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| 1 | Genomic sequencing and analysis of the first imported Middle East Respiratory Syndrome Coronavirus(MERS CoV) in China显示文摘Dear Editors,Middle East Respiratory Syndrome(MERS)has spread to more than 23 countries since the first case of a MERS coronavirus(MERS Co V)infection was confirmed in Sep2012[1].Because MERS Co V has led to mortality as high as 40%,it has become one of the most important emerging pathogens threatening human health.Recently,the outbreak of MERS Co V,which resulted in 172 infections and | XIE Qian CAO YuJuan SU Juan WU XianBo WAN ChengSong KE ChangWen ZHAO Wei ZHANG Bao | 2015 | Science China(Life Sciences)2015，58，8： | 8 |
| 2 | A preliminary analysis of fishery resource exhaustion in the context of biodiversity decline显示文摘Marine biodiversity in almost all oceans is being threatened at the genetic, species, and ecosystem levels. The marine ecosystem is being degraded and the extinction rate of marine organisms has accelerated. In this paper, the potential causes of fishery resource exhaustion in the East China Sea are analyzed, including the change in the stoichiometric composition of seawater with regard to the concentrations of N and P, toxic effects of marine pollution, marine habitat destruction, increased seawater temperatures caused by climate warming, ocean acidification, pressure from overfishing, and the spread of marine pathogenic bacteria. It is believed that the factors mentioned above have significant impact on the exhaustion of fishery resources in the East China Sea. However, considering the cumulative, synergistic, and superimposed effects as well as the amplification effects resulting from their interactions, the actual risk of ecological extinction of marine organisms might be even more severe than that previously estimated. Hence, ecosystem management and research focused on a single risk factor or influencing factor is not enough to prevent marine ecosystem degradation and fishery resource exhaustion. A comprehensive, systematic, effective, and ecosystem-based management policy is imperative for healthy and sustainable fishery development in the East China Sea. | ZHAO ShuJiang Lü BaoQiang LI RuWei ZHU AiYi WU ChangWen | 2016 | Science China Earth Sciences2016，59，2： | 6 |
| 3 | Isolation via enrichment and characterization of ten polymorphic microsatellite loci in the cuttlefish, Sepiella maindroni de Rochebruns显示文摘Ten novel polymorphic microsatellite loci were developed using an enrichment and colony hybridization protocol and characterized for the cuttlefish,Sepiella maindroni.Polymorphism was explored by using 30 individuals from the coastal waters of Zhanjiang,Guangdong province,China,in December 2007.The number of alleles ranged from 5 to 13.The ranges of observed and expected heterozygosity were from 0.578 9 to 1.000 0 and 0.682 8 to 0.925 7,respectively,and the average polymorphic information content (P IC) was 0.778 5.These microsatellite loci will certainly facilitate the detection of the genetic variation and population structure of S.maindroni. | WU Changwen CHI Changfeng HE Guangyuan LU Zhenming XU Meiying | 2010 | Acta Oceanologica Sinica2010，29，6： | 6 |
| 4 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 5 | MATHEMATICAL MODEL OF OVERLAND FLOW AND MECHANISM OF SOIL CONSERVATION FOR FORESTED STEEP HILLSLOPE--(II)Mechanism of Soil Conservation Over Steep Hillslope显示文摘MATHEMATICALMODELOFOVERLANDFLOWANDMECHANISMOFSOILCONSERVATIONFORFORESTEDSTEEPHILLSLOPE--(II)MechanismofSoilConservationOverSt... | WU Changwen and WANG Lixian ( Science. Nanchang College of Water Resources and Hydro Power, 330029)( Dept of Soil and Water Conservation, Beijing Forestry University, 100083,PRC) | 1995 | International Journal of Sediment Research1995，10，2： | 4 |
| 6 | Fixed points and stability in neutural stochastic differential equations with variable delays 显示文摘 | Wu Meng Huang Nanjing Zhao Changwen | 2008 | Hindawi Pubilishing Corporation Fixed PointsTheory and Applications2008，11，： | 1 |
| 7 | A new hybrid DCT-wiener based interpolation scheme for video intra frame up-sampling 显示文摘 | Wu Zhenyu Yu Yongyang CHEN Changwen | 2010 | IEEE Signal Pro- cessing Letters2010，17，10： | 1 |
| 8 | Adsorption mechanism of comb polymer dispersants at the cement/ water interface显示文摘 | Ran Qianping Ponisseril Somasundaran Miao Changwen Liu Jiaping Wu Shishan Shen Jian | 2010 | Adsorption Mechanism of Comb Polymer Dispersants2010，31，6： | 1 |
| 9 | Collaborative Image Coding and Transmission over Wireless Sensor Networks显示文摘 | Min Wu ChangWen Chen | 2007 | EURASIP Joumal on Advances in Signal Processing2007，，1： | 1 |
| 10 | Dechlorination of perchloroethylene using zero-valent metal and microbial community显示文摘 | Changwen Ma Yanqing Wu | 2008 | Environmental Geology2008，，1： | 1 |
| 11 | Phylogenetic and molecular characterization of coxsackievirus A24variant isolates from a 2010acute hemorrhagic conjunctivitis outbreak in Guangdong,China显示文摘 | Wu De Zheng Huanying Li Hui Monagin Corina Guo Xue Liu Leng Zeng Hanri Fang Ling Mo Yanling Zhou Huiqiong Zhang Huan Kou Jing Long Caiyun Hiromu Yoshida and Ke Changwen | 2012 | Virol J2012，9，41： | 1 |
| 12 | Fixed points and stability in neutural stochastic differential equations with variable delays显示文摘 | WU Meng HUANG Nanjing ZHAO Changwen | 2008 | Hindawi Pubilishing Corporation Fixed Points Theory and Applications2008，11，2： | 1 |
| 13 | Dechlorination of perchloro- ethylene using zero-valentmatal and microbial community 显示文摘 | Ma Changwen Wu Yanqing | 2008 | Environ Geol2008，55，： | 1 |
| 14 | Effect of the length of the side chains of comb-like copolymer dispersants on dispersion and rheological properties of concentrated cement suspensions显示文摘 | Qianping Ran Ponisseril Somasundaran Changwen Miao Jiaping Liu Shishan Wu Jian Shen | 2009 | Journal of Colloid And Interface Science2009，，2： | 1 |
| 15 | Dechlorination of perchloroet-hylene using zero-valent metal and microbial community显示文摘 | Ma Changwen Wu Yangqing | 2008 | Environment Geological2008，55，： | 1 |
| 16 | Incorporating CuInS 2 quantum dots into polymer/oxide-nanoarray system for efficient hybrid solar cells显示文摘 | Wenjin Yue Fan Wu Changwen Liu Zeliang Qiu Qi Cui Hui Zhang Feng Gao Wei Shen Qiquan Qiao Mingtai Wang | 2013 | Solar Energy Materials and Solar Cells2013，，： | 1 |
| 17 | Prognostic significance of PD-L1 expression in patients with colorectal cancer: a meta-analysis显示文摘Background The association between the expression of programmed cell death 1(PD-1) or its ligand [programmed cell death ligand-1(PD-L1)] and colorectal cancer(CRC) survival rates remains unclear. Thus, we conducted a meta-analysis to investigate the prognostic value of PD-L1 expression in CRC patients.Methods All eligible studies related to evaluation of PD-L1 expression and survival of CRC patients were searched in PubMed, Medline, Cochrane library, and the EMBASE database. Hazard ratios(HRs) and 95% confidence intervals(CI) of overall survival(OS) were examined to assess the effect of PD-L1 expression on the survival of CRC patients. The outcomes of this meta-analysis were synthesized based on randomeffects model. Subgroup analyses were also performed. Results Seven studies, wherein OS data were stratified according to the expression status of PD-L1, were analyzed. CRC patients showing positive PD-L1 expression were associated with significantly poorer prognoses in terms of overall survival, compared with those displaying negative PD-L1 expression(HR = 1.43, 95% CI: 1.07–1.92; P = 0.02). In the subgroup analyses, H-scores as well as the percentage of stained cells indicated that PD-L1 expression was significantly associated with poor prognosis(HR = 1.90, 95% CI: 1.38–2.62, P < 0.01; HR = 1.81, 95% CI: 1.08–3.03, P = 0.02). Immunohistochemical staining, utilizing a rabbit anti-PD-L1 antibody, revealed significantly superior survival in the PD-L1 negative group compared with the PD-L1 positive expression group(HR = 1.92; 95% CI, 1.40-2.63; P < 0.01). Moreover, PD-L1 expression was significantly associated with poor prognosis when polyclonal antibodies were used(HR = 1.84; 95% CI, 1.30–2.61; P < 0.01). Conclusion Our meta-analysis indicated that PD-L1 expression status is a significant prognostic factor for CRC patients. Positive PD-L1 expression was associated with worse CRC survival. Evaluation via different immunohistochemistry based techniques may partly account for the contradictory results. Therefore, further investigative studies using larger sample sizes are felt to be needed to elucidate the prognostic value of PD-L1 expression in CRC patients. | Siwen Liu Rong Ma Haixia Cao Dan Chen Changwen Jing Zhuo Wang Junying Zhang Yang Wu Jifeng Feng Jianzhong Wu | 2019 | Oncology and Translational Medicine2019，5，2： | 1 |
| 18 | Genomic analysis provides insights into the westward expansion of domesticated peaches in China显示文摘Peach, an economically important model plant of the Rosaceae family, has been domesticated and cultivated in China for approximately5 000 years. The Hexi Corridor, an important corridor connecting east-central China and the Tarim Basin, is the starting point of the Silk Road that links China and the Eurasian region. As a globally distributed fruit tree, the spread of peach was accomplished through historical trade routes in the Hexi Corridor and the Tarim Basin. However, knowledge of peach genetic diversity in these regions remains limited. In this study,we examined the relationships and the spread history of domesticated peaches through sequencing and genomic analysis of 161 peach accessions collected from Northwest China, including 43 from the Hexi Corridor and 104 from the Tarim Basin. The results indicate that peach landraces in the Hexi Corridor and the Tarim Basin are derivatives of peaches from the east and south of China (ESC). Notably, the genetic diversity of accessions from both the Hexi Corridor and the Tarim Basin was lower than that of ESC accessions. Reduction of diversity (ROD) and linkage disequilibrium (LD) analyses detected a genetic bottleneck in peaches from these regions. Additionally, these peaches have undergone varying degrees of selection from natural environment. Moreover, genes responsive to biotic and abiotic stresses were under selection, which could be the result of the climate change of Northwest China after the Last Glacial Maximum (LGM). Our findings provide a better understanding of the genetic basis of peach migration in Northwest China. Furthermore, this study expands the available genomic data for peaches and provides critical information for future peach breeding programs. | Wenqing Li Yong Li Xinwei Wang Guoqing Zhao Gengrui Zhu Ke Cao Weichao Fang Jinlong Wu Kai Ma Changwen Chen Lirong Wang | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 19 | Development of a novel two-stage proportional valve with a pilot digital flow distribution显示文摘Pilot two-stage proportional valves are widely used in high-power hydraulic systems. For the purpose of improving the dynamic performance, reliability, and digitization of the traditional proportional valve, a novel two-stage proportional valve with a pilot digital flow distribution is proposed from the viewpoint of the dual nozzle-flapper valve’s working principle. In particular, the dual nozzle-flapper is decoupled by two high-speed on/off valves (HSVs). First, the working principle and mathematical model of the proposed valve are determined. Then, the influences of the control parameters (duty cycle and switching frequency) and structural parameters (fixed orifice’s diameter and main valve’s spring) on the main valve’s motion are analyzed on the basis of theory, simulation, and experiment. In addition, in optimizing the value of the fixed orifice’s diameter, a new design criterion that considers the maximum pressure sensitivity, flow controllability, and flow linearization is proposed to improve the balance between the effective displacement and the displacement fluctuation of the main valve. The new scheme is verified by simulations and experiments. Experimental results of the closed-loop displacement tracking have demonstrated that the delay time of the main valve is always within 3.5 ms under different working conditions, and the tracking error can be significantly reduced using the higher switching frequency. The amplitude–frequency experiments indicate that a −3 dB-frequency of the proposed valve can reach 9.5 Hz in the case of ±50% full scale and 15 Hz in the case of 0%–50% full scale. The values can be further improved by increasing the flow rate of the pilot HSV. | Qiang GAO Yuchuan ZHU Changwen WU Yulei JIANG | 2021 | Frontiers of Mechanical Engineering2021，16，2： | 0 |
| 20 | Syntheses and Properties of K_17[Ln(CuW_11O_39)_2]·xH_2O显示文摘Heteropoly-complexes K17[Ln(CuW11O39)2].xH2O(Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Dy) were prepared. The properties of the products were investigated by ion-exchange, conductometric titration, IR, UV and X-ray powder diffraction. The results show that the structure of the products is similar to that of U(a-Ge11O39)2 and consistent with the model proposed by Peacock. | Wang Enbo, Wu Qingyin, Huang Rudan and Hu Changwen (Department of Chemistry, Northeast Normal University, Changchun) | 1990 | Chemical Research in Chinese Universities1990，6，2： | 0 |
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