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| 1 | Explicit diagnosis of the local ozone production rate and the ozone-NOx-VOC sensitivities显示文摘In the troposphere, ozone is a harmful gas compound to both human health and vegetation. Ozone is produced from the reaction of NO_x(@NO + NO_2) and VOCs(volatile organic compounds) with light. Due to the highly nonlinear relationships between ozone and its precursors, proper ozone mitigation relies on the knowledge of chemical mechanisms. In this study, an observation-based method is used to simulate ozone formation and elucidate its controlling factors for a rural site on the North China Plain. The instantaneous ozone production rate is calculated utilizing a box model using the dataset obtained from the Wangdu campaign. First, the model was operated in a time-dependent mode to calculate the ozone production rate at each time stamp. The calculated ozone formation rate showed a diurnal average maximum value of 17 ppbv/h(1-h diurnal averaged). The contribution of individual peroxy radicals to ozone production was analyzed. In addition, the functional dependence of calculated P(O_3) reveals that ozone production was in a NO_x-limited regime during the campaign. Furthermore, the missing peroxy radical source will further extend NO_x-limited conditions to earlier in the day, making NO_xlimitation dominate more of a day than the current chemical model predicts. Finally, a multiple scenarios mode,also known as EKMA(empirical kinetic modeling approach), was used to simulate the response of P(O_3) to the imaginary change in precursor concentrations. We found that ozone production was in the NO_x-limited region. However, the use of NO_2 measured by the molybdenum converter and/or the absence of a peroxy radical source in the current chemical model could over-emphasize the VOC-limited effect on ozone production. | Zhaofeng Tan Keding Lu Huabin Dong Min Hu Xin Li Yuhan Liu Sihua Lu Min Shao Rong Su Haichao Wang Yusheng Wu Andreas Wahner Yuanhang Zhang | 2018 | Science Bulletin2018，63，16： | 25 |
| 2 | Exploring atmospheric free-radical chemistry in China:the self-cleansing capacity and the formation of secondary air pollution显示文摘Since 1971,it has been known that the atmospheric free radicals play a pivotal role in maintaining the oxidizing power of the troposphere.The existence of the oxidizing power is an important feature of the troposphere to remove primary air pollutants emitted from human beings as well as those from the biosphere.Nevertheless,serious secondary air-pollution incidents can take place due to fast oxidation of the primary pollutants.Elucidating the atmospheric free-radical chemistry is a demanding task in the field of atmospheric chemistry worldwide,which includes two kinds of work:first,the setup of reliable radical detection systems;second,integrated field studies that enable closure studies on the sources and sinks of targeted radicals such as OH and NO3.In this review,we try to review the Chinese efforts to explore the atmospheric free-radical chemistry in such chemical complex environments and the possible link of this fast gas-phase oxidation with the fast formation of secondary air pollution in the city-cluster areas in China. | Keding Lu Song Guo Zhaofeng Tan Haichao Wang Dongjie Shang Yuhan Liu Xin Li Zhijun Wu Min Hu Yuanhang Zhang | 2019 | National Science Review2019，6，3： | 26 |
| 3 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 4 | A Review of Technical Advances,Barriers,and Solutions in the Power to Hydrogen(P2H)Roadmap显示文摘Power to hydrogen(P2H)provides a promising solution to the geographic mismatch between sources of renewable energy and the market,due to its technological maturity,flexibility,and the availability of technical and economic data from a range of active demonstration projects.In this review,we aim to provide an overview of the status of P2H,analyze its technical barriers and solutions,and propose potential opportunities for future research and industrial demonstrations.We specifically focus on the transport of hydrogen via natural gas pipeline networks and end-user purification.Strong evidence shows that an addition of about 10%hydrogen into natural gas pipelines has negligible effects on the pipelines and utilization appliances,and may therefore extend the asset value of the pipelines after natural gas is depleted.To obtain pure hydrogen from hydrogen-enriched natural gas(HENG)mixtures,end-user separation is inevitable,and can be achieved through membranes,adsorption,and other promising separation technologies.However,novel materials with high selectivity and capacity will be the key to the development of industrial processes,and an integrated membrane-adsorption process may be considered in order to produce high-purity hydrogen from HENG.It is also worth investigating the feasibility of electrochemical separation(hydrogen pumping)at a large scale and its energy analysis.Cryogenics may only be feasible when liquefied natural gas(LNG)is one of the major products.A range of other technological and operational barriers and opportunities,such as water availability,byproduct(oxygen)utilization,and environmental impacts,are also discussed.This review will advance readers’understanding of P2H and foster the development of the hydrogen economy. | Guoping Hu Chao Chen Hiep Thuan Lu Yue Wu Congmin Liu Lefu Tao Yuhan Men Guangli He Kevin Gang Li | 2020 | Engineering2020，6，12： | 7 |
| 5 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 6 | Adjuvant treatment for triple-negative breast cancer: a retrospective study of immunotherapy with autologous cytokine-induced killer cells in 294 patients显示文摘Objective: To examine the efficacy and safety of a sequential combination of chemotherapy and autologous cytokine-induced killer(CIK) cell treatment in triple-negative breast cancer(TNBC) patients.Methods: A total of 294 post-surgery TNBC patients participated in the research from January 1, 2009 to January 1, 2015. After adjuvant chemotherapy, autologous CIK cells were introduced in 147 cases(CIK group), while adjuvant chemotherapy alone was used to treat the remaining 147 cases(control group). The major endpoints of the investigation were the disease-free survival(DFS) and overall survival(OS). Additionally, the side effects of the treatment were evaluated.Results: In the CIK group, the DFS and OS intervals of the patients were significantly longer than those of the control group(DFS:P = 0.047;OS: P = 0.007). The multivariate analysis demonstrated that the TNM(tumor-node-metastasis) stage and adjuvant CIK treatment were independent prognostic factors for both DFS [hazard ratio(HR)= 0.520, 95% confidence interval(CI):0.271-0.998, P = 0.049;HR = 1.449, 95% CI:1.118-1.877, P = 0.005, respectively] and OS(HR=0.414, 95% CI:0.190-0.903, P = 0.027;HR= 1.581, 95% CI:1.204-2.077, P = 0.001, respectively) in patients with TNBC. Additionally, longer DFS and OS intervals were associated with increased number of CIK treatment cycles(DFS: P = 0.020;OS: P = 0.040). The majority of the patients who benefitted from CIK cell therapy were relatively early-stage TNBC patients.Conclusion: Chemotherapy in combination with adjuvant CIK could be used to lower the relapse and metastasis rate, thus effectively extending the survival time of TNBC patients, especially those at early stages. | Yuhan Zhang Shuaibing Wang Beibei Yang Su Lu Yiyi Du Hong Liu | 2019 | Cancer Biology & Medicine2019，16，2： | 6 |
| 7 | Global and regional trends in incidence and mortality of female breast cancer and associated factors at national level in 2000 to 2019显示文摘Background: Female breast cancer (FBC) has become the most prevalent malignancy worldwide. We aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of FBC.Methods: FBC incidence and mortality in 60 selected countries by cancer registry data integrity in 2020 were estimated from the GLOBOCAN database, and their association with the human development index (HDI) was further evaluated. Trends of age-standardized rates of incidence and mortality in 60 countries from 2000 through 2019 were evaluated by joinpoint regression analysis using data of Global Burden of Disease 2019. The association between potential behavioral, metabolic, and socioeconomic risk factor exposure at the nation level retrieved from the World Bank and Global Health Observatory and the incidence and mortality of FBC were evaluated by multivariate linear regression.Results: FBC incidence and mortality varied greatly in the 60 included countries. Higher incidence and mortality rates were typically observed in countries with higher HDIs and vice versa. During 2000 to 2019, significantly increasing trends in incidence and mortality were observed in 26 (average annual percent changes [AAPCs], 0.35-2.96) and nine countries (AAPC, 0.30-1.65), respectively, while significantly decreasing trends in both incidence and mortality were observed in 22 countries, most of which were high-HDI countries. Among the population aged ≥40 years, there were 26 and 11 countries showing significantly increased trends in incidence and mortality, respectively. Ecological analysis showed that countries with higher prevalence rates of high cholesterol and higher health expenditures were more likely to have higher FBC incidence, and countries with higher rates of obesity and poorer universal health coverage were more likely to have higher FBC mortality.Conclusions: Despite decreased or stabilized FBC incidence and mortality rates were observed in some countries with high HDI over the past decades, disease burden became even severer in developing countries, especially for the population aged ≥40 years. Effective targeted preventive programs are strongly encouraged to reduce the FBC disease burden worldwide. | Chenyu Luo Na Li Bin Lu Jie Cai Ming Lu Yuhan Zhang Hongda Chen Min Dai | 2022 | Chinese Medical Journal2022，，1： | 5 |
| 8 | In situ monitoring of atmospheric nitrous acid based on multi-pumping flow system and liquid waveguide capillary cell显示文摘In the last four decades, various techniques including spectroscopic, wet chemical and mass spectrometric methods, have been developed and applied for the detection of ambient nitrous acid(HONO). We developed a HONO detection system based on long path photometry which consists of three independent modules i.e., sampling module, fluid propulsion module and detection module. In the propulsion module, solenoid pumps are applied. With solenoid pumps the pulsed flow can be computer controlled both in terms of pump stroke volume and pulse frequency, which enables the attainment of a very stable flow rate. In the detection module, a customized Liquid Waveguide Capillary Cell(LWCC) is used. The customized LWCC pre-sets the optical fiber in-coupling with the liquid wave guide, providing the option of fast startup and easy maintenance of the absorption photometry. In summer 2014, our system was deployed in a comprehensive campaign at a rural site in the North China Plain. More than one month of high quality HONO data spanning from the limit of detection to 5 ppb were collected. Intercomparison of our system with another established system from Forschungszentrum Juelich is presented and discussed. In conclusion, our instrument achieved a detection limit of 10 ppt V within2 min and a measurement uncertainty of 7%, which is well suited for investigation of the HONO budget from urban to rural conditions in China. | Yuhan Liu Keding Lu Huabin Dong Xin Li Peng Cheng Qi Zou Yusheng Wu Xingang Liu Yuanhang Zhang | 2016 | Journal of Environmental Sciences2016，28，5： | 4 |
| 9 | Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function显示文摘The AMP-activated protein kinase(AMPK)is a central regulator of energy homeostasis.Although much has been learned on how low energy status and glucose starvation activate AMPK,how AMPK activity is properly controlled in vivo is still poorly understood.Here we report that UHRF1,an epigenetic regulator highly expressed in proliferating and cancer cells,interacts with AMPK and serves to suppress AMPK activity under both basal and stressed conditions.As a nuclear protein,UHRF1 promotes AMPK nuclear retention and strongly suppresses nuclear AMPK activity toward substrates H2B and EZH2.Importantly,we demonstrate that UHRF1 also robustly inhibits AMPK activity in the cytoplasm compartment,most likely as a consequence of AMPK nucleocytoplasmic shuttling.Mechanistically,we found that UHRF1 has no obvious effect on AMPK activation by upstream kinases LKB1 and CAMKK2 but inhibits AMPK activity by acting as a bridging factor targeting phosphatase PP2A to dephosphorylate AMPK.Hepatic overexpression of UHRF1 showed profound effects on glucose and lipid metabolism in wild-type mice but not in those with the liver-specific knockout of AMPKα1/α2,whereas knockdown of UHRF1 in adipose tissue led to AMPK activation and reduced sizes of adipocytes and lipogenic activity,highlighting the physiological significance of this regulation in glucose and lipid metabolism.Thus,our study identifies UHRF1 as a novel AMPK gate-keeper with critical roles in cellular metabolism. | Xiang Xu Guangjin Ding Caizhi Liu Yuhan Ding Xiaoxin Chen Xiaoli Huang Chen-Song Zhang Shanxin Lu Yunpeng Zhang Yuanyong Huang Zhaosu Chen Wei Wei Lujian Liao Shu-Hai Lin Jingya Li Wei Liu Jiwen Li Sheng-Cai Lin Xinran Ma Jiemin Wong | 2022 | Cell Research2022，32，1： | 3 |
| 10 | ABM-based emergency evacuation modelling during urban pluvial floods:A“7.20”pluvial flood event study in Zhengzhou,Henan Province显示文摘Increasing urban pluvial flood disasters due to climate change and rapid urbanisation have been a great challenge worldwide.Timely and effective emergency evacuation is important for reducing casualties and losses.This has become a bottleneck for emergency management.This study aimed to develop a commonly used Agent-Based Mode(ABM)for pluvial flood emergency evacuation at the city scale,exploring the cascading impacts of pluvial flooding on human behaviour and emergency evacuation.The July 2021 pluvial flood event in Zhengzhou,Henan Province,claiming 380 lives and 40.9 billion yuan in direct losses,was selected as this case study.A raster-based hydraulic model(ECNU Flood-Urban)was used to predict flood inundation(extent and depth)during an event in Zhengzhou’s centre.Moreover,a comparative analysis of emergency evacuations was conducted before and after the pluvial flood event.The results showed that crowd behaviour plays an important role in an emergency evacuation,and extensive flooding leads to an 11-83%reduction in the number of evacuees.This study highlights the importance of risk education and contingency plans in emergency response.The ABM model developed in this study is proven to be effective and practical and will provide support for decision-making in urban flood emergency management. | Yuhan YANG Jie YIN Dandan WANG Yufan LIU Yi LU Weiguo ZHANG Shiyuan XU | 2023 | Science China Earth Sciences2023，66，2： | 2 |
| 11 | Graphitic carbon nitride-based photocatalysts in the applications of environmental catalysis显示文摘Semiconductor photocatalytic technology has shown great prospects in converting solar energy into chemical energy to mitigate energy crisis and solve environmental pollution problems.The key issue is the development of high-efficiency photocatalysts.Various strategies in the state-of-the-art advancements,such as heterostructure construction,heteroatom doping,metal/single atom loading,and defect engineering,have been presented for the graphitic carbon nitride(g-C3N4)-based nanocomposite catalysts to design their surface chemical environments and internal electronic structures to make them more suitable for different photocatalytic applications.In this review,nanoarchitecture design,synthesis methods,photochemical properties,potential photocatalytic applications,and related reaction mechanisms of the modified high-efficiency carbon nitride-based photocatalysts were briefly summarized.The superior photocatalytic performance was identified to be associated with the enhanced visible-light response,fast photoinduced electron-hole separation,efficient charge migration,and increased unsaturated active sites.Moreover,the further advance of the visible-light harvesting and solar-to-energy conversions are proposed. | Hongxia Lin JinmoWu Fan Zhou Xiaolong Zhao Pengfei Lu Guanghui Sun Yuhan Song Yayun Li Xiaoyong Liu Hongxing Dai | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 12 | Meridional Displacement of the East Asian Upper-tropospheric Westerly Jet and Its Relationship with the East Asian Summer Rainfall in CMIP5 Simulations显示文摘As the first leading mode of upper-tropospheric circulation in observations, the meridional displacement of the East Asian westerly jet (EAJ) varies closely with the East Asian rainfall in summer. In this study, the interannual variation of the EAJ meridional displacement and its relationship with the East Asian summer rainfall are evaluated, using the historical simulations of CMIP5 (phase 5 of the Coupled Model Intercomparison Project). The models can generally reproduce the meridional displacement of the EAJ, which is mainly manifested as the first principal mode in most of the simulations. For the relationship between the meridional displacement of the EAJ and East Asian rainfall, almost all the models depict a weaker correlation than observations and exhibit considerably large spread across the models. It is found that the discrepancy in the interannual relationship is closely related to the simulation of the climate mean state, including the climatological location of the westerly jet in Eurasia and rainfall bias in South Asia and the western North Pacific. In addition, a close relationship between the simulation discrepancy and intensity of EAJ variability is also found: the models with a stronger intensity of the EAJ meridional displacement tend to reproduce a closer interannual relationship, and vice versa. | Yuhan YAN Chaofan LI Riyu LU | 2019 | Advances in Atmospheric Sciences2019，36，11： | 2 |
| 13 | A Chinese version of a Likert-type death anxiety scale for colorectal cancer patients显示文摘Objective:This study aimed to evaluate and validate the performance of a Chinese version of a Likerttype death anxiety scale for colorectal cancer patients.Methods:This study assessed the death anxiety of 50 colorectal cancer patients,which were selected by convenience sampling method,by using the Chinese version of a Likert-type Templer death anxiety scale(CL-TDAS)on the first day of admission.Results:Most of the respondents finished the entire scale in 3e5 min,and the recovery rate was 94.0%.Cronbach's a indicated that the internal consistency was 0.821 for the complete 15 items,and the correlation between the CL-TDAS and the C-TDAS(non-Likert-type)was 0.79(P<0.05).The structural validity of the CL-TDAS revealed that the scale items accounted for>63.78%of the total variability,and that the four-component structure of the data well fitted the model.The mean score of the CL-TDAS was 36.16±9.99(first day of admission).Conclusion:The CL-TDAS showed reliable performance and can thus be a promising instrument for evaluating the death anxiety of cancer patients.Death anxiety varied for different periods and different genders. | Hong Yang Jie Zhang Yuhan Lu Ming Li | 2016 | International Journal of Nursing Sciences2016，3，4： | 2 |
| 14 | Vertical Profiles of Volatile Organic Compounds in Suburban Shanghai显示文摘As Volatile Organic Compounds(VOCs)are one of the precursors of ozone,their distribution and variable concentrations are highly related to local ozone pollution control.In this study,we obtained vertical profiles of VOCs in Shanghai’s Jinshan district on 8 September and 9 September in 2016 to investigate their distribution and impact on local atmospheric oxidation in the near surface layer.Vertical samples were collected from heights between 50 m and 400 m by summa canisters using an unmanned aerial vehicle(UAV).Concentrations of VOCs(VOCs refers to the 52 species measured in this study)varied minimally below 200 m,and decreased by 21.2%from 100 m to 400 m.The concentrations of VOCs above 200 m decreased significantly in comparison to those below 200 m.The proportions of alkanes and aromatics increased from 55.2%and 30.5%to 57.3%and 33.0%,respectively.Additionally,the proportion of alkenes decreased from 13.2%to 8.4%.Toluene and m/p-xylene were the key species in the formation of SOA and ozone.Principal component analysis(PCA)revealed that the VOCs measured in this study mainly originated from industrial emissions. | Yuhan LIU Hongli WANG Shengao JING Ming ZHOU Shenrong LOU Kun QU Wanyi QIU Qian WANG Shule LI Yaqin GAO Yusi LIU Xiaobing LI Zhong-Ren PENG Junhui CHEN Keding LU | 2021 | Advances in Atmospheric Sciences2021，38，7： | 1 |
| 15 | Mirror-enhanced scanning light-field microscopy for long-term high-speed 3D imaging with isotropic resolution显示文摘Various biological behaviors can only be observed in 3D at high speed over the long term with low phototoxicity.Light-field microscopy(LFM)provides an elegant compact solution to record 3D information in a tomographic manner simultaneously,which can facilitate high photon efficiency.However,LFM still suffers from the missing-cone problem,leading to degraded axial resolution and ringing effects after deconvolution.Here,we propose a mirrorenhanced scanning LFM(MiSLFM)to achieve long-term high-speed 3D imaging at super-resolved axial resolution with a single objective,by fully exploiting the extended depth of field of LFM with a tilted mirror placed below samples.To establish the unique capabilities of MiSLFM,we performed extensive experiments,we observed various organelle interactions and intercellular interactions in different types of photosensitive cells under extremely low light conditions.Moreover,we demonstrated that superior axial resolution facilitates more robust blood cell tracking in zebrafish larvae at high speed. | Bo Xiong Tianyi Zhu Yuhan Xiang Xiaopeng Li Jinqiang Yu Zheng Jiang Yihan Niu Dong Jiang Xu Zhang Lu Fang Jiamin Wu Qionghai Dai | 2021 | Light(Science & Applications)2021，10，12： | 1 |
| 16 | Analysis of the Drug Sensitivity of Escherichia coli Isolated from Sheep in Yangling,Shaanxi Province显示文摘This study was conducted to investigate the drug sensitivity of Escherichia coli isolated from sheep,providing data reference for clinical medication. Fifty-four samples were collected from a certain sheep farm in Yangling,Shaanxi Province for E. coli isolation and identification,and K-B disk diffusion method was used to carry out the dug sensitivity test of 40 E. coli to the eight antimicrobials of spectinomycin,amikacin,tobramycin,enrofloxacin,nalidixic acid,levofloxacin,salafloxacin and ciprofloxacin. The results showed that there were 40 positive E. coli strains and the isolation rate was 74. 7%. The resistance rates of the 40 E. coli to spectinomycin,amikacin,tobramycin and nalidixic acid were 85%,95%,97. 5% and 87. 5%,respectively,while the resistance rate to enrofloxacin,levofloxacin,salafloxacin and ciprofloxacin were relatively low and the resistance rates were 35%,20%,25% and 17. 5%,respectively. The isolates showed different levels of drug resistance to eight antimicrobials and the highest resistance rate was 97. 5%. It reminds that the sheep farm should strictly control the dosage according to the antimicrobial sensitive data in clinic. | Ling LI Yuhan LI Lu DAI Haoyuan FENG Chaoxi CHEN | 2018 | Agricultural Biotechnology2018，7，5： | 1 |
| 17 | Electrochemical Carbon Dioxide Reduction to Ethylene:From Mechanistic Understanding to Catalyst Surface Engineering显示文摘Electrochemical carbon dioxide reduction reaction(CO_(2)RR)provides a promising way to convert CO_(2)to chemicals.The multicarbon(C_(2+))products,especially ethylene,are of great interest due to their versatile industrial applications.However,selectively reducing CO_(2)to ethylene is still challenging as the additional energy required for the C–C coupling step results in large overpotential and many competing products.Nonetheless,mechanistic understanding of the key steps and preferred reaction pathways/conditions,as well as rational design of novel catalysts for ethylene production have been regarded as promising approaches to achieving the highly efficient and selective CO_(2)RR.In this review,we first illustrate the key steps for CO_(2)RR to ethylene(e.g.,CO_(2)adsorption/activation,formation of~*CO intermediate,C–C coupling step),offering mechanistic understanding of CO_(2)RR conversion to ethylene.Then the alternative reaction pathways and conditions for the formation of ethylene and competitive products(C_1 and other C_(2+)products)are investigated,guiding the further design and development of preferred conditions for ethylene generation.Engineering strategies of Cu-based catalysts for CO_(2)RR-ethylene are further summarized,and the correlations of reaction mechanism/pathways,engineering strategies and selectivity are elaborated.Finally,major challenges and perspectives in the research area of CO_(2)RR are proposed for future development and practical applications. | Junpeng Qu Xianjun Cao Li Gao Jiayi Li Lu Li Yuhan Xie Yufei Zhao Jinqiang Zhang Minghong Wu Hao Liu | 2023 | Nano-Micro Letters2023，15，10： | 1 |
| 18 | Advances in breast cancer screening modalities and status of global screening programs显示文摘Breast cancer(BC)is the most prevalent malignancy worldwide,and a continued upward trend has been predicted in the coming decades.Screening in selected targeted populations,which is effective in reducing cancer-related mortality,has been widely implemented in many countries.This review summarizes the advances in BC screening techniques,organized or opportunistic BC screening programs across different countries,and screening modalities recommended by different academic authorities.Mammography is the most widely used and effective technique for BC screening.Other complementary techniques include ultrasound,clinical breast examination,and magnetic resonance imaging.Novel screening tests,including digital breast tomosynthesis and liquid biopsies,are still under development.Globally,the implementation status of BC screening programs is uneven,which is reflected by differences in screening modes,techniques,and population coverage.The recommended optimal screening strategies varied according to the authoritative guidelines.The effectiveness of current screening programs is influenced by several factors,including low detection rate,high false-positive rate,and unsatisfactory coverage and uptake rates.Exploration of accurate BC risk prediction models and the development of risk-stratified screening strategies are highly warranted in future research. | Chenyu Luo Le Wang Yuhan Zhang Ming Lu Bin Lu Jie Cai Hongda Chen Min Dai | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 1 |
| 19 | Aeroengine Nonlinear Sliding Mode Control Based on Artificial Bee Colony Algorithm显示文摘For a class of aeroengine nonlinear systems,a novel nonlinear sliding mode controller(SMC)design method based on artificial bee colony(ABC)algorithm is proposed.In view of the strong nonlinearity and uncertainty of aeroengines,sliding mode control strategy is adopted to design controller for the aeroengine.On basis of exact linearization approach,the nonlinear sliding mode controller is obtained conveniently.By using ABC algorithm,the parameters in the designed controller can be tuned to achieve optimal performance,resulting in a closedloop system with satisfactory dynamic performance and high steady accuracy.Simulation on an aeroengine verifies the effectiveness of the presented method. | Lu Binbin Xiao Lingfei Chen Yuhan | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，2： | 1 |
| 20 | Anthropogenic monoterpenes aggravating ozone pollution显示文摘Monoterpenes have been known to have a critical influence on air quality and climate change through their impact on the formation of fine particles.Here we present field evidence that monoterpene oxidations largely enhanced local ozone production in a regional site in eastern China.The observed monoterpene was most likely from biomass burning rather than biogenic emissions,as indicated by the high correlation with CO at night-time,and the observed ratio of these two species was consistent with previously determined values from biomass burning experiments.Fast monoterpene oxidations were determined experimentally based on direct radical measurements,leading to a daily ozone enhancement of 4-18 parts per billion by volume(ppb),which was 6%-16%of the total ozone production,depending on the speciation of monoterpenes.It demonstrates that the previously overlo oked anthropogenic monoterpenes make an important contribution to 0_(3) production in eastern China.The role could possibly be important at similar locations across China and other parts of the world that are characterized by massive emissions,especially where there are high NO_(x) levels.Our results highlight that anthropogenic monoterpenes should be taken into account when proceeding with the coordinated mitigation of O_(3) and particulate matter pollution. | Haichao Wang Xuefei Ma Zhaofeng Tan Hongli Wang Xiaorui Chen Shiyi Chen Yaqin Gao Ying Liu Yuhan Liu Xinping Yang Bin Yuan Limin Zeng Cheng Huang Keding Lu Yuanhang Zhang | 2022 | National Science Review2022，9，9： | 1 |
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