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| 1 | Long-term trend and abrupt events of the Holocene Asian monsoon inferred from a stalagmiteδ^(18)O record from Shennongjia in Central China显示文摘A high-resolution oxygen-isotope record from a thorium-uranium-dated stalagmite from Shanbao Cave at Shennongjia reflects variations in the amount of monsoon precipitation for the period from 11.5 to 2.1 ka (1 ka = 1000 cal aBP). Between 11.5 and 9.3 ka, a sharp decrease in δ18O indicates a rapid increase in monsoon precipitation. An interval of generally high monsoon precipitation is observed between 9.3 and 4.4 ka. An arid period has prevailed between 4.4 and 2.1 ka. The long-term trend of Shanbao record appears to follow summer insolation at 33°N latitude. An abrupt decrease in monsoon precipitation around 4.3 ka is synchronous with the collapse of Neolithic culture in central China. This abrupt change could have resulted from the amplifi- cation of the gradually decreased summer insolation by the positive vegetation-atmosphere-aerosol feed- back. The weakened Asian monsoon events were in concert with decreased Greenland temperature dur- ing the early Holocene, centered at 8.2, 8.6, 9.3, 10.2 and 11.0 ka. This correlation suggests that changes in low-latitude monsoon are connected with climate change in high-latitude polar region. | SHAO Xiaohua WANG Yongjin CHENG Hai KONG Xinggong WU Jiangying EDWARDS R. Lawrence | 2006 | Chinese Science Bulletin2006，51，2： | 64 |
| 2 | Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury显示文摘Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled receptor,and it may be neuroprotective against cerebral ischemia injury.However,the precise mechanisms of the effects of apelin-13 remain to be elucidated.To investigate the effects of apelin-13 on apoptosis and autophagy in models of cerebral ischemia/reperfusion injury,a rat model was established by middle cerebral artery occlusion.Apelin-13(50μg/kg)was injected into the right ventricle as a treatment.In addition,an SH-SY5Y cell model was established by oxygen-glucose deprivation/reperfusion,with cells first cultured in sugar-free medium with 95%N2 and 5%CO2 for 4 hours and then cultured in a normal environment with sugar-containing medium for 5 hours.This SH-SY5Y cell model was treated with 10-7 M apelin-13 for 5 hours.Results showed that apelin-13 protected against cerebral ischemia/reperfusion injury.Apelin-13 treatment alleviated neuronal apoptosis by increasing the ratio of Bcl-2/Bax and significantly decreasing cleaved caspase-3 expression.In addition,apelin-13 significantly inhibited excessive autophagy by regulating the expression of LC3B,p62,and Beclin1.Furthermore,the expression of Bcl-2 and the phosphatidylinositol-3-kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR)pathway was markedly increased.Both LY294002(20μM)and rapamycin(500 nM),which are inhibitors of the PI3K/Akt/mTOR pathway,significantly attenuated the inhibition of autophagy and apoptosis caused by apelin-13.In conclusion,the findings of the present study suggest that Bcl-2 upregulation and mTOR signaling pathway activation lead to the inhibition of apoptosis and excessive autophagy.These effects are involved in apelin-13-induced neuroprotection against cerebral ischemia/reperfusion injury,both in vivo and in vitro.The study was approved by the Animal Ethical and Welfare Committee of Jining Medical University,China(approval No.2018-JS-001)in February 2018. | Zi-Qi Shao Shan-Shan Dou Jun-Ge Zhu Hui-Qing Wang Chun-Mei Wang Bao-Hua Cheng Bo Bai | 2021 | Neural Regeneration Research2021，16，6： | 35 |
| 3 | Quantitative relationship between visibility and mass concentration of PM2.5 in Beijing显示文摘The pollution of particulate matter less than 2.5 mm(PM2.5) is a serio us environmental problem in Beijing. The annual average concentration of PM2.5 i n 2001 from seasonal monitor results was more than 6 times that of the U.S. nati onal ambient air quality standards proposed by U.S. EPA. The major contributors to mass of PM2.5 were organics, crustal elements and sulfate. The chemical compo sition of PM2.5 varied largely with season, but was similar at different monitor stations in the same season. The fine particles (PM2.5) cause atmospheric visib ility deterioration through light extinction. The mass concentrations of PM2.5 w ere anti-correlated to the visibility, the best fits between atmospheric visibil ity and the mass concentrations of PM2.5 were somehow different: power in spring , exponential in summer, logarithmic in autumn, power or exponential in winter. As in each season the meteorological parameters such as air temperature and rela tive humidity change from day to day, probably the reason of above correlations between PM2.5 and visibility obtained at different seasons come from the differe nces in chemical compositions of PM2.5. | WANG Jing-li ZHANG Yuan-hang SHAO Min LIU Xu-lin ZENG Li-min CHENG Cong-lan XU Xiao-feng | 2006 | Journal of Environmental Sciences2006，18，3： | 31 |
| 4 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 5 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 6 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 7 | Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review显示文摘Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis. | Ran Cheng Zhiwu Wu Mingming Li Meiying Shao Tao Hu | 2020 | International Journal of Oral Science2020，12，1： | 18 |
| 8 | Responses of soil nitrogen, phosphorous and organic matter to vegetation succession on the Loess Plateau of China显示文摘Revegetation is a traditional practice widely used for soil protection. We evaluated the effect of natural revegetation succession on soil chemical properties and carbon fractions(particulate organic carbon(POC), humus carbon(HS-C), humic acid carbon(HA-C) and fulvic acid carbon(FA-C)) on the Loess Plateau of China. The vegetation types, in order from the shortest to the longest enclosure duration, were:(a) abandoned overgrazed grassland(Ab G3; 3 years);(b) Hierochloe odorata Beauv.(Hi O7; 7 years);(c) Thymus mongolicus Ronnm(Th M15; 15 years);(d) Artemisia sacrorum Ledeb(At S25; 25 years);(e) Stipa bungeana Trin Ledeb(St B36; 36 years) and(f) Stipa grandis P. Smirn(St G56; 56 years). The results showed that the concentrations of soil organic carbon, total nitrogen and available phosphorus increased with the increase of restoration time except for Th M15. The concentration of NH4-N increased in the medium stage(for Th M15 and At S25) and decreased in the later stage(for St B36 and St G56) of vegetation restoration. However, NO3-N concentration significantly increased in the later stage(for St B36 and St G56). Carbon fractions had a similar increasing trend during natural vegetation restoration. The concentrations of POC, HS-C, FA-C and HA-C accounted for 24.5%–49.1%, 10.6%–15.2%, 5.8%–9.1% and 4.6%–6.1% of total carbon, respectively. For Ab G3, the relative changes of POC, HS-C and FA-C were significantly higher than that of total carbon during the process of revegetation restoration. The higher relative increases in POC, HS-C and FA-C confirmed that soil carbon induced by vegetation restoration was sequestrated by higher physical and chemical protection. The increases of soil C fractions could also result in higher ecological function in semiarid grassland ecosystems. | Man CHENG Shao Shan AN | 2015 | Journal of Arid Land2015，7，2： | 17 |
| 9 | Highly-Sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles显示文摘Lanthanide-based upconversion nanoparticles(UCNPs)have been widely explored in various fields,including optical imaging,in recent years.Although earlier work has shown that UCNPs with different lanthanide(Ln3+)dopants exhibit various colors,multicolor-especially in vivo multiplexed biomedical imaging-using UCNPs has rarely been reported.In this work,we synthesize a series of UCNPs with different emission colors and functionalize them with an amphiphilic polymer to confer water solubility.Multicolor in vivo upconversion luminescence(UCL)imaging is demonstrated by imaging subcutaneously injected UCNPs and applied in multiplexed in vivo lymph node mapping.We also use UCNPs for multicolor cancer cell labeling and realize in vivo cell tracking by UCL imaging.Moreover,for the first time we compare the in vivo imaging sensitivity of quantum dot(QD)-based fluorescence imaging and UCNP-based UCL imaging side by side,and find the in vivo detection limit of UCNPs to be at least one order of magnitude lower than that of QDs in our current non-optimized imaging system.Our data suggest that,by virtue of their unique optical properties,UCNPs have great potential for use in highly-sensitive multiplexed biomedical imaging. | Liang Cheng Kai Yang Shuai Zhang Mingwang Shao Shuittong Lee Zhuang Liu | 2010 | Nano Research2010，3，10： | 17 |
| 10 | Effect of exposure to ambient PM2.5 pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies显示文摘The International Agency for Research on Cancer and the World Health Organization have designated airborne particulates,including particulates of median aerodynamic diameter < 2.5um(PM_(2.5)),as Group 1 carcinogens.It has not been determined,however,whether exposure to ambient PM_(2.5) is associated with an increase in respiratory related diseases.This meta-analysis assessed the association between exposure to ambient fine particulate matter(PM_(2.5)) and the risk of respiratory tract diseases,using relevant articles extracted from PubMed,Web of Science,and Embase.In results,of the 1,126 articles originally identified,35(3.1%) were included in this meta-analysis.PM_(2.5)was found to be associated with respiratory tract diseases.After subdivision by age group,respiratory tract disease,and continent,PM_(2.5) was strongly associated with respiratory tract diseases in children,in persons with cough,lower respiratory illness,and wheezing,and in individuals from North America,Europe,and Asia.The risk of respiratory tract diseases was greater for exposure to traffic-related than non-traffic-related air pollution.In children,the pooled relative risk(RR) represented significant increases in wheezing(8.2%),cough(7.5%),and lower respiratory illness(15.3%).The pooled RRs in children were 1.091(95%CI:1.049,1.135) for exposure to<25 μg/m^3 PM_(2.5),and 1.126(95%CI:1.067,1.190) for exposure to > 25 μg/m^3 PM_(2.5).In conclusion,exposure to ambient PM_(2.5) was significantly associated with the development of respiratory tract diseases,especially in children exposed to high concentrations of PM_(2.5). | Qian Liu Cheng Xu Guixiang Ji Hui Liu Wentao Shao Chunlan Zhang Aihua Gu Peng Zhao | 2017 | The Journal of Biomedical Research2017，31，2： | 16 |
| 11 | Recent advances in g-CN-based heterojunction photocatalysts显示文摘Semiconductor heterojunction photocatalysts have received much concern due to their great application prospect in solar energy utilization and conversion.Rational construction of heterostructure with two or more semiconductor materials can integrate the advantages of multi-components to simultaneously improve the photo-induced charges separation,extend visible light absorption range and retain the high redox ability of photocatalysts.Recently,constructing of g-C3 N4-based heterostructure has become a hot focus due to the multiple merits of g-C3 N4,such as facile synthesis,high stability,unique optical and electronic characteristics.This review tries to give a comprehensive introduction and provide the possible tendency in design and fabrication of g-C3 N4-based heterojunction photocatalysts,especially in rational synthesis of type-II heterojunction,direct Z-scheme heterojunction,new type of S-scheme heterojunction,p-n heterojunction and Schottky heterojunction.Furthermore,the special charges transfer mechanisms of g-C3 N4-based heterojunctions are discussed and their potential applications in photocatalytic water splitting,photo-degradation of contaminants and photo-reduction of CO2 into fuels are also summarized.Finally,we attempt to propose some crucial issues based on the current research,which should be further investigated and resolved in this interesting research area. | Yunfeng Li Minghua Zhou Bei Cheng Yan Shao | 2020 | Journal of Materials Science & Technology2020，56，21： | 16 |
| 12 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 13 | Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients^1显示文摘瞄准:这研究的目的是与类型 2 糖尿病在病人与 repaglinide 的治疗学的效果调查 KCNJ11 E23K 和 ABCC8 exon16 3T/C 的协会。方法:有最新诊断的类型的 100 个中国病人的一个总数 2 糖尿病与 repaglinide 被治疗 24 个星期。精氨酸刺激测试被执行评估贝它房间功能。基因变化与 PCR 限制碎片长度多型性被检测。应答者被定义由一比在 fasting 血浆葡萄糖的 25% 减少大或一比在血红素 A1c (HbA1c ) 价值的 20% 减少大(或) 在 24 星期 repaglinide 治疗以后。结果:基线 HbA1c 和 HbA1c 的减少在有 KCNJ11 E23K 变体的 E/K 和 K/K 遗传型的病人是显著地更高的什么时候与 E/E 同质接合体相比(P=0.0103 并且 0.0221,分别地) 。在 2 h 的减少饭后的血浆葡萄糖(2hPG ) 比 E/E 同质接合体(P=0.0367 ) 在 E/K 异质接合体是显著地更大的。处于到在 E 和 K 等位基因之间的 repaglinide 治疗的反应率有重要差别(68%vs 82% , P=0.0324 ) 。在 fasting 胰岛素和对胰岛素抵抗的动态平衡模型评价的变化在有 ABCC8 exon16 的病人是显著地更大的 3 C/C 对 T/C 和 T/T 遗传型(P=0.0372 并且 0.0274,分别地) 。结论:KCNJ11 E23K 变体与 repaglinide 的治疗学的效果被联系。另外, ABCC8 exon16 3T/C 变体的 C/C 同质接合体比 T/C 和 T/T 遗传型在胰岛素敏感对 repaglinide 更好作出回应。 | Ya-yi HE Rong ZHANG Xin-yu SHAO Cheng HU Cong-rong WANG Jun-xi LU Yu-qian BAO Wei-ping JIA Kun-san XIANG | 2008 | Acta Pharmacologica Sinica2008，29，8： | 14 |
| 14 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 15 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 16 | Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center显示文摘 | Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang Feng Feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 17 | Notoginseng Saponin Rg1 Prevents Cognitive Impairment through Modulating APP Processing in Aβ1-42-injected Rats显示文摘With the intensification of the aging process of the world,Alzheimer's disease(AD),which is the main type of senile dementia,has become a primary problem in the present society.Lots of strategies have been used to prevent and treat AD in animal nlodels and clinical trials,but most of them ended in failure.Panax notoginseng saponins(PNS)contain a variety of monomer compositions which have been separated and identified.Among of the monomer compositions,notoginseng saponin Rg1(Rg1)accounts for 20%of the cultivation of panax notoginseng roots.And now PNS have been reported to be widely used to treat cardicerebrovascular diseases and have neuroprotective effects to restrain theβ-amyloid peptide(Aβ)25-35-niediated apoptosis.Moreover,it is reported that PNS could accelerate the growth of nerve cells,increase the length of axons and promote synaptic plasticity.Whether Rg1 can ameliorate the cognitive impairment and the underlying mechanism has not been elucidated.To study the preventive effect of Rg1 on cognitive impairment and the possible mechanism,we established the cognitive impairment model in rats through Aβ1-42(2.6μg/μL,5μL)injection and then treated the rats with Rg1(25,50 and 100 mg/kg)administered intragastrically for 4 weeks.We observed that Aβ1-42 could induce spatial learning and memory deficits in rats.Simultaneously,Aβ1-42 injection also resulted in the reduced neuron number in comuammonis 1(CA1)and dentate gyrus(DG)of hippocampus,as well as the increased level of hyperphosphorylatedβ-amyloid precursor protein(APP)at Thr668 site with up-regulation ofβ-APP cleaving enzyme 1(BACE1)and presenilin 1(PS1)and down-regulation of a disintegrin and metalloprotease domain-containing protein 10(ADAM 10)and insulindegrading enzyme(IDE).Administration of Rg1 effectively rescued the cognitive impairment and neuronal loss,and inhibited theβ-secretase processing of APP through reducing APP-Thr668 phosphorylation and BACE1/PS1 expression,and increasing the expression of ADAM 10 and IDE.We concluded that Rg1 might have neuroprotective effects and could promote learning and memory ability,which might be a viable candidate in AD therapy probably through reducing the generation of Aβand increasing the degradation of Aβ. | Shang-zhi LIU Wei CHENG Jia-wei SHAO Yun-fan GU Yi-yi ZHU Qi-jing DONG Si-yu BAI Ping WANG Li LIN | 2019 | Current Medical Science2019，39，2： | 11 |
| 18 | RGB-D salient object detection:A survey显示文摘Salient object detection,which simulates human visual perception in locating the most significant object(s)in a scene,has been widely applied to various computer vision tasks.Now,the advent of depth sensors means that depth maps can easily be captured;this additional spatial information can boost the performance of salient object detection.Although various RGB-D based salient object detection models with promising performance have been proposed over the past several years,an in-depth understanding of these models and the challenges in this field remains lacking.In this paper,we provide a comprehensive survey of RGBD based salient object detection models from various perspectives,and review related benchmark datasets in detail.Further,as light fields can also provide depth maps,we review salient object detection models and popular benchmark datasets from this domain too.Moreover,to investigate the ability of existing models to detect salient objects,we have carried out a comprehensive attribute-based evaluation of several representative RGB-D based salient object detection models.Finally,we discuss several challenges and open directions of RGB-D based salient object detection for future research.All collected models,benchmark datasets,datasets constructed for attribute-based evaluation,and related code are publicly available at http://gffzz188fe103f8f1460asxn9n0ccxfucf605f.ffgz.tsg.suse.edu.cn/taozh2017/RGBD-SODsurvey. | Tao Zhou Deng-Ping Fan Ming-Ming Cheng Jianbing Shen Ling Shao | 2021 | Computational Visual Media2021，7，1： | 11 |
| 19 | Water relations and an expression analysis of plasma membrane intrinsic proteins in sensitive and tolerant rice during chilling and recovery显示文摘寒心的损害的症状是在射击的水赤字的开发,源于水运输和蒸发的不平衡。在这个工作,二个米饭变化(Oryza sativa L。var。Wasetoitsu 和 Somewake ) 幼苗是在 7 度 C 的 chilled,在 28 度 C 由恢复列在后面。基于生长显型和电解质漏测试, Somewake 被显示是一个寒心容忍的变化,和 Wasetoitsu 寒心敏感的。寒心的压力显著地减少了叶子,积聚的蒸发和渗透的根的相对的水内容(RWC ) 在两个变化的水力的电导率(Lp ) 。但是当回到了 28 度 C 时, Somewake 的水关系平衡更好恢复了。所有 11 血浆膜的 mRNA 表示侧面内在的蛋白质(果仁) , aquaporins 的亚群,被有 TaqMan 次要的林子文件夹(MGB ) 的 -PCR 探查的即时反向的抄写(RT ) 随后决定源于米饭 var。Nipponbare 在寒心的处理和恢复期间。大多数 PIP 基因在低温度是下面调整的,并且在温暖的温度恢复了。在 Somewake 和 Wasetoitsu 的一些果仁的相对表示在平行减少了在期间寒心。然而在恢复期间, OsPIP1 的相对表示; 1, OsPIP2; 1, OsPIP2; 7 在射击和 OsPIP1; 1, OsPIP2; 1 比 Wasetoitsu 在 Somewake 在根是显著地更高的。这在在寒心的条件以后重建水平衡支持果仁的角色。我们讨论 aquaporin 果仁亚科的成员在植物起的多样化的作用寒心的忍耐取决于 aquaporin isoforms,植物织物和寒心的持续时间的阶段。 | Xin Yu Yan Hui Peng Min Hua Zhang Yan Jun Shao Wei Ai Su Zhang Cheng Tang | 2006 | Cell Research2006，16，6： | 11 |
| 20 | Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study显示文摘Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion inhibitor.We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs.Methods:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in China.Adults on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks.Non-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,respectively.At 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for non-inferiority.For the per-protocol population,the superiority of albuvirtide over NRTI was demonstrated.The frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride concentration.Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group.Conclusions:The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug.This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure.Trial registration:ClinicalTrials.gov Identifier:NCT02369965;http://gffzz90ed6ce9d87f4798sxn9n0ccxfucf605f.ffgz.tsg.suse.edu.cn Clinical Trial Registry No.ChiCTR-TRC-14004276;http://gffzz62a03ee25e6f4a77hxn9n0ccxfucf605f.ffgz.tsg.suse.edu.cn/enindex.aspx. | Bin Su Cheng Yao Qing-Xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-Huang Zheng Ling-Hua Li Jin-Feng Chen Jian-Hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi Jiang Mei-Xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong Zhang Fu-Jie Zhang Hao Wu TALENT Study Team | 2020 | Chinese Medical Journal2020，，24： | 10 |
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