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| 1 | Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children显示文摘To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported cases.Nine(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1%)were symptomatic and 21(42.9%)were asymptomatic.Neither asymptomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control. | Jiehao Cai Xiangshi Wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali Wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning Wang Jianshe Wang Qirong Zhu Xiaowen Zhai Mei Zeng | 2020 | Virologica Sinica2020，35，6： | 4 |
| 2 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 3 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 4 | Heat flow pattern,base of methane hydrates stability zones and BSRs in Shenhu Area,northern South China Sea显示文摘Using the collected 433 heat flow values,we estimated the bases of methane hydrate stability zone (BHSZ),in northern South China Sea (NSCS).Through comparing BHSZs with the depths of bottom simulating reflectors (BSRs),in Shenhu Area (SA),we found that there are big differences between them.In the north of SA,where the water depth is shallow,many slumps developed and the sedimentation rate is high,it appears great negative difference (as large as-192%).However,to the southeast of SA,where the water depth is deeper,sedimentation rate is relatively low and uplift basement topography exists,it changes to positive difference (as large as +45%).The differences change so great,which haven't been observed in other places of the world.After considering the errors from the process of heat flow measurement,the BSR depth,the relationship of thermal conductivity with the sediments depth,and the fluid flow activities,we conclude that the difference should be not caused by these errors.Such big disagreement may be due to the misunderstanding of BSR.The deviant 'BSRs' could represent the paleo-BSRs or just gas-bearing sediment layers,such as unconformities or the specific strata where have different permeability,which are not hydraterelated BSRs. | ZHANG Yi HE Lijuan WANG Jiyang XU Xing SHA Zhibing GONG Yuehua WANG Hongbing LIANG Jinqiang | 2011 | Acta Oceanologica Sinica2011，30，1： | 2 |
| 5 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 6 | Multivariable fuzzy control of residential inverter-driven air conditionings显示文摘A model free intelligent multivariable fuzzy controller (MFC) designed for modulating the vapor compression cycles in a residential inverter-driven air conditioning is proposed. The novel controller combines a traditional fuzzy controller (TFC) and an additional coupling fuzzy controller,the coupling fuzzy controller is introduced to compensate for the unknown cross-coupling effects of this multivariable system. In order to evaluate the control performance of the MFC,it is digitally implemented in terms of regulating the desired evaporating temperature and superheat. The experimental results show the effectiveness of the MFC for improvement of system performance and energy efficiency. | Xu Jinqiang Feng Ziping | 2010 | Engineering Sciences2010，8，2： | 2 |
| 7 | Mirror-enhanced scanning light-field microscopy for long-term high-speed 3D imaging with isotropic resolution显示文摘Various biological behaviors can only be observed in 3D at high speed over the long term with low phototoxicity.Light-field microscopy(LFM)provides an elegant compact solution to record 3D information in a tomographic manner simultaneously,which can facilitate high photon efficiency.However,LFM still suffers from the missing-cone problem,leading to degraded axial resolution and ringing effects after deconvolution.Here,we propose a mirrorenhanced scanning LFM(MiSLFM)to achieve long-term high-speed 3D imaging at super-resolved axial resolution with a single objective,by fully exploiting the extended depth of field of LFM with a tilted mirror placed below samples.To establish the unique capabilities of MiSLFM,we performed extensive experiments,we observed various organelle interactions and intercellular interactions in different types of photosensitive cells under extremely low light conditions.Moreover,we demonstrated that superior axial resolution facilitates more robust blood cell tracking in zebrafish larvae at high speed. | Bo Xiong Tianyi Zhu Yuhan Xiang Xiaopeng Li Jinqiang Yu Zheng Jiang Yihan Niu Dong Jiang Xu Zhang Lu Fang Jiamin Wu Qionghai Dai | 2021 | Light(Science & Applications)2021，10，12： | 1 |
| 8 | Controllable synthesis of a hollow Cr2O3 electrocatalyst for enhanced nitrogen reduction toward ammonia synthesis显示文摘As a fascinating alternative to the energy-intensive Haber-Bosch process,the electrochemically-driven N_(2) reduction reaction(NRR)utilizing the N_(2) and H_(2)O for the production of NH3 has received enormous attention.The development and preparation of promising electrocatalysts are requisite to realize an efficient N_(2) conversion for NH3 production.In this research,we propose a template-assisted strategy to construct the hollow electrocatalyst with controllable morphology.As a paradigm,the hollow Cr_(2)O_(3) nanocatalyst with a uniform size(~170 nm),small cavity and ultrathin shell(~15 nm)is successfully fabricated with this strategy.This promising hollow structure is favourable to trap N_(2) into the cavity,provides abundant active sites to accelerate the three-phase interactions,and facilitates the reactant transfer across the shell.Attributed to these synergetic effects,the designed catalyst displays an outstanding behaviour in N_(2) fixation for NH3 production in ambient condition.In the neutral electrolyte of 0.1 mol·L^(-1) Na_(2)SO_(4),an impressive electrocatalytic performance with the NH3 generation rate of 2.72μg·h^(-1)·cm^(-2) and a high FE of 5.31%is acquired respectively at-0.85 V with the hollow Cr_(2)O_(3) catalyst.Inspired by this work,it is highly expected that this approach could be applied as a universal strategy and extended to fabricating other promising electrocatalysts for realizing highly efficient nitrogen reduction reaction(NRR). | Lei Shi Yu Yin Hong Wu Rajan Arjan Kalyan Hirani Xinyuan Xu Jinqiang Zhang Nasir Rafique Abdul Hannan Asif Shu Zhang Hongqi Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 9 | CoP x synthesis and lithiation by ball-milling for anode materials of lithium ion cells显示文摘 | Zongshuang Zhang Jun Yang Yanna Nuli Baofeng Wang Jinqiang Xu | 2004 | Solid State Ionics2004，，7： | 1 |
| 10 | Additive-containing ionic liquid electrolytes for secondary lithium battery显示文摘 | Jinqiang Xu Jun Yang Yanna NuLi Jiulin Wang Zongshuang Zhang | 2006 | Journal of Power Sources2006，，1： | 1 |
| 11 | Optimal economic dispatching of multi-microgrids by an improved genetic algorithm显示文摘A multi-microgrid economic dispatching strategy based on adaptive mutation genetic algorithm is proposed for multi-microgrid systems with different load types and power demands.Based on the analysis of industrial,residential and commercial loads,considering the synergy and complementarity between multi-microgrids,an optimal dispatching model of multi-microgrids based on the minimum operation cost and environmental protection cost of multi-microgrids is established from the point of view of environmental protection and economy.At the same time,an adaptive mutation genetic algorithm is proposed to optimize the system model and find the optimal economic dispatching scheme. | Haoyu Jiang Shiyuan Ning Quanbo Ge Wang Yun JinQiang Xu Yu Bin | 2021 | IET Cyber-Systems and Robotics2021，3，1： | 1 |
| 12 | Dolomite reservoir formation and diagenesis evolution of the Upper Ediacaran Qigebrak Formation in the Tabei area,Tarim Basin显示文摘Ancient dolomite reservoirs play an increasingly important role in deep oil and gas exploration.The mechanism of formation and preservation of dolomite reservoirs is complex,which is always the key issue.With the discovery of deep oil and gas in the Ediacaran dolomites of the world,the upper Ediacaran Qigebrak Formation in the Tabei area has begun to attract attention,but its reservoir space difference and formation mechanism have yet to be clarified.Based on ultra-deep drilling cores and field outcrops in the Tabei area,the lithofacies,reservoir space,and formation mechanism are systematically analyzed by macro to micro,and qualitative to quantitative petrology:(1)The types of dolomite can be divided into five major categories,including microbial dolomite,granular dolomite,residual granular dolomite,crystalline dolomite and karst breccias.(2)The main types of reservoir space are microbial-framework pores,microbial-mold pores,and non-fabric selective dissolution pores.Spongiomicrobialite,karst breccias,and fine-grained dolomite are the dominant reservoir rock types.(3)High-frequency sedimentary cycles and meteoric dissolution are the key factors of reservoir formation.Two sets of large-scale reservoirs are present:the first set is mainly controlled by the supergene karst of the Keping movement,and the second set is mainly controlled by high-frequency sedimentary cycles in the penecontemporaneous period.The reservoirs formed at the shallow burial stage and were preserved until the deep burial stage.(4)The quality of a deep reservoir depends on the geological events that affect the processes of pore reduction and increase.Cementation,compaction and pressure solution are the main destructive diagenetic processes;however,the reservoir space can still be effectively preserved under the influence of constructive diagenetic processes,such as meteoric dissolution and early dolomitization.This research has important theoretical and practical significance for revealing the formation mechanism of upper Ediacaran deep dolomite reservoirs in the Tarim Basin. | Xudong CHEN Qilu XU Fang HAO Yongquan CHEN Yan YI Fangjie HU Xiaoxue WANG Jinqiang TIAN Guangwei WANG | 2023 | Science China Earth Sciences2023，66，10： | 0 |
| 13 | Cu-substitution P2-Na_(0.66)Mn_(1-x)Cu_(x)O_(2) sodium-ion cathode with enhanced interlayer stability显示文摘P2-type Mn-based layered oxides are viewed as promising cathode materials for sodium ion battery by virtue of their high theoretical capacity.Considering that pure Na_(2/3)MnO_(2)suffers from poor cycling performances,Cu-substitution strategy is proposed to effectively alleviate this issue.However,the structural evolution mechanism of the Cu-containing samples still remains unclear.Herein,we propose that CuSubstitution P2-type Na_(0.66)Mn_(1-x)Cu_(x)O_(2)with enlarged lattice parameters are conducive to improving the interlayer structure stability through mitigating TMO_(2)slabs distortion.Proved by synchrotron XAS spectra and ex/in situ XRD,the expansion/contraction of MnO_6 octahedron is dramatically reduced with the increased Cu content,showing the facilitated Na ion diffusion.Furthermore,when the ratio of Cu to Mn reaches 1:4,the phase transition from P2 to P'2 type at the end of discharge can be suppressed,resulting in the improved interlayer skeleton stability.The Cu-containing samples with stable interlayer structure exhibit high capacity retention and outstanding rate performances(a capacity of 79.9 m Ah g^(-1)at 5C).This Cu-substitution strategy provides a promising approach to designing highly stable cathodes. | Huanqing Liu Xu Gao Jun Chen Jinqiang Gao Haoji Wang Yu Mei Huan Liu Wentao Deng Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 14 | A Compact and Robust Regenerative Amplifier Pump Source for High Repetition Rate Terahertz Parametric Amplifier显示文摘In this paper we report a compact and robust regenerative amplifier developed as the pump laser for a high repetition rate terahertz parametric amplifier.With properly chosen pump source and carefully designed cavity,Nd∶YVO4 crystal,and laser beam collimator,a maximum output pulse energy of 480μJ has been achieved at the repetition rate of 10 kHz.The output laser has a nearly Gaussian transverse profile and a narrow bandwidth of 0.2 nm.Longterm monitoring shows an root mean square power fluctuation of about 1%.These characteristics satisfy all requirements for high repetition rate terahertz parametric amplifier. | Huang Yue Xu Hang Xu Jinqiang Feng Liwen Wang Tianyi Wang Lina Liu Zhongqi Huang Senlin Liu Kexin | 2022 | 激光与光电子学进展2022，59，21： | 0 |
| 15 | Modeling and analysis of air combustion and steam regeneration in methanol to olefins processes显示文摘Light olefins is the incredibly important materials in chemical industry.Methanol to olefins(MTO),which provides a non-oil route for light olefins production,received considerable attention in the past decades.However,the catalyst deactivation is an inevitable feature in MTO processes,and regeneration,therefore,is one of the key steps in industrial MTO processes.Traditionally the MTO catalyst is regenerated by removing the deposited coke via air combustion,which unavoidably transforms coke into carbon dioxide and reduces the carbon utilization efficiency.Recent study shows that the coke species over MTO catalyst can be regenerated via steam,which can promote the light olefins yield as the deactivated coke species can be essentially transferred to industrially useful synthesis gas,is a promising pathway for further MTO processes development.In this work,we modelled and analyzed these two MTO regeneration methods in terms of carbon utilization efficiency and technology economics.As shown,the steam regeneration could achieve a carbon utilization efficiency of 84.31%,compared to 74.74%for air combustion regeneration.The MTO processes using steam regeneration can essentially achieve the near-zero carbon emission.In addition,light olefins production of the MTO processes using steam regeneration is 12.81%higher than that using air combustion regeneration.In this regard,steam regeneration could be considered as a potential yet promising regeneration method for further MTO processes,showing not only great environmental benefits but also competitive economic performance. | Jinqiang Liang Danzhu Liu Shuliang Xu Mao Ye | 2024 | Chinese Journal of Chemical Engineering2024，66，2： | 0 |
| 16 | A Symplectic Method of Numerical Simulation on Local Buckling for Cylindrical Long Shells under Axial Pulse Loads显示文摘In this paper,the local buckling of cylindrical long shells is discussed under axial pulse loads in a Hamiltonian system.Using this system,critical loads and modes of buckling of shells are reduced to symplectic eigenvalues and eigensolutions respectively.By the symplectic method,the solution of the local buckling of shells can be employed to the expansion series of symplectic eigensolutions in this system.As a result,relationships between critical buckling loads and other factors,such as length of pulse load,thickness of shells and circumferential orders,have been achieved.At the same time,symmetric and unsymmetric buckling modes have been discuss.Moreover,numerical results show that modes of post-buckling of shells can be Bamboo node-type,bending type,concave type and so on.Research in this paper provides analytical supports for ultimate load prediction and buckling failure assessment of cylindrical long shells under local axial pulse loads. | Kecheng Li Jianlong Qu Jinqiang Tan Zhanjun Wu Xinsheng Xu | 2021 | Structural Durability & Health Monitoring2021，15，1： | 0 |
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