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| 1 | A new type of internal solitary waves with a re-appearance period of 23 h observed in the South China Sea显示文摘The South China Sea (SCS), in particular the northern SCS, is one of ocean areas where energetic internal solitary waves (ISWs)occur most frequently (Cai et al., 2012; Zheng, 2017). Based on the re-appearance period (RP) at an observation station, Ramp et al.(2004) divided the ISWs into two types:Type-a and Type-b. Type-a ISWs arrive regularly at the same time every day, i.e., the RP is about 24 h, and Type-b ISWs arrive about one hour late every day, i.e., the RP is about 25 h. The discovery of the Types-a and b | CHEN Liang ZHENG Quanan XIONG Xuejun YUAN Yeli XIE Huarong | 2018 | Acta Oceanologica Sinica2018，37，9： | 7 |
| 2 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 3 | An open conformation determined by a structural switch for 2A protease from coxsackievirus A16显示文摘Coxsackievirus A16 belongs to the family Picornaviridae,and is a major agent of hand-foot-and-mouth disease that infects mostly children,and to date no vaccines or antivi-ral therapies are available.2A protease of enterovirus is a nonstructural protein and possesses both self-cleavage activity and the ability to cleave the eukaryotic translation initiation factor 4G.Here we present the crystal structure of coxsackievirus A162A protease,which interestingly forms hexamers in crystal as well as in solution.This structure shows an open conformation,with its active site accessible,ready for substrate binding and cleav-age activity.In conjunction with a previously reported“closed”state structure of human rhinovirus 2,we were able to develop a detailed hypothesis for the conforma-tional conversion triggered by two“switcher”residues Glu88 and Tyr89 located within the bll2-cII loop.Substrate recognition assays revealed that amino acid residues P1′,P2 and P4 are essential for substrate specificity,which was verifi ed by our substrate binding model.In addition,we compared the in vitro cleavage effi ciency of 2A pro-teases from coxsackievirus A16 and enterovirus 71 upon the same substrates by fl uorescence resonance energy transfer(FRET),and observed higher protease activity of enterovirus 71 compared to that of coxsackievirus A16.In conclusion,our study shows an open conformation of coxsackievirus A162A protease and the underlying mechanisms for conformational conversion and substrate specifi city.These new insights should facilitate the future rational design of effi cient 2A protease inhibitors. | Yao Sun Xiangxi Wang Shuai Yuan Minghao Dang Xuemei Li Xuejun CZhang Zihe Rao | 2013 | Protein & Cell2013，4，10： | 3 |
| 4 | Mooring observed mode-2 internal solitary waves in the northern South China Sea显示文摘The mode-2 internal solitary waves(ISWs)generated by mode-2 internal tide(IT)are identified by mooring observations in the northern South China Sea(SCS)from 2016 to 2017.Two mode-2 ISWs with a re-appearance period of 24.9 h observed on 29 and 30 July 2016 are characterized by type-b ISWs.They occurred when the isotherms compressed obviously in the vertical direction.Modal decomposition of IT horizontal currents shows that the vertical compression of the isotherms is mainly caused by diurnal mode-2 IT.The analysis of the role of the density stratification reveals that a deeper and thinner pycnocline is favorable for generation of mode-2 ISWs rather than pycnocline intensity.By comparing the mode-2 nonlinear,dispersion coefficients and the Ursell numbers calculated based on the stratification associated with different kinds of ITs with the observation results,it is shown that the diurnal mode-2 IT plays a crucial role in the generation of the mode-2 ISWs.When the diurnal mode-2 IT interacts with the semidiurnal IT and causes a deeper and thinner pycnocline,the mode-2 ISWs are easily excited. | Liang Chen Xuejun Xiong Quanan Zheng Yeli Yuan Long Yu Yanliang Guo Guangbing Yang Xia Ju Jia Sun Zhenli Hui | 2020 | Acta Oceanologica Sinica2020，39，11： | 3 |
| 5 | HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways显示文摘Dimerization among the EGFR family of tyrosine kinase receptors leads to allosteric activation of the kinase domains of the partners.Unlike other members in the family,the kinase domain of HER3 lacks key amino acid residues for catalytic activity.As a result,HER3 is suggested to serve as an allosteric activator of other EGFR family members which include EGFR,HER2 and HER4.To study the role of intracellular domains in HER3 dimerization and activation of downstream signaling pathways,we constructed HER3/HER2 chimeric receptors by replacing the HER3 kinase domain(HER3-2-3)or both the kinase domain and the C-terminal tail(HER3-2-2)with the HER2 counterparts and expressed the chimeric receptors in Chinese hamster ovary(CHO)cells.While over expression of the intact human HER3 transformed CHO cells with oncogenic properties such as AKT/ERK activation and increased proliferation and migration,CHO cells expressing the HER3-2-3 chimeric receptor showed significantly reduced HER3/HER2 dimerization and decreased phosphorylation of both AKT and ERK1/2 in the presence of neuregulin-1(NRG-1).In contrast,CHO cells expressing the HER3-2-2 chimeric receptor resulted in a total loss of downstream AKT activation in response to NRG-1,but maintained partial activation of ERK1/2.The results demonstrate that the intracellular domains play a crucial role in HER3’s function as an allosteric activator and its role in downstream signaling. | Byung-Kwon Choi Xiumei Cai Bin Yuan Zhao Huang Xuejun Fan Hui Deng Ningyan Zhang Zhiqiang An | 2012 | Protein & Cell2012，3，10： | 3 |
| 6 | Olfactory and gustatory dysfunctions of COVID-19 patients in China:A multicenter study显示文摘Introduction:With the spread of the epidemic worldwide,an increasing number of doctors abroad have observed the following atypical symptoms of coronavirus disease 2019(COVID-19):olfactory or taste disorders.Therefore,clarifying the incidence and clinical characteristics of olfactory and taste disorders in Chinese COVID-19 patients is of great significance and urgency.Materials and Methods:A retrospective study was conducted,which included 229 severe acute respiratory syndrome coronavirus 2 confirmed patients,through face-to-face interviews and telephone follow-up.Following the completion of questionnaires,the patients participating in the study,were categorized according to the degree of olfactory and taste disorders experienced,and the proportion of each clinical type of patient with olfactory and taste disorders and the time when symptoms appeared were recorded.Results:Among the 229 patients,31(13.54%)had olfactory dysfunction,and 44(19.21%)had gustatory dysfunction.For the patients with olfactory dysfunction,6(19.35%)developed severe disease and became critically ill.Olfactory dysfunction appeared before the other symptoms in 21.43%of cases.The proportion of females with olfactory and gustatory dysfunction was higher than that of males(P<0.001).Conclusions:The incidence of olfactory and gustatory dysfunction was much lower than that reported abroad;the prognosis of patients with olfactory dysfunction is relatively favorable;olfactory and gustatory dysfunction can be used as a sign for early screening;females are more prone to olfactory and gustatory dysfunction. | Jianhui Li Yi Sun Enqiang Qin Hu Yuan Mingbo Liu Wenqi Yi Zhu Chen Chengcheng Huang Fengjie Zhou Ruiyao Chen Leibo Zhang Ning Yu Qiong Liu Xuejun Zhou Jingjing He Boyu Li Fusheng Wang Changliang Yang Shiming Yang | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，4： | 2 |
| 7 | Contrasting effects of nitrogen addition on litter decomposition in forests and grasslands in China显示文摘Nitrogen(N)addition has profound impacts on litter-mediated nutrient cycling.Numerous studies have reported different effects of N addition on litter decomposition,exhibiting positive,negative,or neutral effects.Previous meta-analysis of litter decomposition under N addition was mainly based on a small number of samples to allow comparisons among ecosystem types.This study presents the results of a meta-analysis incorporating data from 53 published studies(including 617 observations)across forests,grasslands,wetlands,and croplands in China,to investigate how environmental and experimental factors impact the effects of N addition on litter decomposition.Averaged across all of the studies,N addition significantly slows litter decomposition by 7.02%.Considering ecosystem types,N addition significantly accelerates litter decomposition by 3.70%and 11.22%in grasslands and wetlands,respectively,clearly inhibits litter decomposition by 14.53%in forests,and has no significant effects on litter decomposition in croplands.Regarding the accelerated litter decomposition rate in grasslands due to N addition,litter decomposition rate increases slightly with increasing rates of N addition.However,N addition slows litter decomposition in forests,but litter decomposition is at a significantly increasing rate with increasing amounts of N addition.The responses of litter decomposition to N addition are also influenced by the forms of N addition,experiential duration of N addition,humidity index,litter quality,and soil pH.In summary,N addition alters litter decomposition rate,but the direction and magnitude of the response are affected by the forms of N addition,the rate of N addition,ambient N deposition,experimental duration,and climate factors.Our study highlights the contrasting effects of N addition on litter decomposition in forests and grasslands.This finding could be used in biogeochemical models to better evaluate ecosystem carbon cycling under increasing N deposition due to the differential responses of litter decomposition to N addition rates and ecosystem types. | SU Yuan MA Xiaofei GONG Yanming LI Kaihui HAN Wenxuan LIU Xuejun | 2021 | Journal of Arid Land2021，13，7： | 2 |
| 8 | A NEW APPROACH TO HOLISTIC NITROGEN MANAGEMENT IN CHINA显示文摘Since the 1980s,the widespread use of N fertilizer has not only resulted in a strong increase in agricultural productivity but also caused a number of environmental problems,induced by excess reactive N emissions.A range of approaches to improve N management for increased agricultural production together with reduced environmental impacts has been proposed.The 4R principles(right product,right amount,right time and right place)for N fertilizer application have been essential for improving crop productivity and N use efficiency while reducing N losses.For example,site-specific N management(as part of 4R practice)reduced N fertilizer use by 32%and increased yield by 5%in China.However,it has not been enough to overcome the challenge of producing more food with reduced impact on the environment and health.This paper proposes a new framework of food-chainnitrogen-management(FCNM).This involves good N management including the recycling of organic manures,optimized crop and animal production and improved human diets,with the aim of maximizing resource use efficiency and minimizing environmental emissions.FCNM could meet future challenges for food demand,resource sustainability and environmental safety,key issues for green agricultural transformation in China and other countries. | Xuejun LIU Zhenling CUI Tianxiang HAO Lixing YUAN Ying ZHANG Baojing GU Wen XU Hao YING Weifeng ZHANG Tingyu LI Xiaoyuan YAN Keith GOULDING David KANTER Robert HOWARTH Carly STEVENS Jagdish LADHA Qianqian LI Lei LIU Wim DE VRIES Fusuo ZHANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 2 |
| 9 | Damage evolution of yttria-stabilized zirconia induced by He irradiation显示文摘 | Tengfei Yang Xuejun Huang Yuan Gao Chenxu Wang Yanwen Zhang Jianming Xue Sha Yan Yugang Wang | 2011 | Journal of Nuclear Materials2011，，1： | 1 |
| 10 | Preparation and characterization of hydrophobic TiO 2 pillared clay: The effect of acid hydrolysis catalyst and doped Pt amount on photocatalytic activity显示文摘 | Xuejun Ding Taicheng An Guiying Li Shanqing Zhang Jiaxin Chen Jianmei Yuan Huijun Zhao Hui Chen Guoying Sheng Jiamo Fu | 2008 | Journal of Colloid And Interface Science2008，，： | 1 |
| 11 | Treatment of the wastewater containing low-level 241 Am using flocculation-microfiltration process显示文摘 | Gao Yong Zhao Jun Zhang Guanghui Zhang Dong Cheng Weiwen Yuan Guoqi Liu Xuejun Ma Bangzhong Zeng Junhui Gu Ping | 2004 | Separation and Purification Technology2004，，2： | 1 |
| 12 | Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability显示文摘位于表皮的生长下面的分子的机制在线粒体的因素受体(EGFR ) 本地化仍然保持大部分未知。用有免疫力的电子显微镜学,我们验证了那 EGFR 能在也上局部性外部或线粒体的内部膜。变异的受体缺乏的氨基酸 646660 在移植是有缺陷的到细胞器上,而有有缺点的 endocytosis 的变异的受体显示出在表皮的生长因素(EGF ) 的刺激之上移动到线粒体上的一个更大的能力。Gefitinib, EGFR kinase 的一个禁止者,在还,处理的短时间仅仅在暴露的更长的时间以后减少了房间生存能力以及 mitochondrial EGFR 的数量以后,禁止了受体 endocytosis。而且,当房间暴露于 apoptotic inducer etoposide 时, mitochondrial EGFR 转移的内容被减少。通常在 mitochondrial EGFR 与衰落与一致的导致 EGF 的规划房间死亡。这些数据显示 mitochondrial 局部性的 EGFR 独立于它的成为主观并且可以与房间幸存被相关并且参予导致 ligand 的规划房间死亡。 | Yuan Yao Gang Wang Zhe Li Bing Yan Yinglu Guo Xuejun Jiang Zhijun Xi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 1 |
| 13 | Methane conversion in the presence of oxygen under low-temperature radio frequency plasma显示文摘Methane conversion in the presence of oxygen under low-temperature radio frequency (RF) plasma was investigated.The experiment results indicated that the following four factors,i.e.,discharge voltage,discharge area,O2/CH4 molar ratio and total gas flowrate,affected remarkably the reaction performance.The optimum reaction conditions of methane conversion in the presence of O2 under RF plasma are as follows:discharge voltage 1050 V,discharge area 989.1mm 2,O2/CH4 molar ratio 1/10 and total gas flowrate 200 ml/min.A methane conversion of 91% could be reached under the optimum conditions.Oxygen is good for the breaking of C-H bonds and also acts as a sort of thinner.According to the low-temperature plasma characteristics,the macroscopic kinetics model of methane conversion in the presence of O2 under radio frequency plasma was studied. | Jinhai Yuan Xuejun Zhong Shiyu Tan | 2010 | Journal of Natural Gas Chemistry2010，19，6： | 1 |
| 14 | Development of a PDRA Method for Detection of the D614G Mutation in COVID-19 Virus—Worldwide,2021显示文摘ABSTRACT Background:COVID-19 infection is a major public health problem worldwide,and the D614G mutation enhances the infectivity of COVID-19.Methods:A probe-directed recombinase amplification(PDRA)assay was discussed to detect the D614G mutation at 39℃for 30 min.The sensitivity,specificity,and reproducibility of the PDRA were evaluated by D614 and G614 recombinant plasmids.The clinical performance of PDRA assay was validated by testing of 53 previously confirmed COVID-19 positive RNAs and 10 negative samples.Direct sequencing was carried out in parallel for comparison.Result:With good reproducibility and specificity,the PDRA assay worked well with the concentration in the range of 103–107 copies/reaction.Compared with direct sequencing as a reference,the recombinase-aided amplification(RAA)assay obtained 100%sensitivity and 100%specificity using clinical samples. | Ziwei Chen Xinxin Shen Ji Wang Xiang Zhao Yuan Gao Ruiqin Zhang Jinrong Wang Leping Liu Xinmin Nie Xuejun Ma | 2021 | China CDC weekly2021，3，21： | 1 |
| 15 | Syntheses of CuO nanostructures in ionic liquids显示文摘A simple and efficient approach is developed to fabricate single-crystalline CuO nanostructures through an ionic liquid assisted one-step low-temperature solid-state route.Both nanoparticles(5 nm in size)and nanorods(5-10 nm in diameter and 50-100 nm in length)of monoclinic CuO were obtained. These synthesized CuO nanostructures were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),selected area electron diffraction(SAED),X-ray photoelectron spectros- copy(XPS),energy dispersive spectroscopy(EDS)and nitrogen adsorption analysis.The morpholo- gies of the nanostructures can be controlled by tuning the amount of NaOH and ionic liquids.The growth mechanism of CuO nanostructures is investigated. | WANG Li ZHAO Bin YUAN ZhongYong ZHANG XueJun Wu QingDuan CHANG LiXian ZHENG WenJun | 2007 | Science China Chemistry2007，50，1： | 1 |
| 16 | Strong genetic differentiation of the East-Himalayan Megacodon stylophorus (Gentianaceae) detected by inter-simple sequence repeats (ISSR)显示文摘 | Ge Xuejun Zhang Linbing Yuan Yongmin | | 0，，4： | 1 |
| 17 | Recent advances in the synthesis of C-oligosaceharides显示文摘 | Yuan Xuejun Robert J L | 2005 | Curr Top Med Chem2005，5，14： | 1 |
| 18 | Kinetic and thermodynamic studies of adsorption of gallium(Ⅲ) on nano-TiO_2显示文摘Nano-TiO2 was employed for the adsorption of gallium from aqueous solution in batch equilibrium experiments to investigate its adsorption properties. It was found that the adsorption efficiency of Ga(Ⅲ) was more than 96% at pH 3.0. The adsorption capacities and rates of Ga(Ⅲ) onto nano-TiO2 were evaluated as a function of solution concentration and temperature. The results were analyzed using the Langmuir adsorption isotherms. Adsorption isothermal data could be well interpreted by the Langmuir model. The mean energy of adsorption, 15.81 kJ·mol-1, was calculated from the D-R adsorption isotherm. The kinetic experimental data properly correlate with the pseudo-second-order kinetic model. The thermodynamic parameters for the process of adsorption have been estimated. The △ H Οand △ GΟvalues of gallium(Ⅲ) adsorption on nano-TiO2 showed an endothermic and spontaneous nature of adsorption. | ZHANG Lei ZHU Yuan LI Hongmei LIU Na LIU Xueyan GUO Xuejun | 2010 | Rare Metals2010，29，1： | 1 |
| 19 | High Selectivity for Metal Ion Adsorption: from Mesoporous Phosphonated Titanias to Meso-/Macroporous Titanium Phosphonates 显示文摘 | Ma Tianyi Zhang Xuejun Yuan Zhongyong | 2009 | J Mater Sci2009，44，24： | 1 |
| 20 | The “resultantbifurcation diagram” method and its application tobifurcation behaviors of a symmetric railway bogiesystem显示文摘 | GAO Xuejun LI Yinghui YUE Yuan | 2012 | Nonlinear Dynamics2012，70，1： | 1 |
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