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| 1 | Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes显示文摘 | Zhou Hong Fang Caixia Zhang Lihui Deng Yonggui Wang Mian Meng Fengling | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 2 | Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells显示文摘Cucurbitacin B (崽) ,从 Cucurbitaceae 植物孤立的 triterpenoid 混合物,作为一个有希望的反癌症代理人被报导了,还它的行动机制仍然是争论的。在这研究,我们在鼠科的 B16F10 黑瘤房间探索了崽的潜在的机制。反增长和反侵略效果在有教养的房间被估计,并且在 vivo 反肿瘤,活动在一个鼠科的下的黑瘤模型被评估。流动 cytometry 被采用分析细胞周期分发和反应的氧种(ROS ) 层次。肌动朊层次被西方的污点分析决定,并且微分表示蛋白质的侧面被一条量的 proteomic 途径识别。结果证明那崽在房间增长,殖民地形成,以及移植和黑瘤房间的侵略潜力上施加了禁止的效果。下的黑瘤的生长显著地在当时,与崽对待的老鼠被禁止与控制相比组。而且,崽治疗引起了快速的房间膜 blebbing 和变丑,并且导致了 G2/M-phase 拘捕和 multiploid 房间的形成。尤其是, G 肌动朊水池很快被弄空,肌动朊总数在崽处理以后快速被形成。很多细胞骨架规章的蛋白质是调整的差别。ROS 生产的阻塞显著地减少了 G 肌动朊弄空能力和崽的反肿瘤活动。这些调查结果显示那崽在黑瘤房间通过 ROS 依赖的肌动朊聚集导致 G 肌动朊水池的快速的弄空,它可以部分至少说明它的反肿瘤活动。 | Yanting Zhang Dongyun Ouyang Lihui Xu Yuhua Ji Qingbing Zha Jiye Cai Xianhui He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 19 |
| 3 | A rare Waxy allele coordinately improves rice eating and cooking quality and grain transparency显示文摘In rice(Oryza sativa), amylose content(AC) is the major factor that determines eating and cooking quality(ECQ). The diversity in AC is largely attributed to natural allelic variation at the Waxy(Wx)locus. Here we identified a rare Wx allele, Wx^(mw) ,which combines a favorable AC, improved ECQ and grain transparency. Based on a phylogenetic analysis of Wx genomic sequences from 370 rice accessions, we speculated that Wx^(mw) may have derived from recombination between two important natural Wx alleles, Wx^(in) and Wx^(b). We validated the effects of Wx^(mw) on rice grain quality using both transgenic lines and near-isogenic lines(NILs). When introgressed into the japonica Nipponbare(NIP) background, Wx^(mw) resulted in a moderate AC that was intermediate between that of NILs carrying the Wx^(b)allele and NILs with the Wx^(mp) allele. Notably, mature grains of NILs fixed for Wx^(mw) had an improved transparent endosperm relative to soft rice. Further, we introduced Wx^(mw) into a high-yielding japonica cultivar via molecular marker-assisted selection: the introgressed lines exhibited clear improvements in ECQ and endosperm transparency. Our results suggest that Wx^(mw) is a promising allele to improve grain quality, especially ECQ and grain transparency of high-yielding japonica cultivars, in rice breeding programs. | Changquan Zhang Yong Yang Shengjie Chen Xueju Liu Jihui Zhu Lihui Zhou Yan Lu Qianfeng Li Xiaolei Fan Shuzhu Tang Minghong Gu Qiaoquan Liu | 2021 | Journal of Integrative Plant Biology2021，63，5： | 18 |
| 4 | Distribution and geological significance of 17α(H)-diahopanes from different hydrocarbon source rocks of Yanchang Formation in Ordos Basin显示文摘Based on GC-MS testing data of many saturated hydrocarbon samples, 17α(H)-C30 diahopanes (C30*) are extensively distributed in the lacustrine hydrocarbon source rocks of the Yanchang Formation in Ordos Basin, but show remarkable differences in relative abundance among various source rocks. Generally, Chang 7 high-quality source rock (oil shale) developed in deep lake anoxic environment shows lower C30* content, whereas Chang 6-9 dark mudstone developed in shallow to semi-deep lake, sub-oxidizing environment shows relatively high to high C30* value. Particularly, Chang 7 and Chang 9 black mudstones in Zhidan region in the northeast of the lake basin show extremely high C30* value. A comparative analysis was made based on lithology, organic types and various geochemical parameters indicative of redox environment, and the results indicate that environmental factors such as redox settings and lithology are key factors that control the C30* relative abundance, while organic types and maturity may be minor factors. High to extremely high C30* values are indicative of sub-oxidizing environment of fresh-brackish water and shallow to semi-deep lake. Therefore, research on C30* relative content and distribution in lacustrine hydrocarbon source rocks in the Yanchang Formation, especially on the difference in C30* between Chang 7 high-quality source rocks (oil shale) and Chang 6-91 source rocks (dark mudstone), will provide an important approach for classification of Mesozoic lacustrine crudes and detailed oil-source correlation in the basin. | ZHANG WenZheng YANG Hua HOU LiHui LIU Fei | 2009 | Science China Earth Sciences2009，52，7： | 16 |
| 5 | Down.regulation of E.cadherin enhances prostate cancer chemoresistance via Notch signaling显示文摘Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and metastasis.As a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of chemoresistance.However,the molecular mechanisms underlying PCa chemoresistance remain unclear.The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance.Methods:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were analyzed.PC3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence E-cadherin.Changes of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain reaction.Tumor cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,respectively.The drug sensitivity was evaluated using MTS assay.Results:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 cells.When E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were inhibited.In particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R cells.When E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,particularly,the sensitivity to paclitaxel was decreased.Interestingly,Notch-1 expression was up-regulated in PC3-Tx R and DU145-Tx R cells,whereas the E-cadherin expression was down-regulated in these cells comparing with their parental cells.The use ofγ-secretase inhibitor,a Notch signaling pathway inhibitor,significantly increased the sensitivity of chemoresistant cells to paclitaxel.Conclusion:The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling,and inhibiting the Notch signaling pathway may reverse PCa chemoresistance. | Wenchu Wang Lihui Wang Atsushi Mizokami Junlin Shi Chunlin Zou Jinlu Dai Evan T. Keller Yi Lu Jian Zhang | 2017 | Chinese Journal of Cancer2017，36，3： | 16 |
| 6 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 7 | Synergistic effect between Sn and K promoters on supported platinum catalyst for isobutane dehydrogenation显示文摘Catalytic dehydrogenation of isobutane has recently received considerable attention because of the increasing demand for isobutene.In this study,the synergistic effect between Sn and K on PtSnK/γ-Al2O3 catalysts has been investigated by changing the content of Sn.It was found that with the presence of potassium,suitable addition of Sn could not only increase the metal dispersion,but also reduce the catalyst acidity.In these cases,the synergistic effect could also strengthen the interactions between the metal and support,which resulted in an increase in both catalytic activity and stability.In our experiments,Pt-0.6SnK/Al catalyst exhibited the lowest deactivation rate (12.4%) and showed a selectivity to isobutene higher than 94% at the isobutane conversion of about 45.3% after running the reaction for 6 h.However,with the excessive loading of Sn,surface property of active sites and the interactions between metal and support were changed.As a result,the initial optimal ratio between the metallic function and acid function would be destroyed,which was disadvantageous to the reaction. | Yiwei Zhang Yuming Zhou Lihui Wan Mengwei Xue Yongzheng Duan Xuan Liu | 2011 | Journal of Natural Gas Chemistry2011，20，6： | 12 |
| 8 | Performance of wastewater sludge ecological stabilization显示文摘在这篇文章,废水污泥生态的稳定(WWSES ) 为污泥除去,矿化作用,和稳定,以及为被介绍滤处理。试验性的结果显示了那污泥的飞行员规模的二年不稳定的固体, triphenyltetrazolium 氯化物(TTC ) 脱氢酶活动(DHA ) ,和象指示物的含水量显示出污泥稳定的过程和学位。过程显示出的除去上的观察那弄干的污泥在二年系统操作以后到达了 20%50% 全部的固体的一个内容。第一年里的污泥 TTC-DHA 显然比第二年的低,并且 TTC-DHA 趋于随污泥的弄干的时间的增加减少。污泥的总氮,全部的磷,和器官的内容从顶逐渐地减少了到弄干的污泥层的底部。与与污水污泥对待的看台上的自然看台比较,单个射击显著地更高、粗糙蛋白质,粗糙的脂肪,和在在系统的芦苇根,茎,和叶子的粗糙的纤维内容比野芦苇的高,在系统(7.38%)的芦苇根的特别粗糙的蛋白质内容显然比野芦苇(3.29%)的高。 | CUI Yubo SUN Tieheng ZHAO Lihui JIANG Tingliang ZHANG Liping | 2008 | Journal of Environmental Sciences2008，20，4： | 12 |
| 9 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 10 | The Occurrence of Oleananes in the Beibuwan Basin and Its Application to the Study of Maturity and Oil-Source Rock Correlation显示文摘摘要: oleanane 参数,即,在 Beibuwan 盆的二沉积的列的 OP (oleananes/( oleananes+C30hopanes )),华南海,能被用来限定油产生窗户的顶,与在井 M1 的 0.53 的 Ro (/%)并且 0.55 在井 H1/Hd1/Hd2 ,分别地。与 vitrinite 反射(Ro/%) 作比较, OP 展示一个动态范围和罐头更精确显示油产生窗户。由使用 OP 和另外的 geochemical 索引,油来源关联也被进行。它建议在井 M1 和 M2 的油在 situ 从来源岩石被导出。在 Huachang 的 mudstone 高举不是为在这个区域的油的主要来源岩石。OP 也是在一些第三级的湖的盆的一个有用油来源关联参数。 | LI Meijun WANG Tieguan LIU Ju ZHANG Meizhu LU Hong MA Qinglin GAO Lihui | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 9 |
| 11 | Genetic diversity and DNA fingerprinting in jute(Corchorus spp.) based on SSR markers显示文摘Genetic diversity analysis and DNA finger printing are very useful in breeding programs,seed conservation and management. Jute(Corchorus spp.) is the second most important natural fiber crop after cotton. DNA fingerprinting studies in jute using SSR markers are limited. In this study, 58 jute accessions, including two control varieties(Huangma 179 and Kuanyechangguo) from the official variety registry in China were evaluated with 28 pairs of SSR primers. A total of 184 polymorphic loci were identified. Each primer detected 3 to 15 polymorphic loci, with an average of 6.6. The 58 jute accessions were DNA-fingerprinted with 67 SSR markers from the 28 primer pairs. These markers differentiated the 58 jute accessions from one another, with Co SSR305-120 and Co SSR174-195 differentiating Huangma 179 and Kuanyechangguo, respectively. NTSYS-pc2.10 software was used to analyze the genetic diversity in the 58 jute accessions. Their genetic similarity coefficients ranged from 0.520 to 0.910 with an average of 0.749, indicating relatively great genetic diversity among them. The 58 jute accessions were divided into four groups with the coefficient 0.710 used as a value for classification, consistent with their species and pedigrees. All these results may be useful both for protection of intellectual property rights of jute accessions and for jute improvement. | Liwu Zhang Rongrong Cai Minhang Yuan Aifen Tao Jiantang Xu Lihui Lin Pingping Fang Jianmin Qi | 2015 | The Crop Journal2015，3，5： | 8 |
| 12 | Effect of Ga Addition on Catalytic Performance of PtSnNa/ZSM-5 Catalyst for Propane Dehydrogenation显示文摘PtSnNaGa/ZSM-5 catalysts with different contents of Ga were prepared and characterized by X-ray diffraction (XRD), nitrogen adsorption, hydrogen chemisorption, ammonia temperature-programmed desorption (NH3-TPD), hydrogen temperature-programmed reduction (H2-TPR), and temperature-programmed oxidation (TPO) techniques. The performances of these catalysts for propane dehydrogenation were investigated. The test results indicated that the addition of Ga not only could improve the catalytic stability and propene selectivity, but also could effectively prevent the catalysts from coking. It was found that the PtSnNaGa(0.5 m%)/ZSM-5 catalyst exhibited the best performance in terms of propene selectivity and propane conversion. The high catalytic performance was most probably attributed to the presence of Ga that could strength- en the interaction between metals and the support to stabilize the catalytic active sites. | Liu Xuan Zhou Yuming Zhang Yiwei Duan Yongzheng Xue Mengwei Wan Lihui (School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189) | 2011 | China Petroleum Processing & Petrochemical Technology2011，13，4： | 7 |
| 13 | Synthesis of Cyclic Carbonate Catalyzed by DBU Derived Basic Ionic Liquids显示文摘 | Wei Li Weiguo Cheng Xia Yang Qian su Lihui Dong Pan Zhang Yunan Yi Bin Li Suojiang Zhang | 2018 | Chinese Journal of Chemistry2018，36，4： | 7 |
| 14 | Vertical Distribution Characteristics of PM2.5 Observed by a Mobile Vehicle Lidar in Tianjin, China in 2016显示文摘We present mobile vehicle lidar observations in Tianjin, China during the spring, summer, and winter of 2016. Mobile observations were carried out along the city border road of Tianjin to obtain the vertical distribution characteristics of PM_(2.5). Hygroscopic growth was not considered since relative humidity was less than 60% during the observation experiments. PM_(2.5) profile was obtained with the linear regression equation between the particle extinction coefficient and PM_(2.5) mass concentration. In spring, the vertical distribution of PM_(2.5) exhibited a hierarchical structure. In addition to a layer of particles that gathered near the ground, a portion of particles floated at 0.6–2.5-km height. In summer and winter, the fine particles basically gathered below 1 km near the ground. In spring and summer, the concentration of fine particles in the south was higher than that in the north because of the influence of south wind. In winter, the distribution of fine particles was opposite to that measured during spring and summer. High concentrations of PM_(2.5) were observed in the rural areas of North Tianjin with a maximum of 350 μg m–3 on 13 December2016. It is shown that industrial and ship emissions in spring and summer and coal combustion in winter were the major sources of fine particles that polluted Tianjin. The results provide insights into the mechanisms of haze formation and the effects of meteorological conditions during haze–fog pollution episodes in the Tianjin area. | Lihui LYU Yunsheng DONG Tianshu ZHANG Cheng LIU Wenqing LIU Zhouqing XIE Yan XIANG Yi ZHANG Zhenyi CHEN Guangqiang FAN Leibo ZHANG Yang LIU Yuchen SHI Xiaowen SHU | 2018 | Journal of Meteorological Research2018，32，1： | 5 |
| 15 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 16 | The spatial distribution and factors affecting karst cave development in Guizhou Province显示文摘这研究越过贵州省检验 4960 个洞的分发特征,当探查在洞之间的关系时空间模式和地理元素。这研究基于 hydrogeological 和贵州的地志的地图。ArcGIS 软件被用来处理洞的邻近的索引,空间分析,和联合分析高度和经度,以及岩石性质,岩性学,排水和几乎 5000 个洞的构造分割。基于贵州洞的点模式分析,邻近的索引是 0.53,并且 Tyson 多角形验证的变化的系数到达了 72.469% 。这个数字反映洞的聚类的分发模式。越过全部省,洞被划分成四个集中的区域和一个微弱地影响的区域。四个集中的区域是 Zunyi-Tongren, Bijie, Qianxinan-Liupanshui,和 Guiyang- Anshun-Qinan。一个微弱地影响的地区是 Qiandongnan。大多数在他们之中专注是 Guiyang-Anshun-Qiannan 区域,它盖住 24.67% 全部的省区域,并且说明 36.63% 全部的省洞。在贵州的洞分发在西方的部分作为稠密被描绘并且在东方部分稀少。在这个学习背景下面,形成,包括的岩性学,结构,气候,水文学,和高度的自然元素,和他们洞开发的分发,数字,和空间模式上的效果被分析。 | ZHOU Zhongfa ZHANG Shaoyun XIONG Kangning LI Bo TIAN Zhonghui CHEN Quan YAN Lihui XlAO Shizhen | 2017 | Journal of Geographical Sciences2017，27，8： | 4 |
| 17 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 18 | Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques显示文摘主要 histocompatibility 建筑群(MHC ) 一级信息为在 HIV 种痘和生物医学的模型理解有免疫力的回答的变化是重要的。在这研究, 9 Mamu -- A 和 13 Mamu-B 等位基因从 10 只中国起源的罗猴猕猴的 cDNA 产品被识别。除了被其它报导了的二等位基因,八是新奇的, 12 扩大了在 GenBank 是可得到的部分序列。MHC 一级抗原的另外的信息可能对在人的疾病研究的中国猕猴的可获得性有益。而且,领先的肽的多型性和在 α1 领域的自然漂亮受体识别主题两个都暗示那 Mamu -- A 和 Mamu-B 分子力量玩在自然漂亮房间的天生的有免疫力的回答给角色调音。 | Dongyun Ouyang Lihui Xu Zhengxi Dai Huanjing Shi Gaohong Zhang Yongtang Zheng Xianhui He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 4 |
| 19 | Optimization of Ultrasonic Extraction Conditions of Polyphenols from the Needles of Black Pine (Pinus thunbergii) Using Response Surface Methodology (RSM)显示文摘Ultrasonic extraction conditions of polyphenols from the needles of black pine(Pinus thunbergii) were optimized by single factors analysis and Box-Behnken experiment design. The results showed that both of ethanol concentration and ultrasonic time had a significant effect on polyphenol extraction, and there was significant interaction between any two variables in the three parameters of ethanol concentration, ultrasonic temperature and ultrasonic time. The optimal parameters for polyphenol extraction were the ethanol concentration of 52.67%, ultrasonic temperature at 49.21 ℃and ultrasonic time of 30.76 min. Under these conditions, the actual content of polyphenols was close to the predicted value. Therefore, the process can be used to extract polyphenols from black pine needles. | Xuqin REN Yingchun ZHANG Lirong WANG Xiaofang YANG Ting JI Zhengqian LIANG Lihui WANG | 2019 | Agricultural Biotechnology2019，8，2： | 3 |
| 20 | Using an Improved Clustering Method to Detect Anomaly Activities显示文摘In this paper, an improved k-means based clustering method (IKCM) is proposed. By refining the initial cluster centers and adjusting the number of clusters by splitting and merging procedures, it can avoid the algorithm resulting in the situation of locally optimal solution and reduce the number of clusters dependency. The IKCM has been implemented and tested. We perform experiments on KDD-99 data set. The comparison experiments with H-means+also have been conducted. The results obtained in this study are very encouraging. | LI Han ZHANG Nan BAO Lihui | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 3 |
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