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| 1 | An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites显示文摘mesoporous 硅石 / 黄金(MSN/Au ) nanocomposite 为明确地目标为肿瘤房间的控制相片的药交货被设计。MSN/Au nanocomposite 由基于 MSN 的药搬运人组成,金 nanoparticle (AuNP ) 基于指示物。当基于 MSN 的药搬运人是 mesoporous 硅石时, nanoparticle 与相片可切换的偶氮苯使不能调动(偶氮) 一半,基于 AuNP 的指示物是与矩阵 metalloproteinase (MMP ) 修改的熄灭荧光的 AuNP 底层并且 poly (乙烯乙二醇) 。二种 nanoparticles 被连接由一, cyclodextrin (, CD ) 更暗淡的桥牌。在 vitro,研究证明 nanocomposite 明确地与肿瘤地点 overexpressing MMP-2 交往了,为释放的随后的紫外轻照耀的启用的指导它骗诱药。通过基于 AuNP 的指示物和基于 MSN 的药搬运人的集成, MSN/Au nanocomposite 能精确本地化释放的药到肿瘤地点,显著地从而改进治疗学的功效。 | Guofeng Luo Weihai Chen Huizhen Jia Yunxia Sun Han Cheng Renxi Zhuo Xianzheng Zhang | 2015 | Nano Research2015，8，6： | 6 |
| 2 | Synchronized ovi- position triggered by migratory flight intensifies larval outbreaks of beet webworm 显示文摘 | Cheng Yunxia Luo Lizhi Jiang Xingfu | 2012 | PLoS ONE2012，7，31： | 1 |
| 3 | The clock gene,period,influences migratory flight and reproduction of the oriental armyworm,Mythimna separata(Walker)显示文摘The oriental armyworm,Mythimna separata,is a major long-distance migratory insect pest of grain crops in China and other Asian countries.Migratory flights and reproductive behavior usually occur at night,regulated by a circadian rhythm.However,knowledge about the linkages between adult flight,reproduction,and clock genes is still incomplete.To fill this important gap in our knowledge,a clock gene(designated Msper)was identified and phylogenetic analysis indicated that the encoded protein(MsPER)was highly similar to PER proteins from other insect species.Quantitative RT-PCR assays demonstrated that significantly different spatiotemporal and circadian rhythmic accumulations of mRNA encoding MsPER occurred during development under steady 14 h:10 h light:dark conditions.The highest mRNA accumulation occurred in adult antennae and the lowest in larvae.Msper was expressed rhythmically in adult antennae,relatively less in photophase and more entering scotophase.Injecting small interference RNA(siRNA)into adult heads effectively knocked down Msper mRNA levels within 72 h.Most siRNA-injected adults reduced their evening flight activity significantly and did not exhibit a normal evening peak of flight activity.They also failed to mate and lay eggs within 72 h.Adult mating behavior was restored to control levels by 72 h post injection.We infer that Msper is a prominent clock gene that acts in regulating adult migratory flight and mating behaviors of M.separata.Because of its influence on migration and mating,Msper may be a valuable gene to target for effective management of this migratory insect. | Jiayue Ji Yueqiu Liu Lei Zhang Yunxia Cheng David Stanley Xingfu Jiang | 2023 | Insect Science2023，30，3： | 1 |
| 4 | Synchronized ovi- position triggered by migratory flight intensifies larval out- breaks of beet webworm 显示文摘 | Cheng Yunxia Luo Lizhi Jiang Xingfu | 2012 | PLoS ONE2012，7，31： | 1 |
| 5 | Synthesis,structures,and adsorption properties of two new LaIII-MgIIheterometallic polymers显示文摘 | XU Yun CHE Yunxia CHENG Fangyi | 2011 | Eur J Inorg Chem2011，34，52： | 1 |
| 6 | Highly cross-linked thermosetting resin of maleimidobenzoxazine functionalized with benzocyclobutene显示文摘 | Yuanrong Cheng Tianke Qi Yunxia Jin Dunying Deng Fei Xiao | 2013 | Polymer2013，，1： | 1 |
| 7 | Antioxidative Effect of Lactic Acid-Stabilized Copper Nanoparticles Prepared in Aqueous Solution显示文摘 | Deng Dunying Cheng Yuanrong Jin Yunxia | 2012 | Journal of Materials Chemistry2012，22，23： | 1 |
| 8 | Research Progress in the Direct Synthesis of Dimethyl Carbonate from CO2 and Methanol显示文摘 | Yunxia Cao Hangxin Cheng Lingling Ma Fei Liu Zhiming Liu | 2012 | Catalysis Surveys from Asia2012，，3： | 1 |
| 9 | Ultrabroad-band,white light emission from carbon dot-based materials with hybrid fluorescence/phosphorescence for single component white light-emitting diodes显示文摘Benefiting from the large Stokes shift between fluorescence and phosphorescence,fluorescence/phosphorescence dual-emitting carbon dots(CDs)have gradually entered at the stage of single-phase white light-emitting diodes(WLEDs)as‘green material'.However,most of the developed dual-emitting CDs have weak phosphorescence,short emission wavelength and narrow emission band,resulting in relatively bluish white light emission and low color rendering index(CRI).Herein,an ultrabroad-band fluorescence/phosphorescence dual-emitting CD-based material(UB-CD@BA)is prepared by thermal treatment of boric acid(BA)and CDs with large conjugated structure.The stable covalent bonding between CDs and BA,as well as three-dimensional spatial restriction effect of selfpolymerization BA molecules around CDs during long-term heating efficiently rigidified the single/triplet excited states of CDs from non-radiative deactivation,thus producing strong dual emissive materials with the high phosphorescence quantum yield of 21%.Remarkable,the prepared UB-CD@BA powders exhibit bright pure white light emission with Commission Internationale de l'Eclairage(CIE)coordinates of(0.32,0.33)and the highest reported full width at half maximum of 250 nm.Based on the unique characteristics of UB-CD@BA,it was used as a color conversion layer to prepare a WLED with CIE coordinates of(0.35,0.33)and the CRI value of 87. | Yuchen Li Qijun Li Shuai Meng Yukun Qin Dengke Cheng Hailing Gu Zifei Wang Yunxia Ye Jing Tan | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 10 | Diagnosis and Treatment Guidelines for Mesenchymal Stem Cell Therapy for Coronavirus Disease 2019(Beijing,2021)显示文摘The coronavirus disease 2019(COVID-19)can be caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and has led to millions of deaths among more than 100 million infected people around the world according to the declaration from World Health Organization.Dysregulated immune response of both the innate and adaptive immune systems is subsistent on COVID-19 patients,of which the degree are associated with disease severity,lung damage and long term functional disability.Current treatment options have included antiretroviral drugs,anti-inflammatory factors,antibodies,immune checkpoint inhibitors,and convalescent plasma therapy.More recently,mesenchymal stem cell(MSC)therapy has been explored for the management and control of COVID-19,particularly with the aim of preventing or at least mitigating respiratory co-morbidities.Though the safety and efficacy of stem cell therapy have been validated in multiple phase I–III clinical trials,to date,no standardized stem cell preparation,administration dosage or interval,product QA/QC testing,storage,transportation,or disposal protocols have been established.The present paper proposes a systematic methodology that addresses all the foregoing process steps and evaluation criteria for the efficacious and safe administration of MSCs in the treatment of patients infected with COVID-19. | Ruonan Xu Lei Shi Wei-Fen Xie Zhe Xu Fan-Ping Meng Jun-Liang Fu Xin Yuan Lei Huang Ming Shi Yonggang Li Yuanyuan Li Chen Yao Yu Zhang Zhongmin Liu Chenyan Gao Zhaohui Wu Shufang Meng Weidong Han Charlie Xiang Gui-Qiang Wang Taisheng Li Xiaoying Wang Yunxia Sun Zunyou Wu Wenhong Zhang Chunhua Zhao Yu Hu Tao Cheng Yuquan Wei Qi Zhou Fu-Sheng Wang | 2021 | Infectious Diseases & Immunity2021，1，2： | 0 |
| 11 | Output performance optimization for RTD fluxgate sensor based on dynamic permeability显示文摘The output performance of residence times difference(RTD) fluxgate may vary under different driving conditions(driving currents and frequencies) and core materials. To optimize the RTD fluxgate and simplify its design process, an analytical model is employed to select the parameters and identify the effective factors that dominate the performance. The dynamic permeability parameters(Pi), which reflect the changes in the magnetization curve, are mathematically analyzed in detail. The linear variation functions of Pi in different driving conditions are fitted by using the dynamic arctangent hysteresis model. Consequently, the selection of driving conditions and core materials, which are assessed by comparing the experiment and simulation results,has an important role in achieving the optimal output performance of the RTD fluxgate. | Yanzhang WANG Shujun WU Hao LU Defu CHENG Chen CHEN Na PANG Yunxia WAN Zhijian ZHOU Siyu CHEN | 2016 | Science China(Information Sciences)2016，59，11： | 0 |
| 12 | P311 promotes typeⅡtransforming growth factor-βreceptor mediated fibroblast activation and granulation tissue formation in wound healing显示文摘Background:P311,a highly conserved 8 kDa intracellular protein,has recently been reported to play an important role in aggravating hypertrophic scaring by promoting the differentiation and secretion of fibroblasts.Nevertheless,how P311 regulates the differentiation and function of fibroblasts to affect granulation tissue formation remains unclear.In this work,we studied the underlying mechanisms via which P311 affects fibroblasts and promotes acute skin wound repair.Methods:To explore the role of P311,both in vitro and in vivo wound-healing models were used.Full-thickness skin excisional wounds were made in wild-type and P311−/−C57 adult mice.Wound healing rate,re-epithelialization,granulation tissue formation and collagen deposition were measured at days 3,6 and 9 after skin injury.The biological phenotypes of fibroblasts,the expression of target proteins and relevant signaling pathways were examined both in vitro and in vivo.Results:P311 could promote the proliferation and differentiation of fibroblasts,enhance the ability of myofibroblasts to secrete extracellular matrix and promote cell contraction,and then facilitate the formation of granulation tissue and eventually accelerate skin wound closure.Importantly,we discovered that P311 acts via up-regulating the expression of type II transforming growth factor-βreceptor(TGF-βRII)in fibroblasts and promoting the activation of the TGF-βRII-Smad signaling pathway.Mechanistically,the mammalian target of rapamycin signaling pathway is closely implicated in the regulation of the TGF-βRII-Smad pathway in fibroblasts mediated by P311.Conclusions:P311 plays a critical role in activation of the TGF-βRII-Smad pathway to promote fibroblast proliferation and differentiation as well as granulation tissue formation in the process of skin wound repair. | Jue Wang Ruoyu Shang Jiacai Yang Zhihui Liu Yunxia Chen Cheng Chen Wenxia Zheng Yuanyang Tang Xiaorong Zhang Xiaohong Hu Yong Huang Han-Ming Shen Gaoxing Luo Weifeng He | 2022 | Burns & Trauma2022，10，1： | 0 |
| 13 | Research Status and Key Technologies of Geo-Electromagnetic Magnetic Induction Sensor显示文摘According to different applications,the performance parameters of the several Geo-Electromagnetic Magnetic Induction Sensors( GEMISs) which are the most representative in the world are compared. After discussing the several key technologies for improving the performance of GEMISs,the main conclusions are as follows: the application bandwidth can be expanded by adopting flux negative feedback( 1 m Hz-10 k Hz);'laminated'core structure is useful for suppressing eddy current loss; the effective permeability of the core has increased observably after adding flux concentrators to the two ends of the core; the chopper amplifier is a useful method to suppress 1/f noise for reducing the GEMIS's output noise; the indoor calibration scheme based on'long straight solenoid'proposed to obtain sensor sensitivity. Accordingly,the problem how to reduce the noise of GEMIS is urgent need to be solved,which will improve the performance of GEMIS. And there is plenty of work requires further study on parameters ' optimization of coil and core. In the future,miniaturization,intelligence and three-axis measurement are the development directions of GEMIS. | Yanzhang Wang Yunxia Wan Chen Chen Hongyu Shi Jun Lin Defu Cheng | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，4： | 0 |
| 14 | BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes显示文摘Brain-specific serine/threonine-protein kinase 2(BRSK2)plays critical roles in insulin secretion andβ-cell biology.However,whether BRSK2 is associated with human type 2 diabetes mellitus(T2DM)has not been determined.Here,we report that BRSK2 genetic variants are closely related to worsening glucose metabolism due to hyperinsulinemia and insulin resistance in the Chinese population.BRSK2 protein levels are significantly elevated inβcells from T2DM patients and high-fat diet(HFD)-fed mice due to enhanced protein stability.Mice with inducibleβ-cell-specific Brsk2 knockout(βKO)exhibit normal metabolism with a high potential for insulin secretion under chow-diet conditions.Moreover,βKO mice are protected from HFD-induced hyperinsulinemia,obesity,insulin resistance,and glucose intolerance.Conversely,gain-of-function BRSK2 in matureβcells reversibly triggers hyperglycemia due toβ-cell hypersecretion-coupled insulin resistance.Mechanistically,BRSK2 senses lipid signals and induces basal insulin secretion in a kinase-dependent manner.The enhanced basal insulin secretion drives insulin resistance andβ-cell exhaustion and thus the onset of T2DM in mice fed an HFD or with gain-of-function BRSK2 inβcells.These findings reveal that BRSK2 links hyperinsulinemia to systematic insulin resistance via interplay betweenβcells and insulin-sensitive tissues in the populations carrying human genetic variants or under nutrient-overload conditions. | Rufeng Xu Kaiyuan Wang Zhengjian Yao Yan Zhang Li Jin Jing Pang Yuncai Zhou Kai Wang Dechen Liu Yaqin Zhang Peng Sun Fuqiang Wang Xiaoai Chang Tengli Liu Shusen Wang Yalin Zhang Shuyong Lin Cheng Hu Yunxia Zhu Xiao Han | 2023 | Journal of Molecular Cell Biology2023，15，5： | 0 |
| 15 | Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice显示文摘Background:Delayed wound healing remains a common but challenging problem in patients with acute or chronic wound following accidental scald burn injury.However,the systematic and detailed evaluation of the scald burn injury,including second-degree deep scald(SDDS)and thirddegree scald(TDS),is still unclear.The present study aims to analyze the wound-healing speed,the formation of granulation tissue,and the healing quality after cutaneous damage.Methods:In order to assess SDDS and TDS,the models of SDDS and TDS were established using a scald instrument in C57BL/6 mice.Furthermore,an excisional wound was administered on the dorsal surface in mice(Cut group).The wound-healing rate was first analyzed at days 0,3,5,7,15 and 27,with the Cut group as a control.Then,on the full-thickness wounds,hematoxylin and eosin(H&E)staining,Masson staining,Sirius red staining,Victoria blue staining and immunohistochemistry were performed to examine re-epithelialization,the formation of granulation tissue,vascularization,inflammatory infiltration and the healing quality at different time points in the Cut,SDDS and TDS groups.Results:The presented data revealed that the wound-healing rate was higher in the Cut group,when compared with the SDDS and TDS groups.H&E staining showed that re-epithelialization,formation of granulation tissue and inflammatory infiltration were greater in the Cut group,when compared with the SDDS and TDS groups.Immunohistochemistry revealed that the number of CD31,vascular endothelial growth factor A,transforming growth factor-βandα-smooth muscle actin reached preferential peak in the Cut group,when compared with other groups.In addition,Masson staining,Sirius red staining,Victoria blue staining,Gordon-Sweets staining and stress analysis indicated that the ratio of collagen I to III,reticular fibers,failure stress,Young’s modulus and failure length in the SDDS group were similar to those in the normal group,suggesting that healing quality was better in the SDDS group,when compared with the Cut and TDS groups.Conclusion:Overall,the investigators first administered a comprehensive analysis in the Cut,SDDS and TDS groups through in vivo experiments,which further proved that the obstacle of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice. | Yunxia Chen Xiaorong Zhang Zhihui Liu Jiacai Yang Cheng Chen Jue Wang Zengjun Yang Lei He Pengcheng Xu Xiaohong Hu Gaoxing Luo Weifeng He | 2021 | Burns & Trauma2021，9，1： | 0 |
| 16 | Vascular disrupting agent-induced amplification of tumor targeting and prodrug activation boosts anti-tumor efficacy显示文摘Vadimezan,one of the typical vascular disrupting agents(VDAs) currently in clinical trials,has been extensively implemented for cancer research,whereas its clinical efficacy is adversely affected by the inevitable side effects.Inspired by Vadimezaninduced intratumoral coagulation activation and hypoxia aggravation,we report a strategy by utilizing these biological effects to achieve targeted delivery and activation of hypoxia-activated prodrug(HAP) thus to maximize the therapeutic effect of Vadimezan.By encapsulating HAP tirapazamine into poly(lactic-co-glycolic acid)(PLGA) nanocarriers along with the modification of clot-binding peptide,the obtained nanoplatform could target tumors under the coagulation activation effect of Vadimezan.Meanwhile,the aggravated hypoxia tumor microenvironment induced by Vadimezan can also boost hypoxia-activated chemotherapy.In the murine tumor model,this strategy showed 80.0% suppression of tumor growth,indicating its great potential in tumor treatment.This study offers an ingenious tactic for the combination of vascular disrupting therapy and hypoxia-activated chemotherapy,which may open up a window of the VDAs-based combination therapy. | Sheng Hong Qian-Xiao Huang Ping Ji Xuan Pang Yunxia Sun Si-Xue Cheng Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，10： | 0 |
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