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| 1 | Characteristics of rare-earth elements (REE),strontium and neodymium isotopes in hydrothermal fluorites from the Bailashui tin deposit in the Furong ore field,southern Hunan Province,China显示文摘In this paper the authors present the REE concentrations and Sr and Nd isotopic compositions of fluorites from the Bailashui tin deposit of the Furong ore field,southern Hunan Province. The results showed that the total amount of REE in fluorites is usually low,ranging from 0.705 to 8.785 μg/g with the chondrite-normalized REE dis-tribution patterns similar to those of the Qitianling granites in the study area,characterized by LREE-enrichment patterns with pronounced negative Eu anomalies. The fluorites vary in Sr isotopic composition within the range of 0.7083-0.7091,the values are lower than those of the granites and higher than those of the host carbonate rocks in this area. The εNd(t) values of fluorites vary between -9.4 and +10.3,revealing that both the crust-and mantle-source materials were involved in the ore-forming hydrothermal fluids. Combined with previous studies on this ore deposit,the Bailashui tin deposit is temporally and spatially closely related with granitic magmatism in this area. The hydro-thermal fluorites are the product of fluid/rock interactions between granitic magmatic hydrothermal fluid and marine carbonate rocks. The REE and F in the ore-forming fluid were derived from the granites,whereas Sr in the ore-forming fluid came mainly from the granitic magmatic hydrothermal fluid and marine carbonate rocks,although variations in Sr isotopic composition cannot be explained by a simple mixture of these two end-members. Evidence demonstrated that the ore-forming fluids are of crustal-mantle mixing origin,but that the fluids were probably in-completely homogenized and this may be caused by inhomogeneous mixing of the fluids of different sources. | YUAN Shunda PENG Jiantang HU Ruizhong BI Xianwu QI Liang LI Zhaoli LI Xiaomin SHUANG Yan | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 16 |
| 2 | A review of the phytochemistry and pharmacological activities of Ephedra herb显示文摘Ephedra herb is a traditional Chinese medicine with a long history. Conventionally, it was used as a folk phytomedicine in many ancient medical books and traditional prescriptions. Up to date, a variety of specific ingredients have been found in Ephedra herb, mainly including alkaloids, flavonoids, tannins, polysaccharides, organic acids, volatile oils, and many other active compounds. These components from Ephedra herb account for its use as the accurate treatment of cold, cough, cardiovascular and immune system disease, cancer, microbial infection, and other diseases. Moreover, with the fast development of novel chemistry and medicine technology, new chemical constituents and pharmacological effects of Ephedra herb are increasingly identified, demonstrating their great potential for various diseases treatment. Therefore, further detailed understanding and investigation of this ancient herb will offer new opportunities to develop novel therapeutics. This study systematically reviews its progress of phytochemistry, traditional and modern pharmacology based on research data that have been reported, aiming at providing useful insight for commercial exploitation, further study and precision medication of Ephedra herb in future. | MIAO Shuang-Man ZHANG Qi BI Xiao-Bao CUI Jin-Long WANG Meng-Liang | 2020 | Chinese Journal of Natural Medicines2020，18，5： | 15 |
| 3 | Memory materials and devices:From concept to application显示文摘Memory cells have always been an important element of information technology.With emerging technologies like big data and cloud computing,the scale and complexity of data storage has reached an unprecedented peak with a much higher requirement for memory technology.As is well known,better data storage is mostly achieved by miniaturization.However,as the size of the memory device is reduced,a series of problems,such as drain gate-induced leakage,greatly hinder the performance of memory units.To meet the increasing demands of information technology,novel and high-performance memory is urgently needed.Fortunately,emerging memory technologies are expected to improve memory performance and drive the information revolution.This review will focus on the progress of several emerging memory technologies,including two-dimensional material-based memories,resistance random access memory(RRAM),magnetic random access memory(MRAM),and phasechange random access memory(PCRAM).Advantages,mechanisms,and applications of these diverse memory technologies will be discussed in this review. | Zhenhan Zhang Zongwei Wang Tuo Shi Chong Bi Feng Rao Yimao Cai Qi Liu Huaqiang Wu Peng Zhou | 2020 | InfoMat2020，2，2： | 15 |
| 4 | A voltage resonance-based single-ended online fault location algorithm for DC distribution networks显示文摘A novel single-ended online fault location algorithm is investigated for DC distribution networks. The proposed algorithm calculates the fault distance based on the characteristics of the voltage resonance. The Prony's method is introduced to extract the characteristics. A novel method is proposed to solve the pseudo dual-root problem in the calculation process. The multiple data windows are adopted to enhance the robustness of the proposed algorithm. An index is proposed to evaluate the accuracy and validity of the results derived from the various data windows. The performances of the proposed algorithm in different fault scenarios were evaluated using the PSCAD/EMTDC simulations. The results show that the algorithm can locate the faults with transient resistance using the 1.6 ms data of the DC-side voltage after a fault inception and offers a good precision. | JIA Ke LI Meng BI Tian Shu YANG Qi Xun | 2016 | Science China(Technological Sciences)2016，59，5： | 13 |
| 5 | NbMoTiVSi_(x) refractory high entropy alloys strengthened by forming BCC phase and silicide eutectic structure显示文摘In order to improve mechanical properties of refractory high entropy alloys,silicide was introduced and NbMoTiVSi_(x)(x=0,0.1,0.2,0.3,and 0.4,molar ratio) refractory high entropy alloys are prepared by vacuum arc melting.Phase composition,micro structure evolution and mechanical properties were systematically studied.Results show that the silicide phase is formed in the alloys with addition of silicon,and the volume fraction of silicide increases from 0 to 8.3 % with increasing of silicon.Microstructure observation shows that the morphology of dendrite changes from columnar to near equiaxed,eutectic structure is formed at grain boundaries and composed of secondary BCC phase and silicide phase.The average length of the primary and second dendrites decreases with the increasing of silicon.Whereas,the ratio of eutectic structure increases from 0 to 19.8 % with the increment of silicon.The refinement of microstructure is caused by heterogeneous nucleation from the silicide.Compressive tests show that the yield and ultimate strength of the alloys increases from 1141.5 MPa to 2093.1 MPa and from 1700.1 MPa to 2374.7 MPa with increasing silicon content.The fracture strain decreases from 24.7 %-11.0 %.Fracture mechanism is changed from ductile fracture to ductile and brittle mixed fracture.The improvement of the strength is caused by grain bounda ry strengthening,which includes more boundaries around primary BCC phase and eutectic structure in grain boundary,both of them is resulted from the formation of silicide. | Qin Xu Dezhi Chen Chongyang Tan Xiaoqin Bi Qi Wang Hongzhi Cui Shuyan Zhang Ruirun Chen | 2021 | Journal of Materials Science & Technology2021，，1： | 9 |
| 6 | OpenKG Chain:A Blockchain Infrastructure for Open Knowledge Graphs显示文摘The early concept of knowledge graph originates from the idea of the semantic Web,which aims at using structured graphs to model the knowledge of the world and record the relationships that exist between things.Currently publishing knowledge bases as open data on the Web has gained significant attention.In China,Chinese Information Processing Society of China(CIPS)launched the OpenKG in 2015 to foster the development of Chinese Open Knowledge Graphs.Unlike existing open knowledge-based programs,OpenKG chain is envisioned as a blockchain-based open knowledge infrastructure.This article introduces the first attempt at the implementation of sharing knowledge graphs on OpenKG chain,a blockchain-based trust network.We have completed the test of the underlying blockchain platform,and the on-chain test of OpenKG’s data set and tool set sharing as well as fine-grained knowledge crowdsourcing at the triple level.We have also proposed novel definitions:K-Point and OpenKG Token,which can be considered to be a measurement of knowledge value and user value.1,033 knowledge contributors have been involved in two months of testing on the blockchain,and the cumulative number of on-chain recordings triggered by real knowledge consumers has reached 550,000 with an average daily peak value of more than 10,000.For the first time,we have tested and realized on-chain sharing of knowledge at entity/triple granularity level.At present,all operations on the data sets and tool sets at OpenKG.CN,as well as the triplets at OpenBase,are recorded on the chain,and corresponding value will also be generated and assigned in a trusted mode.Via this effort,OpenKG chain looks forward to providing a more credible and traceable knowledge-sharing platform for the knowledge graph community. | Huajun Chen Ning Hu Guilin Qi Haofen Wang Zhen Bi Jie Li Fan Yang | 2021 | Data Intelligence2021，3，2： | 7 |
| 7 | Mobile Edge Computing and Field Trial Results for 5G Low Latency Scenario显示文摘Through enabling the IT and cloud computation capacities at Radio Access Network(RAN),Mobile Edge Computing(MEC) makes it possible to deploy and provide services locally.Therefore,MEC becomes the potential technology to satisfy the requirements of 5G network to a certain extent,due to its functions of services localization,local breakout,caching,computation offloading,network context information exposure,etc.Especially,MEC can decrease the end-to-end latency dramatically through service localization and caching,which is key requirement of 5G low latency scenario.However,the performance of MEC still needs to be evaluated and verified for future deployment.Thus,the concept of MEC is introduced into5 G architecture and analyzed for different 5G scenarios in this paper.Secondly,the evaluation of MEC performance is conducted and analyzed in detail,especially for network end-to-end latency.In addition,some challenges of the MEC are also discussed for future deployment. | Jianmin Zhang Weiliang Xie Fengyi Yang Qi Bi | 2016 | China Communications2016，13，S2： | 7 |
| 8 | Adsorption of thorium(IV) on magnetic multi-walled carbon nanotubes显示文摘The influences of pH, contact time, solid-liquid ratio, temperature and C60(C(COOH)2)n on Th(IV) adsorption onto the magnetic multi-walled carbon nanotubes(MMWCNTs) were studied by batch technique. The dynamic process showed that the adsorption of Th(IV) onto MMWCNTs could reach equilibrium in 40 h and matched the pseudo-second-order kinetics model. The adsorption of Th(IV) onto MMWCNTs was significantly dependent on pH values, the adsorption ratio increased markedly at pH 3.0–5.0, and then maintained a steady state as pH values increased. At low pH, different C60(C(COOH)2)n content could enhance the adsorption content of Th(IV) onto MMWCNTs, but restrained it at higher pH. Through simulating the adsorption isotherms by Langmuir, Freundlich and Dubini-Radushkevich models, it could be seen respectively that the adsorption pattern of Th(IV) onto MMWCNTs was mainly surface complexation, and that the adsorption process was endothermic and irreversible. | LIU Peng QI Wei DU YaoFang LI Zhan WANG Jing BI JuanJuan WU WangSuo | 2014 | Science China Chemistry2014，57，11： | 7 |
| 9 | Inactivation of the Rho-ROCK signaling pathway to promote neurologic recovery after spinal cord injuries in rats显示文摘 | WU Bin-qi BI Zheng-gang QI Quan | 2013 | Chinese Medical Journal2013，，19： | 6 |
| 10 | Seasonal Variation of Biochemical Components in Clam (Saxidomuspurpuratus Sowerby 1852) in Relation to Its Reproductive Cycle and the Environmental Condition of Sanggou Bay, China显示文摘Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycle of clam.According to the histological analysis,the reproductive cycle of S.purpuratus includes two distinctive phases:a total spent and inactive stage from November to January,and a gametogenesis stage,including ripeness and spawning,during the rest of the year.Gametes were generated at a low temperature(2.1℃) in February.Spawning took place once a year from June to October.The massive spawning occurred in August when the highest water temperature and chlorophyll a level could be observed.The key biochemical components(glycogen,protein and lipid) in five tissues(gonad,foot,mantle,siphon and adductor muscle) were analyzed.The glycogen content was high before gametogenesis,and decreased significantly during the gonad development in the gonad,mantle and foot of both females and males,suggesting that glycogen was an important energy source for gonad development.The protein and lipid contents increased in the ovary during the gonad development,demonstrating that they are the major organic components of oocytes.The lipid and protein contents decreased in the testis,implying that they can provide energy and material for spermatogenesis.The results also showed that protein stored in the mantle and foot could support the reproduction after the glycogen was depleted. | BI Jinhong LI Qi ZHANG Xinjun ZHANG Zhixin TIAN Jinling XU Yushan LIU Wenguang | 2016 | Journal of Ocean University of China2016，15，2： | 6 |
| 11 | Characteristics and risk factors of cerebrovascular accidents after percutaneous coronary interventions in patients with history of stroke显示文摘背景经皮的冠的干预(一种总线标准) 是为管理冠的 diseases.However 的一个生长得很好的方法,一种总线标准的增加的使用导致了与一种总线标准有关的尖锐脑血管的事故(CVA ) 的增加的发生。在这研究,我们与在 2005 年 1 月 1 日和 2009 年 3 月 1 日之间的已知的击 history.Methods 在病人在一种总线标准以后调查了 CVA 的特征和风险因素,有击的历史的 621 个病人经历了 665 一种总线标准过程的一个总数并且在这回顾的研究被包括。人口统计、临床的特征,以前的药,过程,神经赤字,在心脏的 catheterization 实验室以后开发了 CVA 的病人的临床的结果访问的损害和在里面医院并且在分泌物前的地点是 reviewed.Results 尖锐 CVA 在 53 被诊断(8.5%) 病人在手术或 perioperative pedod 期间。十七个病人受不了短暂 ischemic 攻击, 34 个病人受不了受不了的服的梗塞和二个病人服的出血。为在在击病人的一种总线标准以后的 CVA 的风险因素是:有急性冠的症候群的承认,intra大动脉的汽球泵的使用,迫切或紧急情况过程,糖尿病 mellitus ,和穷人离开了室的收缩功能,动脉的纤维性颤动,以前的心肌的梗塞, dyslipidemia ,烟草使用,并且反血小板 medications.Conclusions 的 no/irregular 使用 CVA 的发生在期间并且在在有击的历史的病人的一种总线标准以后没有击的历史,在病人比那高得多。有 atrial 纤维性颤动的病人,以前的心肌的梗塞,糖尿病 mellitus, dyslipidemia,烟草使用,并且没有或反血小板药的不规则的使用在更高的风险因为周期性的 stroke.This 学习在一种总线标准以后显示出在急性冠的症候群和在里面医院击之间的一个强壮的协会。 | ZHANG Hua FENG Li-qun BI Qi WANG Yu-ping | 2010 | Chinese Medical Journal2010，，12： | 6 |
| 12 | Genome-wide identification and expression analyses of cytochrome P450 genes in mulberry(Morus notabilis)显示文摘Cytochrome P450 S play critical roles in the biosynthesis of physiologically important compounds in plants.These compounds often act as defense toxins to prevent herbivory.In the present study,a total of 174 P450 genes of mulberry(Morus notabilis C.K.Schn) were identified based on bioinformatics analyses.These mulberry P450 genes were divided into nine clans and 47 families and were found to be expressed in a tissue-preferential manner.These genes were compared to the P450 genes in Arabidopsis thaliana.Families CYP80,CYP92,CYP728,CYP733,CYP736,and CYP749 were found to exist in mulberry,and they may play important roles in the biosynthesis of mulberry secondary metabolites.Analyses of the functional and metabolic pathways of these genes indicated that mulberry P450 genes may participate in the metabolism of lipids,other secondary metabolites,xenobiotics,amino acids,cofactors,vitamins,terpenoids,and poiyketides.These results provide a foundation for understanding of the structures and biological functions of mulberry P450 genes. | Bi Ma Yiwei Luo Ling Jia Xiwu Qi Qiwei Zeng Zhonghuai Xiang Ningjia He | 2014 | Journal of Integrative Plant Biology2014，56，9： | 5 |
| 13 | Ge-rich hydrothermal solutions and abnormal enrichment of Ge in coal显示文摘AT present, the main source of germanium includes two types of ore deposits: some sulfide-rich Pb, Zn,Cu, Ag and An deposits and some coal deposits. Germanium occurs as an associated element in these oredeposits. The Lincang germanium deposit discovered recently in China occurs in a basin where there areexposed the Neogene coal-bearing clastic rocks with Indosinian Ge-rich ((1.9-5.0)×10-6) granitesas the basement in Lincang County, Yunnan Province. Germanium is mainly concentrated in the coalseams of the first coal-bearing horizon (Nth2) and in regard to its grade (normally n×100×10-6 with themaximum over 1000×10-6) and scale (the proven reserve about 800 t), no such germanium mineralization has been reported so far in other parts of the world. What is the reason? The available studies have indicated that this germanium deposit is of epigenetic origin, whichdetermines that germanium must have been transferred into coal with the help of a kind of medium. It isnoticed that (i) organic germanium in natural waters is stable and it is never involved in its | HU Ruizhong, BI Xianwu, SU Wenchao, QI Huawen and YE Zaojun Intitue of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China | 1999 | Chinese Science Bulletin1999，44，S2： | 5 |
| 14 | Subsynchronous oscillation monitoring and alarm method based on phasor measurements显示文摘Owing to the large-scale grid connection of new energy sources, several installed power electronic devices introduce sub-/supersynchronous inter-harmonics into power signals, resulting in the frequent occurrence of subsynchronous oscillations(SSOs). The SSOs may cause significant harm to generator sets and power systems;thus, online monitoring and accurate alarms for power systems are crucial for their safe and stable operation. Phasor measurement units(PMUs) can realize the dynamic real-time monitoring of power systems. Based on PMU phasor measurements, this study proposes a method for SSO online monitoring and alarm implementation for the main station of a PMU. First, fast Fourier transform frequency spectrum analysis is performed on PMU current phasor amplitude data to obtain subsynchronous frequency components. Second, the support vector machine learning algorithm is trained to obtain the amplitude threshold and subsequently filter out safe components and retain harmful ones. Finally, the adaptive duration threshold is determined according to frequency susceptibility, amplitude attenuation, and energy accumulation to decide whether to transmit an alarm signal. Experiments based on field data verify the effectiveness of the proposed method. | Yuan Qi Jiaxian Li Hao Liu Tianshu Bi | 2020 | Global Energy Interconnection2020，3，5： | 5 |
| 15 | User Association in Heterogeneous Network with Dual Connectivity and Constrained Backhaul显示文摘A novel user association model for heterogeneous network(Het Net) with dual connectivity(DC) and constrained backhaul is proposed in this paper, where not only the best combination of serving macro cell and small cell for each user to associate is selected but also the optimal traffi c split between the macro cell and small cell is determined to enhance both radio resource effi ciency and backhaul capacity utilization. To solve this optimization problem, an intuitive algorithm based on iteratively solving two sub-problems is proposed. One sub-problem is a binary integer programming problem and a corresponding greedy algorithm is proposed, while the other sub-problem is a simple linear programming problem and can be easily solved. Numerical results show that the proposed model and algorithm can achieve better radio resource effi ciency and backhaul capacity utilization compared with user association in Het Net without DC, which validate the capacity enhancement potentials of radio resource coordination in Het Net with DC. | WU Zhouyun XIE Weiliang YANG Fengyi BI Qi | 2016 | China Communications2016，13，2： | 5 |
| 16 | Association between Lipoprotein(a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort显示文摘Objective The association between lipoprotein(a)[Lp(a)] levels and metabolic syndrome(MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort. Methods A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS. Results In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS(30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio(OR) for prevalent MetS [multivariate-adjusted OR 0.45(95% confidence interval 0.39-0.51);P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups. Conclusion Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort. | WU Xue Yan LIN Lin Qi Hong Yan DU Rui HU Chun Yan MA Li Na PENG Kui LI Mian XU Yu XU Min CHEN Yu Hong LU Jie Li BI Yu Fang WANG Wei Qing NING Guang | 2019 | Biomedical and Environmental Sciences2019，32，7： | 5 |
| 17 | First discovery of coesite in eclogite from East Kunlun, northwest China显示文摘Ultrahigh-pressure (UHP)metamorphism plays important roles in continental dynamics.Understanding of this process has been enhanced by the discovery of coesite and micro-diamond from supracrustal rocks [1].Such UHP mineral inclusions provide unequivocal evidence that the least dense part of the lithosphere can be buried to 100-150km or more,and then returned to the surface.Coesite,an ultrahigh-pressure polymorph of SiO2stable above 2.7GPa at metamorphic temperatures,is one of the most important index minerals for UHP metamomhism [1,2]. | Hengzhe Bi Shuguang Song Jinlong Dong Liming Yang Shengsheng Qi Mark B.Allen | 2018 | Science Bulletin2018，63，23： | 4 |
| 18 | Characteristics of soil organic carbon and total nitrogen under various grassland types along a transect in a mountain-basin system in Xinjiang, China显示文摘Soil organic carbon(SOC) and soil total nitrogen(STN) in arid regions are important components of global C and the N cycles, and their response to climate change will have important implications for both ecosystem processes and global climate feedbacks. Grassland ecosystems of Funyun County in the southern foot of the Altay Mountains are characterized by complex topography, suggesting large variability in the spatial distribution of SOC and STN. However, there has been little investigation of SOC and STN on grasslands in arid regions with a mountain-basin structure. Therefore, we investigated the characteristics of SOC and STN in different grassland types in a mountain-basin system at the southern foot of the Altai Mountains, north of the Junggar Basin in China, and explored their potential influencing factors and relationships with meteorological factors and soil properties. We found that the concentrations and storages of SOC and STN varied significantly with grassland type, and showed a decreasing trend along a decreasing elevation gradient in alpine meadow, mountain meadow, temperate typical steppe, temperate steppe desert, and temperate steppe desert. In addition, the SOC and STN concentrations decreased with depth, except in the temperate desert steppe. According to Pearson's correlation values and redundancy analysis, the mean annual precipitation, soil moisture content and soil available N concentration were significantly positively correlated with the SOC and STN concentrations. In contrast, the mean annual temperature, p H, and soil bulk density were significantly and negatively correlated with the SOC and STN concentrations. The mean annual precipitation and mean annual temperature were the primary factors related to the SOC and STN concentrations. The distributions of the SOC and STN concentrations were highly regulated by the elevation-induced differences in meteorological factors. Mean annual precipitation and mean annual temperature together explained 97.85% and 98.38% of the overall variations in the SOC and STN concentrations, respectively, at soil depth of 0–40 cm, with precipitation making the greatest contribution. Our results provide a basis for estimating and predicting SOC and STN concentrations in grasslands in arid regions with a mountain-basin structure. | BI Xu LI Bo NAN Bo FAN Yao FU Qi ZHANG Xinshi | 2018 | Journal of Arid Land2018，10，4： | 4 |
| 19 | Establishment of a Sandwich ELISA Method for Detection of Vascular Endothelial Growth Factor in Serum Samples of Hepatocellular Carcinoma Patients显示文摘Objective To establish a sandwich ELISA method for detecting vascular endothelial growth factor (VEGF) in sera of population and the patients with hepatocellular carcinoma (HCC). Methods Full length and two truncated human VEGF cDNA sequences were amplified from a commercial plasmid pBLAST49-hVEGF by PCR and inserted into the prokaryotic-expression plasmid pET-32a or pGEX-2T. Various VEGF proteins were expressed and purified from E. coli in His-Trx or GST fusion forms. The specific VEGF antibodies were elicited in experimental rabbits and mice by immunization of the full length VEGF fusion protein His-Trx-VEGF1-165. After purification of antibodies with chromatograph of Protein G, a sandwich ELISA technique was established. Serum VEGF levels were evaluated in 229 adults and 291 HCC patients. Results SDS-PAGE displayed that the molecular weights of the expressed full length (His-Trx-VEGF1-165), N-terminal (His-Trx-VEGF1-100) and C-terminal (GST-VEGF100-165) human VEGF fusion proteins were about 38KD, 31KD, and 33KD, respectively. Western blots confirmed that the prepared antisera were able to recognize both prokaryoticly and eukaryoticly expressed recombinant VEGF proteins. Assays of serially diluted His-Trx-VEGF1-100 by the established sandwich ELISA method showed that the linear range of the standard curve was 0.625-320 ng/mL, with the squared correlation coefficient R2=0.991. Screening of a serum panel containing 291 serum samples of HCC patients and 229 health adults revealed that the average VEGF level in HCC patients was higher than that in healthy controls, with a statically significant difference. Conclusion The established sandwich ELISA reflects the level of serum VEGF and provide scientific basis for screening metastasis and recurrence of HCC using serum VEGF as an index. | BING SHAN CHEN GAO JIAN-MING CHEN XIN-Yu BI BAO-YUN ZHANG YAN GUO CHEN-FANG DONG RUN AN QI SHI JING-QUN HU PING ZHAO JUN HAN XIAO-PING DONG | 2008 | Biomedical and Environmental Sciences2008，21，1： | 4 |
| 20 | Avian influenza A(H7N9)virus:from low pathogenic to highly pathogenic显示文摘OriginalTranslation The avian influenza A(H7N9)virus is a zoonotic virus that is closely associated with live poultry markets.It has caused infections in humans in China since 2013.Five waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017.H7N9 with low-pathogenicity dominated in the first four waves,whereas highly pathogenic H7N9 influenza emerged in poultry and spread to humans during the fifth wave,causing wide concern.Specialists and officials from China and other countries responded quickly,controlled the epidemic well thus far,and characterized the virus by using new technologies and surveillance tools that were made possible by their preparedness efforts.Here,we review the characteristics of the H7N9 viruses that were identified while controlling the spread of the disease.It was summarized and discussed from the perspectives of molecular epidemiology,clinical features,virulence and pathogenesis,receptor binding,T-cell responses,monoclonal antibody development,vaccine development,and disease burden.These data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging viruses,such as SARS-CoV-2. | William J.Liu Haixia Xiao Lianpan Dai Di Liu Jianjun Chen Xiaopeng Qi Yuhai Bi Yi Shi George F.Gao Yingxia Liu | 2021 | Frontiers of Medicine2021，15，4： | 4 |
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