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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Evidence of crustal ‘channel flow’ in the eastern margin of Tibetan Plateau from MT measurements显示文摘Magnetotelluric (MT) survey has been carried out in the eastern margin of the Tibetan Plateau and its neighboring Shimian-Leshan area, Sichuan Province. Analysis of this MT data reveals that the electric structure of the Tibetan Plateau differ much from that of the Sichuan block. In general, the electric re-sistivity of crust beneath the Sichuan block in the east is larger than that of the eastern margin of the Tibetan Plateau in the west. The crust of the plateau is divided into upper, middle, and lower layers. The middle crust is a low resistivity layer with minimum down to 3―10 Ωm about 10―15 km thick. It pre-sumably contains partial melt and/or salt-bearing fluids with low viscosity, prone to deform and flow, producing a 'channel flow' under the southeastward squeeze of the eastern Tibetan Plateau. This low-resistivity layer makes the upper crust decoupled mechanically from the lower crust. In the brittle upper crust, faults are dominated by left-lateral strike-slip and thrust motions, leading to surface rising and shallow earthquakes. The low-resistivity layer also cut the Xianshuihe-Anninghe fault zone into two sections vertically. In this region, the thicknesses of upper, middle, and lower crust vary laterally, pro-ducing a transitional zone in the eastern margin of the Tibetan Plateau characterized by thicker crust and higher elevation in the west and thinner crust and lower elevation in the east. | ZHAO GuoZe CHEN XiaoBin WANG LiFeng WANG JiJun TANG Ji WAN ZhanSheng ZHANG JiHong ZHAN Yan XIAO QiBin | 2008 | Chinese Science Bulletin2008，53，12： | 57 |
| 3 | Deep structure beneath the southwestern section of the Longmenshan fault zone and seimogenetic context of the 4.20 Lushan M_S7.0 earthquake显示文摘Magnetotelluric measurements were carried out along two profiles across the middle and southwestern sections of the Longmenshan fault zone(LMSf)from 2009 to 2011,after the 2008 Wenchuan MW7.9 earthquake.The former profile crosses the Wenchuan event epicenter and the latter one crosses 2013 Lushan MS7.0 event epicenter.The data were analyzed using advanced processing techniques,including phase tensor and two-dimensional inversion methods,in order to obtain reliable 2-D profiles of the electrical structure in the vicinity of the two earthquakes.A comparison of the two profiles indicates both similarities and differences in the deep crustal structure of the LMSf.West of the southwestern section,a crustal high conductivity layer(HCL)is present at about 10 km depth below the Songpan-Garzêblock;this is about 10 km shallower than that under the middle section of the LMSf.A high resistivity body(HRB)is observed beneath the southwestern section,extending from the near surface to the top of upper mantle.It has a smaller size than the HRB observed below the middle section.In the middle section,there is a local area of decreased resistivity within the HRB but there is absence of this area.The 2013 Lushan earthquake occurred close to the eastern boundary of HRB and the Shuangshi-Dachuan fault,of which the seismogenic context has both common and different features in comparison with the 2008 Wenchuan event.On a large scale,the 2013 Lushan earthquake is associated with the HCL and deformation in the crust including HCL of the eastern Tibetan Plateau.In order to assess seismic risk,it is important to consider both the stress state and the detailed crustal structure in different parts of the LMSf. | ZHAN Yan ZHAO GuoZe UNSWORTH Martyn WANG LiFeng CHEN XiaoBin LI Tao XIAO QiBin WANG JiJun TANG Ji CAI JunTao WANG YanZhao | 2013 | Chinese Science Bulletin2013，58，28： | 39 |
| 4 | A nomogramfor predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis显示文摘Background:Low-grade endometrial stromal sarcoma(LG-ESS)is a rare tumor that lacks a prognostic prediction model.Our study aimed to develop a nomogram to predict overall survival of LG-ESS patients.Methods:A total of 1172 patients confirmed to have LG-ESS between 1988 and 2015 were selected from the Surveillance,Epidemiology and End Results(SEER)database.They were further divided into a training cohort and a validation cohort.The Akaike information criterion was used to select variables for the nomogram.The discrimination and calibration of the nomogram were evaluated using concordance index(C-index),area under time-dependent receiver operating characteristic curve(time-dependent AUC),and calibration plots.The net benefits of the nomogram at different threshold probabilities were quantified and compared with those of the International Federation of Gynecology and Obstetrics(FIGO)criteria-based tumor staging using decision curve analysis(DCA).Net reclassification index(NRI)and integrated discrimination improvement(IDI)were also used to compare the nomogram’s clinical utilitywith that of the FIGO criteria-based tumor staging.The risk stratifications of the nomogram and the FIGO criteria-based tumor staging were compared.Results:Seven variables were selected to establish the nomogram for LG-ESS.The C-index(0.814 for the training cohort and 0.837 for the validation cohort)and the time-dependent AUC(>0.7)indicated satisfactory discriminative ability of the nomogram.The calibration plots showed favorable consistency between the prediction of the nomogram and actual observations in both the training and validation cohorts.The NRI values(training cohort:0.271 for 5-year and 0.433 for 10-year OS prediction;validation cohort:0.310 for 5-year and 0.383 for 10-year OS prediction)and IDI(training cohort:0.146 for 5-year and 0.185 for 10-year OS prediction;validation cohort:0.177 for 5-year and 0.191 for 10-year OS prediction)indicated that the established nomogram performed significantly better than the FIGO criteria-based tumor staging alone(P<0.05).Furthermore,DCA showed that the nomogram was clinically useful and had better discriminative ability to recognize patients at high risk than the FIGO criteria-based tumor staging.Conclusions:A prognostic nomogram was developed and validated to assist clinicians in evaluating prognosis of LG-ESS patients. | Jie Wu Huibo Zhang Lan Li Mengxue Hu Liang Chen Bin Xu Qibin Song | 2020 | Cancer Communications2020，40，7： | 35 |
| 5 | Electromagnetic anomaly before earthquakes measured by electromagnetic experiments显示文摘Three experiments are carried out for earthquake monitoring using electromagnetic (EM) methods in recent years. Some earthquakes occurred in chance of the measurement time period for each experiment and the anomalies were recorded before the shocks. The observation at a site 20 km away from the epicenter of Zhangbei MS6.2 earthquake in 1998 shows that the apparent resistivity decreases in the strike direction before and/or during the earthquake and the resistivity increases in the de-cline direction. This anomalous variation in apparent resistivity accounts for about 20%. The apparent resistivities at a site in the epicentral area decrease in the strike and decline directions before and/or during the earthquake and increase after shocks. The experiments using artificial electromagnetic signals with super low frequency carried out in 1999 show that the resolution and stability of electric and magnetic spectra are improved. The spectra of electric and magnetic fields and apparent resistivity at the Baodi station began to anomalously change two days before the Qian'an earthquake with 120 km distant to the station. The anomalous variation of electric and magnetic spectra is about twice as great as normal variation and the apparent resistivity changes by about 20%. The measurements in active seismic area of Yunnan province in the year 2005 indicate that the electric and magnetic spectra anomalously change by one order before the Taoyuan earthquake about 100 km away from the observa-tories. But the measurements at the sites in Beijing area 2 000 km away from the epicenter do not show any anomaly. | Guoze Zhao Yan Zhan Lifeng Wang Jijun Wang Ji Tang Qibin Xiao Xiaobin Chen | 2009 | Earthquake Science2009，22，4： | 16 |
| 6 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 7 | NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。 | Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian | 2012 | Cell Research2012，22，5： | 13 |
| 8 | Uncertainty analyses on the calculation of water environmental capacity by an innovative holistic method and its application to the Dongjiang River显示文摘The estimation and allocation of water environmental capacity(WEC) are essential to water quality management and social–economic interests. However, there is inevitable uncertainty in the capacity estimation due to model conceptualization, data collection and parameter calibration. An innovative holistic approach was developed, which took both independence and relevance between parameters into account to analyze the uncertainties in WEC calculation and estimate the margin of safety. The Dongjiang River was taken as the case to demonstrate the method, focusing on the chemical oxygen demand and NH4+–N that were the two major water quality problems in the river. The results showed that the proposed holistic approach is very promising and applicable compared to traditional methods of uncertainty analysis. | Qiuwen Chen Qibin Wang Zhijie Li Ruonan Li | 2014 | Journal of Environmental Sciences2014，26，9： | 9 |
| 9 | Simultaneous denitrification and denitrifying phosphorus removal in a full-scale anoxic–oxic process without internal recycle treating low strength wastewater显示文摘Performance of a full-scale anoxic-oxic activated sludge treatment plant(4.0×10~5 m^3/day for the first-stage project) was followed during a year.The plant performed well for the removal of carbon,nitrogen and phosphorus in the process of treating domestic wastewater within a temperature range of 10.8℃ to 30.5℃.Mass balance calculations indicated that COD utilization mainly occurred in the anoxic phase,accounting for 88.2% of total COD removal.Ammonia nitrogen removal occurred 13.71% in the anoxic zones and 78.77% in the aerobic zones.The contribution of anoxic zones to total nitrogen(TN) removal was 57.41%.Results indicated that nitrogen elimination in the oxic tanks was mainly contributed by simultaneous nitrification and denitrification(SND).The reduction of phosphorus mainly took place in the oxic zones,51.45% of the total removal.Denitrifying phosphorus removal was achieved biologically by 11.29%.Practical experience proved that adaptability to gradually changing temperature of the microbial populations was important to maintain the plant overall stability.Sudden changes in temperature did not cause paralysis of the system just lower removal efficiency,which could be explained by functional redundancy of microorganisms that may compensate the adverse effects of temperature changes to a certain degree.Anoxic-oxic process without internal recycling has great potential to treat low strength wastewater(i.e.,TN < 35 mg/L) as well as reducing operation costs. | Qibin Wang Qiuwen Chen | 2016 | Journal of Environmental Sciences2016，28，1： | 9 |
| 10 | Advances in alternating electromagnetic field data processing for earthquake monitoring in China显示文摘The alternating electromagnetic(EM) field is one of the most sensitive physical fields related to earthquakes. There have been a number of publications reporting EM anomalies associated with earthquakes. With increasing applications and research of artificial-source extremely low frequency EM and satellite EM technologies in earthquake studies, the amount of observed data from the alternating EM method increases rapidly and exponentially, so it is imperative to develop suitable and effective methods for processing and analyzing the influx of big data. This paper presents research on the self-adaptive filter and wavelet techniques and their applications to analyzing EM data obtained from ground measurements and satellite observations, respectively. Analysis results show that the self-adaptive filter method can identify both natural- and artificial-source EM signals, and enhance the ratio between signal and noise of EM field spectra, apparent resistivity, and others. The wavelet analysis is capable of detecting possible correlation between EM anomalies and seismic events. These techniques are effective in processing and analyzing massive data obtained from EM observations. | ZHAO GuoZe BI YaXin WANG LiFeng HAN Bing WANG Xiao XIAO QiBin CAI JunTao ZHAN Yan CHEN XiaoBin TANG Ji WANG JiJun | 2015 | Science China Earth Sciences2015，58，2： | 7 |
| 11 | Deep electrical structure of the Sulu orogen and neighboring areas显示文摘Because of the discovery of ultrahigh pressure metamorphic (UHPM) belt beneath the Sulu (Jiangsu Province-Shandong Province) orogen, this area has become a focused subject of current geoscience, as it has a close relationship with the evolution of the orogen and the neighboring North China craton. Probing the deep structure beneath this area would be of great significance for the geological inter- pretation of this issue. In this study, we make an analysis of magnetotelluric (MT) data along a profile across the Sulu orogen to provide evidence of deep structure below this region. The profile begins in west from the North China block, extending in S129oE, across the Tan-Lu fault, Sulu UHPM zone, and Sulu high pressure metamorphic (HPM) zone, and terminates in the Yangtze block in east. We use the nonlinear conjugate gradient method and TE-TM combined mode to perform inversion and interpreta- tion of the MT data, and obtain an electrical structure image above depth of 150 km along the profile. It shows that the structure can be divided into seven sections in lateral direction, between which the electric boundaries coincide well with the major faults, such as the Tan-Lu, Haizhou-Siyang, and Ji- ashan-Xiangshui faults. In vertical direction the electrical structure can be subdivided into six layers of different resistivities. It is noted that there exist high-conductivity areas in crust below the North China block and Yangtze block, while such a feature is not present beneath the Sulu orogen, which is very different from the Dabie orogen. It is also observed that a fairly continuous zone of relatively low-resistivity exists at depths of 50-90 km of the electrical structure image, which is presumably a weak zone in the uppermost mantle. Just below this low-resistivity zone are the relatively high- resis- tivity layer of the North China block, relatively low-resistivity layer of the Sulu orogen, and relatively high-resistivity layer of the Yangtze block, all in the shallow upper mantle, respectively. From the whole 2D electrical structure image, there is no abnormally low-resistivity layer in the shallow upper mantle beneath the Sulu orogen and neighboring areas, indicating that no hot asthenoshperic material asso- ciated with lithospheric thinning exists at present. | XIAO QiBin ZHAO GuoZe WANG JiJun ZHAN Yan CHEN XiaoBin TANG Ji CAI JunTao WAN ZhanSheng WANG LiFeng MA Wei ZHANG JiHong | 2009 | Science China Earth Sciences2009，52，3： | 7 |
| 12 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 13 | Reprogramming of a defense signaling pathway in rough lemon and sweet orange is a critical element of the early response to‘Candidatus Liberibacter asiaticus’显示文摘Huanglongbing(HLB)in citrus infected by Candidatus Liberibacter asiaticus(CLas)has caused tremendous losses to the citrus industry.No resistant genotypes have been identified in citrus species or close relatives.Among citrus varieties,rough lemon(Citrus jambhiri)has been considered tolerant due to its ability to produce a healthy flush of new growth after infection.The difference between tolerance and susceptibility is often defined by the speed and intensity of a plant’s response to a pathogen,especially early defense responses.RNA-seq data were collected from three biological replicates of CLas-and mock-inoculated rough lemon and sweet orange at week 0 and 7 following infection.Functional analysis of the differentially expressed genes(DEGs)indicated that genes involved in the mitogen activated protein kinase(MAPK)signaling pathway were highly upregulated in rough lemon.MAPK induces the transcription of WRKY and other transcription factors which potentially turn on multiple defense-related genes.A Subnetwork Enrichment Analysis further revealed different patterns of regulation of several functional categories,suggesting DEGs with different functions were subjected to reprogramming.In general,the amplitude of the expression of defense-related genes is much greater in rough lemon than in sweet orange.A quantitative disease resistance response may contribute to the durable tolerance level to HLB observed in rough lemon. | Qibin Yu Chunxian Chen Dongliang Du Ming Huang Jiqiang Yao Fahong Yu Ronald H Brlansky Frederick G.Gmitter Jr | 2017 | Horticulture Research2017，4，1： | 5 |
| 14 | Effect of externally applied Jidesheng anti-venom on skin and soft-tissue necrosis after Chinese cobra bite: a retrospective study显示文摘OBJECTIVE: To evaluate the effects of Jidesheng anti-venom used externally for skin and soft-tissue necrosis from Chinese cobra bite.METHODS: A retrospective review was performed according to the clinical data recorded from January 2002 to December 2012. A total of 126 patients(116 females and 10 males) with skin and soft-tissue necrosis due to Chinese cobra bite were divided into two groups. The control group was treated externally with 40% glyceride magnesium sulfate(n=52), and the treatment group was given Jidesheng anti-venom externally(n=74). The data collected included maximum local necrotic area of skin and soft tissues, de-tumescence time, healing time,and skin-grafting rate.RESULTS: There were no significant differences in gender, age, and disease condition between the control and treatment groups(P>0.05). No statistically significant difference was found in de-tumescence time between the two groups(P>0.05). The maximum local necrotic area of skin and soft tissues was(19.9 ± 7.3) cm2in the treatment group,while it was(23.3±6.4) cm2in the control group.The healing time of the treatment group was shorter than that of the control group [(32.1 ± 3.7) vs(34.4±4.5) days)] The skin-grafting rate in the treatment group was lower than that of the control group(10.81% vs 25.00%). There were statistically significant differences in maximum local necrotic area of skin and soft tissues, healing time, and skin-grafting rate between the control and treatment groups(all P<0.05).CONCLUSION: External application of Jidesheng anti-venom may help to promote wound healing and reduce the skin-grafting rate in cases of skin and soft-tissue necrosis due to Chinese cobra bite. | Quanfang Chen Wei Wang Qibin Li Yulong Bai Xiaoying Zou Yanbin Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 3 |
| 15 | Earthquake Electromagnetic Precursor Anomalies Detected by a New Ground-based Observation Network显示文摘It is a debated topic if there are any observable precursor anomalies prior to the earthquake(EQ hereafter)and if the stronger EQ can be successfully predicted.During last few decades quite a lot of observable electromagnetic(EM)precursors were published by using techniques equipped in either satellites or on ground-based stations.But there are only a few cases that the shortterm precursor anomalies of EM field before earthquakes were observed by using alternate EM fields on ground.This paper will present a new EM observation network built in recent years and show a new finding of EM field with the variation of a one-year cycle observed using the network.As an example,the short-term precursor anomalies of apparent resistivity before the Yangbi EQ(Ms 5.1)occurred on March 27,2017 in Yunnan Province will be studied.The observed anomalous phenomena indicate that the anomaly before the EQ can be captured only if reasonable effective methods including sophisticated analytical techniques are used,and it is believed that continuously observed data on the fixed observation network for a long time is an effective means for studying anomalies that appeared before earthquakes.This network can also play an important role in studying the EM environment from space. | Bing HAN Guoze ZHAO Lifeng WANG Ji TANG Yaxin BI Yan ZHAN Xiaobin CHEN Qibin XIAO Jihong ZHANG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 3 |
| 16 | Flexible mica films for high-temperature energy storage显示文摘Dielectrics used for energy storage are highly desired for power electronics and pulse power applications and the polymer capacitors are the main commercial ones available.The development of flexible electronics and wearable devices require the relative materials being flexible.Besides,high temperature resistance is also desired because of the rising demand for high power devices and large electricity under elevated temperature.The polymer dielectrics for polymer capacitors are flexible but with relatively low working temperature normally less than 100℃.Therefore,fabricating a dielectric material to satisfy the flexibility and high working temperature simultaneously is still a great challenge.Here we propose one solution by demonstrating a hand-exfoliated fluorophlogopite film with micrometer scale thickness.Among which,the mica film with a thickness of around 10μm(Mica-10)exhibits the inorganic-like temperature stability even polymer-like flexibility.From 25℃to 200℃,Mica-10 has an energy density of around 11.27 J/cm^(3)with a variation within 2%,accompanied by a charge-discharge efficiency of around 95%at an electric field of 500 MV/m.Meanwhile,the thin thickness makes Mica-10 flexible,enabling its excellent flexibility and durability.This work revives the traditional material,mica,providing a way for high-temperature energy storage applications. | Xinwei Xu Wenlong Liu Yi Li Yifei Wang Qibin Yuan Jie Chen Rong Ma Feng Xiang Hong Wang | 2018 | Journal of Materiomics2018，4，3： | 3 |
| 17 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 18 | Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis显示文摘Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to facilitate their survival and growth. Prion protein(PrP) is a glycosylated cell surface protein that has been shown to be up-regulated in many cancer cells. Since PrP is a protein prone to misfolding, ER stress can result in under-glycosylated PrP, which in turn may activate ER stress. To assess whether ER stress leads to the production of under-glycosylated PrP and whether underglycosylated PrP may contribute to ER stress thus leading to cancer cell apoptosis, we treated different cancer cells with brefeldin A(BFA), thapsigargin(Thps), and tunicamycin(TM). We found that although BFA, Thps, and TM treatment activated UPR, only ATF4 was consistently activated by these reagents, but not other branches of ER stress. However, the canonical PERK-eIF2α-ATF4 did not account for the observed activation of ATF4 in lung cancer cells. In addition, BFA,but neither Thps nor TM, significantly stimulated the expression of cytosolic PrP. Finally, we found that the levels of PrP contributed to anti-apoptosis activity of BFA-induced cancer cell death. Thus, the pathway of BFA-induced persistent ER stress may be targeted for lung and pancreatic cancer treatment. | Zhenxing Gao Min Peng Liang Chen Xiaowen Yang Huan Li Run Shi Guiru Wu Lili Cai Qibin Song Chaoyang Li | 2019 | Virologica Sinica2019，34，2： | 2 |
| 19 | Molecular Dynamics Simulation of Sulphur Nucleation in S-H2S System 显示文摘 | Li Qibin Liu Chao Chen Xi | 2014 | Molecular Physics2014，112，7： | 1 |
| 20 | Mixed monolayers of Gemini surfaetants and stearie acid at the air/water interface显示文摘 | Li Rong Chen Qibin Zhang Dazhi | 2008 | Journal of Colloid and lnterface Science2008，327，： | 1 |
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