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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 3 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 4 | Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier显示文摘Nowadays,nanoparticles(NPs)are considered to be ideal tools for bioimaging and drug delivery.Although increasing research has focused on NP biodistribution,transportation in the interstitial architecture has been neglected.The entire body is connected by the interstitial architecture,which can provide a long-range and direct pathway for NP biodistribution in a nonvascular system.In this study,we report that 10-nm gold NPs injected directly into the interstitial architecture of the tarsal tunnel of rats(intervaginal space injection(ISI))were delivered to the brain without crossing the blood-brain barrier.Furthermore,NaGdF4 nanoparticles were used to explore the transportation route by magnetic resonance imaging.The results demonstrated that,after ISI,the NaGdF4 nanoparticles were transported through the perivascular interstitial space of the carotid arteries and brain vessels to the brain.This is a special nonvascular transportation route like a stream based on the interstitial architecture that provides an alternative pathway for NP biodistribution. | Nan Hu Xiaoli Shi Qiang Zhang Wentao Liu Yuting Zhu Yuqing Wang Yi Hou Yinglu Ji Yupeng Cao Qian Zeng Zhuo Ao Quanmei Sun Xiaohan Zhou Xiaochun Wu Dong Han | 2019 | Nano Research2019，12，11： | 2 |
| 5 | Characterisation of Lactobacillus fermentum SM-7 isolated from koumiss, a potential probiotic bacterium with cholesterol-lowering effects显示文摘 | PAN Daodong ZENG Xiaoqun YAN Yuting | 2011 | Journal of the Science of Food and Agriculture2011，91，3： | 1 |
| 6 | Ultrasonic- assisted extraction and antioxidant activity of polysaccharides recovered from white button mushroom ( Agaricus bisporus) 显示文摘 | Tian Yuting Zeng Hongliang Xu Zhenbo | 2012 | Carbohydrate Polymers2012，88，2： | 1 |
| 7 | Self-assembled all-inclusive organic-inorganic nanoparticles enable cascade reaction for the detection of glucose显示文摘Traditional colorimetric glucose biosensor generally involves complex assay procedures.Free labile enzymes and peroxidase substrates are used separately for triggering a chromogenic reaction.These limits result in inferior enzyme stability and defective enzymatic catalytic efficiency,making it hard to routinely utilize them for the direct and fast test of glucose.In this work,we provide an all-inclusive substrates/enzymes nanoparticle employed 3,3’5,5’-tetramethylbenzidine(TMB) as chromogenic substrates and glucose oxidase(GOx)/horseradish peroxidase(HRP) as signal amplifier enzymes(TMB-GH NPs) by the molecule self-assembly technique.The 'all-inclusive' nanoparticles can realize the tandem colorimetric reactions,and the oxidation product of TMB(ox-TMB) exhibits a strong NIR laserdrive n photothermal effect,thus allowing qua ntitative photothermal detection of glucose.Owing to the restriction of the molecular motion of GOx,HRP,and TMB,the distance of mass transfer between substrates was s hortened largely,leading to improved catalytic activity for glucose.Overall,our strategy will simplify the analysis procedure,furthermore,these integrated nanoparticles not only display higher stability and activity than that of the free GOx/HRP system and possesses an excellent performance for colorimetric and photothermal bioassay of glucose simultaneously.We believe that this unique technique will give good inspirations to develop simple and precise methods for bioassay. | Ximei Sun Yan Li Qian Yang Yunwei Xiao Yuting Zeng Jindi Gong Ziyu Wang Xiaofeng Tan He Li | 2021 | Chinese Chemical Letters2021，32，5： | 1 |
| 8 | Ultrasonic-assisted extraction and antioxidant activity of polysaccharides recovered from white button mushroom (Agaricus bisporus)显示文摘 | TIAN Yuting ZENG Hongliang XU Zhenbo | 2012 | Carbohydrate Polymers2012，88，2： | 1 |
| 9 | Robust Beamforming Under Channel Prediction Errors for Time-Varying MIMO System显示文摘The accuracy of acquired channel state information(CSI)for beamforming design is essential for achievable performance in multiple-input multiple-output(MIMO)systems.However,in a high-speed moving scene with time-division duplex(TDD)mode,the acquired CSI depending on the channel reciprocity is inevitably outdated,leading to outdated beamforming design and then performance degradation.In this paper,a robust beamforming design under channel prediction errors is proposed for a time-varying MIMO system to combat the degradation further,based on the channel prediction technique.Specifically,the statistical characteristics of historical channel prediction errors are exploited and modeled.Moreover,to deal with random error terms,deterministic equivalents are adopted to further explore potential beamforming gain through the statistical information and ultimately derive the robust design aiming at maximizing weighted sum-rate performance.Simulation results show that the proposed beamforming design can maintain outperformance during the downlink transmission time even when channels vary fast,compared with the traditional beamforming design. | ZHU Yuting LI Zeng ZHANG Hongtao | 2023 | ZTE Communications2023，21，3： | 1 |
| 10 | Characterization of Lactobacillus fermentum SM -7 Isolated from Koumiss, a potential probiotic bacterium with cholesterol-lowering effects显示文摘 | Daodong Pan Xiaoqun Zeng, Yuting Yan | 2011 | Journal of Science of Food and Agriculture2011，91，3： | 1 |
| 11 | Ultrasonic-assisted extraction and antioxidant activity of polysaccharides recovered from white button mushroom (Agaricus bisporus)显示文摘 | TIAN Yuting ZENG Hongliang XU Zhenbo | | 0，，02： | 1 |
| 12 | A biosensing system employing nanowell microelectrode arrays to record the intracellular potential of a single cardiomyocyte显示文摘Electrophysiological recording is a widely used method to investigate cardiovascular pathology,pharmacology and developmental biology.Microelectrode arrays record the electrical potential of cells in a minimally invasive and highthroughput way.However,commonly used microelectrode arays primarily employ planar microelectrodes and cannot work in applications that require a recording of the intracellular action potential of a single cell.In this study,we proposed a novel measuring method that is able to record the intracellular action potential of a single cardiomyocyte by using a nanowell patterned microelectrode array(NWMEA).The NWMEA consists of five nanoscale wells at the center of each circular planar microelectrode.Biphasic pulse electroporation was applied to the NWMEA to penetrate the cardiomyocyte membrane,and the intracellular action potential was continuously recorded.The intracellular potential recording of cardiomyocytes by the NWMEA measured a potential signal with a higher quality(213.76±25.85%),reduced noise root-mean-square(~33%),and higher signal-to-noise ratio(254.36±12.61%)when compared to those of the extracellular recording.Compared to previously reported nanopillar microelectrodes,the NWMEA could ensure single cell electroporation and acquire high-quality action potential of cardiomyocytes with reduced fabrication processes.This NWMEA-based biosensing system is a promising tool to record the intracellular action potential of a single cell to broaden the usage of microelectrode arrays in electrophysiological investigation. | Yuting Xiang Haitao Liu Wenjian Yang Zhongyuan xu Yue Wu Zhajian Tang Zhjing Zhu Zhiyong Zeng Depeng Wang Tianxing Wang Ning Hu Diming Zhang | 2022 | Microsystems & Nanoengineering2022，8，3： | 0 |
| 13 | Well-Dispersed Graphene Enhanced Lithium Complex Grease Toward High-Efcient Lubrication显示文摘Graphene as a lubricating additive holds great potential for industrial lubrication. However, its poor dispersity and compatibility with base oils and grease hinder maximizing performance. Here, the infuence of graphene dispersion on the thickening efect and lubrication function is considered. A well-dispersed lubricant additive was obtained via trihexyl tetradecyl phosphonium bis(2-ethylhexyl) phosphate modifed graphene ([P_(66614)][DEHP]-G). Then lithium complex grease was prepared by saponifcation with 12-OH stearic acid, sebacic acid, and lithium hydroxide, using polyalphaolefn (PAO20) as base oil and the modifed-graphene as lubricating additive, with the original graphene as a comparison. The physicochemical properties and lubrication performance of the as-prepared greases were evaluated in detail. The results show that the as-prepared greases have high dropping point and colloidal stability. Furthermore, modifed-graphene lithium complex grease ofered the best friction reduction and anti-wear abilities, manifesting the reduction of friction coefcient and wear volume up to 18.84% and 67.34%, respectively. With base oil overfow and afux, well-dispersed [P_(66614)][DEHP]-G was readily adsorbed to the worn surfaces, resulting in the formation of a continuous and dense graphene deposition flm. The synergy of deposited graphene-flm, spilled oil, and adhesive grease greatly improves the lubrication function of grease. This research paves the way for modulating high-performance lithium complex grease to reduce the friction and wear of movable machinery. | Kaiyue Lin Zhuang Zhao Yuting Li Zihan Zeng Xiaofeng Wei Xiaoqiang Fan Minhao Zhu | 2023 | Chinese Journal of Mechanical Engineering2023，36，5： | 0 |
| 14 | Combing Type-Aware Attention and Graph Convolutional Networks for Event Detection显示文摘Event detection(ED)is aimed at detecting event occurrences and categorizing them.This task has been previously solved via recognition and classification of event triggers(ETs),which are defined as the phrase or word most clearly expressing event occurrence.Thus,current approaches require both annotated triggers as well as event types in training data.Nevertheless,triggers are non-essential in ED,and it is time-wasting for annotators to identify the“most clearly”word from a sentence,particularly in longer sentences.To decrease manual effort,we evaluate event detectionwithout triggers.We propose a novel framework that combines Type-aware Attention and Graph Convolutional Networks(TA-GCN)for event detection.Specifically,the task is identified as a multi-label classification problem.We first encode the input sentence using a novel type-aware neural network with attention mechanisms.Then,a Graph Convolutional Networks(GCN)-based multilabel classification model is exploited for event detection.Experimental results demonstrate the effectiveness. | Kun Ding Lu Xu Ming Liu Xiaoxiong Zhang Liu Liu Daojian Zeng Yuting Liu Chen Jin | 2023 | Computers, Materials & Continua2023，，1： | 0 |
| 15 | Heptamethine cyanines in bioorthogonal chemistry显示文摘Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological imaging.Heptamethine cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background interference.Bioorthogonal reactions performed in living cells and tissues have developed by leaps and bounds in recent years.The NIR fluorescent labeling technique involving cyanine has attracted widespread attention.This review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,etc.We expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo. | Yuanyuan Liao Yuting Liang Yurou Huang Xiaoyan Zeng Tian He Jun Yin | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 16 | Long-term outcomes of intraoperative radiotherapy for early-stage breast cancer in China: amulticenter real-world study显示文摘Dear Editor,Intraoperative radiotherapy(IORT)is an accelerated par-tial breast irradiation(APBI)treatment that is accom-plished intraoperatively.Numerous clinical trials indicate that IORT is safe and effective,non-inferior to standard whole-breast external beam radiotherapy(EBRT)for low-risk patients who receive breast-conserving surgery[1-3].Nevertheless,these studies mainly included non-Asians and thus lack adequate evidence to support the value of IORT in Asian patients with breast cancer. | Xin Wang Kexin Feng Wenyan Wang Xiangzhi Meng Jiaqi Liu Yang Yang Yuting Zhong Jingruo Li Shikai Wu Minghui Li Pan Ma Qinfu Feng Hongmei Zeng Yuanting Gu Xiru Li Zhaoqing Fan Xiang Wang | 2022 | Cancer Communications2022，42，3： | 0 |
| 17 | Electrocoagulation coupled with electrooxidation for the simultaneous treatment of multiple pollutants in contaminated sediments显示文摘In situ and simultaneous remediation of a variety of pollutants in sediments remains a challenge.In this study,we report that the combination of electrocoagulation(EC)and electrooxidation(EO)is efficient in the immobilization of phosphorus and heavymetals and in the oxidation of ammonium and toxic organicmatter.The integratedmixed metal oxide(MMO)/Fe anode system allowed the facile removal of ammonium and phosphorus in the overlying water(99% of 10 mg/L NH_(4)^(+)-N and 95% of 10 mg/L P disappeared in 15 and 30 min,respectively).Compared with the controls of the single Fe anode and single MMO anode systems,the dual MMO/Fe anode system significantly improved the removal of phenanthrene and promoted the transition of Pb and Cu from the mobile species to the immobile species.The concentrations of Pb and Cu in the toxicity characteristic leaching procedure extracts were reduced by 99%and 97% after an 8 hr operation.Further tests with four real polluted samples indicated that substantial proportions of acid-soluble fraction Pb and Cu were reduced(30%-31% for Pb and 16%–23% for Cu),and the amounts of total organic carbon and NH_(4)^(+)-N decreased by 56%–71% and 32%–63%,respectively.It was proposed that the in situ electrogenerated Fe(II)at the Fe anode and the active oxygen/chlorine species at the MMO anode are conducive to outstanding performance in the co-treatment of multiple pollutants.The results suggest that the EC/EO method is a powerful technology for the in situ remediation of sediments contaminated with different pollutants. | Qingjun Zeng Yifan Zhang Pingshan Chen Yuting He Congli Yi Chunhua Feng | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 18 | Electromagnetic-thermal Coupled Analyses and Joint Optimisation of Electrically-excited Flux-switching Linear Machines显示文摘Electrically-excited flux-switching machines are advantageous in simple and reliable structure,good speed control performance,low cost,etc.,so they have arouse wide concerns from new energy field.However,they have much lower torque density/thrust density compared with the same type PM machines.To overcome this challenge,electromagnetic-thermal coupled analysis is carried out with respect to water-cooled electrically-excited flux-switching linear machines(EEFSLM).The simulation results indicate that the conventional fixed copper loss method(FCLM)is no longer suitable for high thrust density design,since it is unable to consider the strong coupling between the electromagnetic and thermal performance.Hence,a multi-step electromagnetic-thermal joint optimisation method is proposed,which first ensures the consistency between the electromagnetic and thermal modelling and then considers the effect of different field/armature coil sizes.By using the proposed joint optimisation method,it is found that the combination of relatively large size of field coil and relatively low field copper loss is favourable for achieving high thrust force for the current EEFSLM design.Moreover,the thrust force is raised by 13-15%compared with using the FCLM.The electromagnetic and thermal performance of the EEFSLM is validated by the prototype test. | Hui Wen Yufei Wang Yuting Zheng Wen Zeng Xiao Qu Jiongjiong Cai | 2022 | CES Transactions on Electrical Machines and Systems2022，6，4： | 0 |
| 19 | A back analysis scheme for refined soil stratification based on integrating borehole and CPT data显示文摘Utilizing both borehole and Cone Penetration Testing(CPT)data in soil stratification helps to get more convincing soil stratification results.However,the soil classification results revealed by borehole(Unified Soil Classification System,USCS)and CPT tests(soil behavior type,SBT)are commonly not con-sistent.This study proposes a feasible solution to integrate the borehole and CPT data with the tree-based method.The tree-based method is naturally suitable for soil stratification tasks as it aims to divide the subsurface space into several clusters based on the similarities of the soil types.A novel boundary dic-tionary method is proposed to enhance the model performance on complex soil layer conditions.A prob-abilistic mapping matrix between the USCS-SBT system is built based on a collected municipal database with collocated borehole and CPT data.The optimal soil stratification results can be selected based on considering multiple borehole information and pruning the structure of trees.The structure of the trees can be optimized in a back analysis perspective with the Sequential Model-Based Global Optimization(SMBO)algorithm which aims to maximize the possibility of observing the borehole information based on the USCS-SBT probabilistic mapping matrix.The uncertainties of the optimal soil stratification results can be estimated based on a weighted Gini index method.The performance of the proposed method is validated based on a real case in New Zealand with a cross-validation method.The results indicate that the proposed method is robust and effective. | Jiawei Xie Cheng Zeng Jinsong Huang Yuting Zhang Jianlin Lu | 2024 | Geoscience Frontiers2024，15，1： | 0 |
| 20 | Construction of FRET-based metallacycles with efficient photosensitization efficiency and photocatalytic activity显示文摘The fabrication of highly effective photosensitizers has received considerable attention because of their attractive functions and applications in the fields of photodynamic therapy, photosynthesis, photocatalysis, etc. Thus, it is highly desirable to develop a new approach to enhance photosensitization efficiency.Herein, through coordination-driven self-assembly, a series of metallacycles with efficient fluorescence resonance energy transfer(FRET) were effectively constructed, which displayed higher photosensitization efficiency and photocatalytic activity than their model metallacycles without FRET due to broadband absorption and singlet energy transfer from the energy acceptor to the energy donor. Moreover, iodization of fluorophores induced a significant enhancement of the photosensitization efficiency and photocatalytic activity of the metallacycles. This research provides an efficient strategy for improving photosensitization efficiency and a promising platform for the preparation of effective photosensitizers and photocatalysts. | Peipei Jia Yixiong Hu Zhiyong Zeng Yute Wang Bo Song Yanrong Jiang Haitao Sun Ming Wang Wenwei Qiu Lin Xu | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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