|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 3 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 4 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 5 | Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance显示文摘 | Yaqing Zhang Wei Yan Meredith A. Collins Filip Bednar Sabita Rakshit Bruce R. Zetter Ben Z. Stanger Ivy Chung Andrew D. Rhim Marina Pasca di Magliano | 2013 | Cancer Research2013，，20： | 2 |
| 6 | The comet assay for DNA damage and repair显示文摘 | Andrew R. Collins | 2004 | Molecular Biotechnology2004，，3： | 2 |
| 7 | Molecular epiderniology in callcer research显示文摘 | Andrew R Collins | 1998 | Mol Aspects Med1998，19，： | 1 |
| 8 | The kinetics of repair of oxidative DNA damage(strand breaks and oxidized pyrimidines)in human cells显示文摘 | Andrew R Collins Ma Ai-guo Susan J | 1995 | Mut Res1995，338，： | 1 |
| 9 | Dry deposition of gaseous elemental mercury to plants and soils using mercury stable isotopes in a controlled environment显示文摘 | Andrew P. Rutter James J. Schauer Martin M. Shafer Joel E. Creswell Michael R. Olson Michael Robinson Ryan M. Collins Andrew M. Parman Tanya L. Katzman Justin L. Mallek | 2010 | Atmospheric Environment2010，，4： | 1 |
| 10 | Interpersonal Conflict dur-ing Adolescence显示文摘 | Brett Laursen Andrew Collins W | 1994 | Psychological Bulletin1994，115，： | 1 |
| 11 | The Influence of Cell Growth, Detoxifying Enzymes and DNA Repair on Hydrogen Peroxide-Mediated DNA Damage (Measured Using the Comet Assay) in Human Cells显示文摘 | Susan J Duthie Andrew R Collins | 1996 | Free Radical Biology and Medicine1996，，4： | 1 |
| 12 | A study of the role of ion–molecule chemistry in the formation of sporadic sodium layers显示文摘 | Stephen C. Collins John M.C. Plane Michael C. Kelley Timothy G. Wright Pavel Soldán Timothy J. Kane Andrew J. Gerrard Brent W. Grime Rosie J. Rollason Jonathan S. Friedman Sixto A. González Qihou Zhou Michael P. Sulzer Craig A. Tepley | 2002 | Journal of Atmospheric and Solar-Terrestrial Physics2002，，7： | 1 |
| 13 | Effects of Oral Testosterone Treatment on Myocardial Perfusion and Vascular Function in Men With Low Plasma Testosterone and Coronary Heart Disease显示文摘 | Carolyn M. Webb Andrew G. Elkington Mustafa M. Kraidly Niall Keenan Dudley J. Pennell Peter Collins | 2008 | The American Journal of Cardiology2008，，5： | 1 |
| 14 | Biochar: A Synthesis of Its Agronomic Impact beyond Carbon Sequestration显示文摘 | Spokas Kurt A Cantrell Keri B M Novak Jeffrey Archer David W Ippolito James A Collins Harold P Boateng Akwasi A Lima Isabel M Lamb Marshall C McAloon Andrew J Lentz Rodrick D Nichols Kristine A | 2012 | Journal of Environmental Quality2012，，4： | 1 |
| 15 | Oxidative desulphurisation of oils via hydrogen peroxide and heteropolyanion catalysis显示文摘 | Frances M. Collins Andrew R. Lucy Christopher Sharp | 1997 | Journal of Molecular Catalysis. A, Chemical1997，，1： | 1 |
| 16 | Optimal Utilization of Donor Grafts With Extended Criteria: A Single-Center Experience in Over 1000 Liver Transplants显示文摘 | Andrew M. Cameron R Mark Ghobrial Hasan Yersiz Douglas G. Farmer Gerald S. Lipshutz Sherilyn A. Gordon Michael Zimmerman Johnny Hong Thomas E. Collins Jeffery Gornbein Farin Amersi Michael Weaver Carlos Cao Tony Chen Jonathan R. Hiatt Ronald W. Busuttil | 2006 | Annals of Surgery2006，，6： | 1 |
| 17 | Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations显示文摘 | Anwar R. Padhani Guoying Liu Dow Mu-Koh Thomas L. Chenevert Harriet C. Thoeny Taro Takahara Andrew Dzik-Jurasz Brian D. Ross Marc Van Cauteren David Collins Dima A. Hammoud Gordon J.S. Rustin Bachir Taouli Peter L. Choyke | 2009 | Neoplasia2009，，： | 1 |
| 18 | Oxidative desulphurisation of oils via hydrogen peroxide and heteropolyanion catalysis显示文摘 | Frances M. Collins Andrew R. Lucy Christopher Sharp | 1997 | Journal of Molecular Catalysis A Chemical1997，，1： | 1 |
| 19 | New Partnerships for Co-delivery of the 2030 Agenda for Sustainable Development显示文摘Partnerships have become a comer stone of contemporary research that recognizes working across disciplines and co-production with intended users as essential to enabling sustainable resilience-building.Furthermore,research that addresses sustainable development challenges brings an urgent need to reflect on the ways that partnerships are supported,and for the disaster risk management and resilience communities,efforts to support realization of the wider 2030 Agenda for sustainable development bring particular pressures.In November 2019,the UK Disasters Research Group(DRG)brought together a number of key stakeholders focused on disaster risk,resilience,and sustainability research relevant to Official DevelopmeAssistance to consider how fit for purpose existing partnership models are for the pace of change required to deliver the priorities of the wider 2030 Agenda.Participants were invited to discuss how research partnerships across three levels(individual and project-based;national and institutional;and international)could be improved based on elements that facilitate robust partnerships and learning from aspects that hinder them.From the discussions,participanls emphasized the importance of effective communication mechanisms in building partnerships,co-designing projects,and establishing shared objectives.Enhanced approaches to addressing equitable partnerships and funding more substantive timelines will be key to responding to the challenges of the 2030 Agenda. | Adrian Bucher Andrew Collins Ben Heaven Taylor David Pan Emma Visman James Norris Joel CGill John Rees Mark Felling Marta Tufet Bayona Sonia Cassidy Virginia Murray | 2020 | International Journal of Disaster Risk Science2020，11，5： | 1 |
| 20 | Nitrous oxide for the management of labor pain: a systematic review 显示文摘 | Likis FE Andrews JC Collins MR | 2014 | Anesth Analg2014，118，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员