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| 1 | Controllable Synthesis of Fluorescent Carbon Dots and Their Detection Application as Nanoprobes显示文摘Carbon dots(CDs), as a new member of carbon nanomaterial family, have aroused great interest since their discovery in 2004. Because of their outstanding water solubility, high sensitivity and selectivity to target analytes, low toxicity, favorable biocompatibility, and excellent photostability, researchers from diverse disciplines have come together to further develop the fundamental properties of CDs. Many methods for the production of CDs have been reported, therein, hydrothermal and solvothermal technology needs simple equipments, and microwave synthesis needs less reaction time, hence these methods become current common synthesis methods, in which many precursors have been applied to produce CDs. Due to their excellent fluorescence, CDs have made impressive strides in sensitivity and selectivity to a diverse array of salt ions,organic/biological molecules and target gases. The development of CDs as nanoprobes is still in its infancy, but continued progress may lead to their integration into environmental and biological applications. Hydrothermal,solvothermal, and microwave synthesis of fluorescent carbon dots and their detection applications as nanoprobes in salt ions, organic/biological molecules, and target gases will be reviewed. | Zhi Yang Zhaohui Li Minghan Xu Yujie Ma Jing Zhang Yanjie Su Feng Gao Hao Wei Liying Zhang | 2013 | Nano-Micro Letters2013，5，4： | 12 |
| 2 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 3 | Fibrinogen-like protein 2 expression correlates with microthrombosis in rats with type 2 diabetic nephropathy显示文摘Fibrinogen-like protein 2 (fgl2),a novel prothrombinase,is involved in microthrombosis.We examined fgl2 expression in the glomerular and tubulointerstitial capillaries and its correlation with microthromsis in rats with streptozocin-induced type 2 diabetic nephropathy.Our RT-PCR and immunoblotting analysis showed that fgl2 mRNA and protein levels were increased in microvascular endothelial cells of the glomeruli and renal interstitia at week 19 and became significantly elevated with the development of diabetic nephropathy (P < 0.01).Fgl2 was not or only weakly expressed in the renal tissues of normal rats.Furthermore,a direct significant correlation (r=0.543,P < 0.01) was found between fgl2 expression and microthrombotic capillaries in the renal tissues.Enzyme linked immunosorbent assays (ELISA) additionally showed that circulating TNF-α levels in rats with type 2 diabetes were significantly elevated and closely correlated with fgl2 expression (r=0.871,P < 0.01).Our results suggest that fgl2 may activate renal microthrombosis,thus contributing to glomerular hypertension and renal ischemia. | Guanhua Su Kun Liu Yan Wang Jue Wang Xiaowei Li Wenzhu Li Yuhua Liao Zhaohui Wang | 2011 | The Journal of Biomedical Research2011，25，2： | 6 |
| 4 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
| 5 | Polystyrene-based blend nanorods with gradient composition distribution显示文摘The polystyrene-based polymer blends, partially miscible poly(bisphenol A carbonate)/polystyrene (PC/PS) and completely miscible poly(2,6-dimethylphenylene oxide)/polystyrene (PPO/PS), in nanorods with gradient composition distribution were discussed. The polymer blend nanorods were prepared by infiltrating the polymer blends into nanopores of anodic aluminum oxide (AAO) templates via capillary action. Their morphology was investigated by micro-Fourier transform infrared spectroscopy (micro-FTIR) and nano-thermal analysis (nano-TA) with spatial resolution. The composition gradient of polymer blends in the nanopores is governed by the difference of viscosity and miscibility between the two polymers in the blends and the pore diameter. The capillary wetting of porous AAO templates by polymer blends offers a unique method to fabricate functional nanostructured materials with gradient composition distribution for the potential application to nanodevices. | WU Hui SU ZhaoHui TERAYAMA Yuki TAKAHARA Atsushi | 2012 | Science China Chemistry2012，55，5： | 2 |
| 6 | Research and development of recycling utilization of used refractories:A review显示文摘Due to thermal stability and excellent resistance to slag erosion,the used refractories can be recycled as the main raw material for some refractories.In this article the latest developments about used refractories in metallurgical industry has been reviewed,focusing on the results reported in the past decade.The research and reutilization methods of used refractories were discussed.For the research of used refractories,the results of two aspects,the performance and surface corrosion characteristics,are summarized.Then,the advances in research on recycling technology of several main kinds of used refractories,such as MgO-C,Al2O3-SiC-C,Al2O3-MgO-C,magnesium-chrome,and corundum-spinel refractories were summarized and discussed in detail.Some results of the author’s group were reported等线accompanied by these comments.The microstructure and chemical composition were studied by scanning electron microscopy and energy dispersion spectra,and the properties of the refractories were analyzed.Afterwards,the scope of application of materials was determined according to the classification and analysis of refractories.Finally,the large-scale application of used refractories and an outlook is given to future developments of the entire recycling industry. | Wu Xiaowen Chi Peng Cheng Bohao Zhang Yuena Su Wei Min Xin Fang Minghao Liu Yan’gai Huang Zhaohui | 2020 | China's Refractories2020，29，3： | 1 |
| 7 | Harmonic analysis for hyperspectral image classification integrated with PSO opti- mized SVM显示文摘 | Xue Zhaohui Du Peijun Su Hongjun | 2014 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2014，6，7： | 1 |
| 8 | Effects of polymerization conditions on hydrophilic groups in aromatic polyamide thin films显示文摘 | Ying Jin Zhaohui Su | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 9 | Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p显示文摘 | Yingying Su Zhaohui Ni Guoqing Wang Juan Cui Chengguo Wei Jihan Wang Qing Yang Ying Xu Fan Li | 2012 | International Immunopharmacology2012，，4： | 1 |
| 10 | Controlled adsorption of cellulase onto pretreated corncob by pH adjustment显示文摘 | Ruoyu Du Rongxin Su Xuan Li Xiaowei Tantai Zhaohui Liu Jifeng Yang Wei Qi Zhimin He | 2012 | Cellulose2012，，2： | 1 |
| 11 | Surface activity of perfluorode canoyl end capped poly(ethylene oxide) and associated ad sorption behavior to the air-water interface 显示文摘 | Su zhaohui McCarthy T J | 1998 | Polymer1998，39，： | 1 |
| 12 | Multivalency iodine doped TiO2:preparation,characterization,theoretical studies,and visible-light photocatalysis显示文摘 | Su Wenyue Zhang Yongfan Li Zhaohui | 2008 | Langmuir2008，24，7： | 1 |
| 13 | Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia. | Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 14 | Crystallization and orientation of syndiotactic polystyrene in nanorods显示文摘 | Hui Wu Wei wang HuiXian Yang Zhaohui Su | 2007 | Macrolecules2007，40，12： | 1 |
| 15 | Heat transfer characteristics during subcooled flow boiling of a kerosene kind hydrocarbon fuel in a 1<ce:hsp sp='0.25'/>mm diameter channel显示文摘 | Zhaohui Liu Qincheng Bi Yong Guo Qianhua Su | 2012 | International Journal of Heat and Mass Transfer (-)2012，，19： | 1 |
| 16 | On the origin of SARS-CoV-2——The blind watchmaker argument显示文摘In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive.By the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection. | Chung-I Wu Haijun Wen Jian Lu Xiao-dong Su Alice CHughes Weiwei Zhai Chen Chen Hua Chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang Bingjie Chen Zixiao Guo Yongsen Ruan Xuemei Lu Fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang | 2021 | Science China(Life Sciences)2021，64，9： | 1 |
| 17 | Characterization of cocrystals formed by grinding amino acids through terahertz time-domain spectroscopy显示文摘In this paper,we used terahertz time-domain spectroscopy(THz-TDS)over a range of 0.3–2.5 THz to investigate the formation of solid-state cocrystals of amino acids,formed by grinding mixtures of two different kinds of amino acids.For comparison,we prepared dual-layer samples,combined by pressing two single-component pellets together without grinding.In the ground-mixture samples,some extra absorption peaks appeared,different from the characteristic peaks of the pure components,but these peaks did not appear in the dual-layer samples.Thus,these extra absorption peaks in the THz range are unique features of cocrystals.From our results,we believe that THz-TDS is a promising technique to characterize cocrystals. | Xiaoyan Zhao Haixia Su Zhaohui Zhang Zhi Li Han Zhang Tianyao Zhang | 2014 | Chinese Science Bulletin2014，59，24： | 1 |
| 18 | Harmonic Analysis for Hy- perspectral Image Classification Intergrated with PSO Optimized SVM显示文摘 | Zhaohui Xue Peijun Du Hongjun Su | 2014 | IEEE Journal of Selected Topics in Applied Earth Obser- vations and Remote Sensing2014，7，62： | 1 |
| 19 | Multi valency iodine doped Ti02: preparation, characteriza tion, theoretical studies, and visible light photocatalysi 显示文摘 | Su Wenyue Zhang Yongfan Li Zhaohui | 2008 | Langmuir2008，24，7： | 1 |
| 20 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
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