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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Rapid Assessment on Potential Risks of Schistosomiasis Transmission—7 PLADs,China,2019 and 2021显示文摘Summary What is already known about this topic?Oncomelania hupensis(O.hupensis)and livestock are main infection sources of schistosomiasis.The schistosome infected O.hupensis and livestock’s feces are important risk factors in the transmission of schistosomiasis.What is added by this report?The potential risks of schistosomiasis transmission remain prevalent,giving an early warning to local government with information on existing transmission risks.It is expected that the effectiveness and efficiency of schistosomiasis surveillance could be improved by conducting rapid risk assessment at the beginning of transmission season. | Junyi He Hongqing Zhu Ziping Bao Lijuan Zhang Yinlong Li Ting Feng Suying Guo Wangping Deng Can Wang Hui Dang Tiewu Jia Chao Lyu Zhiqiang Qin Chunli Cao Jing Xu Shizhu Li Xiaonong Zhou | 2021 | China CDC weekly2021，3，51： | 5 |
| 3 | Multivariable fuzzy control of residential inverter-driven air conditionings显示文摘A model free intelligent multivariable fuzzy controller (MFC) designed for modulating the vapor compression cycles in a residential inverter-driven air conditioning is proposed. The novel controller combines a traditional fuzzy controller (TFC) and an additional coupling fuzzy controller,the coupling fuzzy controller is introduced to compensate for the unknown cross-coupling effects of this multivariable system. In order to evaluate the control performance of the MFC,it is digitally implemented in terms of regulating the desired evaporating temperature and superheat. The experimental results show the effectiveness of the MFC for improvement of system performance and energy efficiency. | Xu Jinqiang Feng Ziping | 2010 | Engineering Sciences2010，8，2： | 2 |
| 4 | Heating control strategy for variable refrigerant flow air conditioning system with multi-module outdoor units显示文摘 | Tu Qiu Mao Shoubo Feng Ziping | | Energy and Buildings0，，： | 1 |
| 5 | An experimental investigation of the frictional pressure drop of steam-wa- ter two-phase flow in helical coils显示文摘 | Liejin Guo Ziping Feng Xuejun Chen | 2001 | International Jour nal of Heat and Mass Transfer2001，44，： | 1 |
| 6 | An Experimental Investigation of the Frictional Pressure Drop of SteamWater Two-Phase Flow in Helical Coils显示文摘 | Liejin Guo Ziping Feng Xuejun Chen | 2001 | International Journal of Heat and Mass Transfer2001，44，： | 1 |
| 7 | High-accuracy target tracking for multistatic passive radar based on a deep feedforward neural network显示文摘In radar systems,target tracking errors are mainly from motion models and nonlinear measurements.When we evaluate a tracking algorithm,its tracking accuracy is the main criterion.To improve the tracking accuracy,in this paper we formulate the tracking problem into a regression model from measurements to target states.A tracking algorithm based on a modified deep feedforward neural network(MDFNN)is then proposed.In MDFNN,a filter layer is introduced to describe the temporal sequence relationship of the input measurement sequence,and the optimal measurement sequence size is analyzed.Simulations and field experimental data of the passive radar show that the accuracy of the proposed algorithm is better than those of extended Kalman filter(EKF),unscented Kalman filter(UKF),and recurrent neural network(RNN)based tracking methods under the considered scenarios. | Baoxiong XU Jianxin YI Feng CHENG Ziping GONG Xianrong WAN | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，8： | 1 |
| 8 | Antioxidantactivity and total phenolic contentsin peel and pulp of Chinese jujube{Ziziphus Jujuba Mill) fruits 显示文摘 | XUE Ziping FENG Weihua CAO Jiankang | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 9 | An experimental investigation of the frictional pressure drop of steam–water two-phase flow in helical coils显示文摘 | Liejin Guo Ziping Feng Xuejun Chen | 2001 | International Journal of Heat and Mass Transfer2001，，14： | 1 |
| 10 | Two- phase flow in microehannels显示文摘 | SERIZAWA A FENG Ziping KAWARA Z | 2002 | Experimental Ther- mal and Fluid Science2002，26，67： | 1 |
| 11 | Two-phase flow in microchannels显示文摘 | Akimi Serizawa Ziping Feng Zensaku Kawara | 2002 | Experimental Thermal and Fluid Science2002，，6： | 1 |
| 12 | Antioxidant activity and total phenolic contents in peel and pulp of Chinese jujube (Ziziphus Jujuba Mill) Fruits显示文摘 | XUE Ziping FENG Weihua CAO Jiankang | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 13 | Preparation and flow characteristic of a novel phase change {luid for latent heat trans- fer显示文摘 | Zou Deqiu Feng Ziping Xiao Rui | 2010 | Solar Energy Materials and Solar Cells2010，94，12： | 1 |
| 14 | Two-phase flow in microchannels 显示文摘 | Feng Ziping Kawara Zensaku | 2002 | Experimental Thermal and Fluid Science2002，26，： | 1 |
| 15 | Antioxidant Activity And Total Phenolic Contents In Peel And Pulp Of Chinese Jujube (Ziziphus Jujuba Mill) Fruits显示文摘 | Ziping Xue Weihua Feng Jiankang Cao | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 16 | Experimental study on drag-reducing channel flow with surfaxtant additives -spatial structure of turbulence investigated by PIV system显示文摘 | YASUO KAWAGUCHI TAKEHIKO SEGAWA ZIPING FENG | 2002 | International Journal of Heat and Fluid Flow2002，23，： | 1 |
| 17 | An experimental investigation of the frictional pressure drop of steam-water twophase flow in helical coils显示文摘 | Liejin Guo Ziping Feng Xuejun Chen | 2001 | International Journal of Heat and Mass Transfer2001，，44： | 1 |
| 18 | Control mechanisms for gas hydrate production by depressurization in different scale hydrate reservoirs显示文摘 | TANG Liangguang LI Xiaosen FENG Ziping | 2007 | Energy & Fuels2007，21，1： | 1 |
| 19 | Antioxidant activity and total phenolic contents in peel and pulp of chinese jujube (Ziziphus jujuba mill) fruits显示文摘 | XUE Ziping FENG Weihua CAO Jiankang | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 20 | Antioxidant acticity and total phenolic contents in peel and pulp of Chinese jujube (Ziziphusjujuba Mill) fruits显示文摘 | XUE ZIPING FENG WEIHUA CAO JIANKANG | 2009 | Journal of Food Biochemistry2009，，33： | 1 |
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