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| 1 | Exploring atmospheric free-radical chemistry in China:the self-cleansing capacity and the formation of secondary air pollution显示文摘Since 1971,it has been known that the atmospheric free radicals play a pivotal role in maintaining the oxidizing power of the troposphere.The existence of the oxidizing power is an important feature of the troposphere to remove primary air pollutants emitted from human beings as well as those from the biosphere.Nevertheless,serious secondary air-pollution incidents can take place due to fast oxidation of the primary pollutants.Elucidating the atmospheric free-radical chemistry is a demanding task in the field of atmospheric chemistry worldwide,which includes two kinds of work:first,the setup of reliable radical detection systems;second,integrated field studies that enable closure studies on the sources and sinks of targeted radicals such as OH and NO3.In this review,we try to review the Chinese efforts to explore the atmospheric free-radical chemistry in such chemical complex environments and the possible link of this fast gas-phase oxidation with the fast formation of secondary air pollution in the city-cluster areas in China. | Keding Lu Song Guo Zhaofeng Tan Haichao Wang Dongjie Shang Yuhan Liu Xin Li Zhijun Wu Min Hu Yuanhang Zhang | 2019 | National Science Review2019，6，3： | 26 |
| 2 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 3 | Cryo-EM structure of human ATR-ATRIP complex显示文摘ATR (变异毛细管扩张、 Rad3 相关的混乱) 蛋白质 kinase 并且(交往 ATR 蛋白质) 起锚形成建筑群并且响应复制应力和 DNA 损坏起一个关键作用。这里,我们决定了在 4.7 点 ATR 起锚复杂的人的 cryo 电子显微镜学(他们) 结构吗?分辨率并且造了 ATR 的 C 终端催化核心的一个原子模型(残余 1 521-2 644 ) 在 3.9 点?分辨率。建筑群采用空心形状,由在不同符合构造的二 ATR 单体组成。他们地图为起锚表明 14 热在扩大 S 形状重复。ATR 的 conformational 灵活性起锚允许适当地锁二 ATR 单体的 N 终点赞成 ATR 起锚复杂的形成和功能的差异。孤立的头头和尾巴尾巴各个采用假 2 褶层对称。外面的催化衣袋脸和底层存取没被禁止的元素限制。我们的研究为理解集会提供一个结构的基础 ATR 起锚,为描绘调停 ATR 的 DNA 的建筑群和一个框架修理小径。 | Qinhui Rao Mengjie Liu Yuan Tian Yuhan Hao Lei Song Zhaoyu Qin Chen Ding Hong-Wei Wang Jiawei Wang Yanhui Xu | 2018 | Cell Research2018，28，2： | 4 |
| 4 | Effects of miR-101-3p on goat granulosa cells in vitro and ovarian development in vivo via STC1显示文摘Background:MiRNAs act as pivotal post-transcriptional gene mediators in the regulation of diverse biological processes,including proliferation,development and apoptosis.Our previous study has showed that miR-101-3p is differentially expressed in dairy goat ovaries compared single with multiple litters.The objective of this research was to explore the potential function and molecular mechanism of miR-101-3p via its target STC1 in goat ovarian growth and development.Results:cDNA libraries were constructed using goat granulosa cells transfected with miR-101-3p mimics and negative control by RNA-sequencing.In total,142 differentially expressed unigenes(DEGs)were detected between two libraries,including 78 down-regulated and 64 up-regulated genes.GO and KEGG enrichment analysis showed the potential impacts of DEGs on ovarian development.STC1 was singled out from DEGs for further research owing to it regulates reproductive-related processes.In vitro,bioinformatics analysis and 3′-UTR assays confirmed that STC1 was a target of miR-101-3p.ELISA was performed to detect the estrogen(E2)and progesterone(P4)levels.CCK8,EdU and flow cytometry assays were performed to detect the proliferation and apoptosis of granulosa cells.Results showed that miR-101-3p regulated STAR,CYP19A1,CYP11A1 and 3β-HSD steroid hormone synthesis-associated genes by STC1 depletion,thus promoted E2 and P4 secretions.MiR-101-3p also affected the key protein PI3K,PTEN,AKT and mTOR in PI3K-AKT pathway by STC1,thereby suppressing proliferation and promoting apoptosis of granulosa cells.In vivo,the distribution and expression levels of miR-101-3p in mouse ovaries were determined through fluorescence in situ hybridisation(FISH).Immunohistochemistry results showed that STC1 expression was suppressed in mouse ovaries in miR-101-3p-agonist and siRNA-STC1 groups.Small and stunted ovarian fragments,decreased numbers of follicles at diverse stages were observed using Hematoxylin-eosin(HE)staining,thereby showing unusual ovarian development after miR-101-3p overexpression or STC1 depletion.Inhibition of miR-101-3p manifested opposite results.Conclusions:Taken together,our results demonstrated a regulatory mechanism of miR-101-3p via STC1 in goat granulosa cells,and offered the first in vivo example of miR-101-3p and STC1 functions required for ovarian development. | Xiaopeng An Haidong Ma Yuhan Liu Fu Li Yuxuan Song Guang Li Yueyu Bai Binyun Cao | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 5 | Ultrasmall AU10 clusters anchored on pyramid-capped rectangular TiO2 for olefin oxidation显示文摘Ultrasmall Au 10 簇作为一座充电水库有唯一的电子结构和罐头行为捐赠电子或接受费用。这为催化作用是特别地重要的,自从它越过在金种类和氧化物底层之间的接口导致灵巧的费用转移。在催化氧化上决定 Au 10 的电子、结构的效果,一个 TiO 2 费用搬运人为石蜡氧化被选择为底层到锚 Au 10 。在 TiO 2-RP 上支持的 Au 10(RP = 盖住金字塔的圆柱的结构) 展出优异催化活动到 Au 10/TiO2 nanotubes 和 Au 10/P25。另外,支持的 Au 10 簇比支持的 Au 20, Au 144 簇,和 5 nm Au 产生了更高的活动 nanocrystals。Au 10/TiO2-RP 的优异催化能力从 Au 10/TiO2-RP 接口的控告 / 解除效果产生,它有效地在 Au 10, 的终端位置在充满电子的金原子上改进活跃的氧种类的形成并且在 Au 10 的电子缺乏的金原子上支持石蜡 C=C 契约的激活。 | Lixiong Li Shuangshuang Huang Jianjun Song Nating Yang Jingwei Liu Yuyun Chen Yuhan Sun Rongchao Jin Yan Zhu | 2016 | Nano Research2016，9，4： | 2 |
| 6 | Graphitic carbon nitride-based photocatalysts in the applications of environmental catalysis显示文摘Semiconductor photocatalytic technology has shown great prospects in converting solar energy into chemical energy to mitigate energy crisis and solve environmental pollution problems.The key issue is the development of high-efficiency photocatalysts.Various strategies in the state-of-the-art advancements,such as heterostructure construction,heteroatom doping,metal/single atom loading,and defect engineering,have been presented for the graphitic carbon nitride(g-C3N4)-based nanocomposite catalysts to design their surface chemical environments and internal electronic structures to make them more suitable for different photocatalytic applications.In this review,nanoarchitecture design,synthesis methods,photochemical properties,potential photocatalytic applications,and related reaction mechanisms of the modified high-efficiency carbon nitride-based photocatalysts were briefly summarized.The superior photocatalytic performance was identified to be associated with the enhanced visible-light response,fast photoinduced electron-hole separation,efficient charge migration,and increased unsaturated active sites.Moreover,the further advance of the visible-light harvesting and solar-to-energy conversions are proposed. | Hongxia Lin JinmoWu Fan Zhou Xiaolong Zhao Pengfei Lu Guanghui Sun Yuhan Song Yayun Li Xiaoyong Liu Hongxing Dai | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration显示文摘 | Shan Wang Zhiqiang Peng Siying Wang Lihua Yang Yuhan Chen Xue Kong Shanshan Song Pei Pei Chunyan Tian Hui Yan Peipei Ding Weiguo Hu Cui Hua Liu Xin Zhang Fuchu He Lingqiang Zhang | 2018 | Cell Research2018，28，5： | 1 |
| 9 | Effect of radial heat conduction on effective thermal conductivity of carbon nanotube bundles显示文摘The effect of the radial heat conduction on the effective thermal conductivity of carbon nanotube(CNT) bundles is studied by the nonequilibrium molecular dynamics(NEMD) method. The hexagonal CNT bundle consists of seven(10, 10) single-walled carbon nanotubes(SWCNTs). The radial heat conduction is induced by creating the vacancy defects in some segments of the constituent CNTs. Combined with the temperature differences and the inter-tube thermal resistances at the different segments,the radial heat flow in the CNT bundle is calculated. The maximum percentage of the radial heat flow is less than 7% with the presence of four defective CNTs, while the resultant decrement of the effective thermal conductivity of the bundle is about 18%.The present results indicate that the radial heat flow can significantly diminish the axial heat conduction in the CNT bundles,which probably explains the smaller effective thermal conductivity in the CNT assemblies compared to that of the individual CNTs. | WANG JianLi SONG YaMei ZHANG YuFeng HU YuHan YIN Hang GU YunFeng XIA Re CHEN YunFei | 2018 | Science China(Technological Sciences)2018，61，12： | 1 |
| 10 | Development of a Widely Applicable and Simple Prognostic Score for Patients with Acute-on-chronic Liver Failure显示文摘Background and Aims:Acute-on-chronic liver failure(ACLF)tends to progress rapidly with high short-term mortality.We aimed to create a widely applicable,simple prognostic(WASP)score for ACLF patients.Methods:A retrospective cohort of ACLF cases recruited from three centers in China were divided into training and validation sets to develop the new score.A prospective longitudinal cohort was recruited for further validation.Results:A total of 541 cases were included in the training set,and seven independent ACLF prognostic factors were screened to construct a new quantitative WASP-ACLF table.In the validation set of 671 cases,WASP-ACLF showed better predictive ability for 28-day and 90-day mortality than the currently used prognostic scores at baseline,day 3,week 1,and week 2.The predictive efficacy and clinical validity of the model improved over time.Patients were assigned to low-,intermediate-,and high-risk groups by their WASP-ACLF scores.Compared with the other two groups,intermediate-risk patients had a more uncertain prognosis,with a 90-day mortality of 44.4–50.6%.Sequential assessments at weeks 1 and 2 found the 90-day mortality of intermediate-risk groups was<20%forpatients with a≥2 point decrease in WASP-ACLF and was up to 56%for patients with a≥2 points increase.Similar results were observed in prospective data.Conclusions:The new ACLF prognostic score was simple,widely applicable,and had good predictive efficacy.Continuous assessments and trend of change in WASP-ACLF need to be considered,especially for intermediate-risk patients. | Zhenjun Yu Yu Zhang Yuhan Li Feng Zhou Manman Xu Shaoli You Yu Chen Bing Zhu Ming Kong Fangjiao Song Shaojie Xin Zhongping Duan Tao Han China Network for Severe Liver Diseases | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 11 | The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly显示文摘Epithelial morphogenesis and homeostasis are essential for animal development and tissue regeneration,and epithelial disorganization is associated with developmental disorders and tumorigenesis.However,the molecular mechanisms that contribute to the morphogenesis and homeostasis of the epithelium remain elusive.Herein,we report a novel role for the cylindromatosis(CYLD)tumor suppressor in these events.Our results show that CYLD depletion disrupts epithelial organization in both Drosophila egg chambers and mouse skin and intestinal epithelia.Microscopic analysis of proliferating cells in mouse epithelial tissues and cultured organoids reveals that loss of CYLD synergizes with tumor-promoting agents to cause the misorientation of the mitotic spindle.Mechanistic studies show that CYLD accu?mulates at the cell cortex in epithelial tissues and cultured cells,where it promotes the formation of epithelial adherens junctions through the modulation of microtubule dynamics.These data suggest that CYLD controls epithelial morphogenesis and homeostasis by modulating the assembly of adherens junctions and ensuring proper orientation of the mitotic spindle.Our findings thus provide novel insight into the role of CYLD in development,tissue homeostasis,and tumorigenesis. | Wei Xie Yunfan Yang Siqi Gao Ting Song Yuhan Wu Dengwen Li Min Liu Jun Zhou | 2017 | Journal of Genetics and Genomics2017，44，7： | 1 |
| 12 | Gut microbisal methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract显示文摘Dear Editor,Circadian rhythms are the periodic turmover of biological behaviors and physiological functions of many organisms(Allada and Bass,2021).In mammals,circadian rhythms are maintained by the clock system,involving central clock in suprachiasmatic nucleus and peripheral clock in organs like intestine;and at cellular level a cell-autonomous transcriptional and translational feedback loop involving clock genes like BMAL1(brain and muscle ARNT-Like 1,also known as ARNTL),CLOCK(clock circadian regulator),PER1/2/3(period circadian regulator 1/2/3)and CRY1/2(cryptochrome circadian regulator 1/2)(Allada and Bass,2021). | Xiaolin Liu Yue Ma Ying Yu Wenhui Zhang ingjing Shi Xuan Zhang Min Dai Yuhan Wang Hao Zhang Jiahe Zhang Jianghua Shen Faming Zhang Moshi Song Jun Wang | 2023 | Protein & Cell2023，14，4： | 1 |
| 13 | Genetic Analysis and Improvement Strategies of Protein Content in Rice Seeds显示文摘Enhancing the nutritional quality of food crops is a way to improve human nutrition and health.Grain protein content(GPC)is an important nutritional quality trait for rice and many other crops.Therefore,it will be very significant to increase GPC and improve rice quality.This paper mainly reviewed the genetic studies GPC in rice,mapping and cloning of QTLs and genes associated with GPC.However,little is known about the molecular mechanism and gene function related to GPC in rice.Thus,here we put forward the genetic strategy by gene pyramiding or molecular marker assisted selection to improve GPC and nutritional quality in rice.This review could provide important information for genetic improvement of grain nutritional quality of rice. | Bo PENG Yanfang SUN Dongyan KONG Ruihua PANG Xiaohua SONG Huilong LI Lin LIU Xian-wen LI Jintao LI Qiying ZHOU Bin DUAN Huihui LIU Yuhan ZUO Yanlin HAO Shizhi SONG Hongyu YUAN | 2017 | Agricultural Biotechnology2017，6，4： | 1 |
| 14 | Input-to-State Stabilization of Nonlinear Impulsive Delayed Systems: An Observer-Based Control Approach显示文摘This paper addresses the problems of input-to-state stabilization and integral input-to-state stabilization for a class of nonlinear impulsive delayed systems subject to exogenous dis-turbances.Since the information of plant’s states,time delays,and exogenous disturbances is often hard to be obtained,the key design challenge,which we resolve,is the construction of a state observer-based controller.For this purpose,we firstly propose a corresponding observer which is independent of time delays and exogenous disturbances to reconstruct(or estimate)the plant’s states.And then based on the observations,we establish an observer-based control design for the plant to achieve the input-to-state stability(ISS)and integral-ISS(iISS)properties.With the help of the comparison principle and average impulse interval approach,some sufficient conditions are presented,and moreover,two different linear matrix inequalities(LMIs)based criteria are proposed to design the gain matrices.Finally,two numerical examples and their simulations are given to show the effectiveness of our theoretical results. | Yuhan Wang Xiaodi Li Shiji Song | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，7： | 1 |
| 15 | Temperature‑Gated Light‑Guiding Hydrogel Fiber for Thermoregulation During Optogenetic Neuromodulation显示文摘With the rise of optogenetic manipulation of neurons,the effects of optogenetic heating on temperature-sensitive physi-ological processes,and the damage to surrounding tissues have been neglected.This manuscript reports the fabrication of a highly temperature-sensitive semi-interpenetrating optical hydrogel fiber(TSOHF)using the integrated dynamic wet-spinning technique.TSOHF exhibits a structural tunable diameter,clear core/sheath structure,tunable temperature-sensitivity,excellent light propagation property(0.35 dB cm^(-1),650 nm laser light),and good biocompatibility(including tissue-like Young’s modulus,stable dimensional stability,and low cytotoxicity).Based on these properties,a potential application of optogenetic regulation of neural tissue(hypoglossal nerve),with controllable temperature using TSOHF was designed and performed.Further,this work provides new insight into molecular design and a practical approach to continually manufacture a temperature-sensitive hydrogel optical fiber for applications in intelligent photomedicine. | Guoyin Chen Siming Xu Qiangqiang Zhou Yuejiao Zhang Yuhan Song Jing Mi Yuehua Liu Kai Hou Jie Pan | 2023 | Advanced Fiber Materials2023，5，3： | 0 |
| 16 | Tidal Effects on the Bottom Thermal Front of North Yellow Sea Cold Water Mass near Zhangzi Island in Summer 2009显示文摘Three seabed-mounted TD/CTD chains and two upward-looking acoustic Doppler current profilers (ADCPs) in the southwest of Zhangzi Island are used and a simultaneous cruise observation in the northern North Yellow Sea (NYS) is conducted to study temperature variation in the bottom thermal front zone of the NYS Cold Water Mass (NYSCWM) during the summer of 2009. In the flood-ebb tidal cycles, the bottom temperature decreases (increases) during flood (ebb) tides, which are dominated by the tidal-current induced horizontal advection. The ebb tide-induced temperature increase is larger than the flood tide-induced tempera- ture decrease due to seasonal warming. In the spring-neap tidal cycles, the temperature and the vertical temperature structure show notable fortnightly variation from 16 July to 25 August. The bottom temperature increases from neap to spring tides and decreases from spring to neap. The Richardson number demonstrates strengthened vertical mixing during spring tides but enhanced stratifica- tion during neap tides. The spring-neap variation in vertical shear caused by tidal current is the dominant factor that induces the fort- nightly variation in vertical mixing and thus bottom temperature. | XIA Yingying BAO Xianwen SONG Dehai DING Yang WAN Kai YAN Yuhan | 2019 | Journal of Ocean University of China2019，18，4： | 0 |
| 17 | Antioxidant and anti-HepG2 cell activities of a novel bioactive peptide from cowhide collagen in vitro显示文摘In the present study,the antioxidant and anti-human liver cancer(HepG2)cells effects of bioactive peptides from cowhide collagen(BPCC)were evaluated.BPCC exhibited significant scavenging effect on l,1-diphenyl-2-picrylhydrazyl(DPPH)radicals((60.09±3.51)%),2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)radicals((77.40±3.10)%)and hydroxyl radicals((56.00±2.30)%)as well as strong reducing power(0.320士0.025).Meanwhile,BPCC effectively protected biomacromolecules including proteins,lipids and DNA from oxidative damage induced by Cu^(2+)H_(2)O_(2)and 2,2'-azobis(2-methylpropionamidine)dihydrochloride(AAPH).Moreover,BPCC significantly inhibited cell viability of HepG2 cells in a dose-dependent manner with an estimated IC_(50)of 7.61 mg/mL.The results of 4',6-diamidino-2-phenylindole(DAPI)and acridine:orange/ethidium bromide(AO/EB)staining demonstrated the apoptotic morphological changes and cell mediated death in BPCC treated HepG2 cells.In addition,BPCC induced decrease of mitochondrial membrane potential(MMP)in HepG2 cells.Therefore,the present finding proved that BPCC encompasses significant antioxidant activity and anticancer property on HepG2 cells and can be used as alternative food antioxidants for cancer prevention benefits. | Zhike Xie Yuhan Zhai Yuqing Zhang Ming He Xuguang Wang Shaoxuan Yu Haifang Xiao Yuanda Song | 2024 | Journal of Future Foods2024，4，3： | 0 |
| 18 | Enhanced confinement synthesis of atomically dispersed Fe-N-C catalyst from resin polymer for oxygen reduction显示文摘Due to larger atom utilization,unique electronic properties and unsaturated coordination,atomically dispersed non-precious metal catalysts with outstanding performances have received great attention in electrocatalysis.Considering the challenge of serious aggregation,rational synthesis of an atomic catalyst with good dispersion of atoms is paramount to the development of these catalysts.Herein,we report an enhanced confinement strategy to synthesize a catalyst comprised of atomically dispersed Fe supported on porous nitrogen-doped graphitic carbon from the novel and more cross-linkable Melamine-Glyoxal Resin.Densified isolated grid trapping,excessive melamine restricting,and nitrogen anchoring are strongly combined to ensure the final atomic-level dispersion of metal atoms.Experimental studies revealed enhanced kinetics of the obtained catalyst towards oxygen reduction reaction(ORR).This catalytic activity originates from the highly active surface with atomically dispersed iron sites as well as the multi-level three-dimensional structure with fast mass and electron transfer.The enhanced confinement strategy endows the resin-derived atomic catalyst with a great prospect to develop for commercialization in future. | Ailing Song Hao Tian Wang Yang Wu Yang Yuhan Xie Hao Liu Guoxiu Wang Guangjie Shao | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
| 19 | A platform for integrated spectrometers based on solution-processable semiconductors显示文摘Acquiring real-time spectral information in point-of-care diagnosis,internet-of-thing,and other lab-on-chip applications require spectrometers with hetero-integration capability and miniaturized feature.Compared to conventional semiconductors integrated by heteroepitaxy,solution-processable semiconductors provide a much-flexible integration platform due to their solution-processability,and,therefore,more suitable for the multi-material integrated system.However,solution-processable semiconductors are usually incompatible with the micro-fabrication processes.This work proposes a facile and universal platform to fabricate integrated spectrometers with semiconductor substitutability by unprecedently involving the conjugated mode of the bound states in the continuum(conjugated-BIC)photonics.Specifically,exploiting the conjugated-BIC photonics,which remains unexplored in conventional lasing studies,renders the broadband photodiodes with ultra-narrowband detection ability,detection wavelength tunability,and on-chip integration ability while ensuring the device performance.Spectrometers based on these ultra-narrowband photodiode arrays exhibit high spectral resolution and wide/tunable spectral bandwidth.The fabrication processes are compatible with solution-processable semiconductors photodiodes like perovskites and quantum dots,which can be potentially extended to conventional semiconductors.Signals from the spectrometers directly constitute the incident spectra without being computation-intensive,latency-sensitive,and error-intolerant.As an example,the integrated spectrometers based on perovskite photodiodes are capable of realizing narrowband/broadband light reconstruction and in-situ hyperspectral imaging. | Yanhao Li Xiong Jiang Yimu Chen Yuhan Wang Yunkai Wu De Yu Kaiyang Wang Sai Bai Shumin Xiao Qinghai Song | 2023 | Light(Science & Applications)2023，12，9： | 0 |
| 20 | Metformin:A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation显示文摘The occurrence of benign prostate hyperplasia(BPH)was related to disrupted sex steroid hormones,and metformin(Met)had a clinical response to sex steroid hormone-related gynaecological disease.However,whether Met exerts an antiproliferative effect on BPH via sex steroid hormones remains unclear.Here,our clinical study showed that along with prostatic epithelial cell(PEC)proliferation,sex steroid hormones were dysregulated in the serum and prostate of BPH patients.As the major contributor to dysregulated sex steroid hormones,elevated dihydrotestosterone(DHT)had a significant positive relationship with the clinical characteristics of BPH patients.Activation of adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)by Met restored dysregulated sex steroid hormone homeostasis and exerted antiproliferative effects against DHT-induced proliferation by inhibiting the formation of androgen receptor(AR)-mediated Yes-associated protein(YAP1)-TEA domain transcription factor(TEAD4)heterodimers.Met’s anti-proliferative effects were blocked by AMPK inhibitor or YAP1 overexpression in DHT-cultured BPH-1 cells.Our findings indicated that Met would be a promising clinical therapeutic approach for BPH by inhibiting dysregulated steroid hormone-induced PEC proliferation. | Tingting Yanga Jiayu Yuana Yuting Penga Jiale Pang Zhen Qiu Shangxiu Chen Yuhan Huang Zhenzhou Jiang Yilin Fan Junjie Liu Tao Wang Xueyan Zhou Sitong Qian Jinfang Song Yi Xu Qian Lu Xiaoxing Yin | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
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