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| 1 | Biological Activity and Antibacterial Property of Nano-structured TiO_2 Coating Incorporated with Cu Prepared by Micro-arc Oxidation显示文摘Micro-arc oxidized Cu-incorporated TiO2 coatings(Cu—TiO2) were prepared in the Ca,P,Cu-containing electrolyte to obtain an implant material with superior biological activity and antibacterial property.The surface topography,phase,and element composition of the TiO2 and Cu—TiO2 coatings were characterized by scanning electron microscopy(SEM),X-ray diffraction(XRD),and energy-dispersive X-ray spectrometry (EDS),respectively.Staphylococcus aureus(S.aureus) was selected to evaluate the antibacterial property of the Cu—TiO2 coatings,whereas osteoblastic MG63 cells were cultured on the coatings to investigate the biological activity.The obtained results demonstrated that Cu element was successfully incorporated into the porous nano-structured TiO2 coatings,which did not alter apparently the surface topography and phase composition of the coatings as compared to the Cu-free TiO2 coatings.Moreover,the antibacterial studies suggested that the Cu-incorporated TiO2 coatings could significantly inhibit the adhesion of S.aureus.In addition,the in vitro biological evaluation displayed that the adhesion,proliferation and differentiation of MG63 cells on the Cu-incorporated coatings were enhanced as compared to those on the Cu-free coatings and Ti plates.In conclusion,the innovative Cu-incorporated nano-structured TiO2 coatings on Ti substrate with excellent antibacterial property and biological activity are promising candidates for orthopedic implant. | Wei Zhu Zhenxiang Zhang Beibei Gu Junying Sun Lixian Zhu | 2013 | Journal of Materials Science & Technology2013，29，3： | 8 |
| 2 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 3 | Targeted Gene Manipulation in Plants Using the CRISPR/Cas Technology显示文摘The CRISPR/Cas technology is emerging as a revolutionary genome editing tool in diverse organisms including plants,and has quickly evolved into a suite of versatile tools for sequence-specific gene manipulations beyond genome editing.Here,we review the most recent applications of the CRISPR/Cas toolkit in plants and also discuss key factors for improving CRISPR/Cas performance and strategies for reducing the off-target effects.Novel technical breakthroughs in mammalian research regarding the CRISPR/Cas toolkit will also be incorporated into this review in hope to stimulate prospective users from the plant research community to fully explore the potential of these technologies. | Dandan Zhang Zhenxiang Li Jian-Feng Li | 2016 | Journal of Genetics and Genomics2016，43，5： | 3 |
| 4 | QTL analysis across multiple environments reveals promising chromosome regions associated with yield-related traits in maize under drought conditions显示文摘Drought is one of the most critical abiotic stresses influencing maize yield. Improving maize cultivars with drought tolerance using marker-assisted selection requires a better understanding of its genetic basis. In this study, a doubled haploid(DH) population consisting of 217 lines was created by crossing the inbred lines Han 21(drought-tolerant) and Ye 478(drought-sensitive). The population was genotyped with a 6 K SNP assay and 756 SNP(single nucleotide polymorphism) markers were used to construct a linkage map with a length of 1344 c M. Grain yield(GY), ear setting percentage(ESP), and anthesis–silking interval(ASI) were recorded in seven environments under well-watered(WW) and water-stressed(WS) regimes. High phenotypic variation was observed for all traits under both water regimes. Using the LSMEAN(least-squares mean) values from all environments for each trait, 18 QTL were detected, with 9 associated with the WW and 9 with the WS regime. Four chromosome regions,Chr. 3: 219.8–223.7 Mb, Chr. 5: 191.5–194.7 Mb, Chr. 7: 132.2–135.6 Mb, and Chr. 10: 88.2–89.4 Mb, harbored at least 2 QTL in each region, and QTL co-located in a region inherited favorable alleles from the same parent. A set of 64 drought-tolerant BC_3F_6 lines showed preferential accumulation of the favorable alleles in these four regions, supporting an association between the four regions and maize drought tolerance. QTL-by-environment interaction analysis revealed 28 ed QTL(environment-dependent QTL) associated with the WS regime and 22 associated with the WW regime for GY, ESP, and ASI. All WS QTL and55.6% of WW QTL were located in the ed QTL regions. The hotspot genomic regions identified in this work will support further fine mapping and marker-assisted breeding of drought-tolerant maize. | Xinmin Hu Guihua Wang Xuemei Du Hongwei Zhang Zhenxiang Xu Jie Wang Guo Chen Bo Wang Xuhui Li Xunji Chen Junjie Fu Jun Zheng Jianhua Wang Riliang Gu Guoying Wang | 2021 | The Crop Journal2021，9，4： | 3 |
| 5 | Large electrostrain in Bi_(1/2)Na_(1/2)TiO_(3)-based relaxor ferroelectrics:A case study of Bi_(1/2)Na_(1/2)TiO3-Bi_(1/2)K_(1/2)TiO_(3)-Bi(Ni_(2/3)Nb_(1/3))O_(3) ceramics显示文摘(1-x)(0.8Bi_(1/2)Na_(1/2)TiO3-0.2Bi_(1/2)K_(1/2)TiO3)-xBi(Ni_(2/3)Nb_(1/3))O3(BNKT-xBNN)solid solution ceramics were fabricated by high temperature solid-state reaction method.All the compositions possess relaxor ferroelectric features,among which the ergodic BNKT-0.02BNN exhibits large repeatable electrostrain value Suni¼0.51%at electric field of 65 kV/cm,with high piezoelectric stain coefficient d33*of 890 pm/V at 45 kV/cm,while the non-ergodic compositions present unrepeatable large strain response.Based on the electric field-composition phase diagram,the repeatability of strain response in ergodic compositions can be attributed to the reversible electric-field-induced phase transition.In addition,the effects of BNN contents on the macroscopic strain properties are explored by analyzing the existing states of the polar regions with corresponding thermal evolutions and electric-field-induced phase transitions.This research is expected to guide the design of lead free relaxor ferroelectric materials with desired electrostrain properties. | Guangzhi Dong Huiqing Fan Laijun Liu Pengrong Ren Zhenxiang Cheng Shujun Zhang | 2021 | Journal of Materiomics2021，7，3： | 2 |
| 6 | Effects of surface roughness on interfacial dynamic recrystallization and mechanical properties of Ti-6Al-3Nb-2Zr-1Mo alloy joints produced by hot-compression bonding显示文摘The influence of surface roughness on the interfacial dynamic recrystallization kinetics and mechanical properties of Ti-6 Al-3 Nb-2 Zr-1 Mo hot-compression bonding joints was systematically investigated.It is found that for the bonding interface of rough surfaces,elongated fine grains are formed at the bonding interface due to shear deformation of the interfacial area.As the surface roughness increases,the proportion of elongated grains drastically decreases as they further reorient to form equiaxed grains along the bonding interface of rougher surfaces resulting from severe incompatible deformation of the interface area.Meanwhile,high-density geometrically necessary dislocations accumulate around the interfacial recrystallization area to accommodate the incompatible strain and lattice rotation.A rotational dynamic recrystallization mechanism is thereby proposed to rationalize the formation of fine interfacial recrystallization grains during bonding of rough surfaces.In contrast to that of rough surfaces,bonding interface of polished surfaces exists in the form of straight interface grain boundaries without fine grains under the same deformation conditions.While with the increase of deformation strain,small grain nuclei form along the bonding interface,which is associated with discontinuous dynamic recrystallization assisted by strain-induced boundary migration of interface grain boundaries.Moreover,the bonding joints of rough surfaces show lower elongation compared with that of polished surfaces.This is because the formation of heterogeneous fine grains with low Schmid factor along the bonding interface of rough surfaces,leading to worse compatible deformation capability and thereby poor ductility of bonding joints. | Bijun Xie Zhenxiang Yu Haiyang Jiang Bin Xu Chunyang Wang Jianyang Zhang Mingyue Sun Dianzhong Li Yiyi Li | 2022 | Journal of Materials Science & Technology2022，，1： | 2 |
| 7 | Effects of calcium-activated chloride channels on proliferation of pulmonary artery smooth muscle cells in rats under chronic hypoxic condition显示文摘Objective:To investigate the effects of calcium-activated chloride(ClCa)channels on proliferation of pulmonary artery smooth muscle cells(PASMCs)in rats under chronic hypoxic condition.Methods:The cultured PASMCs were placed under normoxic and chronic hypoxic conditions:The cells were observed by light and electron microscope;The cell cycles were observed by flow-cytometry;Immunocytochemistry staining was used to detect the expressions of PCNA,c-fos and c-jun of PASMCs;Cytoplasmic free Ca2+ con-cweenrter actoionntr a([cCtiale2+ ]pi)h einn oPtAypSeM uCndse wr anso rimnvoexsitcig caotnedd ibtiyo nfslu.oOrbessceervnat tqiouna nbtyit atrtaionnsm uissisnigo nfl euloercotsropne cmtriocprohsoctoompee:t Ienr.kRyteospulaltssm:T ohfe c PonAtSraMctCiles phenotype cells,myofilament bundles were abundant and the content of cell organs such as Golgi's bodies were rare.The PASMCs were synthetic phenotype under chronic hypoxic condition.There were increased free ribosomes,dilated rough endoplasmic reticulums,highly developed Golgi complexes,decreased or disappeared thick filaments and dense body in kytoplasm of synthetic phenotype cells.Acofntedri tNioFnA;Tahned NIAFAA-9a4n,d t hIAe sAit-u9a4t iwonesr ew sehroew renv teor sseidg nTifhiec annutmlyb deerc orfe aSs+eG th2Mem P fAroSmM(C2s8.w6±ere1 s.0ig)n%if ticoa(n1t6ly.0 in±cr1e.a6s)e%d iann dch trhoen nicu hmybpeorx oicf Gof0 Gpr1o PliAfeSraMtiCngs scieglnl infuiccalnetulsy ainnctirgeeanse wd afsro smig n(7if1ic.4a±ntl1y.9in)%cr etaos(e8d3;.T9±he1 N.6F)A% a(Pnd < I A0.A01-9).4 I nw cehrer osnhiocw hny ptoo xsiicg nciofnicdaintitolyn sd,etchree eaxsep riet sfsroiomn(81±6)% to(27±7)%(P < 0.01).The expression of c-fos and c-jun were significantly increased in chronic hypoxic conditions;The NFA and IAA-94 were shown to significantly decrease them from 0.15±0.02,0.32±0.05 to 0.05±0.01,0.12±0.05,respectively(toP(<1 01.70.17)±;U15n.d4e)rn mchorlo/Lni(cP h | Zhao Yang Zhenxiang Zhang Yongjian Xu Tao Wang Dan Ma Tao Ye | 2008 | Journal of Nanjing Medical University2008，22，1： | 2 |
| 8 | Core–Shell Structure and Luminescence of SrMoO_4:Eu^(3+)(10%) Phosphors显示文摘SrMoO_4:Eu^(3+)(10%) phosphors were produced via hydrothermal synthesis and co-precipitation.We systematically analyzed how the morphology and luminescence properties of the phosphors were affected by the synthesis conditions,including the p H of the precursor solution,stirring speed,and postsintering temperature.The samples synthesized at p H = 8 and 9 were spindle-like rods with a core–shell structure.When the stirring speed increased to Vs = 150 r/min,the core–shell structure disappeared.Photoluminescence measurements indicated that the Sr Mo O4:Eu3+samples under ultraviolet radiation produced strong red emission centered at 616 nm.The luminescence properties were greatly affected by the p H,stirring during hydrothermal reaction,and use of post-annealing.The related mechansim is discussed. | Yanan Zhu Ganhong Zheng Zhenxiang Dai Lingyun Zhang Jingjing Mu | 2016 | Journal of Materials Science & Technology2016，32，12： | 2 |
| 9 | Photocatalytic and Luminescent Properties of SrMoO_4 Phosphors Prepared via Hydrothermal Method with Different Stirring Speeds显示文摘To probe the potential utilities in the photocatalyst and luminescent materials,a series of SrMoO_4 samples have been prepared via the hydrothermal preparation with different stirring speeds.These SrMoO_4 samples were characterized using X-ray diffraction analysis,scanning electron microscopy,UV–diffuse reflection spectroscopy(UV–vis).It has been found that the lattice parameters and [Mo O4] tetrahedron distortion of SrMoO_4 samples are increased with the increased stirring speed in the process of hydrothermal preparation.By changing the stirring speeds,spindle and succulent-like morphologies have been obtained.UV–vis results show that the band gaps of SrMoO_4 samples are sensitive to the stirring speed.As for the luminescent and photocatalytic properties,our experimental results clearly suggest that,compared with those samples without stirring,the luminescent and photocatalytic activities are enhanced with stirring in the hydrothermal preparation.The photodegradation of methyl blue(MB) over SrMoO_4 system increases from 30% to 50% with stirring,which may be related to small band gaps and porous surfaces.Our results indicate that stirring may be one important technique to improve the photocatalytic properties,especially in the process of hydrothermal method. | Yanan Zhu Ganhong Zheng Zhenxiang Dai Lingyun Zhang Yongqing Ma | 2017 | Journal of Materials Science & Technology2017，33，1： | 2 |
| 10 | Growth, structure and upconversion mechanisms of Ba_2ErCl_7 crystal显示文摘The methods to grow a novel upconversion crystal Ba2ErCI7 are reported in this note. Ba2ErCI7 material was synthesized with Er2O3, BaCI2-2H2O and NH4CI by using a so-called 'direct synthesis method'. High quality Ba2ErCI7 single crystals with size up to 4 mm×8 mm×15 mm were grown by using the Czochralski and the Bridgman methods. Intense yellow-green luminescence was detected when the crystal was pumped by an 803 laser diode (LD). Transmittance spectrum was measured by using HITACH U-3500 spectrophotometer at room temperature for the first time, in which one can see that the transmittance is high in the range from 350 to 1 600 nm and the cut-off wavelength of the crystal was 230 nm. The upconversion mechanisms were discussed. | HAN Jianru, ZHOU Guangyong, ZHANG Shujun, CHENG Zhenxiang & CHEN HuanchuState Key Laboratory of Crystal Materials, Institute of Crystal Materials of Shandong University, Jinan 250100, China | 2000 | Chinese Science Bulletin2000，45，11： | 2 |
| 11 | A novel RNA-guided RNA-targeting CRISPR tool显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)technology has emerged as a programmable RNA-guided DNA-targeting tool for sequence-specific genome editing in diverse organisms.The most frequently used CRISPR/Cas system。 | Dandan Zhang Zhenxiang Li Bingyu Yan Jian-Feng Li | 2016 | Science China(Life Sciences)2016，59，8： | 2 |
| 12 | Characterization of the properties of thermoplastic elastomers containing waste rubber tire powder显示文摘 | Zhang Shuling Xin Zhenxiang Zhang Zhenxiu | 2009 | Waste Management2009，29，5： | 1 |
| 13 | Pervasive hybridization during evolutionary radiation of Rhododendron subgenus Hymenanthes in mountains of southwest China显示文摘Radiations are especially important for generating species biodiversity in mountainous ecosystems.The contribution of hybridization to such radiations has rarely been examined.Here,we use extensive genomic data to test whether hybridization was involved in evolutionary radiation within Rhododendron subgenus Hymenanthes,whose members show strong geographic isolation in the mountains of southwest China.We sequenced genomes for 143 species of this subgenus and 93 species of four other subgenera,and found that Hymenanthes was monophyletic and radiated during the late Oligocene to middle Miocene.Widespread hybridization events were inferred within and between the identified clades and subclades.This suggests that hybridization occurred both early and late during diversification of subgenus Hymenan thes,although the extent to which hybridization,speciation through mixing-isolation-mixing or hybrid speciation,accelerated the diversification needs further exploration.Cycles of isolation and contact in such and other montane ecosystems may have together promoted species radiation through hybridization between diverging populations and species.Similar radiation processes may apply to other montane floras in this region and elsewhere. | Yazhen Ma Xingxing Mao Ji Wang Lei Zhang Yuanzhong Jiang Yuying Geng Tao Ma Liming Cai Shuangquan Huang Pete Hollingsworth Kangshan Mao Minghui Kang Yiling Li Wenlu Yang Haolin Wu Yang Chen Charles C.Davis Nawal Shrestha Richard H.Ree Zhenxiang Xi Quanjun Hu Richard I.Milne Jianquan Liu | 2022 | National Science Review2022，9，12： | 1 |
| 14 | Phylotranscriptomics of Swertiinae(Gentianaceae)reveals that key floral traits are not phylogenetically correlated显示文摘Establishing how lineages with similar traits are phylogenetically related remains critical for understanding the origin of biodiversity on Earth.Floral traits in plants are widely used to explore phylogenetic relationships and to delineate taxonomic groups.The subtribe Swertiinae(Gentianaceae)comprises more than 350 species with high floral diversity ranging from rotate to tubular corollas and possessing diverse nectaries.Here we performed phylogenetic analysis of 60 species from all 15 genera of the subtribe Swertiinae sensu Ho and Liu,representing the range of floral diversity,using data from the nuclear and plastid genomes.Extensive topological conflicts were present between the nuclear and plastome trees.Three of the 15 genera represented by multiple species are polyphyletic in both trees.Key floral traits including corolla type,absence or presence of lobe scales,nectary type,nectary position,and stigma type are randomly distributed in the nuclear and plastome trees without phylogenetic correlation.We also revealed the likely ancient hybrid origin of one large clade comprising 10 genera with diverse floral traits.These results highlight the complex evolutionary history of this subtribe.The phylogenies constructed here provide a basic framework for further exploring the ecological and genetic mechanisms underlying both species diversification and floral diversity. | Chunlin Chen Brad R.Ruhfel Jialiang Li Zefu Wang Lushui Zhang Lei Zhang Xingxing Mao Ji Wang Dashan He Yue Luo Quanjun Hu Yuanwen Duan Xiaoting Xu Zhenxiang Xi Jianquan Liu | 2023 | Journal of Integrative Plant Biology2023，65，6： | 1 |
| 15 | Effect of nuclear factor-κB on airway remodeling in asthmatic rats 显示文摘 | Xu Shuyun Xu Yongjian Zhang Zhenxiang | 2004 | J Huazhong University of Science and Technolog (Med Sci)2004，24，1： | 1 |
| 16 | Contribution Invitation of The Chinese-German Journal of Clinical Oncology显示文摘The Chinese-German Journal of Clinical Oncology is aninternational professional academiic periodical on on-cology,being co-edited by China and Germany.The Journal,with the authors from around world,especially from China,isdominated in introducing the clinical experience of diagnosisand treatment as well as leading scientific research achieve-ment in the tumor domain,in addition to report basic theoryresearches which help instruct the clinical practice of oncolo-gy and closely connect with the discipline.All the manu-scripts are published in English,quarterly issued both inter-nal and external,64-80 pages,big 16 opens domains,artpaper in offset printing,with lay-out by international cus-toms,unified issuing number:ISSN 0178-3351/CN/42-1654/R. | Sheng ZHONG Yongjian XU Zhenxiang ZHANG | 2002 | The Chinese-German Journal of Clinical Oncology2002，1，3： | 1 |
| 17 | Modified penis lengthening surgery: review of 52 cases 显示文摘 | Li Shirong Zhang Xuan Wang Zhenxiang | 2000 | Plast Reconstr Surg2000，105，2： | 1 |
| 18 | Induction of matrix metalloproteinase-9 in alveolar macrophages by TNF-α through NF-κB signal pathway显示文摘Objective: To explore the effect of tumor necrosis factor (TNF)-α on matrix metalloproteinase-9 (MMP-9) expression and activity in alveolar macrophages (AM) from patients with chronic obstructive pulmonary disease (COPD) and study its associated signal pathway. Methods: AM were collected from bronchoalveolar lavage fluid in patients with COPD. The AM were incubated for 1.5 h with pyrrolidine dithiocarbamate(PDTC)at concentrations from 0 μmol/L to 50 μmol/L and then stimulated for 24 h by TNF-α at 10 ng/ml. MMP-9 expression and activity were respectively detected by semi- quantitative reverse transcription-polymerase chain reaction (RT-PCR), Western blotting and Zymography. NF-κB activity was investigated by electrophoretic mobility shift assay (EMSA). Results: Both the mRNA and protein levels of MMP-9 induced by TNF-α in AM were significantly elevated in a dose dependent manner (P<0.05). The level of MMP-9 activity was also correspondingly significantly elevated in the induction (P<0.05), which was possibly related with the over- expression of MMP-9. NF-κB activity was significantly increased when AM were stimulated by 10 ng/mL TNF-α (P<0.05). The expression of MMP-9 induced by TNF-α could be significantly inhibited by PDTC (P< 0.05). Conclusion: The expression and activity of MMP-9 from AM could be induced by TNF-α, and NF-κB signal pathway played an important role in the induction. | Yaqing Li Zhenxiang Zhang Yongjian Xu Wang Ni Shixin Chen | 2006 | Journal of Nanjing Medical University2006，20，1： | 1 |
| 19 | Effects of extruder parameters and silica on physico-mechanical and foaming properties of PP/wood-fiber composites显示文摘 | Zhang Zhenxiu Gao Changyun Xin Zhenxiang | 2012 | Composites Part B : Engineering2012，43，4： | 1 |
| 20 | Characteriza-tion of the properties of thermoplastic elastomers containingwaste rubber tire powder显示文摘 | Zhang Shuling Xin Zhenxiang Zhang Zhenxiu | 2009 | Waste Management2009，29，5： | 1 |
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