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| 1 | Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value显示文摘BACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are < 4 mmol/L.METHODS: This is a retrospective cohort study of septic patients admitted over a 40-month period. Totally 338 patients were divided into three groups based on initial lactate values. Group 1 had lactate levels < 2 mmol/L; group 2: 2–4 mmol/L; and group 3: ≥ 4 mmol/L. The primary outcome was in-hospital mortality.RESULTS: There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. The mortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortality differences to be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical significance.CONCLUSION: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis. | Kimberly A. Chambers Adam Y. Park Rosa C. Banuelos Bryan F. Darge Bindu H. Akkanti Annamaria Macaluso Manoj Thangam Pratik B. Doshi | 2018 | World Journal of Emergency Medicine2018，9，2： | 26 |
| 2 | Synthesis, docking and ADMET prediction of novel 5-((5-substituted-1-H-1,2,4-triazol-3-yl) methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine as antifungal agents显示文摘A novel series of 5-((5-substituted-1H-1,2,4-triazol-3-yl)methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridines 5(a–i) has been synthesized from thienopyridine hydrazide, substituted aromatic nitriles using 4-dimethylaminopyridine(DMAP) as a catalyst under microwave irradiation and evaluated for their in vitro antifungal activity. Compound 5g is found to be more potent against Candida albicans when compared with miconazole. Docking study of the newly synthesized compounds was performed, and results showed good binding mode in the active site of fungal enzyme P450 cytochrome lanosterol 14 ademethylase. ADMET properties of synthesized compounds were also analyzed and showed good drug like properties. The results of in vitro antifungal activity, docking study and ADMET prediction revealed that the synthesized compounds have potential antifungal activity and can be further optimized and developed as a lead compound. | Jaiprakash N. Sangshetti Firoz A. Kalam Khan Rashmi S. Chouthe Manoj G. Damale Devanand B. Shinde | 2014 | Chinese Chemical Letters2014，25，7： | 6 |
| 3 | A comprehensive analysis of various structural parameters of Indian coals with the aid of advanced analytical tools显示文摘 | B. Manoj | 2016 | International Journal of Coal Science & Technology2016，3，2： | 4 |
| 4 | Chemical leaching of an Indian bituminous coal and characterization of the products by vibrational spectroscopic techniques显示文摘High volatile bituminous coal was demineralized by a chemical method. The vibrations of the 'aromatics' structure of graphite, crystalline or non-crystalline, were observed in the spectra at the 1600 cm-1 region. The band at 1477 cm-1 is assigned as VR band, the band at 1392 cm-1 as VL band and the band at 1540 cm-1 as GR band. Graphite structure remains after chemical leaching liberates oxygenated functional groups and mineral groups. The silicate bands between 1010 and 1100 cm-1 are active in the infrared (IR) spectrum but inactive in the Raman spectrum. Absorption arising from C-H stretching in alkenes occurs in the region of 3000 to 2840 cm-1. Raman bands because of symmetric stretch of water molecules were also observed in the spectrum at 3250 cm-1 and 3450 cm-1. Scanning electron microscopy analy-sis revealed the presence of a graphite layer on the surface. Leaching of the sample with hydrofluoric acid decreases the mineral phase and increases the carbon content. The ash content is reduced by 84.5wt% with leaching from its initial value by mainly removing aluminum and silicate containing minerals. | B. Manoj A.G. Kunjomana | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，4： | 3 |
| 5 | Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua显示文摘 | Manoj Goyal B. P. Nagori D. Sasmal | 2009 | Journal of Natural Medicines2009，，4： | 1 |
| 6 | Prognostic significance of Her2/neu overexpression in patients with muscle invasive urinary bladder cancer treated with radical cystectomy显示文摘 | Surendra B. Kolla Amlesh Seth Manoj K. Singh Narmada P. Gupta Ashok K. Hemal Prem N. Dogra Rajeev Kumar | 2008 | International Urology and Nephrology2008，，2： | 1 |
| 7 | Chemoselective transfer hydrogenation reactions over nanosized γ-Fe 2 O 3 catalyst prepared by novel combustion route显示文摘 | Sachin U. Sonavane Manoj B. Gawande Sameer S. Deshpande A. Venkataraman Radha V. Jayaram | 2007 | Catalysis Communications2007，，11： | 1 |
| 8 | Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy显示文摘 | Manoj B. Mahimkar Tanuja A. Samant Sadhana Kannan Jatin Tulsulkar Prathamesh S. Pai Devasena Anantharaman | 2011 | Mol. Carcinog2011，，1： | 1 |
| 9 | Degradation and mineralization of methylene blue by dielectric barrier discharge non-thermal plasma reactor显示文摘 | P. Manoj Kumar Reddy B. Rama Raju J. Karuppiah E. Linga Reddy Ch. Subrahmanyam | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 10 | Robot-assisted Laparoscopic Dismembered Pyeloplasty for Ureteropelvic Junction Obstruction: A Multi-institutional Experience显示文摘 | Ananthakrishnan Sivaraman Raymond J. Leveillee Manoj B. Patel Sanket Chauhan Jorge E. Bracho Charles R. Moore Rafael F. Coelho Kenneth J. Palmer Oscar Schatloff Vincent G. Bird Ravi Munver Vipul R. Patel | 2012 | Urology2012，，2： | 1 |
| 11 | Relevance of Helicobacter pylori genotypes in gastric pathology and its association with plasma malondialdehyde and nitric oxide levels显示文摘 | Santosh K. Tiwari G. Manoj Vishwas Sharma G. Sivaram R. Saikant Avinash Bardia Varun K. Sharma Zakia Abid Aleem A. Khan M. Aejaz Habeeb C. M. Habibullah B. Santhosh Kumar Amrita Nandan | 2010 | Inflammopharmacology2010，，2： | 1 |
| 12 | Microstructural studies and remnant life assessment of eleven years service exposed reformer tube显示文摘 | Ashok Kumar Ray Sudheer Kumar Guguloth Krishna Manoj Gunjan B. Goswami Samir Chandra Bose | 2011 | Materials Science & Engineering A2011，，： | 1 |
| 13 | A potential red emitting K 4 Ca(PO 4 ) 2 : Eu 3+ phosphor for white light emitting diodes显示文摘 | G.R. Dillip S.J. Dhoble L. Manoj C. Madhukar Reddy B. Deva Prasad Raju | 2012 | Journal of Luminescence2012，，11： | 1 |
| 14 | Fretting wear study on Ti–Ca–P biocomposite in dry and simulated body fluid显示文摘 | M. Karanjai B.V. Manoj Kumar R. Sundaresan B. Basu T.R. Rama Mohan B.P. Kashyap | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 15 | The Indian National Association for Study of the Liver (INASL) Consensus on Prevention, Diagnosis and Management of Hepatocellular Carcinoma in India: The Puri Recommendations显示文摘 | Ashish Kumar Subrat K. Acharya Shivaram P. Singh Vivek A. Saraswat Anil Arora Ajay Duseja Mahesh K. Goenka Deepali Jain Premashish Kar Manoj Kumar Vinay Kumaran Kunisshery M. Mohandas Dipanjan Panda Shashi B. Paul Jeyamani Ramachandran Hariharan Ramesh Pa | 2014 | Journal of Clinical and Experimental Hepatology2014，，： | 1 |
| 16 | Catalytic nonthermal plasma reactor for the abatement of low concentrations of benzene显示文摘 | J. Karuppiah E. Linga Reddy P. Manoj Kumar Reddy B. Ramaraju Ch. Subrahmanyam | 2014 | International Journal of Environmental Science and Technology2014，，2： | 1 |
| 17 | Chemoselective transfer hydrogenation reactions over nanosized γ-Fe 2 O 3 catalyst prepared by novel combustion route显示文摘 | Sachin U. Sonavane Manoj B. Gawande Sameer S. Deshpande A. Venkataraman Radha V. Jayaram | 2007 | Catalysis Communications2007，，11： | 1 |
| 18 | Prevalence of Survivor Bias in Observational Studies on Fresh Frozen Plasma: Erythrocyte Ratios in Trauma Requiring Massive Transfusion显示文摘 | Anthony M.-H. Ho Peter W. Dion Janice H. H. Yeung John B. Holcomb Lester A. H. Critchley Calvin S. H. Ng Manoj K. Karmakar Chi W. Cheung Timothy H. Rainer | 2012 | Anesthesiology2012，，3： | 1 |
| 19 | Prevalence of Survivor Bias in Observational Studies on Fresh Frozen Plasma: Erythrocyte Ratios in Trauma Requiring Massive Transfusion显示文摘 | Anthony M.-H. Ho Peter W. Dion Janice H. H. Yeung John B. Holcomb Lester A. H. Critchley Calvin S. H. Ng Manoj K. Karmakar Chi W. Cheung Timothy H. Rainer | 2012 | Anesthesiology2012，，3： | 1 |
| 20 | Assessment of nutrient composition and antioxidant potential of Caulerpaceae seaweeds显示文摘 | Manoj Kumar Vishal Gupta Puja Kumari C.R.K. Reddy B. Jha | 2010 | Journal of Food Composition and Analysis2010，，2： | 1 |
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