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| 1 | Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue显示文摘Excess lipid storage in adipose tissue results in the development of obesity and other metabolic disorders including diabetes,fatty liver and cardiovascular diseases.The lipid droplet(LD)is an important subcellular organelle responsible for lipid storage.We previously observed that Fsp27,a member of the CIDE family proteins,is localized to LD-contact sites and promotes atypical LD fusion and growth.Cidea,a close homolog of Fsp27,is expressed at high levels in brown adipose tissue.However,the exact role of Cidea in promoting LD fusion and lipid storage in adipose tissue remains unknown.Here,we expressed Cidea in Fsp27-knockdown adipocytes and observed that Cidea has similar activity to Fsp27 in promoting lipid storage and LD fusion and growth.Next,we generated Cidea and Fsp27 double-deficient mice and observed that these animals had drastically reduced adipose tissue mass and a strong lean phenotype.In addition,Cidea/Fsp27 double-deficient mice had improved insulin sensitivity and were intolerant to cold.Furthermore,we observed that the brown and white adipose tissues of Cidea/Fsp27double-deficient mice had significantly reduced lipid storage and contained smaller LDs compared to those of Cidea or Fsp27single deficient mice.Overall,these data reveal an important role of Cidea in controlling lipid droplet fusion,lipid storage in brown and white adipose tissue,and the development of obesity. | WU LiZhen ZHOU LinKang CHEN Cheng GONG JingYi XU Li YE Jing LI De LI Peng | 2014 | Science China(Life Sciences)2014，57，1： | 11 |
| 2 | The effect of Scuteilaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats显示文摘Flavonoids 被显示了改进认知功能并且推迟痴呆前进。然而,内在的机制留下逃犯。在现在的学习,我们检验了从 S 提取的黄芩 baicalensis 茎叶总数 flavonoids (SSTF ) 的效果。在脉管的痴呆(VaD ) 的空间学习和记忆上的 baicalensis Georgi 老鼠模型并且探索了它的分子的机制。VaD 老鼠被普通颈动脉动脉的永久双边的吸藏开发。在恢复以后的七天, VaD 老鼠与 SSTF 的 50 或 100 mg/kg 被对待 60 天。空间学习和记忆在莫利斯舞水迷宫(MWM ) 被评估测试。字形物 hyperphosphorylation 和相关蛋白质 kinases 或磷酸酶的层次被西方的污点分析检验。在 VaD 老鼠,在 100 mg/kg 的 SSTF 处理显著地在在 MWM 测试训练试用减少了逃跑潜伏。在探针试用, SSTF 治疗在目标象限增加了寻找的时间和旅行距离。SSTF 处理在 VaD 老鼠在外皮和马头鱼尾的怪兽禁止了字形物 phosphorylation。同时, SSTF 减少了肝糖 synthase kinase 的活动 3 并且 cyclin 依赖的 kinase 5 在 VaD 老鼠。相反, SSTF 处理在 VaD 老鼠增加了蛋白质磷酸酶 2A 子单元 B 的水平。SSTF 处理显著地在 VaD 老鼠改进了空间认知。我们的结果建议 SSTF 可以通过在击以后协调 kinases 和磷酸酶的活动减轻 tau-hyperphosphorylation-induced neurotoxicity。SSTF 可以为 VaD 被开发进有希望的新奇治疗学。 | Yanjing Cao Lizhen Liang Jian Xu Jiali Wu Yongxing Yan Ping Lin Qiang Chen Fengming Zheng Qin Wang Qian Ren Zengmei Gou Yifeng Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 3 | Non-covalently Functionalized Graphene Oxide-Based Coating to Enhance Thermal Stability and Flame Retardancy of PVA Film显示文摘The synergistic effect of conventional flame-retardant elements and graphene has received extensive attention in the development of a new class of flame retardants. Compared to covalent modification, the noncovalent strategy is simpler and expeditious and entirely preserves the original quality of graphene. Thus, non-covalently functionalized graphene oxide(FGO) with a phosphorus–nitrogen compound was successfully prepared via a one-pot process in this study. Polyethyleneimine and FGO were alternatively deposited on the surface of a poly(vinyl alcohol)(PVA) film via layer-by-layer assembly driven by electrostatic interaction, imparting excellent flame retardancy to the coated PVA film. The multilayer FGO-based coating formed a protective shield encapsulating the PVA matrix, effectively blocking the transfer of heat and mass during combustion. The coated PVA has a higher initial decomposition temperature of about 260 °C and a nearly 60% reduction in total heat release than neat PVA does. Our results may have a promising prospect for flame-retardant polymers. | Wenhua Chen Pengju Liu Lizhen Min Yiming Zhou Yuan Liu Qi Wang Wenfeng Duan | 2018 | Nano-Micro Letters2018，10，3： | 8 |
| 4 | Jiaweisinisan facilitates neurogenesis in the hippocampus after stress damage显示文摘The traditional Chinese medicine Jiaweisinisan has antidepressant effects, and can inhibit hypothalamus-pituitary-adrenal gland axis hyperactivity in stress-induced depression. In this study, rat hippocampal neural precursor cells were cultured in serum-free medium in vitro and a stress damage model was established with 120 μM corticosterone. Cells were treated with 10% (v/v) Jiaweisinisan drug-containing serum and the corticosterone antagonist RU38486. Results of the 3-(4,5-dimethylthiazol-2-yl)-3,5-di-phenytetrazoliumromide assay showed that both Jiaweisinisan drug-containing serum and RU38486 promoted the proliferation of neural precursor cells after corticosterone exposure. Immunofluorescence detection showed that after Jiaweisinisan drug-containing serum and RU38486 treatment, the 5-bromo-2-deoxyuridine/terminal deoxynucleotidyl transferase dUTP nick end labeling ratio in hippocampal neural precursor cells significantly increased, and the apoptotic rates of glial cells reduced, and neuron-like cell differentiation from neural precursor cells significantly increased. Our experimental findings indicate that Jiaweisinisan promotes hippocampal neurogenesis after stress damage. | Lili Wu Chuanlian Ran Shukao Liu Lizhen Liao Yanling Chen Hualei Guo Weikang Wu Can Yan | 2013 | Neural Regeneration Research2013，8，12： | 7 |
| 5 | Solubility and metastable zone width measurement of 3,4-bis (3-nitrofurazan-4-yl) furoxan (DNTF) in ethanol + water显示文摘The solubility and supersolubility of 3,4-bis(3-nitrofurazan-4-yl)furoxan(DNTF) in ethanol + water at different operation were determined by laser monitoring system under atmospheric pressure to study the metastable zone width(MSZW). The modified Apelblat equation was adopted to correlate the experimental solubility data, and the correlation result showed perfect consistent with the experimental data. The standard dissolution enthalpy, standard dissolution entropy and Gibbs energy were calculated according to the experimental solubility data. The effect of the cooling rate, stirring rate, temperature and the concentration of ethanol + water on the MSZW was studied. It was found that the MSZW of DNTF increased with the increasing cooling rate, decreasing temperature, decreasing stirring rate and decreasing ratio of water. And the apparent nucleation order of DNTF in ethanol + water was calculated by the relationship between the cooling rate and the MSZW. | Lizhen Chen Liang Song Guanchao Lan Jianlong Wang | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 7 |
| 6 | Clinical applications of free medial tibial flap with posterior tibial artery for head and neck reconstruction after tumor resection显示文摘Tumor resection causes damage in the head and neck which creates problems in swallowing, chewing, articulation,and vision, all of which seriously affect patients' quality of life. In this work, we evaluated the application of a free medial tibial flap in reconstruction of head and neck defects after tumor resection. We discussed the anatomy,surgical technique, and the advantages and disadvantages of the flap. We found several benefits for the flap, such as,it is especially effective for the defects that require thin-layer epithelium to cover or the separated soft tissue defect;a two-team approach can be used because the donor site is far away from the head and neck; and the flap is easy to integrate because of the subcutaneous fat layer of the free medial tibial flap is thin and the flap is soft. Thus, the medial tibial flap could replace the forearm flap for certain applications. | Qi Zhong Jugao Fang Zhigang Huang Xiaohong Chen Lizhen Hou Yang Zhang Pingdong Li Hongzhi Ma Hongbo Xu | 2017 | Chinese Journal of Cancer Research2017，29，3： | 5 |
| 7 | Experimental determination of solubilities and'supersolubilities of 2,2',4,4',6,6'-hexanitrostilbene in different organic solvents显示文摘The laser monitor technique was used to determine solubilities and supersolubilities of HNS in N,N-dimethylformamide, dimethyl sulfoxide, acetonitrile, N-methyl-2-pyrrolidone and 1,4-butyrolactone. The experimental solubility values were correlated with λh equation, modified Apelblat equation and NRTL model. Furthermore, the dissolution enthalpy, dissolution entropy and the Gibbs energy of HNS were calculated by the experimental data. The results show that the solubilities of HNS in the above solvents increase with the increasing temperature. Besides, at the same temperature, the order of solubility is N-methyl-2-pyrrolidone > dimethyl sulfoxide > N,N-dimethylformamide > 1,4-butyrolactone > acetonitrile. The temperature dependence of predicted solubility is in agreement with the experimental data. | Lizhen Chen Liang Song Yupeng Gao Aipeng Zhu Duanlin Cao | 2017 | Chinese Journal of Chemical Engineering2017，25，6： | 4 |
| 8 | A Hierarchically Porous Metal-Organic Framework from Semirigid Ligand for Gas Adsorption显示文摘层次地多孔的材料在便于集体运输和吸附和分离过程的改善效率起一个重要作用。在这份报纸,新策略被建议认识到一个层次地多孔的金属器官的框架([Cu 2(OH)(L)]·(DMF)0.8(FJU-11, H 3L=3,5-(4-carboxybenzyloxy ) 安息香的酸, DMF=N, N-dimethylformamide ) 经由使用半硬的多羧基的酸。有趣地, FJU-11 向公司 2 拥有大吸附能力和小 isosteric 热。为 FJU-11 的列突破实验在烟道气体的分离加亮它的潜在的申请。 | Lizhen Liu Yingxiang Ye Zizhu Yao Liuqin Zhang Ziyin Li Lihua Wang Xiuling Ma Qian-Huo Chen Zhangjing Zhang Shengchang Xiang | 2016 | Chinese Journal of Chemistry2016，34，2： | 4 |
| 9 | Diagonal-symmetrical and Midline-symmetrical Unit Cells with Same Porosity for Bone Implant: Mechanical Properties Evaluation显示文摘In this study, mechanical properties of bionic porous structures with diagonal-symmetrical and midline-symmetrical unit cells were studied when the porosities were same. Three typical unit cells (Diamond (DO), Rhombic Dodecahedron (RD), and Octet Truss (OT)) were selected, in which DO has diagonal-symmetrical shape, while RD and OT share midline-symmetrical structure. Based on the same porosity, corresponding models were designed, and Ti6Al4V samples were manufactured by electron beam melting. Then, using Mechanical Properties Testing (MPT) and Finite Element Analysis (FEA) methodologies, mechanical properties and transmissions of different porous structures were evaluated. Besides, composition and details before and after printing were analyzed with Energy Dispersive Spectrometer (EDS), X-ray diffraction (XRD) and Scanning Electron Microscope (SEM). MPT results showed that midline-symmetrical shape would have superior compressive performance than diagonal-symmetrical shape, but opposite trend for the torsion performance, which were in line with FEA prediction. Furthermore, effective modulus of DO, RD and OT were 2.59 GPa, 4.89 GPa, and 1.77 GPa, approximating the mechanical properties of human bones. Additionally, manufacturing defects and discrepancies between FEA and MPT were found. This study would provide great helps for unit cell selection and initial mechanical properties matching for optimum bone implants. | Jian Li Diansheng Chen Yingying Zhang Yan Yao Zhongjun Mo Lizhen Wang Yubo Fan | 2019 | Journal of Bionic Engineering2019，16，3： | 4 |
| 10 | Severe drought strongly reduces water use and its recovery ability of mature Mongolian Scots pine(Pinus sylvestris var. mongolica Litv.) in a semi-arid sandy environment of northern China显示文摘Trees growing in a semi-arid sandy environment are often exposed to drought conditions due to seasonal variations in precipitation, low soil water retention and deep groundwater level.However, adaptability and plasticity of individuals to the changing drought conditions greatly vary among tree species.In this study, we estimated water use(Ts) of Mongolian Scots pine(MSP;Pinus sylvestris var.mongolica Litv.) based on sap flux density measurements over four successive years(2013–2016) that exhibited significant fluctuations in precipitation in a semi-arid sandy environment of northern China.The results showed that fluctuations in daily Ts synchronously varied with dry-wet cycles of soil moisture over the study period.The daily ratio of water use to reference evapotranspiration(Ts/ET0) on sunny days in each year showed a negative linear relationship with the severity of drought in the upper soil layer(0–1 m;P<0.01).The decrease in Ts induced by erratic drought during the growing season recovered due to precipitation.However, this recovery ability failed under prolonged and severe droughts.The Ts/ET0 ratio significantly declined with the progressive reduction in the groundwater level(gw) over the study period(P<0.01).We concluded that the upper soil layer contributed the most to the Ts of MSP during the growing season.The severity and duration of droughts in this layer greatly reduced Ts.Nevertheless, gw determined whether the Ts could completely recover after the alleviation of long-term soil drought.These results provide practical information for optimizing MSP management to stop ongoing degradation in the semi-arid sandy environments. | DANG Hongzhong ZHANG Lizhen YANG Wenbin FENG Jinchao HAN Hui CHEN Yiben | 2019 | Journal of Arid Land2019，11，6： | 4 |
| 11 | Top-k probabilistic prevalent co-location mining in spatially uncertain data sets显示文摘 | Lizhen WANG Jun HAN Hongmei CHEN Junli LU | 2016 | Frontiers of Computer Science2016，10，3： | 4 |
| 12 | Simultaneous knockdown of p18^INK4C, p27^Kip1 and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow cells in vitro显示文摘外来的造血的生长管理者的联合例如干细胞因素(SCF ) , interleukin (IL )-3 和 IL-6,能导致静止造血的干细胞(HSC ) 的分割,但是它通常损害 HSC 的自强能力。然而,内在的否定房间周期管理者,例如 p18 INK4c (p18 ) p27 Kip1 (p27 ) 和 MAD1,能调整 HSC 的自强。它是未知的是否一些外来的管理者的移动并且经由 RNA 干扰(RNAi ) 的内在的否定房间周期管理者击倒导致 HSC 的前 vivo 扩大。探讨这个问题, lentiviral 基于向量的 RNAi 工具被开发生产小 RNA 的二个拷贝指向多重基因到击倒内在的否定房间周期管理者 pl8, p27 和 MAD1。形成殖民地的房间,长期的开始文化的房间(LTC-IC ) 和嫁接试金被用来评估外来、内在的管理者的效果。结果证明有仅仅 SCF 的媒介,但是没有 IL-3 和 IL-6,能维持 sca-1 + 有高 LTC-IC 的 c 工具包 + 骨头髓房间频率和低房间分割。不管多么 sca-1 +c 工具包 + 骨头髓房间在有仅仅 SCF 的媒介是有教养的并且同时经由 lentiviral 将 pl8, p27 和 MAD1 的表示击倒基于向量的 RNAi,房间展出了两高 LTC-IC 频率和高房间分割,不过,嫁接失败了。因此,同时有仅仅 SCF 的媒介的 pl8, p27 和 MAD1 击倒尽管有嫁接的损失,能导致 LTC-IC 扩大能力。 | Yan-Yi Wang Yong Yang Qingyong Chen Jianping Yu Yongzhong Hou Lizhen Han Jun He Demin Jiao Huihui Yu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 3 |
| 13 | COMPARING PERFORMANCE OF CROP SPECIES MIXTURES AND PURE STANDS显示文摘Intercropping is the planned cultivation of species mixtures on agricultural land.Intercropping has many attributes that make it attractive for developing a more sustainable agriculture,such as high yield,high resource use efficiency,lower input requirements,natural suppression of pests,pathogens and weeds,and building a soil with more organic carbon and nitrogen.Information is needed which species combinations perform best under different circumstances and which management is suitable to bring out the best from intercropping in a given production situation.The literature is replete with case studies on intercropping from across the globe,but evidence synthesis is needed to make this information accessible.Meta-analysis requires a careful choice of metric that is appropriate for answering the question at hand,and which lends itself for a robust meta-analysis.This paper reviews some metrics that may be used in the quantitative synthesis of literature data on intercropping. | Wopke VAN DER WERF Lizhen ZHANG Chunjie LI Ping CHEN Chen FENG Zhan XU Chaochun ZHANG Chunfeng GU Lammert BASTIAANS David MAKOWSKI TjeerdJan STOMPH | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 2 |
| 14 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 15 | Effect of Combined Application of Boron and Molybdenum Microelement Fertilizer on Cowpea Yield and Quality显示文摘Through field plot experiment,we research the influencing factors of cowpea yield and quality after applying boron and molybdenum microelement fertilizer. Results show that the application of boron and molybdenum microelement fertilizer can significantly increase the yield and improve the quality of cowpea. Compared with the control,yield per mu increases by 5. 08- 18. 86%; N content increases by 4. 27%-11. 28%; P content increases by 2. 13%- 13. 57%; K content increases by 2. 00%- 18. 48%; crude protein increases by 4. 16%-19. 94%; vitamin C increases by 2. 71%- 11. 79%; nitrate content decreases by 5%- 15%. Besides,it is better to combine boron with molybdenum than to use each of them separately. | Lizhen CHEN Jianqiu YE Rongxiang WANG Xiaoqing ZHAO | 2016 | Asian Agricultural Research2016，8，10： | 2 |
| 16 | Salidroside protects against MPP + -induced apoptosis in PC12 cells by inhibiting the NO pathway显示文摘 | Xiaofeng Li Xiaoli Ye Xiaobing Li Xin Sun Qiang Liang Lizhen Tao Xiaogang Kang Jianzong Chen | 2011 | Brain Research2011，，： | 1 |
| 17 | Preparation and Characterization of Ag_2S/PMMA Nanocomposites by Microemulsion显示文摘Ag_2S nanoparticles in polymethyl methacrylate(PMMA) are prepared in n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate/water microemulsions.The Ag_2S nanoparticles dispersed in the polymer are characterized by FT-IR spectrum,UV-Vis absorption spectroscopy,transmission electron microscopy(TEM),and X-ray powder diffraction(XRD).The FT-IR spectrum shows that the composite has the characteristic bands of nano-Ag_2S and pure PMMA.The TEM photograph of the sample shows that the Ag_2S nanoparticles are elliptical.The phase structure of the composite is characterized by XRD,which reveals that Ag_2S particles are formed.The UV-Vis absorption recorded at various times indicates an initial rapid formation of the nanoparticles and the quantum confinement effect of Ag_2S nanoparticles. | Yuzhen Li Lizhen Gao Wenjun Chen Weike Zhang Lili Gao Yanqing Yang Likun Shang Meilu Wang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，1： | 1 |
| 18 | Finding proba- bilistic prevalent co-locations in spatially uncertain data sets显示文摘 | Wang Lizhen Wu Pingping Chen Hongmei | 2013 | IEEE Transactions on Knowledge and Data Engineering2013，25，4： | 1 |
| 19 | Insulinoma imaging with glucagon-like peptide-1 receptor targeting probe 18 F-FBEM–Cys 39 -exendin-4显示文摘 | Yuping Xu Donghui Pan Qing Xu Chen Zhu Lizhen Wang Fei Chen Runlin Yang Shineng Luo Min Yang | 2014 | Journal of Cancer Research and Clinical Oncology2014，，9： | 1 |
| 20 | Rho 1 participates in parasitoid wasp eggs maturation and host cellular immunity inhibition显示文摘Endoparasitoid wasps introduce venom into their host insects during the egglaying stage.Venom proteins play various roles in the host physiology,development,immunity,and behavior manipulation and regulation.In this study,we identified a venom protein,MmRhol,a small guanine nucleotide-binding protein derived from ovary in the endoparasitoid wasp Microplitis mediator and found that knockdown of its expression by RNA interference caused down-regulation of vitellogenin and juvenile hormone,egg production,and cocoons formation in the female wasps.We demonstrated that MmRho1 entered the cotton bollworm's(host)hemocytes and suppressed cellular immune responses after parasitism using immunofluorescence staining.Furthermore,wasp MmRhol interacted with the cotton bollworm's actin cytoskeleton rearrangement regulator diaphanous by yeast 2-hybrid and glutathione s-transferase pull-down.In conclusion,this study indicates that MmRho1 plays dual roles in wasp development and the suppression of the host insect cellular immune responses. | Ruijuan Wang Zhe Lin Lizhen Zhou Caihua Chen Xianhao Yu Junje Zhang Zhen Zou Zhiqiang Lu | 2023 | Insect Science2023，30，3： | 1 |
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