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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells显示文摘Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Unfortunately, it is impossible to obtain normal tissue for DIPG because of the vital functions of the pons.Here we report the human fetal hindbrain-derived neural progenitor cells(pontine progenitor cells, PPCs) as normal control cells for DIPG. The PPCs not only harbored similar cell biological and molecular signatures as DIPG glioma stem cells, but also had the potential to be immortalized by the DIPG-specific mutation H3 K27 M in vitro. These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG. | Yu Sun Cheng Xu Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng Zhang Wenhao Wu Yu Wang Deling Li Zhen Wu Junting Zhang Qiaoran Xi Liwei Zhang | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 3 | A Case Study of Applying Metagenomic Sequencing in Precise Epidemiology for the COVID-19 Pandemic-Sichuan Province, China, 2020显示文摘Introduction:Determining the transmission chain of a virus in its incipient stages is extremely time consuming in traditional approaches that rely mainly on case incidence and interview-based contact data.With the development of high-throughput sequencing technology,genome-based epidemiology approach is showing promise in detecting viral transmission.However,there is still insufficient evidence for the relationship between the viral genetic variations and real viral transmission.Methods:To explore the possible relationship between transmission chains and viral genetic variations,we combined both epidemiological data and viral genomes of COVID-19 virus collected from Sichuan Province.A phylogenetic approach was used to infer the transmission chain,which was then compared to the transmission chain that came from epidemiological data.Results:We found that the putative transmission chains were highly concordant to the true transmission chains from epidemiological data,suggesting a strong correlation between viral genetic variations and the viral transmission chain.Discussion:Our results showed advantages of viral genomic sequencing in tracking and perceiving pathogen transmission,which allowed for potential improvements in the design and implementation of population-level public health interventions. | Jianan Xu Ye Wang You Li Huiping Yang Ming Pan Jian Liu Lina Shi Yuliang Feng Li Liu Jin Li Li Zhang Shusen He | 2020 | China CDC weekly2020，2，47： | 2 |
| 4 | P-Cadherin Promotes Liver Metastasis and Is Associated with Poor Prognosis in Colon Cancer显示文摘 | Lichao Sun Hai Hu Liang Peng Zhuan Zhou Xuan Zhao Jian Pan Lixin Sun Zhihua Yang Yuliang Ran | 2011 | The American Journal of Pathology2011，，： | 1 |
| 5 | A reusable SMA actuated non-explosive lockrelease mechanism for space application显示文摘After the satellite is launched with the carrier rocket,it is necessary to separate the satellite from the rocket at an appropriate time to ensure that the satellite enters the intended orbit.In this process,it is vital to ensure a reliable connection and accurate separation.With the increasing use of microsatellite in orbit,the contradiction between the shock of separation and the requirement of the platform’s dynamic environment is becoming increasingly prominent.Therefore,the traditional pyrotechnic separation device can no longer meet the requirements.This paper presents a reusable non-explosive release actuator using shape memory alloy(SMA)wire for high load and low shock.The system is based on the Fast Acting Shock-less Separation Nut(FASSN)technology.Using the shape memory effect of SMA,a biased SMA wire trigger has been developed,which is used as the driver source of the actuator.At the moment of receiving the electrical signal,the SMA wire generates stress and deformation.The trigger set free the constraints on the mechanical components,and the target is released.Experimental results indicate that the trigger device can unlock successfully and well meet the technical objectives. | Xueting Pan Yuliang Zhang Yifan Lu Fei Yang Honghao Yue | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 6 | A Novel Magnetostrictive Drive Rotary Motor 显示文摘 | Jianjun Zhou Yuliang Pan Min Huang | 2007 | Solid State Phenomena (S1662-9779)2007，121，3： | 1 |
| 7 | Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrestin human gastric cancer cells显示文摘 | Jian Pan Hai Hu Zhuan Zhou Lichao Sun Liang Peng Long Yu Lixin Sun Jun Liu Zhihua Yang Yuliang Ran | 2010 | Oncology Reports2010，，1： | 1 |
| 8 | Selective collection and detection of leukemia cells on a magnet-quartz crystal microbalance system using aptamer-conjugated magnetic beads显示文摘 | Pan Yuliang Guo Manli Nie Zhou | 2010 | Biosens Bioelectron2010，25，： | 1 |
| 9 | Combination of Haptoglobin and Osteopontin Could Predict Colorectal Cancer Hepatic Metastasis显示文摘 | Lichao Sun Jian Pan Liang Peng Lv Fang Xuan Zhao Lixin Sun Zhihua Yang Yuliang Ran | 2012 | Annals of Surgical Oncology2012，，7： | 1 |
| 10 | Optimized design of the 4TSQ-2 sugar beet top cutting machine显示文摘To solve the problems faced by 4TSQ-2 sugar beet top cutting machine,i.e.large structure,high power consumption and high manufacturing cost,the multi-roller mechanism for leaves removal and fixed-thickness cutting method was studied.Using five-factor and two-level tests,the structure configuration of the leaf removal device was optimized,and the scheme of two roller shafts defoliation,the roller shaft rotation speed of 800 r/min and the forward speed of 0.8 m/s were determined.Through the working process and mechanical analysis of the top cutting device,the cutting device with the slant profiling plate structure characterized by a profiling angle of 25°-45°for the profiling plate and a cutting angle of 20°-40°was studied.With the two-factor and three-level experiments,the profiling angle of profiling plate of the top cutting device was 35°,and the cutting angle was 30°.Compared with the 4TSQ-2 sugar beet top cutting machine before optimization,the structure size of the machine was reduced by 30%,the weight was reduced by 15%,the cost was reduced by 25%,the qualified rate of top cutting wad was increased by 2.6%,and the push over rate of sugar beet was reduced by 0.5%.Besides,each index met the index requirements of beet top cutting harvest. | Fangyan Wang Zhenyu Zhang Yongfei Pan Yuliang Yun Dongwei Wang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，2： | 1 |
| 11 | The First Case of COVID-19 by an A.27 Lineage Variant Detected in a Returning Employee—Sichuan Province,China,January 7,2021显示文摘On January 7,2021,a 32-year-old returning employee arrived in Chengdu from Algeria via airplane and tested positive for coronavirus disease 2019(COVID-19)by nucleic acid tests.He was transferred to the designated hospital for further diagnosis and treatment.The patient was diagnosed as a mild COVID-19 case on January 16.After medical treatment,this patient recovered and left the hospital on February 18. | Li Liu Tao Luo Gaopeng Lei Yuliang Feng Xiang Zhao Huiping Yang Jianan Xu Ming Pan Linlin Zhou | 2021 | China CDC weekly2021，3，34： | 1 |
| 12 | Progress in NMR-based metabolomics of Catharanthus roseus显示文摘Metabolomics has been rapidly developed as an important field in plant sciences and natural products chemistry.As the only natural source for a diversity of monoterpenoid indole alkaloids(MIAs),especially the low-abundance antitumor agents vinblastine and vincristine,Catharanthus roseus is highly valued and has been studied extensively as a model for medicinal plants improvement.Due to multistep enzymatic biosynthesis and complex regulation,genetic modification in the MIA pathway has resulted in complicated changes of both secondary and primary metabolism in C.roseus,affecting not only the MIA pathway but also other pathways.Research at the metabolic level is necessary to increase knowledge on the genetic regulation of the whole metabolic network connected to MIA biosynthesis.Nuclear magnetic resonance(NMR)is a very suitable and powerful complementary technique for the identification and quantification of metabolites in the plant matrix.NMR-based metabolomics has been used in studies of C.roseus for pathway elucidation,understanding stress responses,classification among different cultivars,safety and quality controls of transgenic plants,cross talk between pathways,and diversion of carbon fluxes,with the aim of fully unravelling MIA biosynthesis,its regulation and the function of the alkaloids in the plant from a systems biology point of view. | Qifang PAN Jingya ZHAO Yuliang WANG Kexuan TANG | 2015 | Frontiers of Agricultural Science and Engineering2015，2，3： | 0 |
| 13 | Core-shell-embedded Mesoporous Silica Capsules for Atmospheric Water Harvesting显示文摘A one-step ultrasonic mechanical method was used to synthesize a kind of atmospheric water harvesting material with high water harvesting performance in a wide relative humidity(RH)range,especially at low RH(RH<40%),namely,mesoporous silica capsule(MSC)with core-shell structure.Transmission electron microscopy(TEM),nitrogen adsorption and other characterization techniques were used to study the formation process of nano-microspheres.A new mechanism of self-adaptive concentration gradient regulation of silicon migration and recombination core-shell structure was proposed to explain the formation of a cavity in the MSC system.The core-shell design can enhance the specific surface area and pore volume while maintaining the monodispersity and mesoporous size.To study the water harvesting performance of MSC,solid silica nanoparticles(SSN)and mesoporous silica nanoparticles(MSN)were prepared.In a small atmospheric water collection test(25℃,40%RH),the water vapour adsorption and desorption kinetics of MSC,SSN,MSN and a commercial silica gel(CSG)were compared and analyzed.The results show that the MSC with mesoporous channels and core-shell structure can provide about 0.324 gwater/gadsorbent,79%higher than the CSG(0.181 gwater/gadsorbent).It is 25.1%higher than that of 0.259 gwater/gadsorbentof un-hollowed MSN and 980%higher than that of0.03 gwater/gadsorbentof un-hollowed SSN.The material has a large specific surface area and pore volume,simple preparation method and low cost,which provides a feasible idea for realising atmospheric water collection in arid and semi-arid regions. | ZHANG Shangsheng XU Shuman LEI Ruicheng PAN Yuliang MA Tao ZHANG Zheng LIU Chunsheng ZHANG Zengzhi | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，5： | 0 |
| 14 | Advances in Clinical Pharmacokinetics of Herbal Medicines显示文摘 | Lei Zhang Yuliang Wang Peng Zou Xinzhu Pan Hanming Zhang Wansheng Chen | 2005 | Journal of US-China Medical Science2005，2，6： | 0 |
| 15 | Unimpaired immunogenicity of yeast-expressed hepatitis B surface antigen stored at elevated temperatures显示文摘病毒(HBV ) 疫苗极大地减少了的肝炎 B 的全球采纳新 HBV 感染。当前的 HBV 疫苗是与铝磷酸盐或铝氢氧化物混合的液体暂停包含 recombinant 肝炎 B 表面抗原(HBsAg ) 粒子。制冷(2-8 楳湯? | Zhongliang Shen Yuliang Rao Shuai Tao Mengjun Luo Lijun Ming Jing Liu Shaokun Pan Youhua Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 0 |
| 16 | Emergence of a SARS-CoV-2 Omicron Subvariant BA.2.2 with a 454-Nucleotide Genomic Deletion-Sichuan Province,China,May 10,2022显示文摘On May 9,2022,3 local residents in Guang’an City,Sichuan Province,tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and were diagnosed as asymptomatic infections with coronavirus disease 2019(COVID-19)in a local outbreak,and as of May 14,a total of 20 confirmed cases and 398 asymptomatic infections were reported.Whole genome sequencing was performed directly on the nasal and throat swab specimens from the initial three asymptomatic infected individuals using the Illumina MiSeq platform(Illumina,San Diego,CA,USA).The complete genome sequences of 3 SARSCoV-2 strains,named SC1215,SC1216,and SC1217,were obtained.The sequence of SC1217 has been deposited in the GISAID database(under the accession number EPI_ISL_12725020). | Yuliang Feng Xiang Zhao Tao Luo Zhixiao Chen Huiping Yang Na Chen Xiaozhen Ma Mingyuan Li Weihua Zhang Sikai Jia Xun Yuan Ming Pan Linlin Zhou | 2022 | China CDC weekly2022，4，40： | 0 |
| 17 | HPC-Atlas:Computationally Constructing A Comprehensive Atlas of Human Protein Complexes显示文摘A fundamental principle of biology is that proteins tend to form complexes to play important roles in the core functions of cells.For a complete understanding of human cellular functions,it is crucial to have a comprehensive atlas of human protein complexes.Unfortunately,we still lack such a comprehensive atlas of experimentally validated protein complexes,which prevents us from gaining a complete understanding of the compositions and functions of human protein complexes,as well as the underlying biological mechanisms.To fill this gap,we built Human Protein Complexes Atlas(HPC-Atlas),as far as we know,the most accurate and comprehensive atlas of human protein complexes available to date.We integrated two latest protein interaction networks,and developed a novel computational method to identify nearly 9000 protein complexes,including many previously uncharacterized complexes.Compared with the existing methods,our method achieved outstanding performance on both testing and independent datasets.Furthermore,with HPC-Atlas we identified 751 severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-affected human protein complexes,and 456 multifunctional proteins that contain many potential moonlighting proteins.These results suggest that HPC-Atlas can serve as not only a computing framework to effectively identify biologically meaningful protein complexes by integrating multiple protein data sources,but also a valuable resource for exploring new biological findings.The HPCAtlas webserver is freely available at http://gffzz6ca2edafa0dc406ahkxxpub669u6c6npo.ffgz.tsg.suse.edu.cn/HPC-Atlas. | Yuliang Pan Ruiyi Li Wengen Li Liuzhenghao Lv Jihong Guan Shuigeng Zhou | 2023 | Genomics, Proteomics & Bioinformatics2023，21，5： | 0 |
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