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| 1 | Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant显示文摘Treatment of implant-associated infection is becoming more challenging,especially when bacterial biofilms form on the surface of the implants.Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter.In this work,TiO2 nanorod arrays in combination with irradiation with 808 nearinfrared(NIR)light are proven to eradicate single specie biofilms by combining photothermal therapy,photodynamic therapy,and physical killing of bacteria.The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species(ROS).Physiologically,the combined actions of hyperthermia,ROS,and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo.More importantly,bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time,the TiO2 nanorod arrays improve the new bone formation around implants.In this protocol,besides the biocompatible TiO2 nanorod arrays,an extra photosensitizer is not needed and no other ions would be released.Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation.The concept and antibacterial system described here have large clinical potential in orthopedic and dental applications. | Xiangyu Zhang Guannan Zhang Maozhou Chai Xiaohong Yao Weiyi Chen Paul KChu | 2021 | Bioactive Materials2021，6，1： | 7 |
| 2 | The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B显示文摘OCT4 is one of the key transcription factors in maintaining the pluripotency and self-renewal of embryonic stem (ES) cells.Human OCT4 can generate two isoforms OCT4A and OCT4B by alternative splicing.OCT4B1 is a recently discovered novel OCT4 spliced variant,which has been considered as a putative marker of stemness.Compared with the OCT4B mRNA,OCT4B1 mRNA is generated by retaining intron 2 as a cryptic exon which contains a TGA stop codon in it.As a result,the protein product of OCT4B1 mRNA could be truncated.Interestingly,we present here that OCT4B1 can indirectly produce the same protein products as OCT4B.We have demonstrated that OCT4B1 mRNA can be spliced into OCT4B mRNA,and encode three protein isoforms.The splicing of OCT4B1 mRNA into OCT4B mRNA can be remarkably inhibited by the mutation of the classical splicing site.Our result suggests that OCT4B mRNA may originate from OCT4B1 mRNA by alternative splicing. | Yuan Gao Xia Wang Jin Han Zhifeng Xiao Bing Chen Guannan Su Jianwu Dai | 2010 | Journal of Genetics and Genomics2010，37，7： | 6 |
| 3 | Application of butane geochemistry of natural gas in hydrocarbon exploration显示文摘In order to distinguish the source and migration direction of natural gas by geochemical characteristics of butane,the components and carbon isotopes of natural gas from major hydrocarbonbearing basins in China were analyzed.The results showed that:(1) Oil-type gas has i-C 4 /n-C 4 <0.8,δ 13 C butane <-28‰,δ 13 C i-butane <-27‰,δ 13 C n-butane <-28.5‰,whereas coal-type gas has i-C 4 /n-C 4 >0.8,δ 13 C butane >-25.5‰,δ 13 C i-butane >-24‰,δ 13 C n-butane >-26‰.(2) When δ 13 C i-butane-δ 13 C n-butane is greater than 0,the maturity of oil-type gas is generally more than 2.4% and that of coal-type gas is greater than 1.4%,whereas when the difference is less than 0,the maturity of oil-type gas is generally less than 1.1% and that of coal-type gas is less than 0.8%.(3) When natural gas migrates through dense cap rocks,the value of i-C 4 /n-C 4 increases,whereas when it migrates laterally along a reservoir,the value of i-C 4 /n-C 4 decreases.(4) Sapropelic transition zone gas with composition and carbon isotopic signatures similar to those of oil-type gas in the low thermal evolution stage is found to have a relatively high butane content.(5) The values of i-C 4 /n-C 4 and δ 13 C n-butane δ 13 C i-butane of gas which has suffered biological degradation are significantly higher than those obtained from thermogenic and bio-thermocatalytic transition zone gas.Thus,natural gas of different genetic types can be recognized through component analysis and carbon isotopic signatures of butane,the natural gas maturity can be estimated from the difference in carbon isotopic content between isobutane and n-butane,and the migration direction of natural gas can be determined from i-C 4 /n-C 4 ratios and transport conditions,which can also be used to thermogenic and bio-thermocatalytic transition zone gas. | Miao Zhongying Chen Jianfa Wang Jing Wang Guannan ZhangChen Li Wei | 2012 | Petroleum Science2012，9，4： | 3 |
| 4 | Clinical characteristics and risk factors for mortality in cancer patients with COVID-19显示文摘Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109(3.4%)cancer patients were included in this study.Among them,23(21.1%)patients died in the hospital.Cancer patients,especially those with hematological malignancies(41.6%),urinary carcinoma(35.7%),malignancies of the digestive system(33.3%),gynecological malignancies(20%),and lung cancer(14.3%),had a much higher mortality than patients without cancer.A total of 19(17.4%)cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening(NRS2002)score≥3(adjusted hazard ratio(HR)11.00;95%confidence interval(CI)4.60–26.32;P<0.001),high-risk type(adjusted HR 18.81;95%CI 4.21–83.93;P<0.001),tumor stage IV(adjusted HR 4.26;95%CI 2.34–7.75;P<0.001),and recent adjuvant therapy(<1 month)(adjusted HR 3.16;95%CI 1.75–5.70;P<0.01)were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score≥3,advanced tumor stage,and recent adjuvant therapy(<1 month)may have high risk of mortality. | Junnan Liang Guannan Jin Tongtong Liu Jingyuan Wen Ganxun Li Lin Chen Wei Wang Yuwei Wang Wei Liao Jia Song Zeyang Ding Xiao-ping Chen Bixiang Zhang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 5 | Genomic Epidemiology of Carbapenemaseproducing Klebsiella pneumoniae in China显示文摘The rapid spread of carbapenemase-producing Klebsiella pneumoniae(cpKP)poses serious threats to public health;however,the underlying genetic basis for its dissemination is still unknown.We conducted a comprehensive genomic epidemiology analysis on 420 cpKP isolates collected from 70 hospitals in 24 provinces/autonomous regions/municipalities of China during 2009–2017 by short-/long-read sequencing.The results showed that most cpKP isolates were categorized into clonal group 258(CG258),in which ST11 was the dominant clone.Phylogenetic analysis revealed three major clades including the top one of Clade 3 for CG258 cpKP isolates.Additionally,carbapenemase gene analysis indicated that blaKPC was dominant in the cpKP isolates,and most blaKPC genes were located in five major incompatibility(Inc)groups of blaKPC-harboring plasmids.Importantly,three advantageous combinations of host–blaKPC-carrying plasmid(Clade 3.1+3.2–IncFIIpHN7A8,Clade 3.1+3.2–IncFIIpHN7A8:IncR,and Clade 3.3–IncFIIpHN7A8:IncpA1763-KPC)were identified to confer cpKP isolates the advantages in both genotypes(strong correlation/coevolution)and phenotypes(resistance/growth/competition)to facilitate the nationwide spread of ST11/CG258 cpKP.Intriguingly,Bayesian skyline analysis illustrated that the three advantageous combinations might be directly associated with the strong population expansion during 2007–2008 and subsequent maintenance of the population of ST11/CG258 cpKP after 2008.We then examined drug resistance profiles of these cpKP isolates and proposed combination treatment regimens for CG258/non-CG258 cpKP infections.Thus,the findings of our systematical analysis shed light on the molecular epidemiology and genetic basis for the dissemination of ST11/CG258 cpKP in China,and much emphasis should be given to the close monitoring of advantageous cpKP–plasmid combinations. | Cuidan Li Xiaoyuan Jiang Tingting Yang Yingjiao Ju Zhe Yin Liya Yue Guannan Ma Xuebing Wang Ying Jing Xinhua Luo Shuangshuang Li Xue Yang Fei Chen Dongsheng Zhou | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 6 | Fabrication and characterization of Ba Ce_(0.8)Y_(0.2)O_(2.9)-Ce_(0.85)Sm_(0.15)O_(1.925) composite electrolytes for IT-SOFCs显示文摘The Ba Ce0.8Y0.2O2.9-Ce0.85Sm0.15O1.925 composite electrolytes were prepared with Ba Ce0.8Y0.2O2.9(BCY) and Ce0.85Sm0.15O1.925(SDC). The SDC and BCY powders were mixed in the weight ratio of 95:5, 85:15, and 75:25, respectively(named as BS95, BS85, and BS75). Because of the composite effect between the SDC and BCY phases, the BS95 and BS85 exhibit improved conductivity compared with the pure SDC and BCY. The conductivity of BS95 is higher than that of BS85, indicating that the composite effect of BS95 is greater than that of BS85. Nevertheless, the composite effect in BS75 does not exist. Hence, we conclude that the composite effect in the BCY-SDC composites will decrease with the increase of the amount of BCY and even disappear when the amount of BCY exceeds a certain value. In our case, the optimum composition of the composite electrolyte is 95 wt% SDC and 5 wt% BCY. The BS95 has the highest conductivity(σ1t=0.07808 S cm-1, at 800 °C) and the fuel cell based on the BS95 shows the best performance(the maximum power density reaches as high as 526 mw cm-2 at 750 °C). The encouraging results suggest that the BCY-SDC composites are the very promising electrolyte materials for IT-SOFCs. | Ji Yu Ning Tian Yufu Deng Guannan Li Ling Liu Liying Cheng Peng Gao Qingchao Pan Yuancheng Wang Xiuyan Chen Kezhen Qi | 2015 | Science China Chemistry2015，58，3： | 1 |
| 7 | Aqueous-based polyurethane with dual-functional curing agent显示文摘 | Chihhao Shao Tazen Wang Guannan Chen Kweiju Chen Jentaut Yeh Kannan Chen | 2000 | Journal of Polymer Research2000，7，1： | 1 |
| 8 | Primary study of temperature distribution measurement in stored grain based on acoustic tomography显示文摘 | Yan Hua Chen Guannan Zhou Yinggang | 2012 | Experimental Thermal and Fluid Science2012，42，10： | 1 |
| 9 | Over‐expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial–mesenchymal transition in hepatocellular carcinoma cells显示文摘 | Minghua Hu Xiaobing Chen Jianmin Zhang Dong Wang Xiaosan Fang Xiaoming Wang Guannan Wang Guoyong Chen Xiaochun Jiang Hongping Xia Yongsheng Wang | 2013 | J Surg Oncol2013，，3： | 1 |
| 10 | Influence of bubbles on the segregated stability of fine coal in a vibrated dense medium gas-solid fluidized bed显示文摘In this paper,the variation of bubble size and number in the separation process of vibrated fluidized bed as well as the influence of bubble movement on the axial distribution of fine coal in different positions of the bed were studied.The result revealed that the size and number of bubbles is correlated with the fine coal separation effect in the separation process.When the bed is in a uniform and stable fluidized state,the size of bubbles in the separation process was in the range of 1-2.5 cm and the number of bubbles was reduced by nearly 50%,which is helpful to promote the stratification and segregation of fine coal.Thereby,after separation,the ash content of refined coal products of anthracite and 1/3 coking coal was reduced to 12.1% and 23.7% respectively,and the content of refined coal was up to 42.5% and 68.5% respectively,which show that the vibrated fluidized bed has a good separation performance,and can separate efficiently the coal of size−6+1 mm. | Enhui Zhou Yadong Zhang Yuemin Zhao Qingqing Tian Zengqiang Chen Guannan lv Xuliang Yang Liang Dong Chenlong Duan | 2021 | Particuology2021，19，5： | 1 |
| 11 | PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice显示文摘 | Liyang Wang Mingsheng Zhao Chun Guo Guannan Wang Faliang Zhu Jianing Wang Xiaoyan Wang Qun Wang Wei Zhao Yongyu Shi Youhai H. Chen Lining Zhang | 2016 | Inflammatory Bowel Diseases2016，，： | 1 |
| 12 | Dual - curing of anionic aqueous - based polyurethane at ambient temperature 显示文摘 | Chen guannan Chen Kannan | 1998 | J Appl Poly Sci1998，67，9： | 1 |
| 13 | Ex- perimental study of sound travel-time estimation method in stored grain 显示文摘 | Yan Hua Chen Guannan Zhou Yinggang | 2012 | J Comput2012，7，4： | 1 |
| 14 | Pri- mary study of temperature distribution measurement in stored grain based on acoustic tomography 显示文摘 | Yan Hua Chen Guannan Zhou Yinggang | 2012 | Exp Therm Fluid Sci2012，42，10： | 1 |
| 15 | Primary study of temperature distribution measurement in stored grain based on acoustic tomography显示文摘 | Hua Yan Guannan Chen Yinggang Zhou Lijun Liu | 2012 | Experimental Thermal and Fluid Science2012，，： | 1 |
| 16 | Experimental Study of Sound Travel-Time Estimation Method in Stored Grain显示文摘 | Hua Yan Guannan Chen Yinggang Zhou Lijun Liu | 2012 | Journal of Computers2012，，4： | 1 |
| 17 | Tlx1/3 and Ptf1a Control the Expression of Distinct Sets of Transmitter and Peptide Receptor Genes in the Developing Dorsal Spinal Cord显示文摘 | Zhen Guo Congling Zhao Menggui Huang Tianwen Huang Mingran Fan Zhiqin Xie Ying Chen Xiaolin Zhao Guannan Xia Junlan Geng Leping Cheng | 2012 | Journal of Neuroscience2012，，： | 1 |
| 18 | Self-curing behaviors of single pack aqeous-based polyurethane system显示文摘 | Chen Guannan Chen Kannan | 1997 | Journal of Applied Polymer Science1997，63，12： | 1 |
| 19 | Effect of Yinlai Decoction on the metabolic pathways in the lung of high-calorie diet-induced pneumonia rats显示文摘Objective:To search for specific metabolites in the lungs of pneumonia rats fed with a high-calorie diet,as well as explore the changes in the lung metabolites of young rats treated with Yinlai Decoction(YD)and its effects on inflammation-related metabolic pathways.Methods:Lipopolysaccharides(LPS)and a special high-calorie diet were used to induce Sprague Dawley(SD)rats to simulate the intestinal state of infant pneumonia.Liquid chromatography-mass spectrometry technology(LC-MS/MS)was used to detect metabolites in each group.Supervised orthogonal partial least squares discriminant analysis(OPLS-DA)model values were used for the detection results to find the differential metabolites.The metabolic pathways that are involved with the differential metabolites were clarified through enrichment analysis and topological analysis.Finally,the T cell receptor signaling pathway(TCR)signal conversion was analyzed by the network pharmacology method.Results:In the high-calorie diet combined with pneumonia group(M3),a total of 55 metabolites were determined to be different from the normal group(N).A total of 36 metabolites were determined to be different from those in the lung metabolites of the YD treatment group(T1).YD had a regulatory effect on glutathione metabolism,arginine and proline metabolism,ascorbic acid and aldehyde metabolism and phenylalanine metabolism.And the small molecule metabolites could act on the FYN and lymphocytespecific protein tyrosine kinase(LCK)target proteins in the TCR signaling pathway,thereby affecting the immune function of the lungs.Conclusion:A high-calorie diet can cause abnormal sphingolipid metabolism in the lungs of young rats,thereby creating chronic lung inflammation in young rats.YD has a beneficial effect when used to treat young rats with LPS-induced pneumonia fed on high-calorie diets.Its mechanisms of action may affect the body’s immune pathways by regulating the oxidative stress pathway affected by glutathione metabolism. | Fuyang Xian Tiegang Liu Chen Bai Guannan Yang Xueyan Ma Bochuan Wang Ling Huang Shaoyang Liu Jianhua Zhen Jianzhen He He Yu Yuling Ma Taiyi Wang Xiaohong Gu | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 1 |
| 20 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
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