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| 1 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 2 | Quantifying the effects of stripe rust disease on wheat canopy spectrum based on eliminating non-physiological stresses显示文摘The wheat canopy reflectance spectrum is affected by many internal and external factors such as diseases and growth stage. Separating the effects of disease stress on the crop from the observed mixed signals is crucial for increasing the precision of remote sensing monitoring of wheat stripe rust. The canopy spectrum of winter wheat infected by stripe rust was processed with the difference-in-differences(DID) algorithm used in econometrics. The monitoring accuracies of wheat stripe rust before and after processing with the DID algorithm were compared in the presence of various external factors, disease severity, and several simulated satellite sensors. The correlation between the normalized difference vegetation index processed by the DID algorithm(NDVI-DID) and the disease severity level(SL) increased in comparison with the NDVI before processing. The increase in precision in the natural disease area in the field in the presence of large differences in growth stage, growth, planting, and management of the crop was greater than that in the controlled experiment. For low disease levels(SL < 20%), the R2 of the regression of NDVI-DIDon SL was 38.8% higher than that of the NDVI and the root mean square error(RMSE) was reduced by 11.1%. The increase in precision was greater than that for the severe level(SL > 40%).According to the measured hyperspectral data, the spectral reflectance of three satellite sensor levels was simulated. The wide-band NDVI was calculated. Compared with the wide-band NDVI and vegetation indexes(VI) before DID processing, there were increases in the correlation between SL and the various types of VIS-DID, as well as in the correlation between SL and NDVI-DID. It is feasible to apply the DID algorithm to multispectral satellite data and diverse types of VISfor monitoring wheat stripe rust. Our results improve the quantification of independent effects of stripe rust infection on canopy reflectance spectrum,increase the precision of remote sensing monitoring of wheat stripe rust, and provide a reference for remote sensing monitoring of other crop diseases. | Xia Jing Kaiqi Du Weina Duan Qin Zou Tingting Zhao Bingyu Li Qixing Ye Lieshen Yan | 2022 | The Crop Journal2022，10，5： | 3 |
| 3 | A novel RNA-guided RNA-targeting CRISPR tool显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)technology has emerged as a programmable RNA-guided DNA-targeting tool for sequence-specific genome editing in diverse organisms.The most frequently used CRISPR/Cas system。 | Dandan Zhang Zhenxiang Li Bingyu Yan Jian-Feng Li | 2016 | Science China(Life Sciences)2016，59，8： | 2 |
| 4 | High performance dielectric elastomers by partially reduced graphene oxide and disruption of hydrogen bonding of polyurethanes显示文摘 | Suting Liu Ming Tian Bingyue Yan Yang Yao Liqun Zhang Toshio Nishi Nanying Ning | 2014 | Polymer2014，，： | 1 |
| 5 | Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia显示文摘 | Lantu Gou Mingde Fu Yanhua Xu Ying Tian Bingyu Yan Luchuan Yang | 2005 | American Heart Journal2005，，5： | 1 |
| 6 | Relationship between plasma lipid concentrations and HDL subclasses显示文摘 | Yuye Yang Bingyu Yan Mingde Fu Yanhua Xu Ying Tian | 2004 | Clinica Chimica Acta2004，，1： | 1 |
| 7 | Origin of new genes after zygotic genome activation in vertebrate显示文摘 | Hai-Bo Xu Yong-Xin Li Yan Li Newton O. Otecko Ya-Ping Zhang Bingyu Mao Dong-Dong Wu | 2018 | Journal of Molecular Cell Biology2018，10，2： | 1 |
| 8 | Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults显示文摘Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change in immune phenotype is a key indication of the diseased or healthy status.However,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed.Here,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known diseases.Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals.The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis.Our initial analysis and machine modelling prediction showed that na.ve T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T cells.This is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and sex.The age of a person's immune system might be different from their chronological age.Our immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction.Our research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice. | Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin | 2023 | Phenomics2023，3，4： | 1 |
| 9 | A significant reduction in hepatitis B virus infection among the children of Shandong Province, China: the effect of 15 years of Universal infant hep- atitis B vaccination 显示文摘 | Zhang Li Xu A Yan Bingyu | 2010 | Int J Infect Dis2010，14，6： | 1 |
| 10 | Application of UAV Multisensor Data and Ensemble Approach for High-Throughput Estimation of Maize Phenotyping Traits显示文摘High-throughput estimation of phenotypic traits from UAV(unmanned aerial vehicle)images is helpful to improve the screening efficiency of breeding maize.Accurately estimating phenotyping traits of breeding maize at plot scale helps to promote gene mining for specific traits and provides a guarantee for accelerating the breeding of superior varieties.Constructing an efficient and accurate estimation model is the key to the application of UAV-based multiple sensors data. | Meiyan Shu Shuaipeng Fei Bingyu Zhang Xiaohong Yang Yan Guo Baoguo Li Yuntao Ma | 2022 | Plant Phenomics2022，4，1： | 1 |
| 11 | Combination of acupuncture and traditional Chinese medicine for functional constipation:A meta-analysis显示文摘To systematically assess the effectiveness and safety of using acupuncture with traditional Chinese medicine for functional constipation so as to provide the evidence-based data for clinical practice.Wanfang databases,CBM,VIP,CNKI,PubMed,Cochrane Library and EMbase were searched for trials based on randomization and control for use of acupuncture in combination with CHM for functional constipation published from the inception of the database to Dec.2019.We used the risk of bias of Cochrane Collaboration for literature quality assessment,extracted trial data in duplicate,and then assessed the risk of bias.The data were discussed by adopting Review Manager 5.3 program.A total of 22 RCTs with 2574 cases were retrieved.Meta-analysis showed that acupuncture with CHM could improve the clinical effectiveness(OR6.10,95%CI 4.72–7.87,P<0.00001);heterogeneity was not identified(Chi^(2)=32.84,P=0.43,I^(2)=2%),and the difference was statistically significant.Second-level outcomes(e.g.,defecation interval time(P<0.00001),Bristol Stool Scale(P=0.002),defecation difficulty(P=0.01)and accompanying symptoms(P<0.00001))in the treatment groups were significantly different after the acupuncture with CHM compared with control groups,whereas defecation symptoms were not significantly different(P=0.06).The use of acupuncture with CHM can significantly improve the clinical efficacy of functional constipation,ameliorate Bristol Stool Scale,defecation difficulty,defecation symptoms,and accompanying symptoms,as well as shorten the defecation interval time,with better safety. | Dongxue Lu Feng Liu Jing Yan Haixia Liu Zhiguang Sun Bingyu Chen Shilin Zhu Fei Ge | 2022 | Medicine in Novel Technology and Devices2022，，4： | 1 |
| 12 | Experimental Study of the Effect of the Bax Gene on Human Hepatocellular Carcinoma and Therapy via Hepatic Artery Delivery显示文摘 | Zhi Guo Wenge Xing Haishan Yang Lin Wang Yunpeng Jiang Bingyu Huang Gong Nu Yan Lu | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 0 |
| 13 | Restructuring of 4H Phase Au Nanowires and its Catalytic Behavior toward CO Electro-oxidation显示文摘Au nanowires in 4H crystalline phase(4H Au NWs)are synthesized by colloid solution methods.The crys-talline phase and surface structure as well as its performance toward electrochemical oxidation of CO be-fore and after removing adsorbed oleylamine molecules(OAs)intro-duced from its synthesis are evaluat-ed by high-resolution transmission electron microscopy(HR-TEM),X-ray diffraction(XRD),underpoten-tial deposition of Pb(Pb-upd)and cyclic voltammetry.Different methods,i.e.acetic acid cleaning,electrochemical oxidation cleaning,and diethylamine replacement,have been tried to remove the adsorbed OAs.For all methods,upon the removal of the adsorbed OAs,the morphology of 4H gold nanoparticles is found to gradually change from nanowires to large dumbbell-shaped nanoparticles,accompanying with a transition from the 4H phase to the face-centered cubic phase.On the other hand,the Pb-upd results show that the sample sur-faces have almost the same facet composition before and after removal of the adsorbed OAs.After electrochemical cleaning with continuous potential scans up to 1.3 V,CO electro-oxida-tion activity of the 4H Au sample is significantly improved.The CO electro-oxidation activi-ty is compared with results on the three basel Au single crystalline surfaces reported in the lit-erature,possible origins for its enhancement are discussed. | Xuxu Ye Bingyu Liu Da Zhou Yan Xia Chen | 2023 | Chinese Journal of Chemical Physics2023，36，5： | 0 |
| 14 | Fine-grained management of I/O optimizations based on workload characteristics显示文摘With the advent of new computing paradigms,parallel file systems serve not only traditional scientific computing applications but also non-scientific computing applications,such as financial computing,business,and public administration.Parallel file systems provide storage services for multiple applications.As a result,various requirements need to be met.However,parallel file systems usually provide a unified storage solution,which cannot meet specific application needs.In this paper,an extended tile handle scheme is proposed to deal with this problem.The original file handle is extended to record I/O optimization information,which allows file systems to specify optimizations for a file or directory based on workload characteristics.Therefore,fine-grained management of I/O optimizations can be achieved.On the basis of the extended file handle scheme,data prefetching and small file optimization mechanisms are proposed for parallel file systems.The experimental results show that the proposed approach improves the aggregate throughput of the overall system by up to 189.75%. | Bing WEI Limin XIAO Bingyu ZHOU Guangjun QIN Baicheng YAN Zhisheng HUO | 2021 | Frontiers of Computer Science2021，15，3： | 0 |
| 15 | Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression显示文摘Sonic hedgehog (Shh) signaling is essential for the proliferation of cerebellar granule neuron progenitors (CGNPs), and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma (MB). During vertebrate neural development, RNF220, a ubiquitin E3 ligase, is involved in spinal cord patterning by modulating the subcellular location of glioma-associated oncogene homologs (Glis) through ubiquitination. RNF220 is also required for full activation of Shh signaling during cerebellum development in an epigenetic manner through targeting embryonic ectoderm development. ZC4H2 was reported to be involved in spinal cord patterning by acting as an RNF220 stabilizer. Here, we provided evidence to show that ZC4H2 is also required for full activation of Shh signaling in CGNP and MB progression by stabilizing RNF220. In addition, we found that the ubiquitin E3 ligase RING finger LIM domain-binding protein (RLIM) is responsible for ZC4H2 stabilization via direct ubiquitination, through which RNF220 is also thus stabilized. RLIM is a direct target of Shh signaling and is also required for full activation of Shh signaling in CGNP and MB cell proliferation. We further provided clinical evidence to show that the RLIM‒ZC4H2‒RNF220 cascade is involved in Shh-group MB progression. Disease-causative human RLIM and ZC4H2 mutations affect their interaction and regulation. Therefore, our study sheds light on the regulation of Shh signaling during cerebellar development and MB progression and provides insights into neural disorders caused by RLIM or ZC4H2 mutations. | Yuwei Li Chencheng Yang Huishan Wang Ling Zhao Qinghua Kong Yu Cang Shuhua Zhao Longbao Lv Yan Li Bingyu Mao Pengcheng Ma | 2022 | Journal of Molecular Cell Biology2022，14，1： | 0 |
| 16 | tsrCert:Traceable Self-Randomization Certificate and Its Application to Blockchain Supervision显示文摘Traditional public key infrastructure(PKI)only provides authentication for network communication,and the standard X.509 certificate used in this architecture reveals the user’s identity.This lack of privacy protection no longer satisfies the increasing demands for personal privacy.Though an optimized anonymous PKI certificate realizes anonymity,it has the potential to be abused due to the lack of identity tracking.Therefore,maintaining a balance between user anonymity and traceability has become an increasing requirement for current PKI.This paper introduces a novel traceable self-randomization certificate authentication scheme based on PKI architecture that achieves both anonymity and traceability.We propose a traceable self-randomization certificate authentication scheme based on the short randomizable signature.Specifically,certificate users can randomize the initial certificate and public key into multiple anonymous certificates and public keys by themselves under the premise of traceability,which possesses lower computational complexity and fewer interactive operations.Users can exhibit different attributes of themselves in different scenarios,randomizing the attributes that do not necessarily need to be displayed.Through security and performance analysis,we demonstrate the suitability of the improved PKI architecture for practical applications.Additionally,we provide an application of the proposed scheme to the permissioned blockchain for supervision. | Yan Zhu Haibin Zheng Bo Qin Wanting Fu Zhenwei Guo Yujue Wang Qianhong Wu Bingyu Li Xuan Ding | 2023 | Tsinghua Science and Technology2023，28，6： | 0 |
| 17 | Contact Electrification Spectrum for Performance Enhancement Mechanism Investigation of Triboelectric Nanogenerators based on Silicone Elastomers with Different Surface Microstructures显示文摘Triboelectric nanogenerators(TENGs)based on conjunctive effects of contact electrification(CE)and electrostatic induction are emerging as a new mechanical energy harvesting and sensing technique for promising applications in smart wearables,Internet of Things(IoTs),etc.The surface microstructure of a flexible triboelectric material for the increase of surface area is a common strategy for performance enhancement of TENGs,but the real roles of surface microstructures on their output performance are still not explicit due to the lack of suitable analysis tool and rational experimental design.Taking advantages of the surface-sensitive characteristic of CE effect,this work exploited and developed the electric signal patterns generated by single impact of TENGs as a kind of CE spectrum to analyze and speculate the real roles of surface microstructures of flexible triboelectric materials on the output performance of TENGs.Firstly,four different kinds of surface microstructures,namely planar surface(PS)and three combinations of two basic surface microstructures,i.e.,micro lens arrays(MLAs),fabric textures(FTs),and hierarchical structures of MLAs on FTs(MLA/FTs),were elaborately designed and introduced for an identical triboelectric material(i.e.,silicone elastomer)by a(micro)molding synthesis route.Then they were used for assembly of TENGs based on vertical contact mode to conduct performance evaluation under the same triggering conditions.Through systematic analysis and comparison of their highly repeatable CE spectra by programmed machine,it was found that the surface microstructure for a flexible triboelectric material to maximally enhance the output performance of a TENG shall achieve a positive synergistic effect of increasing triboelectric charge density,effective contact area and contacting/separating velocity,rather than simple increase of its surface area. | Jianliang Gong Shenyang Ye Yan Luo Liqiong Xia Bingyu Liu Yiwang Chen | 2023 | Chinese Journal of Polymer Science2023，41，10： | 0 |
| 18 | COVID-19 mortality in ICUs associated with critical care staffing显示文摘To the Editor Coronavirus disease 2019(COVID-19)has been around for over a year since December 2019,and the global outlook is not optimistic.Because of its high transmissibility and high mortality,management of the COVID-19 pandemic has become a major challenge for health systems globally,especially for critical care. | Jingjing Xi Lin Zeng Shusheng Li Yuhang Ai Xiandi He Yan Kang Yimin Li Yanping Mo Yue Peng Kejian Qian Bingyu Qin Chunting Wang Jing Yan Fachun Zhou Hua Zhang Penglin Ma | 2021 | Burns & Trauma2021，9，1： | 0 |
| 19 | Reaching consensus for membership dynamic in secret sharing and its application to cross-chain显示文摘The communication efficiency optimization,censorship resilience,and generation of shared randomness are inseparable from the threshold cryptography in the existing Byzantine Fault Tolerant(BFT)consensus.The membership in consensus in a blockchain scenario supports dynamic changes,which effectively prevents the corruption of consensus participants.Especially in cross-chain protocols,the dynamic access to different blockchains will inevitably bring about the demand for member dynamic.Most existing threshold cryptography schemes rely on redefined key shares,leading to a static set of secret sharing participants.In this paper,we propose a general approach to coupling blockchain consensus and dynamic secret sharing.The committee performs consensus confirmation of both dynamic secret sharing and transaction proposals.Our scheme facilitates threshold cryptography membership dynamic,thus underlying support for membership dynamic of threshold cryptographybased BFT consensus schemes.We instantiate a dynamic HotStuff consensus to demonstrate the effectiveness of the scheme.After the correctness and security proof,our scheme achieves the secrecy and integrity of the threshold key shares while ensuring consensus liveness and safety.Experimental results prove that our scheme obtains dynamic membership with negligible overhead. | Yan Zhu Bingyu Li Zhenyang Ding Yang Yang Qianhong Wu Haibin Zheng | 2023 | High-Confidence Computing2023，3，3： | 0 |
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