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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Liquid bridge force between two unequal-sized spheres or a sphere and a plane显示文摘Liquid bridge force acting between wet particles is an important property in particle characterization. This paper deals with liquid bridge force between either two unequal-sized spherical particles or a sphere and a flat plate under conditions where gravitational effect arising from bridge distortion is negligible. In order to calculate the force of the liquid bridge efflciently and accurately, expressions of liquid conflguration and liquid bridge force were derived by building a mechanical model, which assumes the liquid bridge to be circular in shape between either two unequal-sized spheres or a sphere and a plane. To assess the accuracy of the numerical results of the calculated liquid bridge forces, they were compared to the published experimental data. | Youchuan Chen Yongzhi Zhao Hongli Gao Jinyang Zheng | 2011 | Particuology2011，9，4： | 11 |
| 3 | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics显示文摘MicroRNAs(miRNAs) are a class of phylogenetically conserved, non-coding short RNAs,19–22 nt in length which suppress protein expression through base-pairing with the 30-untranslated region of target m RNAs. mi RNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some mi RNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of mi RNAs in the pathogenesis, diagnosis and treatment of IPF. | Huimin Li Xiaoguang Zhao Hongli Shan Haihai Liang | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 9 |
| 4 | Electro-mechanically controlled assembly of reconfigurable 3D mesostructures and electronic devices based on dielectric elastomer platforms显示文摘The manufacture of 3D mesostructures is receiving rapidly increasing attention,because of the fundamental significance and practical applications across wide-ranging areas.The recently developed approach of buckling-guided assembly allows deterministic formation of complex 3D mesostructures in a broad set of functional materials;with feature sizes spanning nanoscale to centimeter-scale.Previous studies mostly exploited mechanically controlled assembly platforms using elastomer substrates;which limits the capabilities to achieve on-demand local assembly;and to reshape assembled mesostructures into distinct 3D configurations.This work introduces a set of design concepts and assembly strategies to utilize dielectric elastomer actuators as powerful platforms for the electro-mechanically controlled 3D assembly.Capabilities of sequential-local loading with desired strain distributions allow access to precisely tailored 3D mesostructures that can be reshaped into distinct geometries,as demonstrated by experimental and theoretical studies of?30 examples.A reconfigurable inductive-capacitive radio-frequency circuit consisting of morphable 3D capacitors serves as an application example. | Wenbo Pang Xu Cheng Haojie Zhao Xiaogang Guo Ziyao Ji Guorui Li Yiming Liang Zhaoguo Xue Honglie Song Fan Zhang Zheng Xu Lei Sang Wen Huang Tiefeng Li Yihui Zhang | 2020 | National Science Review2020，7，2： | 8 |
| 5 | Two-dimensional ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes for enhanced photocatalytic water splitting hydrogen production显示文摘Two-dimensional (2D) ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes were fabricated using an electrospinning-hydrothermal treatment-reduction method.Bare TiO2 nanotubes were fabricated via electrospinning.Then,2D MoS2 lamellae were grown on the surface of the nanotubes and Ti^3+/Ov ions were introduced by reduction.The photocatalytic performance of the 2D MoS2/Ti^3+-TiO2 nanotubes was^15 times better than that of TiO2.The HER enhancement of the MoS2/Ti^3+-TiO2 nanotubes can be attributed to the Pt-like behavior of 2D MoS2 and the presence of Ti^3+-ions,which facilitated the quick diffusion of the photogenerated electrons to water,reducing the H2 activation barrier.The presence of Ov ions in the nanotubes and their hollow structure increased their solar utilization. | Wei Ou Jiaqi Pan Yanyan Liu Shi Li Hongli Li Weijie Zhao Jingjing Wang Changsheng Song Yingying Zheng Chaorong Li | 2020 | Journal of Energy Chemistry2020，29，4： | 7 |
| 6 | Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release显示文摘Thermosensitive 药交货系统(DDS ) 面对主要挑战,例如遥远、可重复的控制在 vivo 温度,尽管这些能增加药的治疗学的功效。处理这个问题,我们涂在红外线附近(NIR ) photothermal Cu 1.75 有 pH/thermos-sensitive 聚合物由的 S nanocrystals 在 situ 聚合。装载内容的 doxorubicine (纪录影片) 直到 40 wt.% ,与纪录影片在正常生理的条件下面正在被漏的不到 8.2 wt.%(pH = 7.4, 37 吗? | Sheng Huang Jing Liu Qian He Hongli Chen Jiabin Cui Suying Xu Yuliang Zhao Chunying Chen Leyu Wang | 2015 | Nano Research2015，8，12： | 7 |
| 7 | The Boreal Summer Intraseasonal Oscillation Simulated by Four Chinese AGCMs Participating in the CMIP5 Project显示文摘The performances of four Chinese AGCMs participating in the Coupled Model Intercomparison Project Phase 5(CMIP5)in the simulation of the boreal summer intraseasonal oscillation(BSISO) are assessed. The authors focus on the major characteristics of BSISO: the intensity, significant period, and propagation. The results show that the four AGCMs can reproduce boreal summer intraseasonal signals of precipitation; however their limitations are also evident. Compared with the Climate Prediction Center Merged Analysis of Precipitation(CMAP) data, the models underestimate the strength of the intraseasonal oscillation(ISO) over the eastern equatorial Indian Ocean(IO) during the boreal summer(May to October),but overestimate the intraseasonal variability over the western Pacific(WP). In the model results, the westward propagation dominates, whereas the eastward propagation dominates in the CMAP data. The northward propagation in these models is tilted southwest–northeast, which is also different from the CMAP result. Thus, there is not a northeast–southwest tilted rain belt revolution off the equator during the BSISO's eastward journey in the models. The biases of the BSISO are consistent with the summer mean state, especially the vertical shear. Analysis also shows that there is a positive feedback between the intraseasonal precipitation and the summer mean precipitation. The positive feedback processes may amplify the models' biases in the BSISO simulation. | ZHAO Chongbo ZHOU Tianjun SONG Lianchun REN Hongli | 2014 | Advances in Atmospheric Sciences2014，31，5： | 7 |
| 8 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 9 | Integrated Train Ground Radio Communication System Based TD-LTE显示文摘In existing metro systems,the train ground radio communication system for different applications are deployed independently.Investing and constructing the communication infrastructures repeatedly wastes substantial social resources,and it brings difficulties to maintain all these infrastructures.We present the communication Quality of service(Qo S) requirement for different train ground radio applications.An integrated TD-LTE based train ground radio communication system for the metro system(LTE-M) is designed next.In order to test the LTEM system performance,an indoor testing environment is set up.The channel simulator and programmable attenuators are used to simulate the real metro environment.Extensive test results show that the designed LTE-M system performance satisfies metro communication requirements. | ZHAO Hongli CAO Yuan ZHU Li XU Wei | 2016 | Chinese Journal of Electronics2016，25，4： | 6 |
| 10 | Post-Rifting Magmatism and the Drowned Reefs in the Xisha Archipelago Domain显示文摘Fourteen isolated drowned reefs have been identified around the Xisha Uplift by multibeam and seismic data. The drowning processes of these reefs can be divided into three different stages, which correspond to three different accelerated tectonic subsidence periods. The drowning of the Xisha reefs is the result of the combined action of tectonic subsidence and sea level fluctuations, and the tectonic subsidence rate had to remain above 0.2 mm yr^(-1 )for a long time. Three abrupt accelerated tectonic subsidence events that occurred in the late Miocene, Pliocene and early Quaternary in the Xisha Uplift were closely related to the thermal subsidence processes after three stages of post-rifting magmatism. The magmatism of the middle Miocene and the following thermal subsidence resulted in the drowning of reefs in the northwestern Xisha uplift(Zone A). During the early Pliocene, massive magmatic intrusions and volcanic eruptions occurred in the Xisha Uplift. Then, the subsequent thermal subsidence started the drowning process of reefs in the northeastern and western regions of the Xisha Uplift(Zone B and C). During the early Quaternary, large-scale magmatism also occurred in the Xisha Uplift. The subsequent thermal subsidence resulted in a new rapid tectonic subsidence, which caused the reefs in the southern and southeastern regions of the Xisha Uplift to drown(Zone D and E). | WANG Hongli ZHAO Qiang WU Shiguo WANG Dawei WANG Bin | 2018 | Journal of Ocean University of China2018，17，1： | 5 |
| 11 | Damage Detection and Material Property Reconstruction of Composite Laminates Using Laser Ultrasonic Technique显示文摘Laser ultrasonic technique has received increasing attentions in the past decade due to its contactless nature and a wide range of applications have been reported. In this review,applications of laser ultrasonic technique developed at Nanjing University of Aeronautics and Astronautics(NUAA)as well as elsewhere for non-destructive testing in composite laminates are presented. The principles of generating and detecting in a laser ultrasonic system are introduced,three different system configurations are also introduced with each configuration's advantages and disadvantages explained. More importantly,two major applications developed at NUAA for composite laminates are presented including damage detection,stiffness reconstruction and fatigue life prediction. Both applications are realized by a fixed-point PZT sensor and scanning pulse laser based on the linear reciprocal theorem. Analytical method and numerical models are employed and developed to realize the functionalities. | QIU Jinhao TAO Chongcong JI Hongli ZHANG Chao ZHAO Jinling | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，1： | 4 |
| 12 | Holocene vegetation change in relation to fire and volcanic events in Jilin, Northeastern China显示文摘Volatiles erupted from large-scale explosive volcanic activities have a significant impact on climate and environmental changes.As an important ecological factor,the occurrence of fire is affected by vegetation cover,and fire can feed back into both vegetation and climatic change.The causes of fire events are diverse;and can include volcanic eruptions.The amount of charcoal in sediment sequences is related to the frequency and intensity of fire,and hence under good preservation conditions fire history can be reconstructed from fossil charcoal abundance.Until now,little research on the role of fire has been carried out in northeastern China.In this study,through research on charcoal and tephra shards from Gushantun and Hanlongwan,Holocene vegetation change in relation to fire and volcanic events in Jilin,Northeastern China,was investigated.Where tephra shards are present in Gushantun it is associated with low level of both conifers and broadleaved trees,and is also associated with a pronounced charcoal peak.This suggests forest cover was greatly reduced from a fire caused by an eruption of the Tianchi volcano.We also detected one tephra layer in Hanlongwan,which also has the almost same depth with low level forest pollen values and one charcoal peak.This was caused probably by an eruption of the Jinlongdingzi volcano. | ZHAO HongLi LI XiaoQiang Valerie A.HALL | 2015 | Science China Earth Sciences2015，58，8： | 4 |
| 13 | Formation and Transportation of High-Salinity Water Produced in Polynyas South of the St.Lawrence Island显示文摘The authors studied variations of temperature and salinity in seawater under sea ice using hydrologic data collected from polynyas south of the St.Lawrence Island during March of 2008 and 2009.The results indicate that the high-salinity water found during the cruises of 2008 and 2009 was due to the formation of polynyas.The salinity observed in 2008 was higher than that in 2009 as a result of higher salt production in 2008.The spatial distributions of high-salinity cores differed between the two cruises.In March 2008, a southeastward flow was formed under the persistent northerly wind in the observation region, which transported the high-salinity water produced by the polynyas to the southeast.The similar flow, however, did not exist in March 2009 because the northerly wind over the study area was interrupted by a southerly wind.Accordingly, the polynyas and the high-salinity water pro-duced by them existed for a short time.As a result, the high-salinity water in 2009 did not spread very far, and stayed within the polynyas.In addition, during the 2009 cruise, two stages of observations in the polynyas showed the core of high-salinity water was shifted to the southwest of the St.Lawrence Island.This result suggested that a southwestward flow might have existed in the area at the onset of the northerly wind, which was consistent with the alongshore and/or offshore flows caused by the northerly wind. | FU Hongli ZHAO Jinping SHI Jiuxin JIAO Yutian | 2010 | Journal of Ocean University of China2010，9，4： | 3 |
| 14 | Versatile zero- to three-dimensional carbon for electrochemical energy storage显示文摘Secondary batteries have been widely developed and used in various fields,such as large-scale energy storage,portable electronics,and electric vehicles.Carbon-based materials have attracted considerable attention due to their abundance,environmental friendliness,tunable structure,and excellent chemical stability.Beyond the commercial carbon for batteries and supercapacitors,many studies focused on advanced and multifunctional carbon with various structures for electrochemical energy storage.This review summarizes the zero-to three-dimensional carbon-based materials and reviews their various electrochemical applications based on their structural characteristics.The importance of carbon structures and the relationship between materials'structures and electrochemical performance are discussed.Then,the prospects and potential challenges of using advanced carbon to formulate designs and develop novel carbonaceous materials with high electrochemical performance are further discussed. | Yuyue Zhao Yunlu Zhang Ying Wang Daxian Cao Xiao Sun Hongli Zhu | 2021 | Carbon Energy2021，3，6： | 3 |
| 15 | Fabrication and characterization of SmO_(0.7)F_(0.2)FeAs bulk with a transition temperature of 56.5 K显示文摘The superconductivity of iron-based superconductor SmO 0.7 F 0.2 FeAs was investigated. The SmO 0.7 F 0.2 FeAs sample was prepared by the two-step solid-state reaction method. The onset resistivity transition temperature is as high as 56.5 K. X-ray diffraction (XRD) results show that the lattice parameters a and c are 0.39261 and 0.84751 nm, respectively. Furthermore, the global J c was more than 2.3 × 10 5 A/cm 2 at T = 10 K and H = 9 T, which was calculated by the formula of J c = 20ΔM/[a(1-a/(3b))]. The upper critical fields, H c2 ≈ 256 T (T = 0 K), was determined according to the Werthamer-Helfand-Hohenberg formula, indicating that the SmO 0.7 F 0.2 FeAs was a superconductor with a very promising application. | LIU Zhiyong MA Lin ZHAO Junjing YAN Binjie SUO Hongli | 2011 | Rare Metals2011，30，5： | 3 |
| 16 | Current status of anticoagulant treatments and improvements for hemodialysis patients in northern Chinese cities: a five-year comparative study显示文摘 | Huang Qi Sun Xuefeng Lin Hongli Zhang Zhimin Hao Lirong Yao Li Li Jijun Zhao Delong Wang Yong Zhu Hanyu Chen Xiangmei | 2014 | Chinese Medical Journal2014，，16： | 3 |
| 17 | AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson's disease diagnosis显示文摘 | Zhao, Hongli Zhao, Jue Hou, Jiapeng Wang, Siqing Ding, Yu Lu, Boxun Wang, Jian | 2017 | Protein & Cell2017，8，9： | 2 |
| 18 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 19 | Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure显示文摘 | Tianyan Chen Yingli He Xiaojing Liu Zhi Yan Ke Wang Hongli Liu Shuling Zhang Yingren Zhao | 2012 | Clinical and Experimental Medicine2012，，3： | 2 |
| 20 | Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi显示文摘 | Xiaoli Bao Chengzhong Wang Jinjin Liu Huihui Yuan Hongli Zhao Minbo Lan | 2013 | Carbohydrate Polymers2013，，： | 1 |
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