synergistically with insulin to promote EC progression. Cell growth in vitro and in vivo, effects of estradiol and insulin on apoptosis and cell cycle distribution, and expression and activation of estrogen receptor(ER), insulin receptor(InsR), and key proteins in the PI3K and MAPK pathways were examined after combined stimulation with estradiol and insulin.Results: Compared to EC cells treated with estradiol or insulin alone, those treated with both estradiol and insulin exhibited stronger stimulation. Estradiol significantly induced phosphorylation of InsR-β and IRS-1, whereas insulin significantly induced phosphorylation of ER-α. In addition, treatment with both insulin and estradiol together significantly increased the expression and phosphorylation of Akt, MAPK, and ERK. Notably, InsR-β inhibition had a limited effect on estradiol-dependent proliferation,cell cycle, and apoptosis, whereas ER-α inhibition had a limited insulin-dependent effect, in EC cell lines. Insulin and estradiol individually and synergistically promoted EC xenograft growth in mice.Conclusions: Estrogen and insulin play synergistic roles in EC carcinogenesis and progression by activating InsR-β and ER-α,promoting a crosstalk between them, and thereby resulting in the activation of downstream PI3K/Akt and MAPK/ERK signaling pathways. | Wenyan Tian Fei Teng Jinping Gao Chao Gao Guoyan Liu Yanfang Zhang Shizhu Yu Wei Zhang Yingmei Wang Fengxia Xue | 2019 | Cancer Biology & Medicine2019，16，1： | 6 |
| 4 | Characterization of OP9 as authentic mesenchymal stem cell line显示文摘Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into various cell types,including osteocytes,chondrocytes,adipocytes,myocytes,and tenocytes.However,the difficulty or failure in expanding the mouse MSCs in vitro greatly hampered important research in animal models.The OP9,a stromal cell line from mouse bone marrow,has hematopoietic supportive capacity.Here,we report that the OP9 has the immunophenotype (CD45-,CD11b-,FLK-1-,CD31-,CD34-,CD44+,CD29+,Sca-1+,CD86-,and MHCII-) identical to canonical mouse MSCs.The expression of CD140a+,CD140b+,α-SMA+ and Calponin+ suggested the perivascular origin of OP9.Functionally,the OP9 had strong clonogenic ability and could be induced into osteocytes,chondrocytes and adipocytes.The lymphocyte transformation test (LTT) and mixed leukocyte reaction (MLR) showed that the OP9 could suppress T lymphocyte proliferation stimulated by nonspecific mitogens (PHA) or allogeneic lymphocytes (BALB/c T cells).Finally,the migration of OP9 could be efficiently induced by bFGF,IGF-1,IL-3,PDGF-BB,TGF-β1 and TGF-β3.In conclusion,the OP9 were bona fide MSCs,and such homogenous cell line will be helpful to delineate biological features of MSCs at the stem cell level. | Jiao Gao Xin-Long Yan Ren Li Yi Liu Wenyan He Shengkun Sun Yu Zhang Bing Liu Jiaxiang Xiong Ning Mao 1 | 2010 | Journal of Genetics and Genomics2010，37，7： | 3 |
| 5 | Isolation and characterization of emerging subgroup J avian leukosis virus associated with hemangioma in egg-type chickens显示文摘 | Hanzhang Lai Henan Zhang Zhangyong Ning Ruiai Chen Wenyan Zhang Aijian Qing Chaoan Xin Kangzhen Yu Weisheng Cao Ming Liao | 2011 | Veterinary Microbiology2011，，3： | 3 |
| 6 | One-pot synthesis of MoSe2 hetero-dimensional hybrid self-assembled by nanodots and nanosheets for electrocatalytic hydrogen evolution and photothermal therapy显示文摘我们基于铝硒化物设计了并且准备一个异种维的混血儿(HDH )(MoSe 2) nanodots (ND ) 经由一个一个壶在很少层 MoSe 2 nanosheets (NS )(MoSe 2 HDH ) 抛锚了热水的过程。MoSe 2 HDH 向氢进化反应展出优秀 electrocatalytic 活动(她的) 。这是因为在一方面,在 MoSe 2 NSs/NDs 的接口的 MoSe 2 ND 和唯一的充满缺点的结构的边丰富的特征能为她引进更活跃的地点;在另一方面,在支持的电极的表面上像薄片的 MoSe 2 NS 叠的随机可以完成有效费用运输。另外, MoSe 2 HDH 显示出好水稳定性,理想的 biocompatibility,和高度近红外线(NIR ) photothermal 变换效率。因此, MoSe 2 HDH 为癌症在 NIR photothermal 治疗(PTT ) 作为 nanomedicine 被调查。明确地, MoSe 2 HDH 能为计算断层摄影术(CT ) 和 photoacoustic 断层摄影术(PA ) 作为一根双形式的探针被使用由于它的强壮的 X 光检查变细能力和 NIR 吸收的成像。因此, MoSe 2 HDH,有进一个系统的 CT/PA 成像的联合 PTT,为指导成像的癌症 theranostics 的抓住伟人潜力。这个工作可以提供机灵的策略准备另外的异种维的分层的转变金属 dichalcogenides。 | Baoguang Mao Tao Bao Jie Yu Lirong Zheng Jinwen Qin Wenyan Yin Minhua Cao | 2017 | Nano Research2017，10，8： | 3 |
| 7 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 8 | High performance of a unique mesoporous polystyrene-based adsorbent for blood purification显示文摘A multi-functional polystyrene based adsorbent(NKU-9)with a unique mesoporous and a high surface area was prepared by suspension polymerization for removal of therapeutic toxins in blood purification.The adsorbent produced had an almost equal amount of mesopore distribution in the range from 2 to 50 nm.The adsorption of serum toxins with different molecular weights were examined by in vitro adsorption assays and compared with some clinical currently used adsorbents such as HA-330,Cytosorb and BL-300 which are produced by China,America and Japan,respectively.Test results indicated that the adsorption rate for pentobarbital by NKU-9 was 81.24%which is nearly as high as HA-330(81.44%).The latter adsorbent is currently used for acute detoxification treatment in China.To reach adsorption equilibrium,NKU-9 was faster than HA-330,which implies short treatment time.For the removal of middle molecular toxins such as b2-microglobulin(98.88%),NKU-9 performed better adsorptive selectivity than Cytosorb(92.80%).In addition,NKU-9 showed high performance for the removal of albumin-bound toxins(e.g.,bilirubin),and its adsorption rate for total bilirubin(80.79%)in plasma was 8.4%higher than that of anion exchange resin BL-300 which is currently used to eliminate bilirubin in clinic.Therefore,our results indicate that the newly developed adsorbent with a wide distribution and almost equal amount of mesopores is a multifunctional adsorbent for high efficient removal of serum toxins with different molecular weights which might be an excellent blood purification adsorbent especially to treat diseases that conventional medical methods are low or not efficient. | Jian Chen Wenyan Han Jie Chen Wenhui Zong Weichao Wang Yue Wang Guanghui Cheng Chunran Li Lailiang Ou Yaoting Yu | 2017 | Regenerative Biomaterials2017，4，1： | 3 |
| 9 | Energy sources identify metabolic phenotypes n pancreatic cancer显示文摘 | Chen Liang Yi Qin Bo Zhang Shunrong Ji Si Shi Wenyan Xu Jiang Liu Jinfeng Xiang Dingkong Liang Qiangsheng Hu Liang Liu Chen Liu Guopei Luo Quanxing Ni Jin xu Xianjun Yu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 10 | A redox-active conjugated microporous polymer cathode for highperformance lithium/potassium-organic batteries显示文摘Organic redox-active materials have emerged as a class of electrode materials for rechargeable batteries due to their high redox activity,low cost,structure diversity and flexibility.However,the high solubility of organic small molecules in organic electrolytes commonly leads to the fast capacity decay with cycling.Herein,we report a redox-active conjugated microporous polymer of poly(pyrene-co-anthraquinone)(Py Aq)cathode material consisting of pyrene and anthraquinone units.Benefiting from the highly cross-linked polymer structure with insoluble nature in organic electrolytes,the high surface area and the plentiful redox-active carbonyl groups,the Py Aq cathode demonstrates outstanding electrochemical performances for both lithium-ion batteries(LIBs)and potassium-ion batteries(KIBs).Specifically,the Py Aq cathode for LIBs delivers a high reversible capacity of 169 m Ah g^-1 at the current density of 20 m A g^-1,a high rate capability(142 m Ah g^-1 at 1000 m A g^-1)and an excellent cycling stability for 4000 cycles.Additionally,the Py Aq cathode for KIBs also exhibits a high reversible capacity of143 m Ah g^-1 with a long cycling life over 800 cycles.The excellent electrochemical performance demonstrates that the newly developed Py Aq could be an attractive cathode material for the advanced energy storage technologies. | Lian-Wei Luo Chong Zhang Peixun Xiong Yongbo Zhao Wenyan Ma Yu Chen Jing Hui Zeng Yunhua Xu Jia-Xing Jiang | 2021 | Science China Chemistry2021，64，1： | 3 |
| 11 | Monitoring landslide associated with reservoir impoundment using synthetic aperture radar interferometry: A case study of the Yalong reservoir显示文摘The construction of large reservoirs can address the problem of uneven distribution of rivers in time and space,thereby meeting the needs of human production and living.However,the huge elevation of the water level in some areas may modify the distribution of the groundwater level,causing geological disasters,such as surface deformation and landslides.The Yalong reservoir supplies water to the downstream area of Shannan,Tibet;however,since the reservoir started storing water in 2017,the government has discovered two ancient landslides.In this study,to monitor the deformation of the Yalong reservoir since its construction in 2014,we first used synthetic aperture radar(SAR) data and the multidimensional small baseline subset(MSBAS) method to obtain the deformation in the east-west and vertical directions.The result indicated the presence of three large,slow-moving landslides:Landslides I and II,located on the right bank of the Yalong reservoir,which are consistent with the results obtained by the actual survey,and a new discovery,Landslide Ⅲ,located on the left side of the reservoir.Meanwhile,the experimental results indicated that the dam had undergone obvious deformation after impoundment,which should not be ignored.The global positioning system and interferometric SAR(InSAR) timeseries deformation residual data were used to verify the accuracy of the InSAR method.The results also showed that the deformation caused by the three landslides had te nded to accele rate after the rese rvoir’s impoundment,and that the failure mode was retrogressive landslide.We found that InSAR plays a vital role in landslide detection and failure mode research around reservoirs,and assists in providing early warning for subsequent landslide disasters. | Zhe Liu Bing Xu Qijie Wang Wenyan Yu Zelang Miao | 2022 | Geodesy and Geodynamics2022，13，2： | 2 |
| 12 | Basic helix-loop-helix(bHLH)transcription factor MdbHLH3 negatively affects the storage performance of postharvest apple fruit显示文摘The storage period of fleshy fruits greatly affects their quality and selection,and is largely controlled by genetic factors.Therefore,it is imperative to elucidate how genetic factors affect fruit ripening and its storage.Here,we evaluated the postharvest storage properties of the basic helix-loop-helix(bHLH)transcription factor MdbHLH3-overexpressing transgenic Royal gala apple fruits.During storage,the contents of starch,malic acid,fructose,glucose,and sucrose in fruits of three MdbHLH3 transgenic lines were always higher than those of the wild-type(WT)control.Interestingly,the sugar-acid ratio also showed the same trend during fruit storage.Additionally,the fruit firmness decreased with increasing storage time,and the contents of cell wall components such as water-soluble pectin and cellulose in transgenic fruits were higher than those in control fruits,while the firmness of transgenic fruits was lower than that in WT control fruits.Though the ethylene release rate in both showed the same trend(firstly increasing,then decreasing,and finally peaking)in 90-day stored fruits,transgenic apples had higher ethylene levels than the WT control throughout storage.Furthermore,the activities of membrane peroxidase,antioxidant enzymes,and fruit ripening enzymes in all transgenic fruits were significantly higher than those in the WT control.Thus,our findings show how MdbHLH3 negatively regulates and reduces apple storage time.This may prove useful for not only developing biotechnological strategies,but also support traditional breeding programs,to help improve the storage time of fleshy fruits. | Wenyan Wang Jianqiang Yu Mengchi Du Jiahui Wang Dagang Hu | 2022 | Horticultural Plant Journal2022，8，6： | 2 |
| 13 | SETD8 induces stemness and epithelial–mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression显示文摘Pancreatic cancer(PC)is one of the most deadly diseases,and its incidence is increasing year by year.The methyltransferase SETD8 has been demonstrated to play an important role in tumor cell proliferation and metastasis.However,little is known about whether SETD8 could affect the invasion and metastasis of PC and the mechanism underlying the regulation.Based on our previous report,here,we further found that SETD8 could promote the invasion and migration of PC cells by inducing the expression of receptor tyrosine kinase-like orphan receptor 1(ROR1).ROR1 was predominantly upregulated in PC tissues and was correlated with lymph node metastasis and worse prognosis.Mechanistically,SETD8 mediated ROR1 activity and regulated PC cells invasion and migration,although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.This promotion effect disappeared when the catalytically inactive mutant SETD8 was overexpressed,which could be counteracted by the SETD8-specific methyltransferase inhibitor UNC0379.Collectively,our results demonstrate that SETD8 may be a novel prognostic factor and a therapeutic target of PC. | Mengqi Liu Yihua Shi Qiangsheng Hu Yi Qin Shunrong Ji Wensheng Liu Qifeng Zhuo Guixiong Fan Zeng Ye Changfeng Song Xianjun Yu Xiaowu Xu Wenyan Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 14 | FGFBPI-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer显示文摘Fibroblast growth factor-binding protein 1(FGFBP1)promotes fibroblast growth factor(FGF)activity by releasing FGFs from extracellular matrix storage.We previously reported that the tumor suppressor F-box and WD repeat domain-containing 7 suppresses FGFBP1 by reducing expression of c-Myc,which inhibits the proliferation and migration of pancreatic cancer cells.However,the potential mechanism by which FGFBP1 facilitates pancreatic ductal adenocarcinoma(PDAC)remains unexplored.In this study,we focused on the function of FGFBP1 in the interplay between cancer-associated fibroblasts(CAFs)and pancreatic cancer cells(PCCs).Decreased FGF22 expression was detected in CAFs co-cultured with PCCs with FGFBP1 abrogation,which was verified in the cell culture medium by enzyme-linked immunosorbent assay.Active cytokine FGF22 significantly facilitated the migration and invasion of PANC-1 and Mia PaCa-2 cells.The number of penetrating PCCs cocultured with CAFs with FGF22 abrogation was significantly less than that of the control group.Interestingly,higher expressions of FGF22 and fibroblast growth factor receptor 2(FGFR2)were associated with worse prognosis of patients with PDAC and FGFR2,an independent prognostic marker of PDAC.The PANC-1 and Mia PaCa-2 cells with silenced FGFR2 showed weaker invasion and metastasis,even if these cells were simultaneously treated with cytokine FGF22.These results revealed that FGFBPI-mediated interaction between CAFs and PCCs via FGF22/FGFR2 facilitates the migration and invasion of PCCs.FGFR2 could act as a prognostic marker for patients with PDAC. | Zheng Zhang Yi Qin Shunrong Ji Wenyan Xu Mengqi Liu Qiangsheng Hu Zeng Ye Guixiong Fan Xianjun Yu Wensheng Liu Xiaowu Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 2 |
| 15 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 16 | LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process显示文摘 | Yi Qin Wenwei Zhu Wenyan Xu Bo Zhang Si Shi Shunrong Ji Jiang Liu Jiang Long Chen Liu Liang Liu Jin Xu Xianjun Yu | 2014 | Cancer Letters2014，，： | 1 |
| 17 | Flocculation of microcystis aeruginosa using modified larch tannin 显示文摘 | Wang Li Liang Wenyan Yu Jian | 2013 | Environmental Science & Technology2013，47，11： | 1 |
| 18 | Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer显示文摘 | Si Shi Shunrong Ji Yi Qin Jin Xu Bo Zhang Wenyan Xu Jiang Liu Jiang Long Chen Liu Liang Liu Quanxing Ni Xianjun Yu | 2015 | Cancer Letters2015，，2： | 1 |
| 19 | Brain natriuretic peptide is related to carotid plaques and predicts atherosclerosis in pre-dialysis patients with chronic kidney disease显示文摘 | Wenyan Zhou Zhaohui Ni Zanzhe Yu Beili Shi Qin Wang | 2012 | European Journal of Internal Medicine2012，，6： | 1 |
| 20 | Combined cell grafting and VPA administration facilitates neural repair through axonal regeneration and synaptogenesis in traumatic brain injury显示文摘Neuronal regeneration and functional recovery are severely compromised following traumatic brain injury(TBl).Treatment options,including cell transplantation and drug therapy,have been shown to benefit TBl,although the underlying mechanisms remain elusive.In this study,neural stem cells(NSCs)are transplanted into TBl-challenged mice,together with olfactory ensheathing cells(OECs)or followed by valproic acid(VPA)treatment.Both OEC grafting and VPA treatment facilitate the differentiation of NSCs into neurons(including endogenous and exogenous neurons)and significantly attenuate neurological functional defects in TBl mice.Combination of NSCs with OECs or VPA administration leads to overt improvement in axonal regeneration,synaptogenesis,and synaptic plasticity in the cerebral cortex in TBl-challenged mice,as shown by retrograde corticospinal tract tracing,electron microscopy,growth-associated protein 43(GAP43),and synaptophysin(SYN)analyses.However,these beneficial effects of VPA are reversed by local delivery of N-methyl-D-aspartate(NMDA)into tissues surrounding the injury epicenter in the cerebral cortex,accompanied by a pronounced drop in axons and synapses in the brain.Our findings reveal that increased axonal regeneration and synaptogenesis evoked by cell grafting and VPA fosters neural repair in a murine model of TBl.Moreover,VPA-induced neuroprotective roles are antagonized by exogenous NMDA administration and its concomitant decrease in the number of neurons of local brain,indicating that increased neurons induced by VPA treatment mediate axonal regeneration and synaptogenesis in mice after TBl operation.Collectively,this study provides new insights into NSC transplantation therapy for TBI. | Sujuan Liu Haili Tian Yanmei Niu Chunxia Yu Lingjian Xie Zhe Jin Wenyan Niu Jun Ren Li Fu Zhi Yao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 1 |
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