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| 1 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 2 | Different Expression Analysis in Fruit Softening and Ethylene Biosynthetic Pathways in Peaches of Different Flesh Textures显示文摘The aim of our study was to assess differences in the expression of genes involved in fruit softening and ethylene biosynthetic pathways under different temperature storage conditions. Different peach cultivars of ‘Xiacui' and ‘Yumyeong', which are stonyhard, ‘Yinhualu', which is softmelting, ‘Hujing Milu', which is hard-melting, and ‘Baby Gold 6', which is non-melting at 80% ripening, were collected as test materials. The results showed that only slight ethylene production was detected after harvesting of ‘Yumyeong' and ‘Xiacui' under either a room temperature(25 °C) or low temperature(4 °C). The fruit firmness of stonyhard cultivars was retained at a high level under room temperature over time, whereas a low temperature induced ‘Yumyeong' fruit to soften. Quantitative real-time PCR results indicated that the PpACS1 gene was highly expressed in soft-melting, hard-melting and non-melting cultivars; however, expression was extremely low in stonyhard peaches. PpACS2 or PpACS3, however,was not detected in all five cultivars. Interestingly, cold treatment significantly decreased firmness along with endo-PG expression obviously upregulated in ‘Yumyeong', but not in ‘Xiacui' peaches. In conclusion, this study revealed that fruit softening of peaches with different flesh textures was closely related to ethylene biosynthesis during the storage period, which was controlled via regulating relevant gene expression levels under different storage temperatures. | YANG Yong MA Ruijuan ZHANG Binbin SONG Zhizhong ZHANG Chunhua GUO Shaolei YU Mingliang | 2016 | Horticultural Plant Journal2016，2，2： | 7 |
| 3 | Research into magnetic guidance technology for directional drilling in SAGD horizontal wells显示文摘SAGD horizontal wells are used to enhance oil recovery from heavy oil reservoirs.This technology requires precise separation between the production well and the injection well to ensure the efficient drainage of the reservoir.By studying the attitude of the downhole probe tube and the production well trajectory,an algorithm is proposed for eliminating ferromagnetic interference while drilling injection wells.A high accuracy filter circuit has been designed to correct the detected magnetic signals,which are ultra-weak,frequency-instable,and narrow-band.The directional drilling magnetic guidance system(DD-MGS) has been developed by integrating these advanced techniques.It contains a sub-system for the ranging calculation software,a magnetic source,a downhole probe tube and a sub-system for collecting & processing the detected signals.The DD-MGS has succeeded in oilfield applications.It can guide the directional drilling trajectory not only in the horizontal section but also in the build section of horizontal injection wells.This new technology has broad potential applications. | Gao Deli Diao Binbin Wu Zhiyong Zhu Yu | 2013 | Petroleum Science2013，10，4： | 7 |
| 4 | Co-doping effects on magnetism and superconductivity in the 112-type EuFeAs2 system显示文摘The discovery of EuFeAs_(2),currently the only charge-neutral parent phase of the 112-type iron-pnictide system,provides a new platform for the study of elemental doping effects on magnetism and superconductivity(SC).In this study,a series of polycrystalline EuFe_(1-y)Co_(y)As_(2)and Eu_(0.9)Pr_(0.1)Fe_(1-y)Co_(y)As_(2)samples are synthesized through solid-state reaction,and the evolutions of SC and magnetism with Co doping in EuFeAs_(2)and Eu_(0.9)Pr_(0.1)FeAs_(2)are investigated by electrical transport and magnetic susceptibility measurements.For EuFe_(1-y)Co_(y)As_(2),the Eu-related antiferromagnetic(AFM)transition around 40 K is barely affected by Co doping,while the Fe-related spin density wave(SDW)transition temperature drops rapidly.Meanwhile,SC is induced by a trace amount of Co doping,with a highest transition temperature T_(c)~28 K found in EuFe0.9Co0.1As_(2).For the Eu_(0.9)Pr_(0.1)Fe1-yCo_(y)As_(2)series,the magnetism and superconductivity show similar evolutions upon Co doping,and the highest T_(c)is enhanced to 30.6 K with an optimum doping level y~0.07.Our results shed light on the competition between SC and SDW with Co doping in the 112-type EuFeAs_(2)system. | Jia Yu Tong Liu BinBin Ruan Kang Zhao QingSong Yang MengHu Zhou ZhiAn Ren | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，6： | 7 |
| 5 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 6 | A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction显示文摘Regeneration of Intervertebral disc(IVD)is a scientific challenge because of the complex structure and composition of tissue,as well as the difficulty in achieving bionic function.Here,an anatomically correct IVD scaffold composed of biomaterials,cells,and growth factors were fabricated via three-dimensional(3D)bioprinting technology.Connective tissue growth factor(CTGF)and transforming growth factor-β3(TGF-β3)were loaded onto polydopamine nanoparticles,which were mixed with bone marrow mesenchymal stem cells(BMSCs)for regenerating and simulating the structure and function of the nucleus pulposus and annular fibrosus.In vitro experiments confirmed that CTGF and TGF-β3 could be released from the IVD scaffold in a spatially controlled manner,and induced the corresponding BMSCs to differentiate into nucleus pulposus like cells and annulus fibrosus like cells.Next,the fabricated IVD scaffold was implanted into the dorsum subcutaneous of nude mice.The reconstructed IVD exhibited a zone-specific matrix that displayed the corresponding histological and immunological phenotypes:primarily type II collagen and glycosaminoglycan in the core zone,and type I collagen in the surrounding zone.The testing results demonstrated that it exhibited good biomechanical function of the reconstructed IVD.The results presented herein reveal the clinical application potential of the dual growth factors-releasing IVD scaffold fabricated via 3D bioprinting.However,the evaluation in large mammal animal models needs to be further studied. | Binbin Sun Meifei Lian Yu Han Xiumei Mo Wenbo Jiang Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，1： | 5 |
| 7 | Dynamic memory paravirtualization transparent to guest OS显示文摘This paper introduces dynamic paravirtualization, which imitates paravirtualization and aims at reducing VM exits of full virtualization with hardware support. In dynamic paravirtualization, VMM (virtual machine monitor) dynamically monitors and replaces the hot instructions, which cause most VM exits. It is transparent to the guest OS such that the legacy OSes can benefit from this optimization. Our study focuses on reducing the overhead of memory virtualization-dynamic memory paravirtualization (DMP). We implant a new memory management mechanism in VMM such that all user-mode page faults can be handled by the guest OS directly without VM exits. We implement a prototype of dynamic memory paravirtulization based on a version of KVM using Intel VT. Our experimental results show that our technique essentially eliminates the overhead of VM exits caused by page faults. Dynamic memory paravirtualization can achieve the effectiveness of paravirtualization without changing the source code of guest OS. | WANG XiaoLin SUN YiFeng LUO YingWei WANG ZhenLin LI Yu ZHANG BinBin CHEN HaoGang LI XiaoMing | 2010 | Science China(Information Sciences)2010，53，1： | 4 |
| 8 | Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza显示文摘Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus,leading to more serious respiratory diseases during this winter.However,the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear.Using a mammalian model,sequential infection was performed in ferrets and in K18-MCE2 mice,with SARS-CoV-2 infection following H1N1.We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19,and enhanced pulmonary damage,but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets.Moreover,mortality was increased in sequentially infected mice compared with single-infection mice.Compared with singlevaccine inoculation,co-inoculation of PiCoVacc(a SARS-CoV-2 vaccine)and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses.Combined immunization effectively protected K18-MCE2 mice against both H1N1 and SARS-CoV-2 infection.Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2,which together notably enhanced pneumonia in ferrets and mice,as well as demonstrated that simultaneous vaccination against HINT and SARS-CoV-2 may be an effective prevention strategy for the coming winter. | Linlin Bao Wei Deng Feifei Qi Qi Lv Zhiqi Song Jiangning Liu Hong Gao Qiang Wei Pin Yu Yanfeng Xu Yajin Qu Fengdi Li Jing Xue Shuran Gong Mingya Liu Guanpeng Wang Shunyi Wang Binbin Zhao Bin Cong Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 4 |
| 9 | Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis显示文摘Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributions to fruit floral quality.However,the details of their biosynthesis and metabolism in tea plants are still unknown.Here,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature treatment.Through the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of eugenol.Vmax/Km ratios showed that eugenol was the most suitable substrate for CsUGT78A15.Sugar donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic acid.The expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of tea.Down-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold stress.The identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside. | Mingyue Zhao Binbin Cai Jieyang Jin Na Zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu Mengting Zhang Yating Li Zhonghua Liu Chuankui Song | 2020 | Horticultural Plant Journal2020，6，6： | 4 |
| 10 | Discrete-Rate Adaptive Modulation with Variable Threshold for Distributed Antenna System in the Presence of Imperfect CSI显示文摘 | YU Xiangbin TAN Wenting WU Binbin LI Yang | 2014 | China Communications2014，11，A01： | 3 |
| 11 | Refinement mechanism of cerium addition on solidification structure and sigma phase of super austenitic stainless steel S32654显示文摘The influence of Ce addition on the solidification structure and σphase of super austenitic stainless steel S32654 was systematically investigated via microstructural characterization and thermodynamic calcula- tion. The results indicate that a small addition of Ce could modify MgO and MnS into Ce-bearing inclu- sions Ce_(2)O_(3)and Ce_(2)O_(2)S. Ce addition led to noticeable refinement of both the dendrite structure and σphase. The refinement mechanism could be attributed to the combined actions of effective Ce-bearing inclusions and solute Ce. Effective Ce-bearing inclusions could serve as heterogeneous nucleation cores of austenite as well as σphase, which provided a favorable prerequisite for their refinement. Solute Ce significantly enhanced the undercooling degree of the system, further promoting dendrite structure re- finement. Meanwhile, solute Ce improved the eutectic precipitation conditions of σphase and further promoted its nucleation, while the dendrite refinement limited its growth space. Finally, more fine and dispersed σphase particles formed in S32654 with Ce addition. The refinement of dendrite structure and σ phase will reduce the temperature and time required for high-temperature homogenization, which is beneficial to the hot working of this steel. | Shucai Zhang Jiangtao Yu Huabing Li Zhouhua Jiang Yifeng Geng Hao Feng Binbin Zhang Hongchun Zhu | 2022 | Journal of Materials Science & Technology2022，，7： | 3 |
| 12 | An iterative learning method for realizing accurate dynamic feedforward control of an industrial hybrid robot显示文摘Feedforward control based on an accurate dynamic model is an effective approach to reduce the dynamic effect of the robot and improve its performance. However, due to the complicated work environment with considerable uncertainty, it is difficult to obtain a high-precision dynamic model of the robot, which severely deteriorates the achievable control performance. This paper proposes an iterative learning method to accurately design the industrial feedforward controller and compensate for the external uncertain dynamic load of the robot. Based on a standard dynamic model, a complete linear feedforward controller is presented.An iterative design strategy is given to iteratively update the feedforward controller by combining the Moore-Penrose Inverse and the PID learning rate. Experiments are carried out on a 5-DOF industrial hybrid robot to validate the effectiveness of the proposed iterative learning method. The experiment results illustrate that the industrial feedforward controller can rapidly converge to the optimal controller and significantly improve the servo performance by using the proposed method. This paper provides an effective method for applying iterative learning control to an unopened industrial control system. It is very useful for the practical control of hybrid robots in industrial field. | WU Jun ZHANG BinBin WANG LiPing YU Guang | 2021 | Science China(Technological Sciences)2021，64，6： | 3 |
| 13 | One-step synthesis of dimethyl ether from syngas on ordered mesoporous copper incorporated alumina显示文摘Ordered mesoporous copper incorporated Al_2O_3(Cu/Al_2O_3) with high Cu dispersion were prepared by a facile solution combustion synthesis method using aluminum nitrate and copper nitrate as oxidants and urea as fuel. It is a facile and green route to synthesize catalysts for dimethyl ether directly from syngas. Cu/Al_2O_3 catalysts were characterized by XRD, N_2 adsorption–desorption, SEM-EDS, and H_2-TPR.The results indicate that the catalysts obtain an ordered mesoporous structure and copper is homogenously dispersed. The mesoporous Cu/Al_2O_3 catalysts were utilized as bifunctional catalysts in syngas to dimethyl ether reaction(STD). The copper content affects the catalytic performance in STD reaction. The CO conversion and DME selectivity of Cu/Al_2O_3 with 15% copper molar ratio achieve 52.9% and 66.1%,respectively. Moreover, the mesoporous Cu/Al_2O_3 catalysts show excellent stability in STD reaction. | Yan Wang Yuexian Chen Feng Yu Dahai Pan Binbin Fan Jinghong Ma Ruifeng Li | 2016 | Journal of Energy Chemistry2016，25，5： | 3 |
| 14 | Analysis of coping styles of elderly women patients with stress urinary incontinence显示文摘Objective:The aim of this study was to survey the coping style and related factors of elderly women with stress urinary incontinence(SUI)and provide a strong theoretical basis for promoting a positive coping style to improve quality of life in these patients.Methods:Cross-sectional surveys addressing SUI cognition and coping techniques of 520 elderly women patients with SUI were administered between July 2013 and February 2014.Results:Elderly women with SUI had significantly higher avoidance and acceptanceresignation scores than the normal population(p<0.05).Age,marital status,education level and stress urinary incontinence cognitive level all influenced the medical coping style of these patients.Conclusions:Elderly female patients with SUI differ in the factors that influence their coping styles;therefore,clinical and community medical staff should include a comprehensive analysis that takes these factors into consideration when working with patients with SUI to guide them in adopting a positive coping style. | Binbin Yu Hongmei Xu Xiaolin Chen Li Liu | 2016 | International Journal of Nursing Sciences2016，3，2： | 2 |
| 15 | High-precision,gelatin-based,hybrid,bilayer scaffolds using melt electro-writing to repair cartilage injury显示文摘Articular cartilage injury is a common disease in the field of orthopedics.Because cartilage has poor self-repairing ability,medical intervention is needed.Using melt electro-writing(MEW)technology,tissue engineering scaffolds with high porosity and high precision can be prepared.However,ordinary materials,especially natural polymer materials,are difficult to print.In this study,gelatin was mixed with poly(lactic-co-glycolic acid)to prepare high-concentration and high-viscosity printer ink,which had good printability and formability.A composite scaffold with full-layer TGF-β1 loading mixed with hydroxyapatite was prepared,and the scaffold was implanted at the cartilage injury site;microfracture surgery was conducted to induce the mesenchyme in the bone marrow.Quality stem cells thereby promoted the repair of damaged cartilage.In summary,this study developed a novel printing method,explored the molding conditions based on MEW printing ink,and constructed a bioactive cartilage repair scaffold.The scaffold can use autologous bone marrow mesenchymal stem cells and induce their differentiation to promote cartilage repair. | Yu Han Bo Jia Meifei Lian Binbin Sun Qiang Wu Benlin Sun Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，7： | 2 |
| 16 | Stem cell homing-based tissue engineering using bioactive materials显示文摘 | Yinxian YU Binbin SUN Chengqing YI Xiumei MO | 2017 | Frontiers of Materials Science2017，11，2： | 2 |
| 17 | Polarization-independent highly efficient generation of Airy optical beams with dielectric metasurfaces显示文摘Airy optical beams have emerged to hold enormous theoretical and experimental research interest due to their outstanding characteristics.Conventional approaches suffer from bulky and costly systems,as well as poor phase discretization.The newly developed metasurface-based Airy beam generators have constraints of polarization dependence or limited generation efficiency.Here,we experimentally demonstrate a polarization-independent silicon dielectric metasurface for generation of high-efficiency Airy optical beams.In our implementation,rather than synchronous manipulation of the amplitude and phase by plasmonic or Huygens’metasurfaces,we employ and impose a 3/2 phase-only manipulation to the dielectric metasurface,consisting of an array of silicon nanopillars with an optimized transmission efficiency as high as 97%.The resultant Airy optical beams possess extraordinarily large deflection angles and relatively narrow beam widths.Our validated scheme will open up a fascinating doorway to broaden the application scenarios of Airy optical beams on ultracompact photonic platforms. | Binbin Yu Jing Wen Lei Chen Leihong Zhang Yulong Fan Bo Dai Saima Kanwal Dangyuan Lei Dawei Zhang | 2020 | Photonics Research2020，8，7： | 2 |
| 18 | Triangulation of red sprites observed above a mesoscale convective system in North China显示文摘The triangulation of red sprites was obtained, based on concurrent observations over a mesoscale convective system(MCS) in North China from two stations separated by about 450 km. In addition, broadband sferics from the sprite-producing lightning were measured at five ground stations, making it possible to locate and identify the individual causative lightning discharges for different elements in this dancing sprite event. The results of our analyses indicate that the sprites were produced above the trailing stratiform region of the MCS, and their parent strokes were located mainly in the peripheral area of the stratiform. The lateral offset between sprites and causative strokes ranges from a few km to more than 50 km. In a particularly bright sprite, with a distinct halo feature and streamers descending down to an altitude of approximately 48 km, the sprite current signal identified in the electric sferic, measured at a range of about 1,110 km, peaked at approximately 1 ms after the return stroke. | YongPing Wang GaoPeng Lu Ming Ma HongBo Zhang YanFeng Fan GuoJin Liu ZheRun Wan Yu Wang Kang-Ming Peng ChangZhi Peng FeiFan Liu BaoYou Zhu BinBin Ni XuDong Gu Long Chen Juan Yi RuoXian Zhou | 2019 | Earth and Planetary Physics2019，3，2： | 2 |
| 19 | Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia显示文摘Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to ICU.Bronchoscopy was performed at bedside within 48 h of ICU admission,and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid.The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy.Sixty-seven patients were included.Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota(R2=0.033;P=0.018),followed by acute kidney injury(AKI;R2=0.032;P=0.011)and plasma MIP-1βlevel(R2=0.027;P=0.044).Random forest identified that the families Prevotellaceae,Moraxellaceae,and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results.Multivariable Cox regression showed that the increase inα-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements.The positive bacteria lab test results,AKI,and plasma MIP-1βlevel were associated with patients’lung microbiota composition on ICU admission.The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements. | Sisi Du Xiaojing Wu Binbin Li Yimin Wang Lianhan Shang Xu Huang Yudi Xia Donghao Yu Naicong Lu Zhibo Liu Chunlei Wang Xinmeng Liu Zhujia Xiong Xiaohui Zou Binghuai Lu Yingmei Liu Qingyuan Zhan Bin Cao | 2022 | Frontiers of Medicine2022，16，3： | 2 |
| 20 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
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