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| 1 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol显示文摘OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. | Wang Songzi Ren Lu Jia Lianqun Gu Zhongyue Fan Xu Chen Wenna Hou Ping Liang Fanrong Rong Peijing Ma Tieming Liu Xulai Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 12 |
| 2 | Therapeutic mechanisms of integrated traditional Chinese and conventional medicine underlying its treatment of precancerous lesions of gastric cancer显示文摘China has a high incidence of gastric cancer. Secondary prevention of gastric cancer is a major public health problem that must be solved urgently. Modern medicine focuses on the pathogenesis of precancerous lesions of gastric cancer(PLGC), and it has been found that there are a variety of abnormal gene expression patterns in PLGC. This study summarizes recent advances in our understanding of the therapeutic mechanisms of PLGC from various clinical studies;this will provide a reference for studying the therapeutic mechanisms of Traditional Chinese Medicine in the treatment of PLGC from the combined points of view of Traditional Chinese and Conventional medicine. | XU Qing WANG Yang LI Zhongyu YAN Jiaxing ZHAO Yingpan WANG Ping WEN Yandong | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 4 |
| 3 | Experimental Investigation of Wave Load and Run-up on the Composite Bucket Foundation Influenced by Regular Waves显示文摘In the design of wind turbine foundations for offshore wind farms, the wave load and run-up slamming on the supporting structure are the quantities that need to be considered. Because of a special arc transition, the interaction between the wave field and the composite bucket foundation(CBF) becomes complicated. In this study, the hydrodynamic characteristics, including wave pressure, load, upwelling, and run-up, around the arc transition of a CBF influenced by regular waves are investigated through physical tests at Shandong Provincial Key Laboratory of Ocean Engineering, Ocean University of China. The distributions of the wave pressures and upwelling ratios around the CBF are described, and the relationship between the wave load and the wave parameters is discussed. New formulae based on the velocity stagnation head theory with linear wave theory and the second-order Stokes wave theory for wave kinematics are proposed to estimate the wave run-up. Moreover, the multiple regression method with nonlinear technology is employed to deduce an empirical formula for predicting run-up heights. Results show that the non-dimensional wave load increases with the increase in the values of the wave scattering parameter and relative wave height. The wave upwelling height is high in front of the CBF and has the lowest value at an angle of 135? with the incoming wave direction. The performance of the new formulae proposed in this study is compared using statistical indices to demonstrate that a good fit is obtained by the multiple regression method and the analytical model based on the velocity stagnation head theory is underdeveloped. | YU Tongshun ZHAO Zishuai SHI Zhongyu XU Yu | 2021 | Journal of Ocean University of China2021，20，2： | 3 |
| 4 | Microstructure and Tribological Properties of Plasma-sprayed Nanostructured Sulfide Coating显示文摘磨擦并且穿喷洒血浆的 nanostructured FeS 的性质涂层在 MHK-500 磨擦上被调查并且在油润滑油和干燥磨擦下面穿测试者状况。微观结构,穿的表面形态学和涂层的阶段作文被扫描电子显微镜学(SEM ) 和 X 光检查衍射(XRD ) 描绘。涂层主要由 FeS 组成,这被发现, Fe_(1-x ) S 和氧化物的小数量也被发现。涂层被 50-100 nm 的小粒子在尺寸形成。涂层的厚度是约 150 亩 m。plasma-sprayednanostructured FeS 涂层的磨擦减小和穿抵抗性质比 GCrl5 钢底层的优异。特别在油润滑油状况下面, nanostructured FeS 涂层的磨擦系数是中的 50% 个 GCrl5 钢,涂层的 wear 疤宽度是,这也在高负担下面归结为 GG15 钢的中的将近 50% 个。涂层的失败主要在油润滑油和干燥磨擦状况下面被归因于塑料变丑。 | Yang XU Yaohui GUAN Zhongyu ZHENG Xiaohui TONG | 2006 | Journal of Materials Science & Technology2006，22，5： | 3 |
| 5 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 6 | What kind of optical model potentials should be used for deuteron stripping reactions?显示文摘This paper presents the results of a study that compares CTOM, a microscopic optical model potential(OMP), which is an optical model co-created by the China Nuclear Data Center & Tuebingen University, to CH89, which is a typical phenomenological OMP.The respective OMPs were tested by applying them to the modelling of nucleon elastic scattering and(d,p) transfer reactions involving14C,36S, and58Ni targets at both low and relatively high energies. The results demonstrated that although both potentials successfully accounted for the angular distributions of both the elastic scattering and transfer cross sections, the absolute values of the transfer cross sections calculated using CTOM were approximately 25% larger than those calculated using CH89. This increased transfer cross sections allowed CTOM to produce single particle strength reduction factors for the three reactions that were consistent with those extracted from(e,e′p) reactions as well as with more recent(p,2p) and(p,pn) reactions. Notch tests suggested that nucleon elastic scattering and transfer reactions are sensitive to different regions of the OMP;accordingly,phenomenological OMPs, which are constrained only by elastic scattering cross sections, may not be sufficient for nucleon transfer reactions. Therefore, we suggest that microscopic OMPs, which reflect more theoretical considerations, should be preferred over phenomenological ones in calculations of direct nuclear reactions. | XiaoYan Yun DanYang Pang YiPing Xu Zhi Zhang RuiRui Xu ZhongYu Ma CenXi Yuan | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，2： | 2 |
| 7 | Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy显示文摘Immunotherapy is emerging as a powerful tool for combating many human diseases.However,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly restricted.The major obstacle is the lack of effective technologies for transporting therapeutic agents across the blood-brain barrier(BBB)and achieving targeted delivery to specific cells once across the BBB.Ferritin,an iron storage protein,traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1(TfR1)overexpressed on BBB endothelial cells.Here,we developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse model.We fused different glioma-targeting moieties on self-assembled ferritin nanoparticles via genetic engineering,and RGE fusion protein nanoparticles(RGE-HFn NPs)were identified as the best candidate.Furthermore,RGE-HFn NPs encapsulating a stimulator of interferon genes(STING)agonist(SR717@RGE-HFn NPs)maintained stable self-assembled structure and targeting properties even after traversing the BBB.In the glioma-bearing mouse model,SR717@RGE-HFn NPs elicited a potent local innate immune response in the tumor microenvironment,resulting in significant tumor growth inhibition and prolonged survival.Overall,this biomimetic brain delivery platform offers new opportunities to overcome the BBB and provides a promising approach for brain drug delivery and immunotherapy in patients with glioma. | Bin Wang Maoping Tang Ziwei Yuan Zhongyu Li Bin Hu Xin Bai Jinxian Chu Xiaoyang Xu Xue-Qing Zhang | 2022 | Bioactive Materials2022，7，10： | 2 |
| 8 | Corrigendum to“SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip”[Sci.Bull.(2021)66(8)783-793]显示文摘The authors would like to correct Fig.2g.An annotation error was introduced in the preparation of this figure for publication.The authors declare that this correction does not change the results or conclusions of this paper.The authors sincerely apologize for having this error in the article,and apologize for any inconvenience caused. | Yaqiong Guo Ronghua Luo Yaqing Wang Pengwei Deng Tianzhang Song Min Zhang Peng Wang Xu Zhang Kangli Cui Tingting Tao Zhongyu Li Wenwen Chen Yongtang Zheng Jianhua Qin | 2021 | Science Bulletin2021，66，20： | 2 |
| 9 | Influence of undercoating on rolling contact fatigue performance of Fe-based coating显示文摘 | Zhongyu Piao Binshi Xu Haidou Wang Chunhuan Pu | 2009 | Tribology International2009，，1： | 1 |
| 10 | Sub-pixel edge detection based on orthogonal polynomial fitting显示文摘 | Xu Zhongyu Ning Chuang | 2013 | Journal of Convergence Information Technology2013，8，4： | 1 |
| 11 | Simulation study on the formation and transition properties of cluster structures in liquid metals during rapid cooling processes显示文摘 | Caixing Zheng Rangsu Liu Kejun Dong Ping Peng Hairong Liu Zhongyu Xu Xiaoyong Lu | 2002 | Science in China Series A: Mathematics2002，，2： | 1 |
| 12 | Effects of Pre-Deforming and Isothermal Treatment on Structural Granular Transformation of as Cast ZA27 Alloy显示文摘 | Xie Hui (谢辉) Xu Lijun (许丽君) Yuan Zhongyue(袁中岳) | 2001 | The Chinese Journal of Nonferrous Metals(中国有色金属学报)2001，11，： | 1 |
| 13 | Influence of undercoating on rolling contact fa- tigue performance of Fe-based coating显示文摘 | PIAO ZhongYu XU Bin-Shi WANG Hai-Dou | | Tribology International0，43，12： | 1 |
| 14 | Influence of undercoating on rolling contact fatigueperformance of Fe-based coating显示文摘 | PIAO Zhongyu XU Binshi WANG Haidou | 2010 | TribologyInternational2010，43，： | 1 |
| 15 | Research progress on compatibility of electrolyte with carbon negative electrode in lithium ion batteries显示文摘 | Xu Zhongyu Zheng Honghe | 2002 | Chinese Journal of Sources2002，24，3： | 1 |
| 16 | Optical pro- perties and photocatalytic activities of spherical ZnO and flower-like ZnO structures synthesized by facile hydrother- mal method 显示文摘 | Fang Yongling Li Zhongyu Xu Song | 2013 | J Alloys Compd2013，575，： | 1 |
| 17 | Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis显示文摘As the major cell precursors in osteogenesis, mesenchymal stem cells(MSCs) are indispensable for bone homeostasis and development. However, the primary mechanisms regulating osteogenic differentiation are controversial. Composed of multiple constituent enhancers, super enhancers(SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. The present study demonstrated that SEs were indispensable for MSC osteogenesis and involved in osteoporosis development. Through integrated analysis, we identified the most common SE-targeted and osteoporosis-related osteogenic gene,ZBTB16. ZBTB16, positively regulated by SEs, promoted MSC osteogenesis but was expressed at lower levels in osteoporosis.Mechanistically, SEs recruited bromodomain containing 4(BRD4) at the site of ZBTB16, which then bound to RNA polymerase IIassociated protein 2(RPAP2) that transported RNA polymerase Ⅱ(POL Ⅱ) into the nucleus. The subsequent synergistic regulation of POL Ⅱ carboxyterminal domain(CTD) phosphorylation by BRD4 and RPAP2 initiated ZBTB16 transcriptional elongation, which facilitated MSC osteogenesis via the key osteogenic transcription factor SP7. Bone-targeting ZBTB16 overexpression had a therapeutic effect on the decreased bone density and remodeling capacity of Brd4^(fl/fl)Prx1-cre mice and osteoporosis(OP) models.Therefore, our study shows that SEs orchestrate the osteogenesis of MSCs by targeting ZBTB16 expression, which provides an attractive focus and therapeutic target for osteoporosis. | Wenhui Yu Zhongyu Xie Jinteng Li Jiajie Lin Zepeng Su Yunshu Che Feng Ye Zhaoqiang Zhang Peitao Xu Yipeng Zeng Xiaojun Xu Zhikun Li Pei Feng Rujia Mi Yanfeng Wu Huiyong Shen | 2023 | Bone Research2023，11，3： | 1 |
| 18 | Antenna-functionalized dendritic b-diketonates and europium complexes: synthetic approaches to generation growth 显示文摘 | Shangfeng Li Weihong Zhu Zhongyu Xu | 2006 | Tetrahedron 12006，62，： | 1 |
| 19 | Characteristics and application of enzyme-modified carboxymethyl starch in sausages显示文摘 | Zhigang Luo Zhongyue Xu | 2011 | LWT - Food Science and Technology2011，，10： | 1 |
| 20 | Influence of undercoating on rolling contact fatigue performance of Fe-based coating显示文摘 | PIAO Zhongyu XU Binshi WANG Haidou | 2010 | Tribology International2010，43，12： | 1 |
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