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| 1 | Possible early Neoproterozoic magmatism associated with slab window in the Pingshui segment of the Jiangshan-Shaoxing suture zone: Evidence from zircon LA-ICP-MS U-Pb geochronology and geochemistry显示文摘We report here geochemical data, U-Pb zircon ages, and Hf isotopes for the high-Mg diorites (HMDs), Nb-enriched basaltic porphyrys (NEBPs) and plagiogranites (PLAGs) in the Pingshui segment of the Jiangshan-Shaoxing suture zone. The HMDs are characterized by high Mg# (>60), high Na and LREE contents, depletion of HREE and HFSE, and pronounced positive εNd(t) values of 7.0 to 7.7, similar to some adakitic high-Mg andesites. The NEBPs are relatively Na-rich (Na2O/K2O>6) and display high abundances of P2O5 (~1.00%), TiO2 (~3.08%) and HFSE (e.g., Nb=9.53-10.27 ppm). Their Nd isotopic compositions (εNd(t)=6.8-8.0) are comparable to those of the HMDs. The PLAGs are metaluminous (A/CNK=0.84-0.89) and sodic (Na2O/K2O>10). Their depletion in HFSE (e.g., Nb, Ta) is consistent with 'SSZ-type' plagiogranite. Zircon LA-ICP-MS U-Pb dating yields an age of 932±7 Ma for the HMD, 916±6 Ma for the NEBP, and 902±5 Ma for the PLAG, respectively, indicating that they were products of early Neoproterozoic magmatism. The PLAGs exhibit relatively high zircon Hf isotopes and positive εHf(t) values of 11.0 to 16.2, consistent with their Nd isotopic data (εNd(t)=7.5-8.4). Such features are similar to those of oceanic plagiogranites in ophiolites and distinct from those of crust-derived granites. The PLAGs were most likely derived from partial melting of subducted oceanic crust in an active continental margin. Considering these results in the context of the regional geology, we suggest that a slab window in the subducting oceanic crust between the Yangtze Block and Cathaysia Block was possibly the principal cause for the unique arc magmatism in the area. The upwelling asthenosphere below the slab window may have provided significant thermodynamic conditions. | CHEN ZhiHong GUO KunYi DONG YongGuan CHEN Rong LI LongMing LIANG YiHong LI ChunHai YU XiMing ZHAO Ling XING GuangFu | 2009 | Science China Earth Sciences2009，52，7： | 26 |
| 2 | Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation显示文摘通过 ubiquitination 小径的 p53 蛋白质周转是在它的 transcriptional 活动的规定的重要机制;然而,很少通过 proteasome 独立的小径对 p53 周转被知道。消化机关扩大因素(Def ) 蛋白质为消化机关的发展是必要的。在 zebrafish, def 的功能的损失有选择地 upregulates p53 反应基因的表示,它提出至于是在 Def 和 p53 之间的关系的一个问题。我们这里报导 Def 是核仁的蛋白质并且 def 的功能的损失导致 p53 蛋白质的 upregulation,它令人惊讶地在 nucleoli 积累。我们的广泛的研究证明了 Def 能调停这个过程是的 p53 蛋白质和那的降级在 Calpain3 的活动独立于 proteasome 小径,却依赖,半胱氨酸朊酶。我们的调查结果定义调整 p53 的周转功能的一条新奇核仁的小径,它将在 organogenesis 和 tumorigenesis 推进我们 p53 的角色的理解。 | Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng | 2013 | Cell Research2013，23，5： | 8 |
| 3 | Expanded endoscopic therapy criteria should be cautiously used in intramucosal gastric cancer显示文摘Objective: Accurate estimation of lymph node metastasis(LNM) in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM.Methods: A retrospective review of data from 386 intramucosal gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed.Results: LNM was detected in 40(10.4%) of the 386 patients. Histological type and vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection(ESD) indication also revealed that the undifferential type was the only significant factor for LNM.Conclusions: It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients. | Hongshan Wang Heng Zhang Cong Wang Yong Fang Xuefei Wang Weidong Chen Fenglin Liu Kuntang Shen Xinyu Qin Zhenbin Shen Yihong Sun | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 4 | Electrospinning nanofiber scaffolds for soft and hard tissue regeneration显示文摘Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and organs.The three fundamental pillars of tissue engineering are scaffolds,cells,and biomolecules.Electrospun nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected pores.In this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue engineering.We first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial fabrication.Next,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament applications.Finally,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas. | Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi Allison E.Fetz Gary L.Bowlin Mohamed El-Newehy Xiumei Mo | 2020 | Journal of Materials Science & Technology2020，59，24： | 5 |
| 5 | Cellular Caspase-3 Contributes to EV-A71 2Apro-Mediated Down-Regulation of IFNAR1 at the Translation Level显示文摘Enterovirus A71(EV-A71) is the major pathogen responsible for the severe hand, foot and mouth disease worldwide, for which few effective antiviral drugs are presently available. Interferon-a(IFN-a) has been used in antiviral therapy for decades;it has been reported that EV-A71 antagonizes the antiviral activity of IFN-a based on viral 2 Apro-mediated reduction of the interferon-alpha receptor 1(IFNAR1);however, the mechanism remains unknown. Here, we showed a significant increase in IFNAR1 protein induced by IFN-a in RD cells, whereas EV-A71 infection caused obvious downregulation of the IFNAR1 protein and blockage of IFN-a signaling. Subsequently, we observed that EV-A71 2 Apro inhibited IFNAR1 translation by cleavage of the eukaryotic initiation factor 4 GI(eIF4GI), without affecting IFNAR1 m RNA levels induced by IFN-a. The inhibition of IFNAR1 translation also occurred in puromycin-induced apoptotic cells when caspase-3 cleaved e IF4 GI. Importantly, we verified that 2 Aprocould activate cellular caspase-3, which was subsequently involved in e IF4 GI cleavage mediated by 2 Apro. Furthermore, inhibition of caspase-3 activation resulted in the partial restoration of IFNAR1 in cells transfected with 2 A or infected with EV-A71, suggesting the pivotal role of both viral 2 Aproand caspase-3 activation in the disturbance of IFN-a signaling. Collectively, we elucidate a novel mechanism by which cellular caspase-3 contributes to viral 2 Apro-mediated down-regulation of IFNAR1 at the translation level during EV-A71 infection, indicating that caspase-3 inhibition could be a potential complementary strategy to improve clinical anti-EV-A71 therapy with IFN-a. | Bangtao Chen Yuya Wang Xinyi Pei Sanyuan Wang Hao Zhang Yihong Peng | 2020 | Virologica Sinica2020，35，1： | 5 |
| 6 | Isolation of a novel characterized Issatchenkia terricola from red raspberry fruits on the degradation of citric acid and enrichment of flavonoid and volatile profiles in fermented red raspberry juice显示文摘High content of citric acid in red raspberry juice leads to poor sensory experience. This study developed a feasible method to degrade citric acid in red raspberry juice using a novel characterized Issatchenkia terricola WJL-G4 isolated from red raspberry fruits. I. terricola WJL-G4 exhibited a potent capability of reducing the citric acid contents from(22.8 ± 0.08) g/L to(6.2 ± 0.02) g/L within 36 h fermentation, then completely depleted after 48 h. Furthermore, the contents of phenolic compound, including neochlorogenic acid, p-coumaric acid, raspberry ketone, and rutin significantly increased after 36 h fermentation. Fermentation increased total flavonoid contents in red raspberry juice, compared to that in control group. Volatile profiles exhibited to be enriched after fermentation, which contributed to the improvement of the juice taste. Our findings showed that I. terricola WJL-G4 can be applied in deacidification, enrichment of flavonoid compounds and volatile profiles in fermented red raspberry juice.. | Ying Jiang Ting Luo Ying Tang Sirui Chen Hui Ni Qihe Chen Xingshun Song Yihong Bao Zeyuan Deng Jinling Wang | 2022 | Food Science and Human Wellness2022，11，4： | 3 |
| 7 | Research on the random seismic response analysis for multi- and large-span structures to multi-support excitations显示文摘The pseudo excitation method(PEM) has been improved into a more practical form,on which the analytic formulae of seismic response power spectral density(PSD) of simplified large-span structural models have been derived.The analytic formulae and numerical computing results of seismic response PSD have been derived to study the mechanism of multi-support excitation effects,such as the wave-passage effect and incoherence effect,for the seismic response of multiand large-span structures.By using a multi-span truss as an example,the influence of multi-support excitation effects on the seismic response of such structures is studied. | Zhao Bo Wang Yuanqing Chen Zhihua Shi Yongjiu Jiang Yang Wang Yihong | 2015 | Earthquake Engineering and Engineering Vibration2015，14，3： | 2 |
| 8 | Hazard Footprint-Based Normalization of Economic Losses from Tropical Cyclones in China During 1983–2015显示文摘Loss normalization is the prerequisite for understanding the effects of socioeconomic development,vulnerability, and climate changes on the economic losses from tropical cyclones. In China, limited studies have been done on loss normalization methods of damages caused by tropical cyclones, and most of them have adopted an administrative division-based approach to define the exposure levels. In this study, a hazard footprint-based normalization method was proposed to improve the spatial resolution of affected areas and the associated exposures to influential tropical cyclones in China. The meteorological records of precipitation and near-surface wind speed were used to identify the hazard footprint of each influential tropical cyclone. Provincial-level and national-level(total)economic loss normalization(PLN and TLN) were carried out based on the respective hazard footprints, covering loss records between 1999–2015 and 1983–2015, respectively.Socioeconomic factors—inflation, population, and wealth(GDP per capita)—were used to normalize the losses. A significant increasing trend was found in inflation-adjusted losses during 1983–2015, while no significant trend was found after normalization with the TLN method. The proposed hazard footprint-based method contributes to amore realistic estimation of the population and wealth affected by the influential tropical cyclones for the original year and the present scenario. | Wenfang Chen Yi Lu Shao Sun Yihong Duan Gregor C.Leckebusch | 2018 | International Journal of Disaster Risk Science2018，9，2： | 2 |
| 9 | Benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids:Design,synthesis and in vitro anti-mycobacterial activity evaluation显示文摘A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H_(37)Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents. | Yaohuan Zhang Ruo Wang Tesen Zhang Weitao Yan Yihong Chen Yanping Zhang Muyang Zhou | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 10 | A compact polarization-integrated long wavelength infrared focal plane array based on In As/GaSb superlattice显示文摘Real-time polarization imaging plays a vital role in target detection,recognition,and tracking in complex scenes.However,large optical crosstalk and the integration technology are difficult problems in the development of polarization-integrated infrared detectors.We demonstrate a monolithic long wavelength infrared(LWIR)In As/Ga Sb superlattice focal plane array(FPA)integrated with the polarizer.To obtain high performance and real-time polarization imaging devices,the parameters of the grating were optimized and the optical crosstalk between adjacent polarization bands was studied.We analyze the light diffraction depending on the distance between the polarizer and photosensitive elements and the coupling between oblique incident light and device.The fabrication process of the antireflective polarizer,the integration technology of the polarizer and the FPA composed of 512×4×3 pixels were explored.Finally,a polarization integrated focal plane array(PI-FPA)was fabricated to detect polarized light with different oscillating directions.The large response extinction ratio of corresponding polarization bands was measured as 50:1,49:1,and 44:1 of 0°,60°,and 120°,respectively. | Jian ZHOU Yi ZHOU Ying SHI Fangfang WANG Zhicheng XU Zhizhong BAI Min HUANG Lulu ZHENG Zhaoming LIANG Yihong ZHU Qingqing XU Yiming SHEN Xiangxiao YING Jianxin CHEN | 2022 | Science China(Information Sciences)2022，65，2： | 2 |
| 11 | Transarterial infusion chemotherapy with FOLFOX for advanced hepatocellular carcinoma:a multi-center propensity score matched analysis of real-world practice显示文摘Background:To compare the treatment effectiveness and safety among transarterial infusion chemotherapy(TAI)with FOLFOX regimen,transarterial chemoembolization(TACE),and sorafenib in patients with BCLC stage C hepatocellular carcinoma(HCC).Methods:The data of consecutive patients with BCLC stage C HCC treated with TAI,TACE,or sorafenib from January 2015 to December 2018 at three centers were retrospectively analyzed.Propensity-score matched(PSM)analysis was pairwise performed to reduce selection bias.Treatment effectiveness and safety were evaluated and compared using the Kaplan-Meier method,log-rank test,Cox regression models,andχ2 test.Results:The median overall survival(OS)in the matched TAI cohort was significantly longer than the sorafenib cohort(19.6 vs.7.5 months,P=0.009),and the TACE cohort(estimated 27.8 vs.6.6 months,P<0.001).The difference in median progression-free survival(PFS)between the matched TAI and sorafenib cohorts was not significant(5.8 vs.2.3 months,P=0.219).The median PFS in the matched TAI cohort was significantly longer than the TACE cohort(6.5 vs.2.8 months,P<0.001).The objective response rate(ORR)in the matched TAI cohort was significantly higher than the sorafenib cohort(36.4%vs.0.0%,P<0.001)and the TACE cohort(48.7%vs.4.7%,P<0.001).The incidences of adverse events(AEs)were similar among these three cohorts.Conclusions:TAI with FOLFOX regimen was an effective and safe therapy that improved survival of patients with BCLC stage C HCC. | Shaohua Li Jie Mei Qiaoxuan Wang Feng Shi Hongyan Liu Ming Zhao Lianghe Lu Yihong Ling Zhixing Guo Yabing Guo Xiaoming Chen Ming Shi Wan Yee Lau Wei Wei Rongping Guo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 2 |
| 12 | Involvement of the crebellum in sequential finger movement learning:Evidence from functional magnetic resonance imaging显示文摘Whether the cerebellum is involved in volun-tary motor learning or motor performance is the subject of a new debate. Using functional magnetic resonance imaging (fMRI), we examined cerebellar activation in eight volun-teers before and after an extended period of training. Activa-tion volume on both sides of cerebellum after learning was significantly reduced compared to that before learning even under the same motor frequency. Remarkably, while motor frequency for the training sequence was significantly higher than the control sequence after 41 d of learning, activation in the cerebellum for both sequences, with respect to activation loci and volumes, was very similar. These results suggest that the cerebellum was involved in motor learning but not motor performance. Changes of cerebellar activation from training thus appear to be associated with learning but not with im-provement on task performance. | ZHU Yihong DI Haibo YUAN Yi REN Jin'ge YU Wei ZHANG Zhaoqi GAO Jiahong WENG Xuchu CHEN Yizhang | 2005 | Chinese Science Bulletin2005，50，17： | 2 |
| 13 | The glial actin cytoskeleton regulates neuronal ciliogenesis显示文摘 | Hao Zhu Lianwan Chen Yihong Yang Zhiwen Zhu Xianliang Zhang Wei Li Long Miao Yan Zhang Guangshuo Ou | 2017 | Cell Research2017，27，3： | 1 |
| 14 | Non‑Leaching,Rapid Bactericidal and Biocompatible Polyester Fabrics Finished with Benzophenone Terminated N‑halamine显示文摘Pathogenic bacteria can proliferate rapidly on porous fabrics to form bacterial plaques/bioflms,resulting in potential sources of cross-transmissions of diseases and increasing cross-infection in public environments.Many works on antibacterial modifcation of cotton fabrics have been reported,while very few works were reported to endow poly(ethylene terephthalate)(PET)fabrics with non-leaching antibacterial function without compromising their innate physicochemical properties though PET is the most widely used fabric.Therefore,it is urgent to impart the PET fabrics with non-leaching antibacterial activity.Herein,a novel N-halamine compound,1-chloro-3-benzophenone-5,5-dimethylhydantoin(Cl-BPDMH),was developed to be covalently bonded onto PET fabrics,rendering non-leaching antibacterial activity while negligible cytotoxicity based on contact-killing principle.Bacterial was easily adhered to Cl-BPDMH fnished PET fabrics,and then it was inactivated quickly within 10 s.Furthermore,the breaking strength,breaking elongation,tearing strength,water vapor permeability,air permeability and whiteness of Cl-BPDMH fnished PET fabrics were improved obviously compared to raw PET fabrics.Hence,this work developed a facile approach to fabricate multifunctional synthetic textiles to render outstanding and rapid bactericidal activity without compromising their physicochemical properties and biocompatibility. | Shu Wang JianNa Li Yihong Cao JingWei Gu YuanFeng Wang ShiGuo Chen | 2022 | Advanced Fiber Materials2022，4，1： | 1 |
| 15 | Characteristics and antioxidaut activity of water-soluble Maillard reactionproducts from interactions in a whey protein isolate and sugars system显示文摘 | WANG WENQIONG BAO YIHONG CHEN YING | 2013 | Food Chemistry2013，，139： | 1 |
| 16 | Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks显示文摘 | Xiaowen Ge Haixing Wang Haiying Zeng Xuejuan Jin Akesu Sujie Chen Xu Yalan Liu Jie Huang Yuan Ji Yunshan Tan Tianshu Liu Yingyong Hou Jing Qin Yihong Sun Xinyu Qin | 2015 | Human Pathology2015，，6： | 1 |
| 17 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 18 | Effects of Rehmannia glutinosa oligosaccharide on human adipose-derived mesenchymal stem cells in vitro显示文摘 | Yu Zhang Yuhong Wang Lei Wang Yanqin Zhang Yihong Qin Ting Chen Weidong Han Guanghui Chen | 2012 | 2012 (25-2)2012，，25： | 1 |
| 19 | Study of the mechanical properties of Nd:YVO4 crystal by use of laser interferometry and finite-element analysis显示文摘 | Peng Xiaoyuan Asundi A Chen Yihong | 2001 | Appl Opt2001，40，9： | 1 |
| 20 | Multiple-Bits-Slot Reservation Aloha Protocol for Tag Identification显示文摘 | CHEN YIHONG FENG QUANYUAN ZHENG MA | 2013 | IEEE Transactions on Consumer Electronics2013，59，1： | 1 |
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