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| 1 | Simulation of shock wave buffet and its suppression on an OAT15A supercritical airfoil by IDDES显示文摘In the present paper,extremely unsteady shock wave buffet induced by strong shock wave/boundary-layer interactions (SWBLI) on the upper surface of an OAT15A supercritical airfoil at Mach number of 0.73 and angle of attack of 3.5 degrees is first numerically simulated by IDDES,one of the most advanced RANS/LES hybrid methods.The results imply that conventional URANS methods are unable to effectively predict the buffet phenomenon on the wing surface;IDDES,which involves more flow physics,predicted buffet phenomenon.Some complex flow phenomena are predicted and demonstrated,such as periodical oscillations of shock wave in the streamwise direction,strong shear layer detached from the shock wave due to SWBLI and plenty of small scale structures broken down by the shear layer instability and in the wake.The root mean square (RMS) of fluctuating pressure coefficients and streamwise range of shock wave oscillation reasonably agree with experimental data.Then,two vortex generators (VG) both with an inclination angle of 30 degrees to the main flow directions are mounted in front of the shock wave region on the upper surface to suppress shock wave buffet.The results show that shock wave buffet can be significantly suppressed by VGs,the RMS level of pressure in the buffet region is effectively reduced,and averaged shock wave position is obviously pushed downstream,resulting in increased total lift. | HUANG JingBo XIAO ZhiXiang LIU Jian FU Song | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 24 |
| 2 | Studies of the unsteady supersonic base flows around three afterbodies显示文摘<正> Unsteady supersonic base flows around threeafterbodies,cylindrical(Cy),boattailed(BT)and three-step(MS),are investigated in this paper.Reynolds-averagedNavier-Stokes(RANS)and two RANS/LES(large-eddysimulation)hybrid methods,detached eddy simulation(DES)and delayed-DES(DDES),are used to predict the base flowcharacteristics around the baseline Cy afterbody.All theRANS and hybrid methods are based on the two-equationSST(shear-stress transport)model with compressible correc-tions(CC).According to the comparison of measurements,both DES and DDES can produce more satisfactory resultsthan RANS.RANS can only present the 'stable' flow pat-terns,while the hybrid methods can demonstrate unsteadyflow structures.DDES and DES results are little differentfrom one another although the latter exhibits better agree-ment with the experiment.DES is taken to investigate the5~ BT and three-step afterbodies.The mean flow data andthe instantaneous turbulent coherent structures are comparedagainst available measurements. | Zhixiang Xiao Song Fu School of Aerospace Engineering,Tsinghua University, 100084 Beijing, China | 2009 | Acta Mechanica Sinica2009，25，4： | 12 |
| 3 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 4 | Prediction of separation flows around a 6:1 prolate spheroid using RANS/LES hybrid approaches显示文摘这篇论文论述混合平均 Reynolds 的 Navier 司烧(RANS ) 并且为在在 6:1 附近的攻击的高角度的分开的流动的 large-eddy-simulation (LES ) 方法延长球状体。在这个工作学习的 RANS/LES 混合方法基于 Spalart Allmaras ( S A )包括分开的旋涡模拟( DES ), Menter 的 k ω
shear-stress-transport ( SST )和有弱非线性的旋涡粘性明确的表达的 k ω
(威尔科克斯Durbin+,WD+)模型和 zonal-RANS/LES 方法基于 SST 和WD+模型。从到在核心流动区域的 LES 的墙附近的 RANS 的开关通过为带的混合方法混合功能的一个流动依赖者的实现是光滑的。所有混合方法被设计为依附的流动有一个 RANS 模式并且为分开的流动有 LES 行为。这篇论文的主要目的是使用混合方法因为高级雷纳兹数字在延长球状体附近分开了流动在高发生。有第四顺序的人工的粘性的一个第四顺序的中央计划被申请空间 differencing。充分含蓄更低上面对称 -- 有假时间亚重复的高斯 Seidel 作为时间的区别被拿。有可得到的大小的比较为速度的压力分发,皮肤磨擦,和侧面被执行,等等。对实验的合理同意,为格子和基本骚乱上的效果的财务当模特儿,为分离流动被获得。 | Zhixiang Xiao Yufei Zhang Jingbo Huang Haixin Chen Song Fu School of Aerospace Engineering,Tsinghua University,Beijing 100084,China | 2007 | Acta Mechanica Sinica2007，23，4： | 10 |
| 5 | Secondary instability control of compressible flow by suction for a swept wing显示文摘The crossflow instability of a three-dimensional boundary layer is a main factor affecting the transition around the swept-wing.The three-dimensional boundary layer flow affected by the saturated crossflow vortex is very sensitive to the high frequency disturbances,which foreshadows that the swept wing flow transition will happen.The primary instability of the compressible flow over a swept wing is investigated with nonlinear parabolized stability equations (NPSE).The Floquet theory is then applied to the analysis of the influence of localized steady suction on the secondary instability of crossflow vortex.The results show that suction can significantly suppress the growth of the crossflow mode as well as the secondary instability modes. | XU GuoLiang XIAO ZhiXiang FU Song | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 6 |
| 6 | Growth and wood properties of a 38-year-old Populus simonii 3 P.nigra plantation established with different densities in semi-arid areas of northeastern China显示文摘To characterize the effects of plantation densities on the growth characteristics(diameter at breast level,tree height and volume)and the common wood properties,38-year-old Populus simonii 9 P.nigra clones planted with four levels of spacing(2 m 92 m,3 m 93 m,4 m 94 m,and 5 m 95 m)in a semi-arid area in northeastern China were examined.The results of ANOVA showed significant differences(P\0.01)for all the investigated growth traits and wood properties under different plantation densities,except for the chemical composition of wood.The repeatability and phenotypic variations of all the traits varied from 0.34 to 0.99 and from 13.45 to 59.65%,respectively.Except for wood density,which was significantly negatively correlated with the growth traits,a positive correlation was observed between the growth traits and all the other wood mechanical properties.However,most of the correlations between the growth traits and the chemical composition of the wood were not significant.The path analysis for the wood mechanical characteristics and the growth in the prediction of volume were significant and ranged from 0.18 to 0.72 for wood density and diameter at breast height,respectively,while those for the chemical composition of wood ranged from 0.001 to 0.336,which showed a low impact on the volume.The highest stand volume(610 m3)per hectare was observed with the 2 m 92 m spacing,which consequently provided a high total price and income,while a high individual volume growth per tree was observed with the 5 m 95 m spacing.The results suggested that for the poplar trees younger than 40 years in a semi-arid area in China,2 m 92 m spacing is suitable for obtaining a high volume per hectare,while 5 m 95 m spacing is best for obtaining a high individual volume per tree. | Ammar Khalil Mohamed Ahmed Zhixiang Fu Changjun Ding Luping Jiang Xidong Han Aiguo Yang Yinghui Ma Xiyang Zhao | 2020 | Journal of Forestry Research2020，31，2： | 6 |
| 7 | Study of control effects of vortex generators on a supercritical wing显示文摘Flows around vortex generators(VGs),which serve as one of the important flow control methods,are investigated by solving Reynolds-averaged Navier-Stokes(RANS)equations.The influences on the main flow of VGs are intended to explore.Firstly, the flow around a single VG on a flat plane is computed to validate the schemes and to acquire basic knowledge of this kind of flow.Secondly,transonic flow past a standard model,named by ONERA-M6 wing,is predicted to investigate the flow features of shockwave/boundary-layer interactions(SWBLI).Thirdly,the effects of a row of VGs mounted about 25%local chord on a supercritical wing are analyzed in transonic condition with strong SWBLI.Lastly,VGs are mounted more upwind(about 3.5%local chord)to explore the effects at low speed and high incidence condition.The numerical results show that seven VGs can effectively suppress the separations behind the strong SWBLI and decrease spanwise flow and wing-tip vortex in transonic condition.VGs also can decrease the large scope of separation over the wing at low speed with high angle of attack. | HUANG JingBo 1 ,XIAO ZhiXiang 1 ,FU Song 1 &ZHANG Miao 2 1 School of Aerospace Engineering,Tsinghua University,Beijing 100084,China 2 Shanghai Aircraft Design and Research Institute of COMAC,Shanghai 200232,China | 2010 | Science China(Technological Sciences)2010，53，8： | 5 |
| 8 | Analysis of the secondary instability of the incompressible flows over a swept wing显示文摘The crossflow instability of a three-dimensional (3-D) boundary layer is an important factor which affects the transition over a swept-wing.In this report,the primary instability of the incompressible flow over a swept wing is investigated by solving nonlinear parabolized stability equations (NPSE).The Floquet theory is applied to study the dependence of the secondary and high-frequency instabilities on curvature,Reynolds number and angle of swept (AOS).The computational results show that the curvature in the present case has no significant effect on the secondary instabilities.It is generally believed that the secondary instability growth rate increases with the magnitude of the nonlinear mode of crossflow vortex.But,at a certain state,when the Reynolds number is 3.2 million,we find that the secondary instability growth rate becomes smaller even when the magnitude of the nonlinear mode of the crossflow vortex is larger.The effect of the angle of swept at 35,45 and 55 degrees,respectively,is also studied in the framework of the secondary linear stability theory.Larger angles of swept tend to decrease the spanwise spacing of the crossflow vortices,which correspondingly helps the stimulation of 'z' mode. | XU GuoLiang XIAO ZhiXiang FU Song | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 5 |
| 9 | Connecting Calcium-Based Nanomaterials and Cancer:From Diagnosis to Therapy显示文摘As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins.The importance of calcium ions(Ca^(2+))makes its“Janus nature”strictly regulated by its concentration.Abnormal regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role.“Calcium overload,”for example,is characterized by excessive enrichment of intracellular Ca^(2+),which irreversibly switches calcium signaling from“positive regulation”to“reverse destruction,”leading to cell death.However,this undesirable death could be defined as“calcicoptosis”to offer a novel approach for cancer treatment.Indeed,Ca^(2+)is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT imaging.In paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly available.This review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel perspective.Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics. | Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu | 2022 | Nano-Micro Letters2022，14，9： | 2 |
| 10 | Linear Time Probabilistic Algorithms for the Singular Haplotype Reconstruction Problem from SNP Fragments显示文摘 | Chen Zhixiang Fu Bin Schweller R | 2008 | Journal of Computational Biology2008，15，5： | 1 |
| 11 | Thermal conductivity and fire resistance of epoxy molding compounds filled with Si3N4 and Al (OH)3 显示文摘 | Shi Zhixiang Fu Renli Agathopoulos S | 2012 | Materials and Design2012，34，： | 1 |
| 12 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 13 | Community Diversity of Associated Bacteria of Radopholus similis显示文摘[Objective] The paper was to reveal the species abundance of associated bacterial community of Radopholus similis, and the diversity of its bacteria. [Methods] Through the construction of 16S rDNA cloning library of bacteria, the positive clone was carried out ARDRA analysis, and the phylogenetic tree was constructed. [Results] OUT (Operational Taxonomic Units) was classified according to sequences similarity of 97%, and the constructed 16S rDNA library of bacteria contained 13 OTUs, belonging to Alphaproteobacteria, Betaproteobacteria and Gammaproteobacteria, respectively. The dominant species was Betaproteobacteria, especially Burkholderia was the dominant bacterium. [Conclusions] The diversity of associated bacteria of R. similis was high, and these bacteria may have certain ecological significance to R. similis. | Fen ZHENG Meiying FU Zhixiang ZHAO Miancai CHEN | 2012 | Plant Diseases and Pests2012，3，2： | 1 |
| 14 | Optimal Algorithms for Finding User Access Sessions from Very Large Web Logs显示文摘 | Chen Zhixiang Fu A W Tong F C | 2003 | World Wide Web2003，6，3： | 1 |
| 15 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 16 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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