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| 1 | Generation of graphene-based aerogel microspheres for broadband and tunable high-performance microwave absorption by electrospinning-freeze drying process显示文摘 | Fanbin Meng Huagao Wang Wei Zijian Chen Tian Li Chunyuan Li Yu Xuan Zuowan Zhou | 2018 | Nano Research2018，11，5： | 9 |
| 2 | Identification of abnormal conditions in high-dimensional chemical process based on feature selection and deep learning显示文摘Identification of abnormal conditions is essential in the chemical process.With the rapid development of artificial intelligence technology,deep learning has attracted a lot of attention as a promising fault identification method in chemical process recently.In the high-dimensional data identification using deep neural networks,problems such as insufficient data and missing data,measurement noise,redundant variables,and high coupling of data are often encountered.To tackle these problems,a feature based deep belief networks(DBN)method is proposed in this paper.First,a generative adversarial network(GAN)is used to reconstruct the random and non-random missing data of chemical process.Second,the feature variables are selected by Spearman’s rank correlation coefficient(SRCC)from high-dimensional data to eliminate the noise and redundant variables and,as a consequence,compress data dimension of chemical process.Finally,the feature filtered data is deeply abstracted,learned and tuned by DBN for multi-case fault identification.The application in the Tennessee Eastman(TE)process demonstrates the fast convergence and high accuracy of this proposal in identifying abnormal conditions for chemical process,compared with the traditional fault identification algorithms. | Wende Tian Zijian Liu Lening Li Shifa Zhang Chuankun Li | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 3 |
| 3 | Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discover显示文摘Technology advances in genomics,proteomics,and metabolomics largely expanded the pool of potential therapeutic targets.Compared with the in vitro setting,cell-based screening assays have been playing a key role in the processes of drug discovery and development.Besides the commonly used strategies based on colorimetric and cell viability,we reason that methods that capture the dynamic cellular events will facilitate optimal hit identification with high sensitivity and specificity.Herein,we propose a live-cell screening strategy using structured illumination microscopy (SIM) combined with an automated cell colocalization analysis software,CellprofilerTM,to screen and discover drugs for mitochondria and lysosomes interaction at a nanoscale resolution in living cells.This strategy quantitatively benchmarks the mitochondria-lysosome interactions such as mitochondria and lysosomes contact (MLC) and mitophagy.The automatic quantitative analysis also resolves fine changes of the mitochondria-lysosome interaction in response to genetic and pharmacological interventions.Super-resolution live-cell imaging on the basis of quantitative analysis opens up new avenues for drug screening and development by targeting dynamic organelle interactions at the nanoscale resolution,which could facilitate optimal hit identification and potentially shorten the cycle of drug discovery. | Qixin Chen Xintian Shao Zhiqi Tian Yang Chen Payel Mondal Fei Liu Fengshan Wang Peixue Ling Weijiang He Kai Zhang Zijian Guo Jiajie Diao | 2019 | Nano Research2019，12，5： | 2 |
| 4 | High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。 | Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian | 2014 | Cell Research2014，24，3： | 2 |
| 5 | Improved algorithm for navigation of rescue robots in underground mines显示文摘 | TIAN Zijian ZHANG Liya CHEN Wei | 2013 | Computers and Electrical Engineering2013，39，4： | 1 |
| 6 | Assessing the magnetic order dependent γ-surface of Cr-Co-Ni alloys显示文摘In order to efficiently explore the nearly infinite composition space in multicomponent solid solution alloys for reaching higher mechanical performance,it is important to establish predictive design strategies using computation-aided methods.Here,using ab initio calculations we systematically study the effects of magnetism and chemical composition on the generalized stacking fault energy surface(γ-surface) of Cr-Co-Ni medium entropy alloys and show that both chemistry and the coupled magnetic state strongly affect the γ-surface,consequently,the primary deformation modes.The relations among various stable and unstable stacking fault energies are revealed and discussed.The present findings are useful for studying the deformation behaviors of Cr-Co-Ni alloys and facilitate a density functional theory based design of transformation-induced plasticity and twinning-induced plasticity mechanisms in Cr-Co-Ni alloys. | Zhibiao Yang Song Lu Yanzhong Tian Zijian Gu Huahai Mao Jian Sun Levente Vitos | 2021 | Journal of Materials Science & Technology2021，，21： | 1 |
| 7 | Analysis on the Structure and Electrical Property of PI/MWNTs Films 显示文摘 | Wu Zijian Zhang Mingyan Tian Feng | 2009 | Proceeding of the 8th ICPADM2009，2，： | 1 |
| 8 | Highly Stretchable and Permeable Conductors Based on Shrinkable Electrospun Fiber Mats显示文摘Wearable on-skin electrodes or conductors should be vapor permeable,strain-insensitive,isotropically stretchable and stable under cyclic stretching.Various strategies have been proposed to prepare the required conductors up to now;however,it is a challenge to fabricate them with above properties in a simple manner.In this paper,a highly permeable and stretchable conductor based on electrospun fluorine rubber fiber mat is reported.The fibers are pre-stretched in electric field during electrospinning,and they shrink isotropically by~35-40%in area after being detached from the substrate.The obtained fiber mat conductor demonstrates high stretchability up to~170%,and the resistance changes only 0.8 under 60%strain,which is superior to many other strain-insensitive conductors.The conductor possesses high stability,no cracks or structure damage are observed after washing and cyclic stretching.Moreover,the conductor is vapor permeable with a water vapor transmission rate of~850 g m−2 day−1,which is comparable to the normal water evaporation in ambient conditions,indicating that it would not disturb the sweat evaporation when being used on skin.The conductor is successfully used as stretchable yarns and electromyography(EMG)electrodes,showing high reliability in E-textiles and on-skin applications. | Qingsong Li Chen Ding Wei Yuan Ruijie Xie Xiaomeng Zhou Yang Zhao Mei Yu Zijian Yang Jing Sun Qiong Tian Fei Han Hanfei Li Xinping Deng Guanglin Li Zhiyuan Liu | 2021 | Advanced Fiber Materials2021，3，5： | 1 |
| 9 | Intraspecific variation in microhabitat selection in reintroduced Chinese giant salamanders显示文摘Reintroduction of captive-bred Chinese giant salamanders is a primary approach for restoring wild populations.Despite previous studies have investigated the habitat preferences of reintroduced Chinese giant salamanders,the intraspecific variation in their habitat selection has been neglected.In the present study,30 captive-bred Chinese giant salamanders belonging to 3 groups(i.e.,10 males,10 females,and 10 juveniles)were released into a montane stream to explore whether intraspecific variation in habitat selection occurred in this species using radiotelemetry.Our results indicated that linear home range and daily movement of males were significantly higher than those of females and juveniles.Male sedentariness was significantly lower than that of females and juveniles.No significant differences were detected between females and juveniles in these measures.Importantly,we found that males preferred microhabitats with low water conductivity and deep water depth.Females preferred microhabitats with high water conductivity,low dissolved oxygen and ammonium-nitrogen,and slow current velocity,while juveniles occupied microhabitats with low ammonium-nitrogen.In addition,males and juveniles exhibited higher niche breadth than females.Niche overlap was high between adults and juveniles but low between males and females.Our study revealed the presence of spatial segregation in reintroduced Chinese giant salamanders.Males,females,and juveniles exhibited variation in microhabitat selection.These results provide important information for use when planning strategies for conservation of Chinese giant salamanders. | Chunlin Zhao Jianyi Feng Zijian Sun Wei Zhu Jiang Chang Wenbo Fan Jianping Jiang Bisong Yue Tian Zhao | 2023 | Current Zoology2023，69，2： | 0 |
| 10 | CAS Array:design and assessment of a genotyping array for Chinese biobanking显示文摘Background:Chronic diseases are becoming a critical challenge to the aging Chinese population.Biobanks with extensive genomic and environmental data offer opportunities to elucidate the complex gene-environment interactions underlying their aetiology.Genome-wide genotyping array remains an efficient approach for large-scale genomic data collection.However,most commercial arrays have reduced performance for biobanking in the Chinese population.Materials and methods:Deep whole-genome sequencing data from 2641 Chinese individuals were used as a reference to develop the CAS array,a custom-designed genotyping array for precision medicine.Evaluation of the array was performed by comparing data from 384 individuals assayed both by the array and whole-genome sequencing.Validation of its mitochondrial copy number estimating capacity was conducted by examining its association with established covariates among 10162 Chinese elderly.Results:The CAS Array adopts the proven Axiom technology and is restricted to 652429 single-nucleotide polymorphism(SNP)markers.Its call rate of 99.79% and concordance rate of 99.89% are both higher than for commercial arrays.Its imputation-based genome coverage reached 98.3% for common SNPs and 63.0% for low-frequency SNPs,both comparable to commercial arrays with larger SNP capacity.After validating its mitochondrial copy number estimates,we developed a publicly available software tool to facilitate the array utility.Conclusion:Based on recent advances in genomic science,we designed and implemented a high-throughput and low-cost genotyping array.It is more cost-effective than commercial arrays for large-scale Chinese biobanking. | Zijian Tian Fei Chen Jing Wang Benrui Wu Jian Shao Ziqing Liu Li Zheng You Wang Tao Xu Kaixin Zhou | 2023 | Precision Clinical Medicine2023，6，1： | 0 |
| 11 | Highly Stretchable Ionic and Electronic Conductive Fabric显示文摘Wearable devices redefine the way people interact with machines.Despite the intensive effort in the design and fabrication of synthetic fibers to improve wearable device properties in terms of electronic and ionic conductivity,stretchability,com-fort,and washability,challenges remain in fabricating single fiber materials that optimize all properties simultaneously.In this work,we demonstrate a highly stretchable,ionic,and electronic conductive fabric via(1)the natural nanoscale chan-nels in fibers for effective ion transportation,(2)confining the electronic conductive material with the cellulose fibers,and(3)decoupling the property degradation of the fiber from deformation using the knitted pattern.The hierarchical structure created by cotton fibers can serve as ionic conductive channels as well as a robust multiscale scaffold to host infiltrated elec-tronic conductive materials.Cotton strands with ionic and electronic conductivity can be knitted into fabrics that are highly stretchable(~300%).Moreover,high ionic and electronic conductivity are observed with 2 S/m and 5 S/m,respectively,even under a strain of 175%.With the inherent advantages of cotton fabrics such as moisture-wicking,washability,comfort,and light-weightiness for wearable applications,our approach of directly functionalized cellulose can potentially be a promising route towards highly stretchable and wearable mixed conductors. | Pengfei Deng Xuan Li Yanbin Wang Zijian He Wenkai Zhu Yun Zhang Gabriella M.Schalm Tian Li | 2023 | Advanced Fiber Materials2023，5，1： | 0 |
| 12 | Themed Issue on Nanomolecular Imaging and Biosensing显示文摘Nanomolecular imaging and biosensing is an interdisciplinary research field generated from the combination of nanoscience,molecular imaging and biomedicine.In the past few decades,experts in chemistry,photophysics,material sciences and biomedicine have worked together to design novel nanoprobes with tunable physical-chemical properties for widespread biomedicine applications.With the booming development of nanomolecular imaging and biosensing technologies,this emerging research field has not only improved our understanding of complex life systems,but also revolutionized the diagnosis,treatment and prognosis evaluation of diseases. | GUO Zijian FAN Chunhai TIAN Yang WANG Qiangbin | 2021 | Chemical Research in Chinese Universities2021，37，4： | 0 |
| 13 | Dihydromyricetin‑Incorporated Multilayer Nanofibers Accelerate Chronic Wound Healing by Remodeling the Harsh Wound Microenvironment显示文摘The harsh microenvironment in wound(HMW)remains a major obstacle to chronic wound healing.Although a series of bioactive materials have been developed,few of them are multi-functional and able to accelerate wound healing via precisely remodeling the HMW.Herein,a series of dihydromyricetin(DHM)-incorporated multilayer nanofibers(termed DQHP-n,n=0,2,6 and 10)are fabricated using a layer-by-layer(LBL)self-assembly technique.The average diameters of DQHP-n significantly increase from 0.30±0.16μm to 0.84±0.28μm(P<0.05)along with the n value increased from 0 to 10,the tensile strength of that is also significantly improved from 1.12±0.15 MPa to 2.16±0.30 MPa(P<0.05),and the water contact angle of that significantly decreases from 129.1±1.5°to 76.6±3.9°(P<0.05).The DQHP-n are found to be biocompatible,in which DQHP-6 promoted cell migration through activation of the epithelial–mesenchymal transformation(EMT)pathway and reconstruction of the HMW by stopping bleeding,killing bacteria,eliminating inflammation,and scavenging reactive oxygen species(ROS).The in vivo evaluation is carried out via an E.coli-infected rat skin regeneration model.The DQHP-6 group demonstrates the best effect,as it healed up to 98.5±1.0%of the wound area at day 15.DQHP-6 differentially regulates the mRNA expressions of several cytokines(FGF2,PDGF,IL-1α,IL-6,IL10,and TGF-β),which ends to reductions of total inflammatory cells(CD45^(+) cells)and M1 macrophages(CD80^(+) and CD86^(+) cells),proliferation of host cell(Ki67^(+) cells),and enhancement of collagen synthesis.In conclusion,DQHP-6 exhibits multifunctional properties for HMW,and can serve as a promising wound dressing for clinical transformation. | Zijian Wang Wenjie You Wang Wang Weiqun Tian Fangjin Chen Yu Xiao Yun Chen Xinghuan Wang | 2022 | Advanced Fiber Materials2022，4，6： | 0 |
| 14 | Giant room temperature elastocaloric effect in metal-free thinfilm perovskites显示文摘Solid-state refrigeration which is environmentally benign has attracted considerable attention.Mechanocaloric(mC)materials,in which the phase transitions can be induced by mechanical stresses,represent one of the most promising types of solid-state caloric materials.Herein,we have developed a thermodynamic phenomenological model and predicted extraordinarily large elastocaloric(eC)strengths for the(111)-oriented metal-free perovskite ferroelectric[MDABCO](NH_(4))I_(3)thin-films.The predicted room temperature isothermal eC ΔS_(eC)/Δσ(eC entropy change under unit stress change)and adiabatic eCΔTeC/Δσ(eC temperature change under unit stress change)for[MDABCO](NH_(4))I_(3) are−60.0 J K^(−1)kg^(−1)GPa^(−1) and 17.9 K GPa^(−1),respectively,which are 20 times higher than the traditional ferroelectric oxides such as BaTiO_(3) thin films.We have also demonstrated that the eC performance can be improved by reducing the Young’s modulus or enhancing the thermal expansion coefficient(which could be realized through chemical doping,etc.).We expect these discoveries to spur further interest in the potential applications of metal-free organic ferroelectrics materials towards next-generation eC refrigeration devices. | Cheng Li Yu Hui Huang Jian-Jun Wang Bo Wang Yong Jun Wu He Tian Long-Qing Chen Zijian Hong | 2021 | npj Computational Materials2021，，1： | 0 |
| 15 | Biocompatible and antibacterial soy protein isolate/quaternized chitosan composite sponges for acute upper gastrointestinal hemostasis显示文摘Innovative biomedical applications have high requirements for biomedical materials.Herein,a series of biocompatible,antibacterial and hemostatic sponges were successfully fabricated for the treatment of acute upper gastrointestinal bleeding(AUGB).Quaternized chitosan(QC)and soy protein isolate(SPI)were chemically cross-linked to obtain porous SPI/QC sponges(named SQS-n,with n¼30,40,50 or 60 corresponding to the weight percentage of the QC content).The chemical composition,physical properties and biological activity of SQS-n were investigated.SQS-n could support the adhesion and proliferation of L929 cells while triggering no obvious blood toxicity.Meanwhile,SQS-n exhibited good broad-spectrum antibacterial activity against both grampositive bacteria(Staphylococcus aureus)and gram-negative bacteria(Escherichia coli).The in vivo hemostatic effect of SQS-n was evaluated using three different bleeding models.The results revealed that SQS-50 performed best in reducing blood loss and hemostatic time.The overall hemostatic effect of SQS-50 was comparable to that of a commercial gelatin sponge.The enhanced antibacterial and hemostatic activities of SQS-n were mainly attributed to the QC component.In conclusion,this work developed a QC-functionalized hemostatic sponge that is highly desirable for innovative biomedical applications,such as AUGB. | Zijian Wang MeiFang Ke Liu He Qi Dong Xiao Liang Jun Rao Junjie Ai Chuan Tian Xinwei Han Yanan Zhao | 2021 | Regenerative Biomaterials2021，8，4： | 0 |
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